Turkiye Klinikleri Journal of Veterinary Sciences

.: ORIGINAL RESEARCH
Ultrasonographic Evidence of the Gut-Heart Axis: Increased Colon Wall Thickness in Dogs with Congestive Heart Failure: Case Control Research
Kalp-Bağırsak Ekseninin Ultrasonografik Kanıtı: Konjestif Kalp Yetersizliği Bulunan Köpeklerde Artan Kolon Duvar Kalınlığı: Olgu Kontrol Araştırması
Kerem URALa , Cansu BALIKÇIa , Hasan ERDOĞANa , Songül ERDOĞANa
aAydın Adnan Menderes University Faculty of Veterinary, Department of Internal Medicine, Aydın, Türkiye
Turkiye Klinikleri J Vet Sci. 2024;15(2):47-53
doi: 10.5336/vetsci.2024-101423
Article Language: EN
Full Text
ABSTRACT
 Objective: The potential role of the intestine in the pathophysiological process of heart diseases is a matter of curiosity due to the bidirectional interaction between the intestinal microbiota and the cardiovascular system, called the gut-heart axis. In our study, intestinal ultrasonographic evaluation was performed in dogs with congestive heart failure (CHF), under the name of heart-gut axis; It was aimed to evaluate the correlation between CHF severity and colon wall thickness (CoWt). Material and Methods: Eight dogs with CHF were used to evaluate CoWt, using intestinal ultrasonography. In addition to calculating the left atrium/aorta ratio in echocardiographic examination, visual evaluation, systolic and diastolic function evaluations, and regurgitation evaluation with color Doppler were also performed. Intestinal ultrasonography was performed and CoWt was measured from the beginning of the mucosa to the end of the serosa excluding the lumen. Results: We found that the CoWt in dogs with heart failure increased between 3.3 and 3.8 mm. CoWt measurements obtained from a limited number of dogs showed a statistically insignificant correlation with E/A and ejection fraction (%) at r=0.80 and r=-0.65, respectively. Conclusion: Our research shows a noticeable increase in CoWt in dogs suffering from CHF. More comprehensive studies with a larger data pool are needed to truly understand the link between CoWt elevation and diastolic dysfunction in dogs with CHF.

Keywords: Colon wall thickness; congestive heart failure; diastolic dysfunction; dog
ÖZET
 Amaç: Bağırsak mikrobiyotası ile bağırsak-kalp ekseni adı verilen kardiyovasküler sistem arasındaki çift yönlü etkileşim nedeniyle bağırsağın kalp hastalıklarının patofizyolojik sürecindeki potansiyel rolü merak konusudur. Çalışmamızda konjestif kalp yetersizliği (KKY) olan köpeklerde intestinal ultrasonografik değerlendirme yapılarak, kalp-bağırsak ekseni adı altında; KKY şiddeti ile kolon duvar kalınlığı [colon wall thickness (CoWt)] arası korelasyonun değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: Bağırsak ultrasonografisi kullanılarak CoWt'yi değerlendirmek için KKY olan 8 köpek kullanıldı. Ekokardiyografik incelemede, sol atriyum/aort oranının hesaplanmasına ek olarak görsel değerlendirme, sistolik ve diyastolik fonksiyon değerlendirmeleri ve renkli Doppler ile regürjitasyon değerlendirmesi de yapıldı. Bağırsak ultrasonografisi yapıldı ve CoWt, mukozanın başlangıcından lümen hariç serozanın sonuna kadar ölçüldü. Bulgular: Kalp yetersizliği olan köpeklerde CoWt'nin 3,3-3,8 mm arasında değişen düzeylerde arttığını tespit ettik. Sınırlı sayıda köpekten elde edilen CoWt ölçümleri, E/A ve ejeksiyon fraksiyonu (%) ile sırasıyla r=0,80 ve r=-0,65 düzeylerinde istatistiksel olarak anlamsız bir korelasyon gösterdi. Sonuç: Araştırmamız KKY'den muzdarip köpeklerde CoWt'de gözle görülür bir artış olduğunu göstermektedir. KKY'li köpeklerde CoWt yükselmesi ile diyastolik fonksiyon bozukluğu arasındaki bağlantıyı gerçekten anlamak için daha geniş bir veri havuzunu içeren daha kapsamlı çalışmalara ihtiyaç vardır.

Anahtar Kelimeler: Kolon duvar kalınlığı; konjestif kalp yetersizliği; diyastolik disfonksiyon; köpek
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