.: ORİJİNAL ARAŞTIRMA
Psödoeksfoliasyonlu Hastalarda Retina Sinir Lifi Kalınlığı ve Koroid Kalınlığının İncelemesi
Evaluation of Retinal Nerve Fiber Layer Thickness and Choroidal Thickness in Pseudoexfoliation Cases
Turkiye Klinikleri J Ophthalmol. 2019;28(2):86-90
doi: 10.5336/ophthal.2018-61345
Makale Dili: TR
Tam Metin
ÖZET
Amaç: Psödoeksfoliasyon sendromu (PES) ve psödoeksfoliasyon glokomu (PEG) olan hastalarda retina sinir lifi kalınlığı (RSLK) ve koroid kalınlığı (KK) ölçümlerinin sağlıklı bireylerle karşılaştırılmasıdır. Gereç ve Yöntemler: Psödoeksfoliasyon sendromu olan 12 hastanın 23 gözü (grup 1), psödoeksfoliasyon glokomu olan 15 hastanın 29 gözü (grup 2) ve benzer yaş dağılımına sahip 26 sağlıklı bireyin 52 gözü (grup 3) çalışma kapsamına alındı. Tüm hastalara pupiller dilatasyon sonrası optik koherens tomografi cihazı (Cirrus SD OKT) ile RSLK ölçümleri (ortalama ve kadran) ve KK ölçümleri (subfoveal, nazal 500 μm, 1.500 μm, 2.000 μm ve temporal 500 μm, 1.500 μm, 2.000 μm) yapılarak sonuçlar kaydedildi. Veriler istatistiksel olarak karşılaştırıldı. İstatistiksel anlamlılık sınırı p<0,05 olarak kabul edildi. Bulgular: Grup 2 RSLK ortalama ve kadran ölçümleri (süperior, inferior, nazal, temporal) ve KK ölçüm değerleri (subfoveal, nasal 500 μm, 1.500 μm, 2.000 μm ve temporal 500 μm, 1.500 μm, 2.000 μm) kontrol grubu (grup 3) ile karşılaştırıldığında, tüm parametrelerde istatistiksel olarak anlamlı farklılık saptandı. Grup 1 verileri grup 3 ile mukayese edildiğinde ise, RSLK değerlerinde nazal ve temporal kadran hariç, diğer tüm parametrelerde anlamlı farklılık bulundu. Sonuç: Psödoeksfoliasyon glokomu olan hastalarda sağlıklı bireylere göre RSLK ve KK daha ince saptandı. Psödoeksfoliasyon sendromu olan hastalarda ise RSLK'nin nazal ve temporal kadranları hariç diğer tüm parametreler açısından anlamlı incelme belirlendi.
Anahtar Kelimeler: Psödoeksfoliasyon glokom; retina sinir lifi kalınlığı; koroid kalınlığı, optik koherens tomografi
Amaç: Psödoeksfoliasyon sendromu (PES) ve psödoeksfoliasyon glokomu (PEG) olan hastalarda retina sinir lifi kalınlığı (RSLK) ve koroid kalınlığı (KK) ölçümlerinin sağlıklı bireylerle karşılaştırılmasıdır. Gereç ve Yöntemler: Psödoeksfoliasyon sendromu olan 12 hastanın 23 gözü (grup 1), psödoeksfoliasyon glokomu olan 15 hastanın 29 gözü (grup 2) ve benzer yaş dağılımına sahip 26 sağlıklı bireyin 52 gözü (grup 3) çalışma kapsamına alındı. Tüm hastalara pupiller dilatasyon sonrası optik koherens tomografi cihazı (Cirrus SD OKT) ile RSLK ölçümleri (ortalama ve kadran) ve KK ölçümleri (subfoveal, nazal 500 μm, 1.500 μm, 2.000 μm ve temporal 500 μm, 1.500 μm, 2.000 μm) yapılarak sonuçlar kaydedildi. Veriler istatistiksel olarak karşılaştırıldı. İstatistiksel anlamlılık sınırı p<0,05 olarak kabul edildi. Bulgular: Grup 2 RSLK ortalama ve kadran ölçümleri (süperior, inferior, nazal, temporal) ve KK ölçüm değerleri (subfoveal, nasal 500 μm, 1.500 μm, 2.000 μm ve temporal 500 μm, 1.500 μm, 2.000 μm) kontrol grubu (grup 3) ile karşılaştırıldığında, tüm parametrelerde istatistiksel olarak anlamlı farklılık saptandı. Grup 1 verileri grup 3 ile mukayese edildiğinde ise, RSLK değerlerinde nazal ve temporal kadran hariç, diğer tüm parametrelerde anlamlı farklılık bulundu. Sonuç: Psödoeksfoliasyon glokomu olan hastalarda sağlıklı bireylere göre RSLK ve KK daha ince saptandı. Psödoeksfoliasyon sendromu olan hastalarda ise RSLK'nin nazal ve temporal kadranları hariç diğer tüm parametreler açısından anlamlı incelme belirlendi.
Anahtar Kelimeler: Psödoeksfoliasyon glokom; retina sinir lifi kalınlığı; koroid kalınlığı, optik koherens tomografi
ABSTRACT
Objective: To compare retinal nerve fiber layer thickness (RNFLT) and choroidal thickness (CT) measurement in eyes with pseudoexfoliation syndrome, pseudoexfoliation glaucoma and healthy control subjects. Material and Methods: Twenty three eyes of 12 patients with pseudoexfoliative syndrome (group 1), 29 eyes of 15 patients with pseudoexfoliative glaucoma (group 2), and 52 healty eyes of 26 healthy subjects in the similar age (group 3) were in the study. RNLFT (average and quadrants) and CT (subfoveal, nasal 500 μm, 1.500 μm, 2.000 μm and temporal 500 μm, 1.500 μm, 2.000 μm) were measured by using Cirrus SD OCT. Data was compared statistically and p value of <0,05 was accepted as significant level. Results: When group 2 was compared with control group (group 3) in terms of average and quadrants RNFLT measurement and CT (subfoveal, nasal 500 μm, 1500 μm, 2000 μm and temporal 500 μm, 1.500 μm, 2.000 μm) measurement, a significant difference was determined statistically in all parameters (p<0.05). Group 1 was compared with group 3 and a significant difference was determined in all parameters excluding RNFLT values in nasal and temporal quadrants. Conclusion: Compared to healty individuals, RNFLT and CT measurement were more thin in the case of pseudoexfoliative glaucoma. However in the case of pseudoexfoliation syndrome, a significant thining was determined in all parameters excluding nasal and temporal quadrants RNFLT values.
Keywords: Pseudoexfoliation glaucoma; retinal neve fiber thickness; choroid thickness, optic coherence tomography
Objective: To compare retinal nerve fiber layer thickness (RNFLT) and choroidal thickness (CT) measurement in eyes with pseudoexfoliation syndrome, pseudoexfoliation glaucoma and healthy control subjects. Material and Methods: Twenty three eyes of 12 patients with pseudoexfoliative syndrome (group 1), 29 eyes of 15 patients with pseudoexfoliative glaucoma (group 2), and 52 healty eyes of 26 healthy subjects in the similar age (group 3) were in the study. RNLFT (average and quadrants) and CT (subfoveal, nasal 500 μm, 1.500 μm, 2.000 μm and temporal 500 μm, 1.500 μm, 2.000 μm) were measured by using Cirrus SD OCT. Data was compared statistically and p value of <0,05 was accepted as significant level. Results: When group 2 was compared with control group (group 3) in terms of average and quadrants RNFLT measurement and CT (subfoveal, nasal 500 μm, 1500 μm, 2000 μm and temporal 500 μm, 1.500 μm, 2.000 μm) measurement, a significant difference was determined statistically in all parameters (p<0.05). Group 1 was compared with group 3 and a significant difference was determined in all parameters excluding RNFLT values in nasal and temporal quadrants. Conclusion: Compared to healty individuals, RNFLT and CT measurement were more thin in the case of pseudoexfoliative glaucoma. However in the case of pseudoexfoliation syndrome, a significant thining was determined in all parameters excluding nasal and temporal quadrants RNFLT values.
Keywords: Pseudoexfoliation glaucoma; retinal neve fiber thickness; choroid thickness, optic coherence tomography
REFERANSLAR:
- Ritch R, Schlötzer-Schrehardt U. Exfoliation syndrome. Surv Ophthalmol. 2001;45(4):265-315. [Crossref]
- Ritch R. Systemic associations of exfoliation syndrome. Asia Pac J Ophthalmol (Phila). 2016;5(1): 45-50. [Crossref] [PubMed]
- Meyer E, Haim T, Zonis S, Gidoni O, Gitay H, Levanon D, et al. Pseudoexfoliation: epidemiology, clinical and scanning electron microscopic study. Ophthalmologica. 1984;188(3):141-7. [Crossref] [PubMed]
- Naumann GO, Schlötzer-Schrehardt U, Küchle M. Pseudoexfoliation syndrome for the comprehensive ophthalmologist. Intraocular and systemic manifestations. Ophthalmology. 1998;105(6):951-68. [Crossref]
- Streeten BW, Li ZY, Wallace RN, Eagle RC Jr, Keshgegian AA. Pseudoexfoliative fibrillopathy in visceral organs of a patient with pseudoexfoliation syndrome. Arch Ophthalmol. 1992;110(12):1757-62. [Crossref] [PubMed]
- Plateroti P, Plateroti AM, Abdolrahimzadeh S, Scuderi G. Pseudoexfoliation syndrome and pseudoexfoliation glaucoma: a review of the literature with updates on surgical management. J Ophthalmol. 2015;2015:370371. [Crossref][PubMed][PMC]
- Ritch R. Exfoliation syndrome-the most common identifiable cause of open-angle glaucoma. J Glaucoma. 1994;3(2):176-7. [Crossref][PubMed]
- Puska PM. Unilateral exfoliation syndrome: conversion to bilateral exfoliation and to glaucoma: a prospective 10-year follow-up study. J Glaucoma. 2002;11(6):517-24. [Crossref][PubMed]
- Sarıcaoğlu MS, Mısır R, Karakurt A, Hasiripi H. [The analysis of retinal nerve fiber layer thicknesses in patients with ocular hypertension and open angle glaucoma]. Glo-Kat. 2011;6(2):92-6.
- Saricaoglu MS, Karakurt A, Hamurcu, Ekicier S. Comparison of the ganglion cell complex and retinal nerve fiber layer thickness in pseudoexfoliation syndrome, pseudoexfoliation glaucoma and healthy subjects. New Frontiers in Ophthalmol. 2017;3(4):1-4. [Crossref]
- Yüksel N, Karabaş VL, Arslan A, Demirci A, Cağlar Y. Ocular hemodynamics in pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Ophthalmology. 2001;108(6):1043-9. [Crossref]
- Gugleta K, Polunina A, Kochkorov A, Waldmann N, Portmann N, Katamay R, et al. Association between risk factors and glaucomatous damage in untreated primary open-angle glaucoma. J Glaucoma. 2013;22(6):501-5. [Crossref][PubMed]
- Yiu G. Advances in choroidal imaging with EDIOCT. Retina Today. 2014;82-5.
- Ruiz-Medrano J, Flores-Moreno I, Peña-García P, Montero JA, Duker JS, Ruiz-Moreno JM. Macular choroidal thickness profile in a healthy population measured by swept-source optical coherence tomography. Invest Ophthalmol Vis Sci. 2014;55(6): 3532-42. [Crossref] [PubMed]
- Nawaz S, Akbar E, Querishi T, Afzal A. Measurement of choroidal thickness in patients of pseudoexfoliation syndrome using spectral domain optical coherence tomography. Ophthalmology Research: An International Journal. 2016;5(2):1-7. [Crossref] [PMC]
- Zengin MO, Cinar E, Karahan E, Tuncer I, Yilmaz S, Kocaturk T, et al. Choroidal thickness changes in patients with pseudoexfoliation syndrome. Int Ophthalmol. 2015;35(4):513-7. [Crossref][PubMed]
- Ozge G, Koylu MT, Mumcuoglu T, Gundogan FC, Ozgonul C, Ayyildiz O, et al. Evaluation of retinal nerve fiber layer thickness and choroidal thickness in pseudoexfoliative glaucoma and pseudoexfoliative syndrome. Postgrad Med. 2016;128(4):444-8. [Crossref] [PubMed]
- Demircan S, Yilmaz U, Küçük E, Ulusoy MD, Ataş M, Gülhan A, et al. The effect of pseudoexfoliation syndrome on the retinal nerve fiber layer and choroid thickness. Semin Ophthalmol. 2016;32(3): 341-7. [Crossref] [PubMed]
- Mohamed MM. Detection of early glaucomatous damage in pseudoexfoliation syndrome by assessment of retinal nerve fiber layer thickness. Middle East Afr J Ophthalmol. 2009;16(3):141-5. [Crossref] [PubMed][PMC]
- Goktas S, Sakarya Y, Ozcimen M, Sakarya R, Bukus A, Ivacik IS, et al. Choroidal thinning in pseudoexfoliation syndrome detected by enhanced depth imaging optical coherence tomography. Eur J Ophthalmol. 2014;24(6):879-84. [Crossref] [PubMed]
- Bayhan HA, Bayhan SA, Can İ. Evaluation of the macular choroidal thickness using spectral optical coherence tomography in pseudoexfoliation glaucoma. J Glaucoma. 2016;25(2):184-7. [Crossref][PubMed]
- Sahinoglu-Keskek N, Canan H. Effect of latanoprost on choroidal thickness. J Glaucoma. 2018;27(7):635-7. [Crossref][PubMed]
- Maul EA, Friedman DS, Chang DS, Boland MV, Ramulu PY, Jampel HD, et al. Choroidal thickness measured by spectral domain optical coherence tomography: factors affecting thickness in glaucoma patients. Ophthalmology. 2011;118(8): 1571-9. [Crossref][PubMed] [PMC]
- Akyol N, Kalkisim A, Turk A, Kola M, Imamoglu HI. Evaluation of the effects on choroidal thickness of bimatoprost 0.03% versus a brinzolamide 1.0%/timolol maleate 0.5% fixed combination. Cutan Ocul Toxicol. 2017;36(4):397-403. [Crossref][PubMed]
.: İşlem Listesi