Turkiye Klinikleri Journal of Medical Sciences

.: ORIGINAL RESEARCH
Comparison of Thorax Computed Tomography Based Body Composition Parameters Between COVID-19 Positive and Negative Patients: A Cross-Sectional Study
COVID-19 Pozitif ve Negatif Hastalar Arasında Toraks Bilgisayarlı Tomografi Tabanlı Vücut Kompozisyon Parametrelerinin Karşılaştırılması: Kesitsel Bir Çalışma
Duygu İMRE YETKİNa, Yeliz ÇİÇEKb, Hıdır SARIc, Cihan AKGÜL ÖZMENd
aClinic of Radiology, Midyat State Hospital, Mardin, Türkiye
bDepartment of Clinical Microbiology and Infectious Diseases, Dicle University Faculty of Medicine, Diyarbakır, Türkiye
cDepartment of Public Health, Dicle University Faculty of Medicine, Diyarbakır, Türkiye
dDepartment of Radiology, Dicle University Faculty of Medicine, Diyarbakır, Türkiye
Turkiye Klinikleri J Med Sci. 2023;43(1):104-11
doi: 10.5336/medsci.2022-90450
Article Language: EN
Full Text
ABSTRACT
 Objective: To compare body fat-muscle and visceral obesity indices that can be measured with thorax computed tomography (CT) between reverse transcriptase-polymerase chain reaction (RTPCR) positive and negative patients. Material and Methods: This retrospective, comparative study included 141 PCR (+) and 150 PCR (-) patients who applied to our hospital with flu-like symptoms without having the comorbid diseases and undergone thoracic CT between April 1, 2020-July 1, 2020. For the each patient, the ratio of thoracic subcutaneous adipose tissue thickness to pectoralis major muscle thickness (TSAT/PMJ), epicardial adipose tissue thickness (EAT), liver density (LD), abdominal subcutaneous adipose tissue thickness to psoas major muscle thickness ratio (ASAT/ PSM), subcutaneous abdominal adipose tissue thickness to erector spinae muscle thickness ratio (ASAT/ESM) was measured. The comparison was made between the subgroups in terms of age, gender, and measured parameters. Results: Statistically significant difference was found between PCR (+) and (-) individuals in terms of EAT mean (p0.05) in terms of TSAT/PMJ, ASAT/PSM, LD, ASAT/ESM. Conclusion: Higher EAT values can increase the risk of getting coronavirus disease-2019 (COVID-19) infection. Peripheral fat-muscle indices don't increase the risk of contracting COVID-19 infection.

Keywords: COVID-19 infection; obesity; thorax computed tomography
ÖZET
 Amaç: Ters transkriptaz-polimeraz zincir reaksiyonu [polymerase chain reaction (RT-PCR)] pozitif ve negatif hastalarda toraks bilgisayarlı tomografi (BT) ile ölçülebilen vücut yağ-kas ve viseral obezite indekslerini karşılaştırmaktır. Gereç ve Yöntemler: Bu retrospektif, karşılaştırmalı çalışmaya, 1 Nisan 2020-1 Temmuz 2020 tarihleri arasında hastanemize, grip benzeri semptomlarla yandaş hastalıkları olmaksızın başvuran ve toraks BT'si bulunan, 141 PCR (+) ve 150 PCR (-) hasta dâhil edildi. Her hasta için torasik subkütan yağ dokusu kalınlığının pektoralis majör kası kalınlığına oranı [thoracic subcutaneous adipose tissue/major muscle thickness (TSAT/PMJ)], epikardiyal yağ dokusu kalınlığı [epicardial adipose tissue thickness (EAT)], karaciğer yoğunluğu [liver density (LD)], abdominal subkütan yağ dokusu kalınlığının psoas majör kası kalınlığına oranı [abdominal subcutaneous adipose tissue thickness/psoas major muscle thickness (ASAT/PSM)], subkütan karın yağ dokusu kalınlığının erector spinae kası kalınlığına oranı [erector spinae muscle (ASAT/ESM)] ölçüldü. Alt gruplar arasında yaş, cinsiyet ve ölçülen parametreler açısından karşılaştırma yapıldı. Bulgular: PCR (+) ve (-) bireyler arasında EAT ortalamaları açısından istatistiksel olarak anlamlı fark bulundu (p0,05). Sonuç: Yüksek EAT değerleri, koronavirüs hastalığı-2019 [coronavirus disease-2019 (COVID-19)] enfeksiyonuna yakalanma riskini artırabilir. Periferik yağ-kas indeksleri, COVID 19 enfeksiyonu olan ve olmayan hastalarda farklılık göstermemektedir.

Anahtar Kelimeler: COVID-19 enfeksiyonu; obezite; toraks bilgisayarlı tomografisi
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