.: OLGU SUNUMU
Submandibular Apse Kaynaklı Cilt Nekrozunun Tedavisinde Trombositten Zengin Fibrin Kullanımı
Use of Platelet Rich Fibrin in the Treatment of Submandibular Abscess-Induced Skin Necrosis
Turkiye Klinikleri J Dental Sci. 2020;26(2):285-90
doi: 10.5336/dentalsci.2018-64430
Makale Dili: TR
Tam Metin
Ücretsiz Erişim
ÖZET
Anatomik vücut boşluğu veya deri yüzeyi ile patolojik bölge arasında bağlantı sağlayan yapıya fistül denir. Odontojenik apseler daha derin dokulara yayılarak fasiyal alanlara yayılabilir. Yüzeyel enfeksiyonlar; "insizyon ve drenaj" ve ampirik antibiyotik kullanımı ile başarılı bir şekilde tedavi edilebilmesine rağmen, daha ciddi enfeksiyonlarda ilk olarak kültür ve antibiyotik duyarlılık testi yapılmalıdır. Trombositten Zengin Fibrin (TZF)'de bulunan ve TZF'ye immün özellik kazandırarak savunmada rol oynayan interlökin (IL)-1β, IL-6, IL-4 ve tümör nekrozis faktör-alfa (TNF-α) gibi sitokinler, TZF'nin, immün sistemdeki destekleyici etkisiyle savunma mekanizmasını stimüle edebileceğini ve yumuşak doku yara iyileşmesinde önem taşıyabileceğini göstermektedir. Bu çalışmada, odontojenik apse kaynaklı ekstaoral fistül yolu ve nekrotik alanın elde edilen kültür ve antibiyogram duyarlılık testi sonucu antibiyoterapi ve TZF ile tedavisinin özetlenmesi amaçlanmıştır.
Anahtar Kelimeler: Trombositten zengin fibrin; nekroz; yara iyileşmesi
Anatomik vücut boşluğu veya deri yüzeyi ile patolojik bölge arasında bağlantı sağlayan yapıya fistül denir. Odontojenik apseler daha derin dokulara yayılarak fasiyal alanlara yayılabilir. Yüzeyel enfeksiyonlar; "insizyon ve drenaj" ve ampirik antibiyotik kullanımı ile başarılı bir şekilde tedavi edilebilmesine rağmen, daha ciddi enfeksiyonlarda ilk olarak kültür ve antibiyotik duyarlılık testi yapılmalıdır. Trombositten Zengin Fibrin (TZF)'de bulunan ve TZF'ye immün özellik kazandırarak savunmada rol oynayan interlökin (IL)-1β, IL-6, IL-4 ve tümör nekrozis faktör-alfa (TNF-α) gibi sitokinler, TZF'nin, immün sistemdeki destekleyici etkisiyle savunma mekanizmasını stimüle edebileceğini ve yumuşak doku yara iyileşmesinde önem taşıyabileceğini göstermektedir. Bu çalışmada, odontojenik apse kaynaklı ekstaoral fistül yolu ve nekrotik alanın elde edilen kültür ve antibiyogram duyarlılık testi sonucu antibiyoterapi ve TZF ile tedavisinin özetlenmesi amaçlanmıştır.
Anahtar Kelimeler: Trombositten zengin fibrin; nekroz; yara iyileşmesi
ABSTRACT
The structure that provides connection between the anatomical body cavity or the skin surface and the pathological region is called fistula. Odontogenic abscesses may spread to the deeper tissues and spread to the facial areas. Superficial infections; Although it can be successfully treated with incision, drainage and empirical antibiotic use, culture and antibiotic susceptibility testing should be performed in more severe infections. Cytokines such as interleukin (IL)-1β, IL-6, IL-4, and tumor necrosis factor-alpha (TNF-α), which play a role in defenses by introducing Platelet Rich Fibrin-PRF to immune function, can stimulate the defense mechanism of PRF with its supportive effect in the immune system and shows that can be important in wound healing. In this study, it was aimed to summarize the treatment with antibiotherapy which result of the culture and antibiogram susceptibility and PRF as a test of the necrosis field and extraoral fistula path originating from odontogenic abscess.
Keywords: Platelet-rich fibrin; necrosis; wound healing
The structure that provides connection between the anatomical body cavity or the skin surface and the pathological region is called fistula. Odontogenic abscesses may spread to the deeper tissues and spread to the facial areas. Superficial infections; Although it can be successfully treated with incision, drainage and empirical antibiotic use, culture and antibiotic susceptibility testing should be performed in more severe infections. Cytokines such as interleukin (IL)-1β, IL-6, IL-4, and tumor necrosis factor-alpha (TNF-α), which play a role in defenses by introducing Platelet Rich Fibrin-PRF to immune function, can stimulate the defense mechanism of PRF with its supportive effect in the immune system and shows that can be important in wound healing. In this study, it was aimed to summarize the treatment with antibiotherapy which result of the culture and antibiogram susceptibility and PRF as a test of the necrosis field and extraoral fistula path originating from odontogenic abscess.
Keywords: Platelet-rich fibrin; necrosis; wound healing
REFERANSLAR:
- Altuntaş Z, Gündeşlioğlu AÖ, İnce B, Dadacı M, Savacı N. [Platelet rich plasma (PRP), platelet poor plasma (PPP), plateler rich fibrine (PRF) concepts, their biological roles on woung healing and clinical applications in plastıc surgery]. Turk J Plast Surg. 2014;22(2):49-53.
- Goss JR. Rejeneration versusu repair. In: Cohen IK, Diegelman Lindblad WJ, eds. Wound Healing, Biochemical and Clinical Aspects. 1st ed. Philadelphia: WB Saunders; 1992. p.40-62.
- Linden MD, Jackson DE. Platelets: pleiotropic roles in atherogenesis and atherothrombosis. Int J Biochem Cell Biol. 2010;42(11):1762-6. [Crossref] [PubMed]
- Thushara RM, Hemshekhar M, Basappa, Kemparaju K, Rangappa KS, Girish KS. Biologicals, platelet apoptosis and human diseases: an outlook. Crit Rev Oncol Hematol. 2015;93(3):149-58. [Crossref] [PubMed]
- Barrientos S, Brem H, Stojadinovic O, Tomic-Canic M. Clinical application of growth factors and cytokines in wound healing. Wound Repair Regen. 2014;22(5):569-78. [Crossref] [PubMed] [PMC]
- Page-McCaw A, Ewald AJ, Werb Z. Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol. 2007;8(3):221-33. [Crossref] [PubMed] [PMC]
- Dohan Ehrenfest DM, de Peppo GM, Doglioli P, Sammartino G. Slow release of growth factors and thrombospondin-1 in Choukroun's platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors. 2009;27(1):63-9. [Crossref] [PubMed]
- Sclafani AP. Applications of platelet-rich fibrin matrix in facial plastic surgery. Facial Plast Surg. 2009;25(4):270-6. [Crossref] [PubMed]
- Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101(3):e51-5. [Crossref] [PubMed]
- Passaretti F, Tia M, D'Esposito V, De Pascale M, Del Corso M, Sepulveres R, et al. Growthpromoting action and growth factor release by different platelet derivatives. Platelets. 2014;25(4):252-6. [Crossref] [PubMed]
- Eren G, Atilla G. [The role of platelet rich fibrin in soft and hard tissue wound healing mechanisms]. Turkiye Klinikleri J Periodontol-Special Topics. 2017;3(3):122-8.
- Langlais PR, Bricker SL, Cottone AJ, Baker BR. Oral diagnosis, oral medicine and treatment planning. Wood NK, Goaz PW, eds. Solitary Oral Ulcers and Fissures. 1st ed. Philadelphia: Saunders; 1984. p.179-80.
- McWalter GM, Alexander JB, del Rio CE, Knott JW. Cutaneous sinus tracts of dental etiology. Oral Surg Oral Med Oral Pathol. 1988;66(5):608-14. [Crossref]
- Cohen S, Burns RC. Pathways of the pulp. Lous H, ed. Diagnosis. 7th ed. St. Louis: Mosby; 2002. p.26.
- Kaban LB. Draining skin lesions of dental origin: the path of spread of chronic odontogenic infection. Plast Reconstr Surg. 1980;66(5): 711-7. [Crossref] [PubMed]
- Williams BL, McCann GF, Schoenknecht FD. Bacteriology of dental abscesses of endodontic origin. J Clin Microbiol, 1983;18(4):770-4. [Crossref] [PubMed] [PMC]
- Goldberg MH. Topazian RG. Odontogenic infections and deep fascial space infections of dental origin. In: Topazian RG, Goldberg MH, Hupp JR, et al. Oral and Maxillofacial Infections. 4th ed. Philadelphia: WB Saunders; 2002. p.158-87.
- Venugopal A, Pace C, Word S. Management of acute dentoalveolar abscess and potential facial space infection- an evidence based approach. J Bjoms. 2009;47(7):e66. [Crossref]
- Vieira F, Allen SM, Stocks RM, Thompson JW. Deep neck infection. Otolaryngol Clin North Am. 2008;41(3):459-83. [Crossref] [PubMed]
- Williams TP. Surgical pathology. In: Fonseca RJ, eds. Oral and Maxillofacial Surgery. 5th ed. Philadelphia: Saunders; 2000. p.77-117.
- Peker E, Karaca İR. [Fascial space abscess originating from odontogenic infections]. GÜ Diş Hek Fak Derg. 2012;29(2):129-137.
- Siqueira Jr JF, Rôças IN. Microbiology and treatment of acute apical abscesses. Clin Microbiol Rev. 2013;26(2):255-73. [Crossref] [PubMed] [PMC]
- Lewis MA, Carmichael F, MacFarlane TW, Milligan SG. A randomised trial of co-amoxiclav (Augmentin) versus penicillin V in the treatment of acute dentoalveolar abscess. Br Dent J. 1993;175(5):169-74. [Crossref] [PubMed]
- Kuriyama T, Absi EG, Williams DW, Lewis M. An outcome audit of the treatment of acute dentoalveolar infection: impact of penicillin resistance. Br Dent J. 2005;198(12):759-63. [Crossref] [PubMed]
- Gill Y, Scully C. Orofacial odontogenic infections: review of microbiology and current treatment. Oral Surg Oral Med Oral Pathol. 1990;70(2):155-8. [Crossref]
- Daramola OO, Flanagan CE, Maisel RH, Odland RM. Diagnosis and treatment of deep neck space abscesses. Otolaryngol Head Neck Surg. 2009;141(1):123-30. [Crossref] [PubMed]
- Sculean A, Gruber R, Bosshardt DD. Soft tissue wound healing around teeth and dental implants. J Clin Periodontol. 2014;41 Suppl 15:S6-22. [Crossref] [PubMed]
- Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M. Growth factors and cytokines in wound healing. Wound Repair Regen. 2008;16(5):585-601. [Crossref] [PubMed]
- Miron RJ, Fujioka-Kobayashi M, Bishara M, Zhang Y, Hernandez M, Choukroun J. Platelet-rich fibrin and soft tissue wound healing: a systematic review. Tissue Eng Part B Rev. 2017;23(1):83-99. [Crossref] [PubMed]
- Tsai CH, Shen SY, Zhao JH, Chang YC. Platelet-rich fibrin modulates cell proliferation of human periodontally related cells in vitro. J Dent Sci. 2009;4(3):130-5. [Crossref]
.: İşlem Listesi