Kurkumin; kurkumin (diferuloilmetan) (%77), demetoksikurkumin (%17) ve bisdemethoksikurkumin (%3) olmak üzere Curcuma longa (zerdeçal) bitkisinin kökünden elde edilen doğal bir üründür. Diyabet, bozulmuş glukoz seviyesi ile devam eden metabolik bir hastalık olarak tanımlanmaktadır. Dünya nüfusunun artması ile Tip 2 diyabet görülme sıklığındaki artış ilişkilidir. 2040 yılında toplam dünya nüfusunun %13,5'i kadarının diyabetli olacağı tahmin edilmektedir. Diyabet ve diyabetin komplikasyonları sonucu sadece 2012 yılında 1,5 milyon insan ölmüştür. Dünya çapında büyük bir prevalansı olan diyabet ve komplikasyonları ile baş edebilmek için etkili önleme yöntemleri gereklidir. Bu yöntemlerden birsi de kurkumin takviyesi yapılmasıdır. Biyoyararlanım, besin takviyesi olarak kurkumin kullanımında ana konudur. Kurkuminin vücuttan hızlıca atılması ve gastrointestinal sistemden az miktarda absorbe edilememesi biyoyarlanımını ve farmakokinetik etkilerini sınırlamaktadır. Birçok çalışmada, kurkuminin biyoyararlanımının azlığından bahsedilmektedir ve bu yararlanma oranın artırılması için multidisipliner çalışmalara ihtiyaç olduğu belirtilmektedir. Geleneksel Çin tıbbından bu yana yapılan çalışmalarda; kurkuminin antikanser, antiinflamatuar, antioksidan gibi etkileri olan bir fitokimyasal olduğu belirtilmektedir. Kurkumin insülin direnci, hiperglisemi, hiperlipidemi ve adacık apoptozu ve nekrozu gibi diyabetin önde gelen komplikasyonlarının çoğunu olumlu şekilde etkilediği araştırmalarda gösterilmektedir. Kurkuminin klinik çalışmalarından elde edilen sonuçlarına göre diyabetik nefropati, mikroanjiyopati ve retinopatiyi tedavi etmek için etkili bir ajan olduğu gösterilmiştir. Ancak kurkumin ile ilgili yapılan çalışmaların çok azı diyabet ve komplikasyonları üzerine odaklanmıştır. Bu derlemenin amacı, kurkuminin diyabet ve komplikasyonlarını önlemek için kullanılabilirliğini incelemektir.
Anahtar Kelimeler: Kurkumin; diyabet; retinopati; nöropati; demetoksikurkumin; diyabetin komplikasyonları
Curcumin; Curcuma (turmeric) is a natural product obtained from the root of the Curcuma Longa (turmeric) plant, which is curcumin (diferuloylmethane) (77%), demetoxicurcumin (17%) and bisdemethoxycurcumin (3%). Diabetes is defined as a metabolic disease that continues with impaired glucose level. The increase in the world population is associated with an increase in the frequency of type 2 diabetes. It is estimated that 13.5% of the total world population will have diabetes in 2040. As a result of diabetes and its complications, 1.5 million people died in 2012 alone. Effective prevention methods are necessary to deal with diabetes and its complications, which is a major prevalence worldwide. One of these methods is to make curcumin supplements. Bioavailability is the main issue in the use of curcumin as a nutritional supplement. The rapid removal of curcumin from the body and its low absorption from the gastrointestinal tract limits its bioavailability and pharmacokinetic effects. In many studies, the low bioavailability of curcumin is mentioned and it is stated that multidisciplinary studies are needed to increase this utilization rate. In studies conducted since traditional Chinese medicine, curcumin is stated to be a phytochemical with effects such as anti cancer, anti-inflammatory and antioxidant. Studies show that curcumin has positive effects on many of the leading complications of diabetes, such as insulin resistance, hyperglycemia, hyperlipidemia, and islet apoptosis and necrosis. Curcumin has been shown to be an effective agent to treat diabetic nephropathy, microangiopathy and retinopathy, according to results from clinical trials. However, few studies of curcumin have focused on diabetes and its complications. The aim of this review is to examine the usability of curcumin to prevent diabetes and its complications.
Keywords: Curcumin; diabetes; retinopathy; neuropathy; demethoxycurcumin; diabetes complications
- Rashid K, Chowdhury S, Ghosh S, Sil PC. Curcumin attenuates oxidative stress induced NFκB mediated inflammation and endoplasmic reticulum dependent apoptosis of splenocytes in diabetes. Biochem Pharmacol. 2017;143:140-55. [Crossref] [PubMed]
- Cicero AFG, Sahebkar A, Fogacci F, Bove M, Giovannini M, Borghi C. Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial. Eur J Nutr. 2020;59(2):477-83. [Crossref] [PubMed] [PMC]
- Su LQ, Wang YD, Chi HY. Effect of curcumin on glucose and lipid metabolism, FFAs and TNF-α in serum of type 2 diabetes mellitus rat models. Saudi J Biol Sci. 2017;24(8):1776-80. [Crossref] [PubMed] [PMC]
- Zhang DW, Fu M, Gao SH, Liu JL. Curcumin and diabetes: a systematic review. Evid Based Complement Alternat Med. 2013;2013:636053. [Crossref] [PubMed] [PMC]
- Ghosh S, Banerjee S, Sil PC. The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update. Food Chem Toxicol. 2015;83:111-24. [Crossref] [PubMed]
- Radomska-Leśniewska DM, Osiecka-Iwan A, Hyc A, Góźdź A, Dąbrowska AM, Skopiński P. Therapeutic potential of curcumin in eye diseases. Cent Eur J Immunol. 2019;44(2):181-9. [Crossref] [PubMed] [PMC]
- Lv J, Cao L, Zhang R, Bai F, Wei P. A curcumin derivative J147 ameliorates diabetic peripheral neuropathy in streptozotocin (STZ)-induced DPN rat models through negative regulation AMPK on TRPA1. Acta Cir Bras. 2018;33(6):533-41. [Crossref] [PubMed]
- Rivera-Mancía S, Lozada-García MC, Pedraza-Chaverri J. Experimental evidence for curcumin and its analogs for management of diabetes mellitus and its associated complications. Eur J Pharmacol. 2015 ;756:30-7. [Crossref] [PubMed]
- Jeenger MK, Shrivastava S, Yerra VG, Naidu VG, Ramakrishna S, Kumar A. Curcumin: a pleiotropic phytonutrient in diabetic complications. Nutrition. 2015;31(2):276-82. [Crossref] [PubMed]
- Roxo DF, Arcaro CA, Gutierres VO, Costa MC, Oliveira JO, Lima TFO, et al. Curcumin combined with metformin decreases glycemia and dyslipidemia, and increases paraoxonase activity in diabetic rats. Diabetol Metab Syndr. 2019;11:33. [Crossref] [PubMed] [PMC]
- Jiang CS, Liang LF, Guo YW. Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades. Acta Pharmacol Sin. 2012;33(10):1217-45. [Crossref] [PubMed] [PMC]
- Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care. 2012;35(11):2121-7. [Crossref] [PubMed] [PMC]
- Akolade JO, Oloyede HOB, Onyenekwe PC. Encapsulation in chitosan-based polyelectrolyte complexes enhances antidiabetic activity of curcumin. J Funct Foods. 2017;35:584-94. [Crossref]
- Sunagawa Y, Katanasaka Y, Hasegawa K, Morimoto T. Clinical applications of curcumin. PharmaNutrition. 2015;3(4):131-5. [Crossref]
- Shehzad A, Ha T, Subhan F, Lee YS. New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases. Eur J Nutr. 2011;50(3):151-61. [Crossref] [PubMed]
- Vickers NJ. Animal communication: when i'm calling you, will you answer too? Curr Biol. 2017;27(14):R713-R715. [Crossref] [PubMed]
- Saraf-Bank S, Ahmadi A, Paknahad Z, Maracy M, Nourian M. Effects of curcumin on cardiovascular risk factors in obese and overweight adolescent girls: a randomized clinical trial. Sao Paulo Med J. 2019;137(5):414-22. [Crossref] [PubMed]
- Akbari M, Lankarani KB, Tabrizi R, Ghayour-Mobarhan M, Peymani P, Ferns G, et al. The effects of curcumin on weight loss among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Front Pharmacol. 2019;10:649. [Crossref] [PubMed] [PMC]
- Baziar N, Parohan M. The effects of curcumin supplementation on body mass index, body weight, and waist circumference in patients with nonalcoholic fatty liver disease: A systematic review and dose-response meta-analysis of randomized controlled trials. Phytother Res. 2020;34(3):464-74. [Crossref] [PubMed]
- Seo KI, Choi MS, Jung UJ, Kim HJ, Yeo J, Jeon SM,et al Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice. Mol Nutr Food Res. 2008;52(9):995-1004. [Crossref] [PubMed]
- Poolsup N, Suksomboon N, Kurnianta PDM, Deawjaroen K. Effects of curcumin on glycemic control and lipid profile in prediabetes and type 2 diabetes mellitus: A systematic review and meta-analysis. PLoS One. 2019;14(4):e0215840. Retraction in: PLoS One. 2020;15(5):e0233919. [Crossref] [PubMed] [PMC]
- Pivari F, Mingione A, Brasacchio C, Soldati L. Curcumin and type 2 diabetes mellitus: prevention and treatment. Nutrients. 2019;11(8):1837. [Crossref] [PubMed] [PMC]
- Hodaei H, Adibian M, Nikpayam O, Hedayati M, Sohrab G. The effect of curcumin supplementation on anthropometric indices, insulin resistance and oxidative stress in patients with type 2 diabetes: a randomized, double-blind clinical trial. Diabetol Metab Syndr. 2019;11:41. [Crossref] [PubMed] [PMC]
- Karlowicz-Bodalska K, Han S, Freier J, Smolenski M, Bodalska A. Curcuma longa as medicinal herb in the treatment of diabet-ic complications. Acta Pol Pharm. 2017;74(2):605-10. [PubMed]
- Azhdari M, Karandish M, Mansoori A. Metabolic benefits of curcumin supplementation in patients with metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2019;33(5):1289-301. [Crossref] [PubMed]
- Lu X, Wu F, Jiang M, Sun X, Tian G. Curcumin ameliorates gestational diabetes in mice partly through activating AMPK. Pharm Biol. 2019;57(1):250-4. [Crossref] [PubMed] [PMC]
- Bi X, Lim J, Henry CJ. Spices in the management of diabetes mellitus. Food Chem. 2017;217:281-93. [Crossref] [PubMed]
- Yang JW, Yeo HK, Yun JH, Lee JU. Theracurmin (Highly Bioavailable Curcumin) prevents high fat diet-induced hepatic steatosis development in mice. Toxicol Res. 2019;35(4):403-10. [Crossref] [PubMed] [PMC]
- Ariamoghaddam AR, Ebrahimi-Hosseinzadeh B, Hatamian-Zarmi A, Sahraeian R. In vivo anti-obesity efficacy of curcumin loaded nanofibers transdermal patches in high-fat diet induced obese rats. Mater Sci Eng C Mater Biol Appl. 2018;92:161-71. Erratum in: Mater Sci Eng C Mater Biol Appl. 2020;106:110149. [Crossref] [PubMed]
- Woo HM, Kang JH, Kawada T, Yoo H, Sung MK, Yu R. Active spice-derived components can inhibit inflammatory responses of adipose tissue in obesity by suppressing inflammatory actions of macrophages and release of monocyte chemoattractant protein-1 from adipocytes. Life Sci. 2007;80(10):926-31. [Crossref] [PubMed]
- Ohara K, Uchida A, Nagasaka R, Ushio H, Ohshima T. The effects of hydroxycinnamic acid derivatives on adiponectin secretion. Phytomedicine. 2009;16(2-3):130-7. [Crossref] [PubMed]
- Weisberg SP, Leibel R, Tortoriello DV. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology. 2008;149(7):3549-58. [Crossref] [PubMed] [PMC]
- Pérez-Torres I, Ruiz-Ramírez A, Ba-os G, El-Hafidi M. Hibiscus sabdariffa Linnaeus (Malvaceae), curcumin and resveratrol as alternative medicinal agents against metabolic syndrome. Cardiovasc Hematol Agents Med Chem. 2013;11(1):25-37. [Crossref] [PubMed]
- Wu LY, Chen CW, Chen LK, Chou HY, Chang CL, Juan CC. Curcumin attenuates adipogenesis by inducing preadipocyte apoptosis and inhibiting adipocyte differentiation. Nutrients. 2019;11(10):2307. [Crossref] [PubMed] [PMC]
- Buonomo AR, Scotto R, Nappa S, Arcopinto M, Salzano A, Marra AM, et al. The role of curcumin in liver diseases. Arch Med Sci. 2019;15(6):1608-20. [Crossref] [PubMed] [PMC]
- Kurt M, Atmaca A, Gürlek A. [Diabetic nephropathy]. Hacettepe Tıp Dergisi. 2004;35:12-7. [Link]
- Soetikno V, Sari FR, Sukumaran V, Lakshmanan AP, Harima M, Suzuki K, et al. Curcumin decreases renal triglyceride accumulation through AMPK-SREBP signaling pathway in streptozotocin-induced type 1 diabetic rats. J Nutr Biochem. 2013;24(5):796-802. [Crossref] [PubMed]
- Wang C, He X, Huang Q, Fu X, Liu S. Physicochemical properties and application of micronized cornstarch in low fat cream. J Food Eng. 2013;116(4):881-8. [Crossref]
- Sun LN, Yang ZY, Lv SS, Liu XC, Guan GJ, Liu G. Curcumin prevents diabetic nephropathy against inflammatory response via reversing caveolin-1 Tyr14 phosphorylation influenced TLR4 activation. Int Immunopharmacol. 2014;23(1):236-46. [Crossref] [PubMed]
- Platania CBM, Fidilio A, Lazzara F, Piazza C, Geraci F, Giurdanella G,et al. Retinal protection and distribution of curcumin in vitro and in vivo. Front Pharmacol. 2018;9:670. [Crossref] [PubMed] [PMC]
- Premanand C, Rema M, Sameer MZ, Sujatha M, Balasubramanyam M. Effect of curcumin on proliferation of human retinal endothelial cells under in vitro conditions. Invest Ophthalmol Vis Sci. 2006;47(5):2179-84. [Crossref] [PubMed]
- Steigerwal R, Nebbioso M, Appendino G, Belcaro G, Ciammaichella G, Cornelli U, et al. Meriva®, a lecithinized curcumin delivery system, in diabetic microangiopathy and retinopathy. Panminerva Medica. 2012;54(1 Suppl 4):11-6. [Link]
- Zheng J, Cheng J, Zheng S, Feng Q, Xiao X. Curcumin, a polyphenolic curcuminoid with its protective effects and molecular mechanisms in diabetes and diabetic cardiomyopathy. Front Pharmacol. 2018;9:472. [Crossref] [PubMed] [PMC]
- Bulboacă AE, Porfire AS, Tefas LR, Boarescu PM, Bolboacă SD, Stănescu IC, et al. Liposomal curcumin is better than curcumin to alleviate complications in experimental diabetic mellitus. Molecules. 2019;24(5):846. [Crossref] [PubMed] [PMC]
- Niu Y, He J, Ahmad H, Shen M, Zhao Y, Gan Z,et al. Dietary curcumin supplementation increases antioxidant capacity, upregulates nrf2 and hmox1 levels in the liver of piglet model with intrauterine growth retardation. Nutrients. 2019;11(12):2978. [Crossref] [PubMed] [PMC]
- Sudirman S, Lai CS, Yan YL, Yeh HI, Kong ZL. Histological evidence of chitosan-encapsulated curcumin suppresses heart and kidney damages on streptozotocin-induced type-1 diabetes in mice model. Sci Rep. 2019;9(1):15233. [Crossref] [PubMed] [PMC]
- Becit M, Aydın S, Başaran N. [Evaluation of therapeutic and toxic effects of curcumin: review]. Turkiye Klin J Pharm Sci. 2017;6(2):126-42. [Crossref]
- Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA. The essential medicinal chemistry of curcumin. J Med Chem. 2017;60(5):1620-37. [Crossref] [PubMed] [PMC]
- Gupte PA, Giramkar SA, Harke SM, Kulkarni SK, Deshmukh AP, Hingorani LL, et al. Evaluation of the efficacy and safety of Capsule Longvida® Optimized Curcumin (solid lipid curcumin particles) in knee osteoarthritis: a pilot clinical study. J Inflamm Res. 2019 ;12:145-52. [Crossref] [PubMed] [PMC]
- Ghosh S, Banerjee S, Sil PC. The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update. Food Chem Toxicol. 2015;83:111-24. [Crossref] [PubMed]
- Khajehdehi P. Turmeric: Reemerging of a neglected Asian traditional remedy. J Nephropathol. 2012;1(1):17-22. [Crossref] [PubMed] [PMC]
.: İşlem Listesi