Journal of Traditional Medical Complementary Therapies

.: REVIEW
Kurkumin ve Kurkuminoidlerin Diyabetin Komplikasyonları Üzerine Etkisi, Doz Planlaması ve Biyoyaralanımı
The Effect of Curcumin and Curcuminoids on Complications of Diabetes Dosage Planning and Bioavailable
M. Ali ÇAKIRa, Oğuzhan KESKİNa,b
aKırklareli Üniversitesi Sağlık Yüksekokulu, Beslenme ve Diyetetik Bölümü, Kırklareli, TÜRKİYE
bKırklareli Üniversitesi Sağlık Bilimleri Enstitüsü, Halk Sağlığı Yüksek Lisans Programı, Kırklareli, TÜRKİYE
J Tradit Complem Med. 2021;4(1):65-76
doi: 10.5336/jtracom.2020-74453
Article Language: TR
Full Text
ÖZET
 Kurkumin; kurkumin (diferuloilmetan) (%77), demetoksikurkumin (%17) ve bisdemethoksikurkumin (%3) olmak üzere Curcuma longa (zerdeçal) bitkisinin kökünden elde edilen doğal bir üründür. Diyabet, bozulmuş glukoz seviyesi ile devam eden metabolik bir hastalık olarak tanımlanmaktadır. Dünya nüfusunun artması ile Tip 2 diyabet görülme sıklığındaki artış ilişkilidir. 2040 yılında toplam dünya nüfusunun %13,5'i kadarının diyabetli olacağı tahmin edilmektedir. Diyabet ve diyabetin komplikasyonları sonucu sadece 2012 yılında 1,5 milyon insan ölmüştür. Dünya çapında büyük bir prevalansı olan diyabet ve komplikasyonları ile baş edebilmek için etkili önleme yöntemleri gereklidir. Bu yöntemlerden birsi de kurkumin takviyesi yapılmasıdır. Biyoyararlanım, besin takviyesi olarak kurkumin kullanımında ana konudur. Kurkuminin vücuttan hızlıca atılması ve gastrointestinal sistemden az miktarda absorbe edilememesi biyoyarlanımını ve farmakokinetik etkilerini sınırlamaktadır. Birçok çalışmada, kurkuminin biyoyararlanımının azlığından bahsedilmektedir ve bu yararlanma oranın artırılması için multidisipliner çalışmalara ihtiyaç olduğu belirtilmektedir. Geleneksel Çin tıbbından bu yana yapılan çalışmalarda; kurkuminin antikanser, antiinflamatuar, antioksidan gibi etkileri olan bir fitokimyasal olduğu belirtilmektedir. Kurkumin insülin direnci, hiperglisemi, hiperlipidemi ve adacık apoptozu ve nekrozu gibi diyabetin önde gelen komplikasyonlarının çoğunu olumlu şekilde etkilediği araştırmalarda gösterilmektedir. Kurkuminin klinik çalışmalarından elde edilen sonuçlarına göre diyabetik nefropati, mikroanjiyopati ve retinopatiyi tedavi etmek için etkili bir ajan olduğu gösterilmiştir. Ancak kurkumin ile ilgili yapılan çalışmaların çok azı diyabet ve komplikasyonları üzerine odaklanmıştır. Bu derlemenin amacı, kurkuminin diyabet ve komplikasyonlarını önlemek için kullanılabilirliğini incelemektir.

Anahtar Kelimeler: Kurkumin; diyabet; retinopati; nöropati; demetoksikurkumin; diyabetin komplikasyonları
ABSTRACT
 Curcumin; Curcuma (turmeric) is a natural product obtained from the root of the Curcuma Longa (turmeric) plant, which is curcumin (diferuloylmethane) (77%), demetoxicurcumin (17%) and bisdemethoxycurcumin (3%). Diabetes is defined as a metabolic disease that continues with impaired glucose level. The increase in the world population is associated with an increase in the frequency of type 2 diabetes. It is estimated that 13.5% of the total world population will have diabetes in 2040. As a result of diabetes and its complications, 1.5 million people died in 2012 alone. Effective prevention methods are necessary to deal with diabetes and its complications, which is a major prevalence worldwide. One of these methods is to make curcumin supplements. Bioavailability is the main issue in the use of curcumin as a nutritional supplement. The rapid removal of curcumin from the body and its low absorption from the gastrointestinal tract limits its bioavailability and pharmacokinetic effects. In many studies, the low bioavailability of curcumin is mentioned and it is stated that multidisciplinary studies are needed to increase this utilization rate. In studies conducted since traditional Chinese medicine, curcumin is stated to be a phytochemical with effects such as anti cancer, anti-inflammatory and antioxidant. Studies show that curcumin has positive effects on many of the leading complications of diabetes, such as insulin resistance, hyperglycemia, hyperlipidemia, and islet apoptosis and necrosis. Curcumin has been shown to be an effective agent to treat diabetic nephropathy, microangiopathy and retinopathy, according to results from clinical trials. However, few studies of curcumin have focused on diabetes and its complications. The aim of this review is to examine the usability of curcumin to prevent diabetes and its complications.

Keywords: Curcumin; diabetes; retinopathy; neuropathy; demethoxycurcumin; diabetes complications
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"Turkiye Klinikleri" in its sole discretion may change the hereby "Terms of Use" anytime announcing within the "SITE". The changed terms of the hereby "Terms of Use" will become valid when they are announced. Hereby "Terms of Use" cannot be changed by unilateral declarations of users.

7. FORCE MAJEURE

"Turkiye Klinikleri" is not responsible for executing late or never of this hereby "Terms of Use", privacy policy and "USER Contract" in any situation legally taken into account as force majeure. Being late or failure of performance or non-defaulting of this and similar cases like this will not be the case from the viewpoint of "Turkiye Klinikleri", and "Turkiye Klinikleri" will not have any damage liability for these situations. "Force majeure" term will be regarded as outside of the concerned party's reasonable control and any situation that "Turkiye Klinikleri" cannot prevent even though it shows due diligence. Also, force majeure situations include but not limited to natural disasters, rebellion, war, strike, communication problems, infrastructure and internet failure, power cut and bad weather conditions.

8. LAW AND AUTHORISATION TO FOLLOW

Turkish Law will be applied in practicing, interpreting the hereby "Terms of Use" and managing the emerging legal relationships within this "Terms of Use" in case of finding element of foreignness, except for the rules of Turkish conflict of laws. Ankara Courts and Enforcement Offices are entitled in any controversy happened or may happen due to hereby contract.

9. CLOSING AND AGREEMENT

Hereby "Terms of Use" come into force when announced in the "SITE" by "Turkiye Klinikleri". The users are regarded to agree to hereby contract terms by using the "SITE". "Turkiye Klinikleri" may change the contract terms and the changes will be come into force by specifying the version number and the date of change on time it is published in the "SITE".

 

30.03.2014

Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com