Turkiye Klinikleri Journal of Dental Sciences

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Submandibular Apse Kaynaklı Cilt Nekrozunun Tedavisinde Trombositten Zengin Fibrin Kullanımı
Use of Platelet Rich Fibrin in the Treatment of Submandibular Abscess-Induced Skin Necrosis
Ümit ERTAŞa, Yunus Emre AŞÇIa, Mustafa Seçkin YAZARa
aAtatürk Üniversitesi Diş Hekimliği Fakültesi, Ağız Diş Çene Cerrahisi ABD, Erzurum, TÜRKİYE
Turkiye Klinikleri J Dental Sci. 2020;26(2):285-90
doi: 10.5336/dentalsci.2018-64430
Article Language: TR
Full Text
ÖZET
 Anatomik vücut boşluğu veya deri yüzeyi ile patolojik bölge arasında bağlantı sağlayan yapıya fistül denir. Odontojenik apseler daha derin dokulara yayılarak fasiyal alanlara yayılabilir. Yüzeyel enfeksiyonlar; "insizyon ve drenaj" ve ampirik antibiyotik kullanımı ile başarılı bir şekilde tedavi edilebilmesine rağmen, daha ciddi enfeksiyonlarda ilk olarak kültür ve antibiyotik duyarlılık testi yapılmalıdır. Trombositten Zengin Fibrin (TZF)'de bulunan ve TZF'ye immün özellik kazandırarak savunmada rol oynayan interlökin (IL)-1β, IL-6, IL-4 ve tümör nekrozis faktör-alfa (TNF-α) gibi sitokinler, TZF'nin, immün sistemdeki destekleyici etkisiyle savunma mekanizmasını stimüle edebileceğini ve yumuşak doku yara iyileşmesinde önem taşıyabileceğini göstermektedir. Bu çalışmada, odontojenik apse kaynaklı ekstaoral fistül yolu ve nekrotik alanın elde edilen kültür ve antibiyogram duyarlılık testi sonucu antibiyoterapi ve TZF ile tedavisinin özetlenmesi amaçlanmıştır.

Anahtar Kelimeler: Trombositten zengin fibrin; nekroz; yara iyileşmesi
ABSTRACT
 The structure that provides connection between the anatomical body cavity or the skin surface and the pathological region is called fistula. Odontogenic abscesses may spread to the deeper tissues and spread to the facial areas. Superficial infections; Although it can be successfully treated with incision, drainage and empirical antibiotic use, culture and antibiotic susceptibility testing should be performed in more severe infections. Cytokines such as interleukin (IL)-1β, IL-6, IL-4, and tumor necrosis factor-alpha (TNF-α), which play a role in defenses by introducing Platelet Rich Fibrin-PRF to immune function, can stimulate the defense mechanism of PRF with its supportive effect in the immune system and shows that can be important in wound healing. In this study, it was aimed to summarize the treatment with antibiotherapy which result of the culture and antibiogram susceptibility and PRF as a test of the necrosis field and extraoral fistula path originating from odontogenic abscess.

Keywords: Platelet-rich fibrin; necrosis; wound healing
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