.: DERLEME
Gece Çalışmanın Meme Kanseri Üzerine Etkisi
The Effect on Breast Cancer of Night Shift Work
Turkiye Klinikleri J Health Sci. 2019;4(3):369-74
doi: 10.5336/healthsci.2018-62463
Makale Dili: TR
Tam Metin
ÖZET
Meme kanseri, hem gelişmiş hem de gelişmekte olan ülkelerdeki kadınlar arasında en sık görülen kanser türlerinden biridir. Kadın kanserleri içerisinde ilk sırada yer alan meme kanseri, dünyada kanser olan her dört kadından birinde görülmektedir. Genetik özellikler ve yaşam tarzı ile ilgili bazı faktörlerin meme kanseri riskini artırdığı bilinmektedir. Bilinen risk faktörlerinin yanı sıra son zamanlarda, gece vardiyasında çalışmanın bireyin hem sirkadiyen ritmini hem de melatonin salınımını etkilediği, bu nedenle meme kanseri oluşumunda rol oynadığı öne sürülmektedir. Melatonin, epifiz bezinden gece sentezlenir. En önemli özellikleri arasında güçlü bir anti-oksidan, anti-östrojenik ve anti-kanserojen olması yer alır. Tüm hücrelerin yenilenmesine, bağışıklık sisteminin güçlenmesine ve vücudun yeniden direnç kazanmasına destek olur. Ayrıca kanserli dokularda hücre proliferasyonunu durdurur. Gece vardiyasında çalışma, melatoninin salgılanmasında azalmaya neden olarak hormonun faydalı özelliklerinden yararlanılmasını engeller. Bu nedenle de gece çalışan bireylerde hormonal dengesizlikler, uyku bozuklukları, kronik hastalıklar ve hatta kanser görülme riski artabilir. Bu derlemede, literatür bilgileri ışığında gece çalışmasının meme kanseri ile olan ilişkisinin ele alınması amaçlanmıştır.
Anahtar Kelimeler: Gece vardiyası; melatonin; meme kanseri; sirkadiyen ritim
Meme kanseri, hem gelişmiş hem de gelişmekte olan ülkelerdeki kadınlar arasında en sık görülen kanser türlerinden biridir. Kadın kanserleri içerisinde ilk sırada yer alan meme kanseri, dünyada kanser olan her dört kadından birinde görülmektedir. Genetik özellikler ve yaşam tarzı ile ilgili bazı faktörlerin meme kanseri riskini artırdığı bilinmektedir. Bilinen risk faktörlerinin yanı sıra son zamanlarda, gece vardiyasında çalışmanın bireyin hem sirkadiyen ritmini hem de melatonin salınımını etkilediği, bu nedenle meme kanseri oluşumunda rol oynadığı öne sürülmektedir. Melatonin, epifiz bezinden gece sentezlenir. En önemli özellikleri arasında güçlü bir anti-oksidan, anti-östrojenik ve anti-kanserojen olması yer alır. Tüm hücrelerin yenilenmesine, bağışıklık sisteminin güçlenmesine ve vücudun yeniden direnç kazanmasına destek olur. Ayrıca kanserli dokularda hücre proliferasyonunu durdurur. Gece vardiyasında çalışma, melatoninin salgılanmasında azalmaya neden olarak hormonun faydalı özelliklerinden yararlanılmasını engeller. Bu nedenle de gece çalışan bireylerde hormonal dengesizlikler, uyku bozuklukları, kronik hastalıklar ve hatta kanser görülme riski artabilir. Bu derlemede, literatür bilgileri ışığında gece çalışmasının meme kanseri ile olan ilişkisinin ele alınması amaçlanmıştır.
Anahtar Kelimeler: Gece vardiyası; melatonin; meme kanseri; sirkadiyen ritim
ABSTRACT
Breast cancer is one of the most common types of cancer among women in both developed and developing countries. Breast cancer, which is the first among female cancers, is seen in one of every four females with cancer in the world. It is known that genetic characteristics and some factors related to lifestyle increase the risk of breast cancer. Besides the known risk factors, it has recently been suggested that working on night shifts affects both circadian rhythm and melatonin release, thus playing a role in breast cancer development. Melatonin is synthesized night from the pineal gland. Its the most important features it takes place to be a strong anti-oxidant, anti-estrogenic and anti-carcinogenic. It supports the renewal of all cells, strengthening of the immune system and re-resistance of the body. It also stops cell proliferation in cancerous tissues. Night shift work prevents the beneficial properties of the hormone from being used by decreasing the secretion of melatonin. Therefore, the risk of hormonal imbalances, sleep disturbances, chronic illnesses and even cancer may increase in individuals who work at night. In this review, it is aimed to discuss the relationship between night shift work and breast cancer in the light of literature.
Keywords: Night shift work; melatonin; breast cancer; circadien rhtym
Breast cancer is one of the most common types of cancer among women in both developed and developing countries. Breast cancer, which is the first among female cancers, is seen in one of every four females with cancer in the world. It is known that genetic characteristics and some factors related to lifestyle increase the risk of breast cancer. Besides the known risk factors, it has recently been suggested that working on night shifts affects both circadian rhythm and melatonin release, thus playing a role in breast cancer development. Melatonin is synthesized night from the pineal gland. Its the most important features it takes place to be a strong anti-oxidant, anti-estrogenic and anti-carcinogenic. It supports the renewal of all cells, strengthening of the immune system and re-resistance of the body. It also stops cell proliferation in cancerous tissues. Night shift work prevents the beneficial properties of the hormone from being used by decreasing the secretion of melatonin. Therefore, the risk of hormonal imbalances, sleep disturbances, chronic illnesses and even cancer may increase in individuals who work at night. In this review, it is aimed to discuss the relationship between night shift work and breast cancer in the light of literature.
Keywords: Night shift work; melatonin; breast cancer; circadien rhtym
REFERANSLAR:
- Figueiro MG, White RD. Health consequences of shift work and implications for structural design. J Perinatol. 2013;33 Suppl 1:S17-23. [Crossref] [PubMed]
- Ucok K. [Electrical activity of the brain, sleep-wake states, & circadian rhythms]. In: Barrett KM, Barman SM, Boitano S, Brooks HL, eds. Gokbel H, Ceiviri editoru. Ganong'un Tibbi Fizyolojisi. 24. Baski. Istanbul: Nobel Tip Kitabevi; 2015. p.278-80.
- Forrester JV, Dick AD, McMenamin P, Roberts F, Pearlman E. Physiology of vision and the visual system. In: Dick AD, Forrester JV, McMenamin P, eds. The Eye: Basic Sciences in Practice. 4th ed. Philadelphia, PA: Elseiver; 2016. p.269-337. [Crossref]
- Berry R. Circadian rhythm sleep disorders. Fundamentals of Sleep Medicine. 1st ed. Philadelphia, PA: Elsevier; 2012. p.515-43. [Crossref]
- Kalat J. Wakefulness and sleep. In: Lipp OV, ed. Biological Psychology. 10th ed. Canada: Wadsorth; 2009. p.260-6.
- Touitou Y, Reinberg A, Touitou D. Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: health impacts and mechanisms of circadian disruption. Life Sci. 2017;173:94-106. [Crossref]
- Ikinci O. [Biological imperative: dark]. Bilim ve Tek. 2011;32-7.
- Topal T, Oter S, Korkmaz A. [Melatonin and its relation to cancer]. Genel Tip Derg. 2009;19:137-43.
- Kazanci E, Bacak B. [Assesment of pyhsiological, psychological and sociological effects that night shift workers encounter in Turkish work life]. Uluslararasi Emek ve Toplum Derg. 2014;6(3):133-49.
- Stevens RG, Hansen J, Costa G, Haus E, Kauppinen T, Aronson KJ, et al. Considerations of circadian impact for defining 'shift work' in cancer studies: IARC Working Group Report. Occup Environ Med. 2011;68(2):154-62. [Crossref] [PubMed]
- Guzel Ozdemir P, Okmen AC, Yilmaz O. [Shift work disorder and mental and physical effects of shift work]. Curr Approaches Psychiatry. 2018;10(1):71-83. [Crossref]
- Wang F, Yeung KL, Chan WC, Kwok CC, Leung SL, Wu C, et al. A meta-analysis on dose-response relationship between night shift work and the risk of breast cancer. Ann Oncol. 2013;24(11):2724-32. [Crossref]
- Haus EL, Smolensky MH. Shift work and cancer risk: potential mechanistic roles of circadian disruption, light at night, and sleep deprivation. Sleep Med Rev. 2013;17(4):273-84. [Crossref] [PubMed]
- Dickerman B, Liu J. Does current scientific evidence support a link between light at night and breast cancer among female night-shift nurses? Review of evidence and implications for occupational and environmental health nurses. Workplace Health Saf. 2012;60(6): 273-81. [Crossref] [PMC]
- Ghoncheh M, Pournamdar Z, Salehiniya H. Incidence and mortality and epidemiology of breast cancer in the world. Asian Pacific J Cancer Prev. 2016;17(S3):43-6. [Crossref]
- Taskin L. [Breast neoplasms]. Taskin L editor. Dogum ve Kadin Sagligi Hemsireligi. 13. Baski. Ankara: Akademisyen Tip Kitabevi; 2016. p.816-7.
- Knutsson A, Alfredsson L, Karlsson B, Akerstedt T, Fransson EI, Westerholm P, et al. Breast cancer among shift workers: results of the WOLF longitudinal cohort study. Scand J Work Environ Health. 2013;39(2):170-7. [Crossref]
- Lin X, Chen W, Wei F, Ying M, Wei W, Xie X. Night-shift work increases morbidity of breast cancer and all-cause mortality: a meta-analysis of 16 prospective cohort studies. Sleep Med. 2015;16(11):1381-7. [Crossref] [PubMed]
- Papantoniou K, Pozo OJ, Espinosa A, Marcos J, Casta-o-Vinyals G, Basaga-a X, et al. Increased and mistimed sex hormone production in night shift workers. Cancer Epidemiol Biomarkers Prev. 2015;24(5):854-63. [Crossref] [PubMed]
- Cordina-Duverger E, Koudou Y, Truong T, Arveux P, Kerbrat P, Menegaux F, et al. Night work and breast cancer risk defined by human epidermal growth factor receptor-2 (HER2) and hormone receptor status: a population-based case-control study in France. Chronobiol Int. 2016;33(6):783-7. [Crossref] [PubMed]
- He C, Anand ST, Ebell MH, Vena JE, Robb SW. Circadian disrupting exposures and breast cancer risk: a meta-analysis. Int Arch Occup Environ Health. 2015;88(5):533-47. [Crossref] [PubMed]
- Hansen J, Lassen CF. Nested case-control study of night shift work and breast cancer risk among women in the Danish military. Occup Environ Med. 2012;69(8):551-6. [Crossref] [PubMed]
- Kamdar BB, Tergas AI, Mateen FJ, Bhayani NH, Oh J. Night-shift work and risk of breast cancer: a systematic review and meta-analysis. Breast Cancer Res Treat. 2013;138(1): 291-301. [Crossref] [PubMed]
- Villeneuve S, Fevotte J, Anger A, Truong T, Lamkarkach F, Gaye O, et al. Breast cancer risk by occupation and industry: analysis of the CECILE study, a population-based case-control study in France. Am J Ind Med. 2011;509(7):499-509. [Crossref] [PubMed]
- Zienolddiny S, Haugen A, Lie JA, Kjuus H, Anmarkrud KH, Kjaerheim K. Analysis of polymorphisms in the circadian-related genes and breast cancer risk in Norwegian nurses working night shifts. Breast Cancer Res. 2013;15(4):R53. [Crossref] [PubMed] [PMC]
- Davis S, Mirick DK, Stevens RG. Night shift work, light at night, and risk of breast cancer. J Natl Cancer Inst. 2001;93(20):1557-62. [Crossref] [PubMed]
- Grundy A, Richardson H, Burstyn I, Lohrisch C, SenGupta SK, Lai AS, et al. Increased risk of breast cancer associated with long-term shift work in Canada. Occup Environ Med. 2013;70(12):831-8. [Crossref] [PubMed]
- Pesch B, Harth V, Rabstein S, Baisch C, Schiffermann M, Pallapies D, et al. Night work and breast cancer-results from the German GENICA study. Scand J Work Environ Health. 2010;36(2)134-41. [Crossref] [PubMed]
- Akerstedt T, Knutsson A, Narusyte J, Svedberg P, Kecklund G, Alexanderson K. Night work and breast cancer in women: a Swedish cohort study. BMJ Open. 2015;5(4):e008127. [Crossref] [PMC]
- Monsees GM, Kraft P, Hankinson SE, Hunter DJ, Schernhammer ES. Circadian genes and breast cancer susceptibility in rotating shift workers. Int J Cancer. 2012;131(11):2547-52. [Crossref] [PubMed] [PMC]
- Travis RC, Balkwill A, Fensom GK, Appleby PN, Reeves GK, Wang XS, et al. Night shift work and breast cancer incidence: three prospective studies and meta-analysis of published studies. J Natl Cancer Inst. 2016;108(11):1-9. [Crossref] [PubMed] [PMC]
- Merklinger-Gruchala A, Ellison PT, Lipson SF, Thune I, Jasienska G. Low estradiol levels in women of reproductive age having low sleep variation. Eur J Cancer Prev. 2008;17(5):467-72. [Crossref] [PubMed]
- Gomez-Acebo I, Dierssen-Sotos T, Papantoniou K, Garcia-Unzueta MT, Santos-Benito MF, Llorca J. Association between exposure to rotating night shift versus day shift using levels of 6-sulfatoxymelatonin and cortisol and other sex hormones in women. Chronobiol Int. 2015;32(1):128-35. [Crossref]
- Bracci M, Copertaro A, Manzella N, Staffolani S, Strafella E, Nocchi L, et al. Influence of night-shift and napping at work on urinary meratonin, 17-β-estradiol and clock gene expression in premennopausal nurses. J Biol Regul Homeost Agents. 2013;27(1):267-74.
- Bracci M, Manzella N, Copertaro A, Staffolani S, Strafella E, Barbaresi M, et al. Rotating-shift nurses after a day off: peripheral clock gene expression, urinary melatonin, and serum 17-β-estradiol levels. Scand J Work Environ Health. 2014;40(3):295-304. [Crossref] [PubMed]
- Davis S, Mirick DK, Chen C, Stanczyk FZ. Night shift work and hormone levels in women. Cancer Epidemiol Biomarkers Prev. 2012;21 (4):609-18. [Crossref] [PubMed]
- Wang P, Ren FM, Lin Y, Su FX, Jia WH, Su XF, et al. Night-shift work, sleep duration, daytime napping, and breast cancer risk. Sleep Med. 2015;16(4):462-8. [Crossref] [PubMed]
- Menegaux F, Truong T, Anger A, Cordina-Duverger E, Lamkarkach F, Arveux P, et al. Night work and breast cancer: a population-based case-control study in France (the CECILE study). Int J Cancer. 2012;132(4):924-31. [Crossref] [PubMed]
.: İşlem Listesi