Sağlık bakımı ile ilişkili enfeksiyonlar, her yıl dünya çapında yüz milyonlarca insanı etkilemektedir. Cerrahi alan enfeksiyonları (CAE); cerrahi girişim sonrası yara bölgesinde gelişen ancak önlenebilir enfeksiyonlardandır. Gelişiminde çevresel faktörler önemli rol oynamasına rağmen enfeksiyonlar genellikle bireyin kendi florasından kaynaklı gelişmektedir. Normal şartlarda epidermis, bakteriyel invazyonlara karşı vücudu korumakta ve birincil bariyer görevi görerek mikroorganizmaların vücuda girişini engellemektedir. Ancak cerrahi veya diğer invaziv girişimlerde, epidermis bütünlüğü bozulduğundan mikroorganizmaların cilt altına geçişi kolaylaşmaktadır. Bu bakımdan, enfeksiyonların çoğunun kişinin kendi cilt florasından kaynaklandığı düşünüldüğünde, ameliyat öncesi dönemde cilt hazırlığının yapılması ve antisepsisinin sağlanması önem taşımaktadır. Ameliyat öncesi cilt hazırlığının temel amacı, bireyin vücudunda yer alan mikroorganizma yükünün mümkün olduğunca azaltılmasıdır. Optimal antisepsi uygulamaları sonrası dahi cilt florası tamamen yok edilememekte, kontamine cerrahilerde flora yükü daha fazla olmaktadır. Dolayısıyla, ameliyat öncesi cilt hazırlığı uygulamalarının güncel rehberler doğrultusunda doğru bir şekilde uygulanması CAE'lerini azaltmada önemli rol oynamaktadır. Cilt hazırlığı bileşenleri Perioperatif Hemşireler Birliği kılavuzunda; dekolonizasyon, ameliyat öncesi duş, cerrahi alandaki tüyler, cerrahi alan antiseptiğinin seçimi, cerrahi alan antiseptiğinin uygulanması, antiseptiklerin güvenli taşınması ve saklanması, kalite olmak üzere 7 başlık altında ayrılmaktadır. Cilt hazırlığının doğru yapılabilmesi için bu bileşenlerin her birinde dikkat edilmesi gereken önemli noktalar bulunmaktadır. Bu derleme makalede de ameliyat öncesi cilt hazırlığına ilişkin güncel rehber önerileri ve uygulamada dikkat edilmesi gereken noktaların incelenmesi amaçlandı.
Anahtar Kelimeler: Cerrahi yara enfeksiyonu; antisepsis; ameliyat öncesi dönem; cilt; kanıta dayalı uygulamalar
Healthcare-associated infections affect hundreds of millions of people worldwide each year. Surgical site infections are preventable infections that develop in the wound area after surgical intervention. Although environmental factors play an important role in its development, infections generally develop due to the individual's flora. Under normal conditions, the epidermis protects the body against bacterial invasions and acts as a primary barrier, preventing microorganisms from entering the body. However, as the integrity of the epidermis is disrupted in surgical or other invasive interventions, it becomes easier for microorganisms to pass under the skin. Considering that the person's skin flora causes most infections, preparing the skin and providing antisepsis in the preoperative period is crucial. The primary purpose of preoperative skin preparation is to reduce the microorganism load on the individual's body as much as possible. Even after optimal antisepsis applications, skin flora cannot be wholly destroyed, and the flora load is higher in contaminated surgeries. Therefore, the correct application of preoperative skin preparation practices in accordance with current guidelines plays an important role in reducing surgical site infections. Skin preparation ingredients; The Association of perioperative Registered Nurses guideline is divided under 7 headings; decolonization, preoperative bathing, surgical site hair, selection of surgical site antiseptic, application of surgical site antiseptic, handling and storage of antiseptics, and quality. There are essential points to consider in each of these components in order to prepare the skin correctly. This review article aimed to examine the current guideline recommendations regarding preoperative skin preparation and the points to be considered in practice.
Keywords: Surgical wound infection; antisepsis; preoperative period; skin; evidence-based practice
- Allegranzi B, Bischoff P, de Jonge S, Kubilay NZ, Zayed B, Gomes SM, et al. New WHO recommendations on preoperative measures for surgical site infection prevention: an evidence-based global perspective. Lancet Infect Dis. 2016;16(12):e276-e87. [Crossref] [PubMed]
- U.S. Department of Health and Human Services [Internet]. [Cited: November 5, 2023]. Health Care-Associated Infections. 2021. Available from: [Link]
- Centers for Disease Control and Prevention [Internet]. [Cited: November 5, 2023]. HAI Data. 2018. Available from: [Link]
- Raoofi S, Pashazadeh Kan F, Rafiei S, Hosseinipalangi Z, Noorani Mejareh Z, Khani S, et al. Global prevalence of nosocomial infection: a systematic review and meta-analysis. PLoS One. 2023;18(1):e0274248. [Crossref] [PubMed] [PMC]
- Centers for Disease Control and Prevention [Internet]. [Cited: November 5, 2023]. Types of Healthcare-associated Infections. 2014. Available from: [Link]
- European Centre for Disease Prevention and Control [Internet]. [Cited: November 5, 2023]. Healthcare-associated infections. Available from: [Link]
- Healthy People 2030 [Internet]. [Cited: November 5, 2023]. Healthcare-Associated Infections Workgroup. Available from: [Link]
- Association for Professionals in Infection Control and Epidemiology [Internet]. [Cited: November 5, 2023]. What are healthcare-associated infections?. Available from: [Link]
- Natıonal Institute for Health and Care Excellence. Surgical site infections: prevention and treatment. Clinical Guideline-National Insitute of Health and care Excellence. 2020. p.1-29. www.nice.org.uk/guidance/ng125
- Centers for Disease Control and Prevention [Internet]. [Cited: November 5, 2023]. Surgical Site Infection (SSI). 2010. Available from: [Link]
- Mengistu DA, Alemu A, Abdukadir AA, Mohammed Husen A, Ahmed F, Mohammed B, et al. Global incidence of surgical site infection among patients: systematic review and meta-analysis. Inquiry. 2023;60:469580231162549. [Crossref] [PubMed] [PMC]
- Bashaw MA, Keister KJ. Perioperative strategies for surgical site infection prevention. AORN J. 2019;109(1):68-78. [Crossref] [PubMed]
- Dhamnaskar S, Mandal S, Koranne M, Patil P. Preoperative surgical site hair removal for elective abdominal surgery: does it have impact on surgical site infection. Surg J (N Y). 2022;8(3):e179-e86. [Crossref] [PubMed] [PMC]
- Gupta N, Nagar A, Meena D, Meena RS, Kumar S. Clinical evaluation of preoperative skin preparation with aqueous povidone iodine only and in combination with alcoholic chlorhexidine in patients undergoing clean elective surgeries. Journal of Clinical Images and Medical Case Reports. 2023;4(3):2319. [Crossref]
- Jolivet S, Lucet JC. Surgical field and skin preparation. Orthop Traumatol Surg Res. 2019;105(1S):S1-S6. [Crossref] [PubMed]
- Beausoleil C, Comstock SL, Werner D, Li L, Eby JM, Zook EC. Antimicrobial persistence of two alcoholic preoperative skin preparation solutions. J Hosp Infect. 2022;129:8-16. [Crossref] [PubMed]
- Scallan RM, Gerathy S, Price J, Lazarus AM, Metter EJ, Talbot LA. Preoperative chlorhexidine gluconate bathing on a military medical-surgical unit. Mil Med. 2020;185(Suppl 2):15-20. [Crossref] [PubMed]
- Edmiston CE Jr, Leaper D. Should preoperative showering or cleansing with chlorhexidine gluconate (CHG) be part of the surgical care bundle to prevent surgical site infection? J Infect Prev. 2017;18(6):311-4. [Crossref] [PubMed] [PMC]
- Cowperthwaite L, Holm RL. Guideline implementation: preoperative patient skin antisepsis. AORN J. 2015;101(1):71-7; quiz 78-80. [Crossref] [PubMed]
- Link T. Guidelines in practice: preoperative patient skin antisepsis. AORN J. 2022;115(2):156-66. [Crossref] [PubMed]
- Septimus EJ, Schweizer ML. Decolonization in prevention of health care-associated infections. Clin Microbiol Rev. 2016;29(2):201-22. [Crossref] [PubMed] [PMC]
- Stanton C. Guideline for preoperative patient skin antisepsis. AORN J. 2021;113(4):P5-P7. [Crossref] [PubMed]
- WHO. Global Guidelines for the Prevention of Surgical Site Infection, second edition [Internet]. World Health Organization. Geneva; 2018. Available from: [Link]
- Ling ML, Apisarnthanarak A, Abbas A, Morikane K, Lee KY, Warrier A, et al. APSIC guidelines for the prevention of surgical site infections. Antimicrob Resist Infect Control. 2019;8:174. [Crossref] [PubMed] [PMC]
- Calderwood MS, Anderson DJ, Bratzler DW, Dellinger EP, Garcia-Houchins S, Maragakis LL, et al. Strategies to prevent surgical site infections in acute-care hospitals: 2022 update. Infect Control Hosp Epidemiol. 2023;44(5):695-720. [Crossref] [PubMed] [PMC]
- Franco LM, Cota GF, Pinto TS, Ercole FF. Preoperative bathing of the surgical site with chlorhexidine for infection prevention: Systematic review with meta-analysis. Am J Infect Control. 2017;45(4):343-9. [Crossref] [PubMed]
- Ammanuel SG, Edwards CS, Chan AK, Mummaneni PV, Kidane J, Vargas E, et al. Are preoperative chlorhexidine gluconate showers associated with a reduction in surgical site infection following craniotomy? A retrospective cohort analysis of 3126 surgical procedures. J Neurosurg. 2021;135(6):1889-97. [Crossref] [PubMed] [PMC]
- Prayugo B, Siregar A, Hutahaean L, Hasibuan M. The effectiveness of pre-operative bath with 4% chlorhexidine gluconate for prevention of surgical site infection at the universitas sumatera utara hospital. Open Access Macedonian Journal of Medical Sciences. 2022;10(G):233-7. [Crossref]
- Webster J, Osborne S. Preoperative bathing or showering with skin antiseptics to prevent surgical site infection. Cochrane Database Syst Rev. 2015;2015(2):CD004985. [Crossref] [PubMed] [PMC]
- WHO. Global Guidelines for the Prevention of Surgical Site Infection, second edition [Internet]. World Health Organization. Geneva; 2016. Available from: [Link]
- Berríos-Torres SI, Umscheid CA, Bratzler DW, Leas B, Stone EC, Kelz RR, et al. Centers for Disease control and prevention guideline for the prevention of surgical site infection, 2017. JAMA Surg. 2017;152(8):784-91. Erratum in: JAMA Surg. 2017;152(8):803. [Crossref] [PubMed]
- Corby M, Meller C, Park S. Does perioperative skin preparation reduce surgical site infection? Laryngoscope. 2018;128(9):1987-9. [Crossref] [PubMed]
- Omolabake BI, Ozoila KN. A comparison of postoperative wound infection rates after preoperative hair removal with razors versus clippers in a sub-urban setting. International Surgery Journal. 2020;7(11):3627-32. [Crossref]
- Varia DM, Kacheriwala S. Pre-operative shaving versus trimming and their relation to post operative surgical site infection (ssi), a randomized controlled trial. Journal of Medical Science And clinical Research. 2016;4(8):12272-7. [Link]
- Grober ED, Domes T, Fanipour M, Copp JE. Preoperative hair removal on the male genitalia: clippers vs. razors. J Sex Med. 2013;10(2):589-94. [Crossref] [PubMed]
- Tanner J, Melen K. Preoperative hair removal to reduce surgical site infection. Cochrane Database Syst Rev. 2021;8(8):CD004122. [Crossref] [PubMed] [PMC]
- Jalalzadeh H, Groenen H, Buis DR, Dreissen YE, Goosen JH, Ijpma FF, et al. Efficacy of different preoperative skin antiseptics on the incidence of surgical site infections: a systematic review, GRADE assessment, and network meta-analysis. Lancet Microbe. 2022;3(10):e762-e71. Erratum in: Lancet Microbe. 2022;3(10):e732. [Crossref] [PubMed]
- Candan Dönmez Y. Ameliyat öncesi cilt hazırlığı [Preoperative skin preparation]. Türkiye Klinikleri J Surg Nurs-Special Topics. 2016;2(2):11-6. [Link]
- Álvarez CA, Guevara CE, Valderrama SL, Sefair CF, Cortes JA, Jimenez MF, et al. Practical recommendations for preoperative skin antisepsis. Infectio. 2018;22(1):46-54. [Crossref]
- Australasian College for Infection Prevention and Control. [Internet]. [Cited: February 14, 2024].Position Statement Preoperative Skin Antisepsis. 2019.
- Anggrahita T, Wardhana A, Sudjatmiko G. Chlorhexidine-alcohol versus povidone-iodine as preoperative skin preparation to prevent surgical site infection: a meta-analysis. Medical Journal of Indonesia. 2017;26(1):54-61. [Crossref]
- Dumville JC, McFarlane E, Edwards P, Lipp A, Holmes A. Preoperative skin antiseptics for preventing surgical wound infections after clean surgery. Cochrane Database Syst Rev. 2013;(3):CD003949. Update in: Cochrane Database Syst Rev. 2015;(4):CD003949. [Crossref] [PubMed]
- Elshamy E, Ali YZA, Khalafallah M, Soliman A. Chlorhexidine-alcohol versus povidone-iodine for skin preparation before elective cesarean section: a prospective observational study. J Matern Fetal Neonatal Med. 2020;33(2):272-6. [Crossref] [PubMed]
- Luwang AL, Saha PK, Rohilla M, Sikka P, Saha L, Gautam V. Chlorhexidine-alcohol versus povidone-iodine as preoperative skin antisepsis for prevention of surgical site infection in cesarean delivery-a pilot randomized control trial. Trials. 2021;22(1):540. [Crossref] [PubMed] [PMC]
- Valappil RK, Sajesh PT, Krishnan S. Preoperative skin preparation with chlorhexidine alcohol and povidone iodine: a comparative study. Journal of Medical Science and Clinical Research. 2017;5(12):32071-5. [Crossref]
- Haas DM, Morgan S, Contreras K, Kimball S. Vaginal preparation with antiseptic solution before cesarean section for preventing postoperative infections. Cochrane Database Syst Rev. 2020;4(4):CD007892. [Crossref] [PubMed] [PMC]
- Fink K, Örgel M, Baier C, Brauckmann V, Giannoudis V, Liodakis E. Quality of lower limb preoperative skin preparation using colorless versus colored disinfectants-results of an experimental, randomized study in a close to reality setting. PLoS One. 2023;18(3):e0282662. [Crossref] [PubMed] [PMC]
- The U.S. Food and Drug Administration [Internet]. [Cited: November 10, 2023]. FDA Drug Safety Communication: FDA requests label changes and single-use packaging for some over-the-counter topical antiseptic products to decrease risk of infection. 2013. Available from: [Link]
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