Journal of Traditional Medical Complementary Therapies

.: REVIEW
Triptofan ve Sağlık
Tryptophan and Health
Meryem Elif ÖZTÜRKa, Nurcan YABANCI AYHANb
aKaramanoğlu Mehmetbey Üniversitesi Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, Karaman TÜRKİYE
bAnkara Üniversitesi Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, Ankara, TÜRKİYE
J Tradit Complem Med. 2020;3(3):406-14
doi: 10.5336/jtracom.2020-74288
Article Language: TR
Full Text
ÖZET
 Triptofan; serotonin, melatonin, triptamin, nikotinik asit gibi önemli bileşiklerin sentezinde rol alan esansiyel aromatik bir amino asittir. Bu nedenle iştah, ağırlık kazanımı, uyku, ruh durumu, ağrı gibi pek çok fizyolojik durum ile ilişkilidir. Günlük triptofan gereksinimi, vücut ağırlığının kg'ı başına 5 mg'dır. Triptofanın beyine alınması ve aktif metabolitlere dönüşümü, alım miktarıyla ilişkili olduğu kadar ortamdaki diğer amino asitlerin özellikle büyük nötral amino asitlerin (valin, lösin, izolösin, fenilalanin, tirozin) varlığına da bağlıdır. Akut triptofan eksikliğinin, hafif şişman bireylerde şekerli besinlerden gelen enerji alımını artırdığı, düzelmiş depresyon hastalarında depresif yanıtı uyardığı, uyku süresi ve kalitesinde azalmaya, uzun süreli bellek işlevlerinde bozukluğa, migren hastalarında ışık kaynaklı ağrının ve migren ataklarının artmasına yol açtığı saptanmıştır. Triptofanın uyku üzerine olumlu etkisi dışında besin olarak alımının, vücutta ilaç benzeri hastalıklara karşı aktif bir işlevine rastlanmamıştır. Bununla birlikte triptofan destekleri, özellikle depresyon, bazı kognitif bozukluklar, kronik ağrı ve uyku bozukluklarında uzun süredir kullanılmaktadır. Ayrıca bu desteklerin, hafif şişman bireylerde tek başına enerji alımını azalttığı ve ağırlık kaybını sağladığı görülmüştür. Ancak triptofan desteklerinin, 1989 yılında eozinofili miyalji hastalığına yol açması ve bu durumdan pek çok kişinin zarar görmesi sebebiyle Amerikan Gıda ve İlaç Dairesi tarafından kullanımı bir süre yasaklanmış olup, 2005 yılında bu yasak kalkmıştır. Bununla birlikte 2005 yılından itibaren triptofan desteği kullanım sonucu, 2 adet eozinofilia miyalji ve 2 adet miyalji tanısı almış toplam 4 olgu bulunmaktadır.

Anahtar Kelimeler: Triptofan; obezite; uyku; ağrı
ABSTRACT
 Tryptophan is an essential aromatic aminoacid. It plays role for the important substances synthesis such as serotonine, melatonine, tryptamine, nicotinic acid. Therefore, it affects some physiological conditions such as weight gain, sleep activity, mood, pain. Daily triptophan requirement is 5 mg per kg body weight. Brain tryptophan uptake and conversion to active metabolites there, related with its amount of intake and presence of other aminoacids especially large neutral amino acids (valine, leucine, isoleucine, phenylalanine, tyrosine) in blood. Acute tryptophan depletion increases energy intake from foods high in sugar in overweight adults, stimulates depressive responses in patients with depression, decreases sleep duration and efficiancy, causes impaired long-term memory functioning and increases migraine symptoms and photophobia in patients who suffer from migraine. Except for sleep problems, there is no drug-like, active effects of tryptophan taken in food for diseases. Neverthless, tryptophan supplement has been used for a long time especially for depression, some cognitive problems, chronic pain and sleep problems. Besides, it is reported that tryptophan supplement decreases energy intake and provides weight loss alone in overweight adults. However, in 1989 since it caused eosinophilia myalgia syndrome and most of people harmed, it was banned by Food and Drug Administration for a while and in 2005, this ban was lifted. Because of using tryptophan two cases having eosinophilia myalgia sendrome and 2 cases having myalgias have been reported since 2005.

Keywords: Tryptophan; obesity; sleep; pain
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5.2. Within hereby "Terms of Use", "Turkiye Klinikleri" reserves the rights for "Turkiye Klinikleri" services, "Turkiye Klinikleri" information, the products associated with "Turkiye Klinikleri" copyrights, "Turkiye Klinikleri" trademarks, "Turkiye Klinikleri" trade looks or its all rights for other entity and information it has through this website unless it is explicitly authorized by "Turkiye Klinikleri".

6. CHANGES IN THE TERMS OF USE

"Turkiye Klinikleri" in its sole discretion may change the hereby "Terms of Use" anytime announcing within the "SITE". The changed terms of the hereby "Terms of Use" will become valid when they are announced. Hereby "Terms of Use" cannot be changed by unilateral declarations of users.

7. FORCE MAJEURE

"Turkiye Klinikleri" is not responsible for executing late or never of this hereby "Terms of Use", privacy policy and "USER Contract" in any situation legally taken into account as force majeure. Being late or failure of performance or non-defaulting of this and similar cases like this will not be the case from the viewpoint of "Turkiye Klinikleri", and "Turkiye Klinikleri" will not have any damage liability for these situations. "Force majeure" term will be regarded as outside of the concerned party's reasonable control and any situation that "Turkiye Klinikleri" cannot prevent even though it shows due diligence. Also, force majeure situations include but not limited to natural disasters, rebellion, war, strike, communication problems, infrastructure and internet failure, power cut and bad weather conditions.

8. LAW AND AUTHORISATION TO FOLLOW

Turkish Law will be applied in practicing, interpreting the hereby "Terms of Use" and managing the emerging legal relationships within this "Terms of Use" in case of finding element of foreignness, except for the rules of Turkish conflict of laws. Ankara Courts and Enforcement Offices are entitled in any controversy happened or may happen due to hereby contract.

9. CLOSING AND AGREEMENT

Hereby "Terms of Use" come into force when announced in the "SITE" by "Turkiye Klinikleri". The users are regarded to agree to hereby contract terms by using the "SITE". "Turkiye Klinikleri" may change the contract terms and the changes will be come into force by specifying the version number and the date of change on time it is published in the "SITE".

 

30.03.2014

Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com