Objective: This study was conducted to determine the interrelationships of gastroesophageal reflux, laryngopharyngeal reflux and sleep quality in adults. Sleep quality in adults is important for health protection in terms of physiological and psychological and increasing performance. Recent studies have emphasized a strong association between sleep disorders and gastrointestinal disorders. Material and Methods: This cross-sectional study was carried out with 400 individuals who are >18 years old who were registered family health centers from east, west, north, and south of Elazığ province between April and June 2018. A Personal Information Form, Gastroesophageal Reflux Disease Questionnaire, Reflux Symptom Index, and the Pittsburgh Sleep Quality Index were used as data collection tools. Results: The results of simple linear regression indicate that Pittsburgh Sleep Quality Index global score was associated with Gastroesophageal Reflux Disease Questionnaire, Reflux Symptom Index, age, gender, educational status, marital status, working status, monthly income perception, health perception and the person living together. By the multiple regression analysis, Reflux Symptom Index, Gastroesophageal Reflux Disease Questionnaire, the employment status and being widow are the most correlated variables on the Pittsburgh Sleep Quality Index global score and explained 27% of the total variance. Conclusion: In addition to being a significant relationship between reflux and sleep quality, it can be asserted that some sociodemographic variables besides reflux is the important parameters required while evaluating the sleep-related problems.
Keywords: Sleep quality; gastroesophageal reflux disease; laryngopharyngeal reflux
Amaç: Bu çalışma, erişkinlerde gastroözofageal reflü, laringofaringeal reflü ve uyku kalitesinin ilişkilerini belirlemek amacıyla yapılmıştır. Yetişkinlerde uyku kalitesi, fizyolojik ve psikolojik açıdan sağlığın korunması ve performansın artması açısından önemlidir. Son çalışmalar, uyku bozuklukları ve gastrointestinal bozukluklar arasında güçlü bir ilişki olduğunu vurgulamaktadır. Gereç ve Yöntemler: Bu kesitsel çalışma, Nisan ve Haziran 2018 tarihleri arasında Elazığ ilinin doğu, batı, kuzey ve güneyinden aile sağlığı merkezlerine kayıtlı 18 yaş ve üzeri 400 kişi ile gerçekleştirildi. Veri toplama araçları olarak Kişisel Bilgi Formu, Gastroözofageal Reflü Hastalığı Anketi, Reflü Semptom İndeksi ve Pittsburgh Uyku Kalitesi İndeksi kullanıldı. Bulgular: Basit doğrusal regresyon sonuçları, Pittsburgh Uyku Kalitesi İndeksi skorunun Gastroözofageal Reflü Hastalığı Anketi, Reflü Semptom İndeksi, yaş, cinsiyet, eğitim durumu, medeni durum, çalışma durumu, aylık gelir algısı, sağlık algısı ve birlikte yaşama ile ilişkili olduğunu göstermektedir. Çoklu regresyon analizi ile Reflü Semptom İndeksi, Gastroözofageal Reflü Hastalığı Anketi, istihdam durumu ve dul olma Pittsburgh Uyku Kalitesi İndeksi skorunda en çok ilişkili değişkenler olup toplam varyansın %27'sini açıklamıştır. Sonuç: Reflü ile uyku kalitesi arasında anlamlı bir ilişki olmasının yanı sıra reflü dışında bazı sosyodemografik değişkenlerin de uyku ile ilgili sorunları değerlendirirken gerekli olan önemli parametreler olduğu söylenebilir.
Anahtar Kelimeler: Uyku kalitesi; gastroözofageal reflü; laringofaringeal reflü
- Aysan E, Karaköse S, Zaybak A, İsmailoğlu EG. Üniversite öğrencilerinde uyku kalitesi ve etkileyen faktörler. [Sleep quality among undregraduate students and influencing factors]. Dokuz Eylül Üniversitesi Hemşirelik Yüksekokulu Elektronik Dergisi. 2014;7(3):193-8. [Link]
- National Institutes of Health (NIH). [Internet]. [cited: 22.07.2020]. Brain Basics: Understanding Sleep. Available from: [Link]
- Berhanu H, Mossie A, Tadesse S, Geleta D. Prevalence and Associated factors of sleep quality among adults in jimma town, southwest ethiopia: a community-based cross-sectional study. Sleep Disord. 2018;2018:8342328. [Crossref] [PubMed] [PMC]
- Simşek Y, Tekgül N. Sleep quality in adolescents in relation to age and sleep-related habitual and environmental factors. J Pediatr Res. 2019;6(4):307-13. [Crossref]
- Altintaş A, Soylu A, Yegin Y, Çelik M, Kaya KH. Impact of laryngopharyngeal reflux on the levels of depression and anxiety in patients with obstructive sleep apnea syndrome. J Craniofac Surg. 2017;28(2):e121-e4. [Crossref] [PubMed]
- Badillo R, Francis D. Diagnosis and treatment of gastroesophageal reflux disease. World J Gastrointest Pharmacol Ther. 2014;5(3):105-12. [PubMed] [PMC]
- Kowalik K, Krzeski A. The role of pepsin in the laryngopharyngeal reflux. Otolaryngol Pol. 2017;71(6):7-13. [Crossref] [PubMed]
- Ozan Z, Ataseven H. Uyku bozuklukları ve gastrointestinal sistem. [Sleep disorders and the gastrointestinal system]. Bozok Tıp Dergisi. 2018;8:26-33. [Link]
- Piper AJ, Grunstein RR. Obesity hypoventilation syndrome: mechanisms and management. Am J Respir Crit Care Med. 2011;183(3):292-8. [Crossref] [PubMed]
- Khanijow V, Prakash P, Emsellem HA, Borum ML, Doman DB. Sleep dysfunction and gastrointestinal diseases. Gastroenterol Hepatol (N Y). 2015;11(12):817-25. [PubMed] [PMC]
- Jaimchariyatam N, Tantipornsinchai W, Desudchit T, Gonlachanvit S. Association between respiratory events and nocturnal gastroesophageal reflux events in patients with coexisting obstructive sleep apnea and gastroesophageal reflux disease. Sleep Med. 2016;22:33-8. [Crossref] [PubMed]
- Yi CH, Lei WY, Hung JS, Liu TT, Orr WC, Chen CL. Relevance of sleep disturbance to the integrity and characteristics of secondary peristalsis in patients with gastroesophageal reflux disease. Scand J Gastroenterol. 2017;52(2):136-42. [Crossref] [PubMed]
- Lloyd AT, Ruddy BH, Silverman E, Lewis VM, Lehman JJ. Quantifying laryngopharyngeal reflux in singers: perceptual and objective findings. BioMed research international. 2017;7:1-10. [Crossref] [PubMed] [PMC]
- Jung HK, Choung RS, Talley NJ. Gastroesophageal reflux disease and sleep disorders: evidence for a causal link and therapeutic implications. J Neurogastroenterol Motil. 2010;16(1):22-9. [Crossref] [PubMed] [PMC]
- Yamasaki T, Hemond C, Eisa M, Ganocy S, Fass R. The Changing epidemiology of gastroesophageal reflux disease: are patients getting younger? J Neurogastroenterol Motil. 2018;24(4):559-69. [Crossref] [PubMed] [PMC]
- Mungan Z. Prevalence and demographic determinants of gastroesophageal reflux disease (GERD) in the Turkish general population: a population-based cross-sectional study. Turk J Gastroenterol. 2012;23(4):323-32. [Crossref] [PubMed]
- Lee JS, Heo SJ, Kim JS, Ahn D, Sohn JH, Kim H. Relationship between the severity of laryngopharyngeal reflux and sleep apnea: using drug-induced sleep endoscopy (DISE). Eur Arch Otorhinolaryngol. 2018;275(1):219-24. [Crossref] [PubMed]
- Okuyama M, Takaishi O, Nakahara K, Iwakura N, Hasegawa T, Oyama M, et al. Associations among gastroesophageal reflux disease, psychological stress, and sleep disturbances in Japanese adults. Scand J Gastroenterol. 2017;52(1):44-9. [Crossref] [PubMed]
- Jeon JY. Association between chronotype and obstructive sleep apnea syndrome in Korea. Sleep Medicine. 2017;40(1): e149-e50. [Crossref]
- Chen CL, Robert JJ, Orr WC. Sleep symptoms and gastroesophageal reflux. J Clin Gastroenterol. 2008;42(1):13-7. [Crossref] [PubMed]
- Drinnan M, Powell J, Nikkar-Esfahani A, Heading RC, Doyle J, Griffin SM, et al. Gastroesophageal and extraesophageal reflux symptoms: similarities and differences. Laryngoscope. 2015;125(2):424-30. [Crossref] [PubMed]
- Gouveia CJ, Yalamanchili A, Ghadersohi S, Price CPE, Bove M, Attarian HP, et al. Are chronic cough and laryngopharyngeal reflux more common in obstructive sleep apnea patients? Laryngoscope. 2019;129(5):1244-9. [Crossref] [PubMed]
- Şahin Köybaşı E, Yeşiltepe Oskay Ü. Gebelik sürecinin uyku kalitesine etkisi. [Effects of pregnancy process on the quality of sleep]. Gülhane Tıp Derg. 2017;59:1-5. [Link]
- Wong MW, Bair MJ, Chang WC, Hsu CS, Hung JS, Liu TT, et al. Clinical and psychological characteristics in gastroesophageal reflux disease patients overlapping with laryngopharyngeal reflux symptoms. J Gastroenterol Hepatol. 2019;34(10):1720-6. [Crossref] [PubMed]
- Yanıkkerem E, Saruhan A. Effect of nursing education on sleep and quality of life among pregnant women with gastroesophageal reflux diseases. F.Ü.Sağ.Bil.Tıp Derg. 2012;26(1):7-14. [Link]
- Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193-213. [Crossref] [PubMed]
- Belafsky PC, Postma GN, Koufman JA. Validity and reliability of the reflux symptom index (RSI). J Voice. 2002;16(2):274-7. [Crossref] [PubMed]
- Agargun MY, Kara H, Anlar O. Pittsburgh Uyku Kalitesi İndeksinin geçerlik ve güvenirliği. [The validity and reliability of the pittsburgh sleep quality index]. Turkish Journal of Psychiatry. 1996;7(2):107-11. [Link]
- Smagula SF, Stone KL, Fabio A, Cauley JA. Risk factors for sleep disturbances in older adults: Evidence from prospective studies. Sleep Med Rev. 2016;25:21-30. [Crossref] [PubMed] [PMC]
- Furihata R, Uchiyama M, Takahashi S, Suzuki M, Konno C, Osaki K, et al. The association between sleep problems and perceived health status: a Japanese nationwide general population survey. Sleep Med. 2012;13(7):831-7. [Crossref] [PubMed]
- Hosseini SR, Saadat P, Esmaili M, Bijani A. The prevalence of self-reported sleep problems and some factors affecting it among the elderly in amirkola. Shiraz E-Med J. 2018;19(3):59461. [Crossref]
- Simões ND, Monteiro LHB, Lucchese R, Amorim TAD, Denardi TC, Vera I, et al. Quality and sleep duration among public health network users. Acta Paul Enferm. 2019;32(5):530-7. [Crossref]
- Wang P, Song L, Wang K, Han X, Cong L, Wang Y, et al. Prevalence and associated factors of poor sleep quality among Chinese older adults living in a rural area: a population-based study. Aging Clin Exp Res. 2020;32(1):125-31. [Crossref] [PubMed] [PMC]
- Laohasiriwong S, Johnston N, Woodson BT. Extra-esophageal reflux, NOSE score, and sleep quality in an adult clinic population. Laryngoscope. 2013;123(12):3233-8. [Crossref] [PubMed]
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