.: ORİJİNAL ARAŞTIRMA
Akut Renal Hasarlı Köpeklerde Bağırsak Ultrasonografisi: Bağırsak-Renal Ekseni Odaklı Prospektif Değerlendirmeler: Randomize Klinik Çalışma
Intestinal Ultrasonography in Dogs with Acute Renal Injury: Prospective Assessment of the Renal-Intestinal Axis: A Randomized Clinical Study
Turkiye Klinikleri J Vet Sci. 2024;15(1):15-22
doi: 10.5336/vetsci.2023-100293
Makale Dili: TR
Tam Metin
Ücretsiz Erişim
ÖZET
Amaç: Bu çalışma ile akut renal hasarı (ARH) bulunan köpeklerde, renal ve intestinal ilişkinin ultrasonografik olarak belirlenmesi ve ultrasonografik intestinal verilerin, ARH'ın erken belirteci olup olmayacağının ortaya konulması amaçlanmıştır. Gereç ve Yöntemler: Doğal yolla oluşan, ARH tanısı konulan ve herhangi bir şikâyeti bulunmayan sağlıklı olmak üzere her iki cinsiyetten ve farklı yaşlardaki (yaş aralığı 1-13) toplamda 64 köpek çalışmaya dâhil edilmiştir. Birinci grubu (n=24) sağlıklı köpekler, ikinci grubu (n=33) subklinik ARH'lı ve üçüncü grubu (n=7) tübüler zararla ilişkili ARH bulunan köpekler oluşturulmuştur. Bulgular: Subklinik ARH ile tübüler zararla ilişkili ARH kreatinin düzeyleri ve tüpüler zararla ilişkili ARH bulunan hastalarla, sağlıklı grup arasında anlamlı (p<0,001) bir farklılık tespit edilmiştir. Tübüler zararla ilişkili ARH bulunan hastalarda; kolon 3,3±0,1 mm, duodenum 5,1±0,4 mm, jejunum 4,4±0,3 mm olarak bulunurken, subklinik ARH grubuna dâhil edilen hastalarda; duvar kalınlıkları kolon 3,8±0,2 mm, duodenum 5,5±0,2 mm, jejunum 4,6±10,8 mm olarak tespit edilmiştir. Renal intestinal ilişki değerlendirildiğinde, yanlızca subklinik ARH'li köpeklerdeki intestinal değişimler sağlıklılara kıyasla anlamlı olarak kolon (p<0,001), duodenum (p<0,01) ve jejunum (p<0,05) bulunmuştur. Sonuç: ARH mevcut olan köpeklerde intestinal duvar kalınlıklarında artış görülmüştür. Elde edilen bu sonuçlar köpeklerde, böbrek-bağırsak iletişimini destekler niteliktedir.
Anahtar Kelimeler: Akut renal hasar; disbiyozis; köpek; ultrasonografi
Amaç: Bu çalışma ile akut renal hasarı (ARH) bulunan köpeklerde, renal ve intestinal ilişkinin ultrasonografik olarak belirlenmesi ve ultrasonografik intestinal verilerin, ARH'ın erken belirteci olup olmayacağının ortaya konulması amaçlanmıştır. Gereç ve Yöntemler: Doğal yolla oluşan, ARH tanısı konulan ve herhangi bir şikâyeti bulunmayan sağlıklı olmak üzere her iki cinsiyetten ve farklı yaşlardaki (yaş aralığı 1-13) toplamda 64 köpek çalışmaya dâhil edilmiştir. Birinci grubu (n=24) sağlıklı köpekler, ikinci grubu (n=33) subklinik ARH'lı ve üçüncü grubu (n=7) tübüler zararla ilişkili ARH bulunan köpekler oluşturulmuştur. Bulgular: Subklinik ARH ile tübüler zararla ilişkili ARH kreatinin düzeyleri ve tüpüler zararla ilişkili ARH bulunan hastalarla, sağlıklı grup arasında anlamlı (p<0,001) bir farklılık tespit edilmiştir. Tübüler zararla ilişkili ARH bulunan hastalarda; kolon 3,3±0,1 mm, duodenum 5,1±0,4 mm, jejunum 4,4±0,3 mm olarak bulunurken, subklinik ARH grubuna dâhil edilen hastalarda; duvar kalınlıkları kolon 3,8±0,2 mm, duodenum 5,5±0,2 mm, jejunum 4,6±10,8 mm olarak tespit edilmiştir. Renal intestinal ilişki değerlendirildiğinde, yanlızca subklinik ARH'li köpeklerdeki intestinal değişimler sağlıklılara kıyasla anlamlı olarak kolon (p<0,001), duodenum (p<0,01) ve jejunum (p<0,05) bulunmuştur. Sonuç: ARH mevcut olan köpeklerde intestinal duvar kalınlıklarında artış görülmüştür. Elde edilen bu sonuçlar köpeklerde, böbrek-bağırsak iletişimini destekler niteliktedir.
Anahtar Kelimeler: Akut renal hasar; disbiyozis; köpek; ultrasonografi
ABSTRACT
Objective: This study aims to elucidate the ultrasonographic interactions between the renal and intestinal domains in dogs afflicted with acute renal injury (ARI) and to ascertain the potential of ultrasonographic intestinal data as early indicators of ARI. Material and Methods: A cohort of 64 dogs, naturally diagnosed with ARI, encompassing both sexes and spanning diverse ages (1 to 13 years) was enrolled in the study. The first group (n=24) consisted of healthy dogs, the second group (n=33) comprised subjects with subclinical ARI, and the third group (n=7) consisted of individuals with ARI featuring tubular damage. Results: A significant difference (p<0.001) was observed in creatinine levels between subclinical ARI and ARI associated with tubular damage, as well as between patients with tubular damage-associated ARI and the healthy control group. In patients with ARI linked to tubular damage, the colon exhibited a wall thickness of 3.3±0.1 mm, the duodenum 5.1±0.4 mm, and the jejunum 4.4±0.3 mm, whereas those with subclinical ARI had a colon wall thickness of 3.8±0.2 mm, duodenum 5.5±0.2 mm, and jejunum 4.6±10.8 mm. Evaluation of the renalintestinal relationship revealed significant intestinal changes in dogs with only subclinical ARI compared to healthy dogs, particularly in the colon (p<0.001), duodenum (p<0.01), and jejunum (p<0.05) Conclusion: Dogs manifesting ARI demonstrated discernible augmentations in intestinal wall thickness. These findings lend support to the concept of renal-intestinal intercommunication in canine physiology.
Keywords: Acute renal injury; dysbiosis; dog; ultrasonography
Objective: This study aims to elucidate the ultrasonographic interactions between the renal and intestinal domains in dogs afflicted with acute renal injury (ARI) and to ascertain the potential of ultrasonographic intestinal data as early indicators of ARI. Material and Methods: A cohort of 64 dogs, naturally diagnosed with ARI, encompassing both sexes and spanning diverse ages (1 to 13 years) was enrolled in the study. The first group (n=24) consisted of healthy dogs, the second group (n=33) comprised subjects with subclinical ARI, and the third group (n=7) consisted of individuals with ARI featuring tubular damage. Results: A significant difference (p<0.001) was observed in creatinine levels between subclinical ARI and ARI associated with tubular damage, as well as between patients with tubular damage-associated ARI and the healthy control group. In patients with ARI linked to tubular damage, the colon exhibited a wall thickness of 3.3±0.1 mm, the duodenum 5.1±0.4 mm, and the jejunum 4.4±0.3 mm, whereas those with subclinical ARI had a colon wall thickness of 3.8±0.2 mm, duodenum 5.5±0.2 mm, and jejunum 4.6±10.8 mm. Evaluation of the renalintestinal relationship revealed significant intestinal changes in dogs with only subclinical ARI compared to healthy dogs, particularly in the colon (p<0.001), duodenum (p<0.01), and jejunum (p<0.05) Conclusion: Dogs manifesting ARI demonstrated discernible augmentations in intestinal wall thickness. These findings lend support to the concept of renal-intestinal intercommunication in canine physiology.
Keywords: Acute renal injury; dysbiosis; dog; ultrasonography
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