Journal of Literature Pharmacy Sciences

Peptik Ülser Tedavisinde Kullanılan Bazı Tıbbi ve Aromatik Bitkilerin Farmakognozik Açıdan Değerlendirilmesi: Geleneksel Derleme
Evaluation of Some Medicinal and Aromatic Plants Used in the Treatment of Peptic Ulcer in Terms of Pharmacognosy: Traditional Review
Ecem HESEKİa , Ahsen Sevde ÇINAR KOÇb , Belma KONUKLUGİLb
aLokman Hekim Üniversitesi Eczacılık Fakültesi, Ankara, Türkiye
bLokman Hekim Üniversitesi Eczacılık Fakültesi, Farmasötik Botanik/Farmakognozi ABD, Ankara, Türkiye
J Lit Pharm Sci. 2024;13(1):28-34
doi: 10.5336/pharmsci.2023-98907
Article Language: TR
Full Text
ÖZET
 Fitoterapi terimi, tıbbi bitkilerin hastalıkların tedavi edilmesi ya da tedaviye yardımcı olması amacıyla kullanılması olarak tanımlanmakta ve günümüzde birçok hastalığın tedavi sürecine destek olmak amacıyla kullanılmaktadır. Peptik ülser, dünya popülasyonunun %5- 10'unda yaşam boyunca en az bir kere görülen, mide, duodenum veya özofagusta rastlanan, asit veya pepsinden kaynaklanan bir doku kaybı olarak tanımlanmaktadır. Uygulanan konvansiyonel tedavinin yan etkileri, tedavi maliyeti, Helicobacter pylori'nin antimikrobiyal ilaçlara karşı direnç göstermesi, ülserasyonların tekrarlaması gibi sebeplerden dolayı alternatif tedavi yöntemleri ilgi çekmiş ve tıbbi bitkilerin kullanıldığı tamamlayıcı tedaviler araştırılmaya başlanmıştır. Peptik ülser hastalığının önlemesinde ve/veya tedavi edilmesinde, geleneksel olarak kullanılan bitkiler içinde üzerinde klinik çalışma yapılmış bazı bitkiler Glycyrrhiza glabra, Nigella sativa, Zingiber officinale; üzerinde in vivo çalışma yapılmış bazı bitkiler Allium sativum, Camellia sinensis, Carum carvi, Foeniculum vulgare, Hypericum perforatum, Laurus nobilis, Matricaria chamomilla, Momordica charantia, Melissa officinalis, Mentha piperita, Olea europaea, Thymus vulgaris bu derleme için seçilip değerlendirilmiştir. Bu değerlendirme sonucunda, tıbbi bitkilerin üzerinde yapılan bilimsel araştırmaların sayısında artış olmasına rağmen klinik çalışmalarının kapsamlı şekilde yapılmaması, etki mekanizmalarının aydınlatılmaması, yan etki profillerinin detaylı olarak raporlanmaması gibi eksiklikler nedeniyle tıbbi bitkilerden elde edilen güvenilir preparatların üretilmesinin zorlaştığı belirlenmiştir. Bu eksikliklerin giderilmesiyle birlikte yeni geliştirilecek preparat ve ilaçların hem doğal kaynaklı ilaç hammaddeleri hakkındaki çalışmalara hem de insan sağlığına önemli ölçüde etkisi olacağı düşünülmektedir.

Anahtar Kelimeler: Fitoterapi; tibbi bitkiler; peptik ülser
ABSTRACT
 The term phytotherapy is defined as the use of medicinal plants for the treatment of diseases or to assist treatment and is used today to support the treatment process of many diseases. Peptic ulcer is defined as a tissue loss caused by acid or pepsin, occurring in the stomach, duodenum, or esophagus at least once in a lifetime in 5- 10% of the world population. Alternative treatment methods have attracted attention due to the side effects of conventional treatment, cost of treatment, resistance of Helicobacter pylori to antimicrobial drugs, recurrence of ulcerations and complementary therapies using medicinal plants have begun to be investigated. Some plants that have been clinically studied in the traditionally used plants for the prevention and/or treatment of peptic ulcer disease Glycyrrhiza glabra, Nigella sativa, and Zingiber officinale; some plants on which in vivo studies have been conducted are Allium sativum, Camellia sinensis, Carum carvi, Foeniculum vulgare, Hypericum perforatum, Laurus nobilis, Matricaria chamomilla, Momordica charantia, Melissa officinalis, Mentha piperita, Olea europaea, Thymus vulgaris selected and evaluated for this review. As a result of this evaluation, despite the increase in the number of scientific studies on medicinal plants, it has been determined that it is difficult to produce reliable preparations obtained from medicinal plants due to deficiencies such as clinical studies are not carried out comprehensively, the mechanism of action is not clarified and the side effect profiles are not reported in detail. With the elimination of these deficiencies, it is thought that the new preparations and drugs to be developed will have a significant impact on both the studies on natural origin drug raw materials and human health.

Keywords: Phytotherapy; medicinal plants; peptic ulcer
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5.2. Within hereby "Terms of Use", "Turkiye Klinikleri" reserves the rights for "Turkiye Klinikleri" services, "Turkiye Klinikleri" information, the products associated with "Turkiye Klinikleri" copyrights, "Turkiye Klinikleri" trademarks, "Turkiye Klinikleri" trade looks or its all rights for other entity and information it has through this website unless it is explicitly authorized by "Turkiye Klinikleri".

6. CHANGES IN THE TERMS OF USE

"Turkiye Klinikleri" in its sole discretion may change the hereby "Terms of Use" anytime announcing within the "SITE". The changed terms of the hereby "Terms of Use" will become valid when they are announced. Hereby "Terms of Use" cannot be changed by unilateral declarations of users.

7. FORCE MAJEURE

"Turkiye Klinikleri" is not responsible for executing late or never of this hereby "Terms of Use", privacy policy and "USER Contract" in any situation legally taken into account as force majeure. Being late or failure of performance or non-defaulting of this and similar cases like this will not be the case from the viewpoint of "Turkiye Klinikleri", and "Turkiye Klinikleri" will not have any damage liability for these situations. "Force majeure" term will be regarded as outside of the concerned party's reasonable control and any situation that "Turkiye Klinikleri" cannot prevent even though it shows due diligence. Also, force majeure situations include but not limited to natural disasters, rebellion, war, strike, communication problems, infrastructure and internet failure, power cut and bad weather conditions.

8. LAW AND AUTHORISATION TO FOLLOW

Turkish Law will be applied in practicing, interpreting the hereby "Terms of Use" and managing the emerging legal relationships within this "Terms of Use" in case of finding element of foreignness, except for the rules of Turkish conflict of laws. Ankara Courts and Enforcement Offices are entitled in any controversy happened or may happen due to hereby contract.

9. CLOSING AND AGREEMENT

Hereby "Terms of Use" come into force when announced in the "SITE" by "Turkiye Klinikleri". The users are regarded to agree to hereby contract terms by using the "SITE". "Turkiye Klinikleri" may change the contract terms and the changes will be come into force by specifying the version number and the date of change on time it is published in the "SITE".

 

30.03.2014

Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com