.: ORİJİNAL ARAŞTIRMA
Comparison of Thorax Computed Tomography Based Body Composition Parameters Between COVID-19 Positive and Negative Patients: A Cross-Sectional Study
COVID-19 Pozitif ve Negatif Hastalar Arasında Toraks Bilgisayarlı Tomografi Tabanlı Vücut Kompozisyon Parametrelerinin Karşılaştırılması: Kesitsel Bir Çalışma
Turkiye Klinikleri J Med Sci. 2023;43(1):104-11
doi: 10.5336/medsci.2022-90450
Makale Dili: EN
Tam Metin
ABSTRACT
Objective: To compare body fat-muscle and visceral obesity indices that can be measured with thorax computed tomography (CT) between reverse transcriptase-polymerase chain reaction (RTPCR) positive and negative patients. Material and Methods: This retrospective, comparative study included 141 PCR (+) and 150 PCR (-) patients who applied to our hospital with flu-like symptoms without having the comorbid diseases and undergone thoracic CT between April 1, 2020-July 1, 2020. For the each patient, the ratio of thoracic subcutaneous adipose tissue thickness to pectoralis major muscle thickness (TSAT/PMJ), epicardial adipose tissue thickness (EAT), liver density (LD), abdominal subcutaneous adipose tissue thickness to psoas major muscle thickness ratio (ASAT/ PSM), subcutaneous abdominal adipose tissue thickness to erector spinae muscle thickness ratio (ASAT/ESM) was measured. The comparison was made between the subgroups in terms of age, gender, and measured parameters. Results: Statistically significant difference was found between PCR (+) and (-) individuals in terms of EAT mean (p0.05) in terms of TSAT/PMJ, ASAT/PSM, LD, ASAT/ESM. Conclusion: Higher EAT values can increase the risk of getting coronavirus disease-2019 (COVID-19) infection. Peripheral fat-muscle indices don't increase the risk of contracting COVID-19 infection.
Keywords: COVID-19 infection; obesity; thorax computed tomography
Objective: To compare body fat-muscle and visceral obesity indices that can be measured with thorax computed tomography (CT) between reverse transcriptase-polymerase chain reaction (RTPCR) positive and negative patients. Material and Methods: This retrospective, comparative study included 141 PCR (+) and 150 PCR (-) patients who applied to our hospital with flu-like symptoms without having the comorbid diseases and undergone thoracic CT between April 1, 2020-July 1, 2020. For the each patient, the ratio of thoracic subcutaneous adipose tissue thickness to pectoralis major muscle thickness (TSAT/PMJ), epicardial adipose tissue thickness (EAT), liver density (LD), abdominal subcutaneous adipose tissue thickness to psoas major muscle thickness ratio (ASAT/ PSM), subcutaneous abdominal adipose tissue thickness to erector spinae muscle thickness ratio (ASAT/ESM) was measured. The comparison was made between the subgroups in terms of age, gender, and measured parameters. Results: Statistically significant difference was found between PCR (+) and (-) individuals in terms of EAT mean (p0.05) in terms of TSAT/PMJ, ASAT/PSM, LD, ASAT/ESM. Conclusion: Higher EAT values can increase the risk of getting coronavirus disease-2019 (COVID-19) infection. Peripheral fat-muscle indices don't increase the risk of contracting COVID-19 infection.
Keywords: COVID-19 infection; obesity; thorax computed tomography
ÖZET
Amaç: Ters transkriptaz-polimeraz zincir reaksiyonu [polymerase chain reaction (RT-PCR)] pozitif ve negatif hastalarda toraks bilgisayarlı tomografi (BT) ile ölçülebilen vücut yağ-kas ve viseral obezite indekslerini karşılaştırmaktır. Gereç ve Yöntemler: Bu retrospektif, karşılaştırmalı çalışmaya, 1 Nisan 2020-1 Temmuz 2020 tarihleri arasında hastanemize, grip benzeri semptomlarla yandaş hastalıkları olmaksızın başvuran ve toraks BT'si bulunan, 141 PCR (+) ve 150 PCR (-) hasta dâhil edildi. Her hasta için torasik subkütan yağ dokusu kalınlığının pektoralis majör kası kalınlığına oranı [thoracic subcutaneous adipose tissue/major muscle thickness (TSAT/PMJ)], epikardiyal yağ dokusu kalınlığı [epicardial adipose tissue thickness (EAT)], karaciğer yoğunluğu [liver density (LD)], abdominal subkütan yağ dokusu kalınlığının psoas majör kası kalınlığına oranı [abdominal subcutaneous adipose tissue thickness/psoas major muscle thickness (ASAT/PSM)], subkütan karın yağ dokusu kalınlığının erector spinae kası kalınlığına oranı [erector spinae muscle (ASAT/ESM)] ölçüldü. Alt gruplar arasında yaş, cinsiyet ve ölçülen parametreler açısından karşılaştırma yapıldı. Bulgular: PCR (+) ve (-) bireyler arasında EAT ortalamaları açısından istatistiksel olarak anlamlı fark bulundu (p0,05). Sonuç: Yüksek EAT değerleri, koronavirüs hastalığı-2019 [coronavirus disease-2019 (COVID-19)] enfeksiyonuna yakalanma riskini artırabilir. Periferik yağ-kas indeksleri, COVID 19 enfeksiyonu olan ve olmayan hastalarda farklılık göstermemektedir.
Anahtar Kelimeler: COVID-19 enfeksiyonu; obezite; toraks bilgisayarlı tomografisi
Amaç: Ters transkriptaz-polimeraz zincir reaksiyonu [polymerase chain reaction (RT-PCR)] pozitif ve negatif hastalarda toraks bilgisayarlı tomografi (BT) ile ölçülebilen vücut yağ-kas ve viseral obezite indekslerini karşılaştırmaktır. Gereç ve Yöntemler: Bu retrospektif, karşılaştırmalı çalışmaya, 1 Nisan 2020-1 Temmuz 2020 tarihleri arasında hastanemize, grip benzeri semptomlarla yandaş hastalıkları olmaksızın başvuran ve toraks BT'si bulunan, 141 PCR (+) ve 150 PCR (-) hasta dâhil edildi. Her hasta için torasik subkütan yağ dokusu kalınlığının pektoralis majör kası kalınlığına oranı [thoracic subcutaneous adipose tissue/major muscle thickness (TSAT/PMJ)], epikardiyal yağ dokusu kalınlığı [epicardial adipose tissue thickness (EAT)], karaciğer yoğunluğu [liver density (LD)], abdominal subkütan yağ dokusu kalınlığının psoas majör kası kalınlığına oranı [abdominal subcutaneous adipose tissue thickness/psoas major muscle thickness (ASAT/PSM)], subkütan karın yağ dokusu kalınlığının erector spinae kası kalınlığına oranı [erector spinae muscle (ASAT/ESM)] ölçüldü. Alt gruplar arasında yaş, cinsiyet ve ölçülen parametreler açısından karşılaştırma yapıldı. Bulgular: PCR (+) ve (-) bireyler arasında EAT ortalamaları açısından istatistiksel olarak anlamlı fark bulundu (p0,05). Sonuç: Yüksek EAT değerleri, koronavirüs hastalığı-2019 [coronavirus disease-2019 (COVID-19)] enfeksiyonuna yakalanma riskini artırabilir. Periferik yağ-kas indeksleri, COVID 19 enfeksiyonu olan ve olmayan hastalarda farklılık göstermemektedir.
Anahtar Kelimeler: COVID-19 enfeksiyonu; obezite; toraks bilgisayarlı tomografisi
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