Turkiye Klinikleri Journal of Health Sciences

.: REVIEW
Yaşlanma ve Sirkadiyen Ritmin Moleküler Mekanizmaları
Molecular Mechanisms of Aging and Circadian Rhythms
Hilal FINDIK KIYANa, Toros KIYANb
aMoleküler Tıp AD, İstanbul Üniversitesi Aziz Sancar Deneysel Tıp Araştırma Enstitüsü, İstanbul, TÜRKİYE
bTıbbi Biyokimya Kliniği, Erzincan Binali Yıldırım Üniversitesi Mengücek Gazi Eğitim ve Araştırma Hastanesi, Erzincan, TÜRKİYE
Turkiye Klinikleri J Health Sci. 2019;4(3):400-10
doi: 10.5336/healthsci.2018-63684
Article Language: TR
Full Text
ÖZET
 Organizmalar 24 saatlik gündüz-gece döngüsüne adapte olmuşlardır. Bu sirkadiyen ritimler, fizyolojik ve metabolik süreçleri kontrol eden içsel bir hücresel mekanizma tarafından üretilmişlerdir. Bilindiği üzere yaşlanma sürecinde sirkadiyen sistem zayıflamakta ve biyolojik değişimler yavaşlamaktadır. Sirkadiyen genlerin genetik olarak değişimi ve moleküler saatin bozulması yaşlanma süreciyle ilişkilidir. Ayrıca çevresel koşullar da (Örn; Kalori kısıtlaması) yaşlanma sürecine etki eden önemli faktörlerdendir. Besinsel sensörleri içeren hücre içi yolaklar, yaşlanma sürecini kontrol eden hücresel ve epigenetik mekanizmaları etkilemektedirler. Yapılan çalışmalarla bu yolakların hem yaşlanma sürecinin düzenlenmesinde hem de moleküler saatin kontrolünde görev aldığı gösterilmiştir. Bu nedenle, sirkadiyen saatin ve besin algılama yolaklarının kontrolüne yönelik terapötik stratejiler, yaşlanma sürecindeki olumsuz etkileri azaltarak, bu sürecin daha verimli olmasını sağlayacak gibi görünmektedir.

Anahtar Kelimeler: Sirkadiyen ritim; yaşlanma; epigenetik
ABSTRACT
 Organizations have been adapting to the 24-hour day/night cycle. These circadian rhythms are produced by an internal cellular mechanism that controls physiological and metabolic processes. In the aging process the circadian system is weakening and biological changes are slowing down. The genetic change of circadian genes and the deterioration of the molecular clock are related to the aging process. In addition, environmental conditions (eg; calorie restriction) are important factors affecting the aging process. Intracellular pathways involving nutritional sensors influence cellular and epigenetic mechanisms that control the aging process. Studies have shown that these pathways are involved in both the modulation of the aging process and the control of the molecular clock. Therapeutic strategies focused at controlling the circadian clock and the nutrient sensing pathways might beneficially influence the negative effects of aging and make more efficient this process.

Keywords: Circadian rhythm; aging; epigenetics
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"Turkiye Klinikleri" in its sole discretion may change the hereby "Terms of Use" anytime announcing within the "SITE". The changed terms of the hereby "Terms of Use" will become valid when they are announced. Hereby "Terms of Use" cannot be changed by unilateral declarations of users.

7. FORCE MAJEURE

"Turkiye Klinikleri" is not responsible for executing late or never of this hereby "Terms of Use", privacy policy and "USER Contract" in any situation legally taken into account as force majeure. Being late or failure of performance or non-defaulting of this and similar cases like this will not be the case from the viewpoint of "Turkiye Klinikleri", and "Turkiye Klinikleri" will not have any damage liability for these situations. "Force majeure" term will be regarded as outside of the concerned party's reasonable control and any situation that "Turkiye Klinikleri" cannot prevent even though it shows due diligence. Also, force majeure situations include but not limited to natural disasters, rebellion, war, strike, communication problems, infrastructure and internet failure, power cut and bad weather conditions.

8. LAW AND AUTHORISATION TO FOLLOW

Turkish Law will be applied in practicing, interpreting the hereby "Terms of Use" and managing the emerging legal relationships within this "Terms of Use" in case of finding element of foreignness, except for the rules of Turkish conflict of laws. Ankara Courts and Enforcement Offices are entitled in any controversy happened or may happen due to hereby contract.

9. CLOSING AND AGREEMENT

Hereby "Terms of Use" come into force when announced in the "SITE" by "Turkiye Klinikleri". The users are regarded to agree to hereby contract terms by using the "SITE". "Turkiye Klinikleri" may change the contract terms and the changes will be come into force by specifying the version number and the date of change on time it is published in the "SITE".

 

30.03.2014

Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com