Turkiye Klinikleri Journal of Ophthalmology

.: ORIGINAL RESEARCH
Topografik Gözyaşı Filmi Kırılma Zamanı Testi ve Meibografik Korelasyon Analizleri:
Bir Korelasyon Çalışması Topographic Tear Film Break Up Time Test and Meibographic Correlation Analysis: A Correlation Study
Yakup ACETa, Yaşar DAĞa
aMardin Eğitim ve Araştırma Hastanesi, Göz Hastalıkları Kliniği, Mardin, Türkiye
Turkiye Klinikleri J Ophthalmol. 2022;31(4):223-33
doi: 10.5336/ophthal.2022-88913
Article Language: TR
Full Text
ÖZET
 Amaç: Topografik gözyaşı filmi kırılma zamanı testi (TKZ) ile meibomian bez (MB) kaybı arasındaki ilişkiyi incelemek. Gereç ve Yöntemler: Prospektif çalışmamız 295 gönüllünün 295 gözü ile yapılmıştır. Her gönüllünün TKZ testindeki topografik gözyaşı filmi ilk kırılma zamanı (T-İKZ) ve topografik gözyaşı filmi ortalama kırılma zamanı (T-OKZ) parametreleri ile meibografide MB kayıp miktarını hem kantitatif hem de kalitatif değerler açısından inceledik. Bulgular: T-İKZ 7,1 sn ve üzeri olan olguların alt kapak MB kayıp düzeyi, T-İKZ değeri 5 sn ve altı olan olgulardan daha düşük bulundu (p=0,047). T-İKZ değeri arttıkça MB kayıp değerleri azalmaktadır. Ancak bu ilişki istatistiksel olarak anlamlı değildi (sırasıyla alt ve üst kapak MB kayıp oranları için korelasyon Ꞌr=-0,114, p=0,092, ve Ꞌr=-0,049, p=0,469). Sonuç: TKZ testindeki ilk kırılma zamanı ve ortalama kırılma zamanı parametreleri ile MB kayıp parametreleri arasında anlamlı ilişki saptamadık. Ancak MB kayıp miktarı %25'in altı ve üstü olarak ve TKZ parametrelerini ≤5 sn, 5,1-7 sn ve ≥7,1 sn olacak şekilde değer aralıklarına ayırdığımızda MB kayıp değerleri ile TKZ parametreleri arasında daha anlamlı sonuçların çıktığını gördük. T-İKZ değeri ≤5 sn olan gözlerde daha fazla MB kaybı varken, MB kayıp oranı ≥%25 olan olgularda ise T-İKZ değerinin ≤5 sn olma oranı daha fazlaydı. MB kaybı ile gözyaşı filmi kırılma zamanı arasındaki karmaşık ilişkinin araştırılmasında ek parametrelere ve testlere ihtiyaç olduğunu düşünmekteyiz.

Anahtar Kelimeler: Meibografi; topografik gözyaşı filmi kırılma zamanı testi; topografik ilk kırılma zamanı; topografik ortalama kırılma zamanı; Scheimpflug kamera
ABSTRACT
 Objective: To evaluate the relationship between topographic tear film break-up time (T-BUT) and meibomian gland (MG) loss. Material and Methods: Our prospective study was conducted with 295 eyes of 295 participants. We examined the topographical first tear film break-up time (Tf-BUT), topographical average tear film break-up time (Ta-BUT) parameters and the amount of MG loss in meibography in each participant's T-BUT test, both quantitatively and qualitatively. Results: The lower lid MG losses in cases with Tf-BUT value ≥7.1 sec was found to be lower than those with Tf-BUT≤5 (p=0.047). We found a negative correlation between T-BUT and MG loss parameters. However, this correlation is not statistically significant (correlation Ꞌr=-0.114, p=0.092, and Ꞌr=-0.049, p=0.469 for lower and upper lid MG loss rates, respectively). Conclusion: We did not detect a significant correlation between the first break-up time and average break-up time parameters in the T-BUT test, which is one of the tests evaluating tear film stability, and the MG loss parameters. However, loss rates above and below a 25% cut-off value in MG and/or when we divided the T-BUT parameters into value ranges of ≤5 sec, 5.1-7 sec and ≥7.1 sec, we found that more significant results were obtained between MG loss values and T-BUT parameters. We detected more MG loss in patients with a Tf-BUT value of ≤5 seconds, and a higher rate of ≤5 seconds in patients with a MGloss rate of ≥25%. We conclude that additional parameters and tests are needed to investigate the complex relationship between MG loss and tear film break-up time tests.

Keywords: Meibography; topographic tear film break-up time test; topographic first break-up time; topographic mean break-up time; Scheimpflug camera
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