Turkiye Klinikleri Journal of Medical Sciences

.: ORIGINAL RESEARCH
The Effects of Oral Retinoids on Hearing Status: A Prospective Clinical Study
Oral Retinoidlerin İşitme Düzeyi Üzerine Olan Etkileri: Prospektif Bir Klinik Çalışma
Nermin KARAOSMANOĞLUa, Ahmet AKKOÇb, Özlem AKKOCAb, Hatice Meral EKŞİOĞLUa
Departments of
aDermatology,
bEar Nose and Throat, Ankara Training and Research Hospital, Ankara, TURKEY
Turkiye Klinikleri J Med Sci. 2019;39(3):245-50
doi: 10.5336/medsci.2018-63914
Article Language: EN
Full Text
ABSTRACT
 Objective: The main purpose of this study was to analyse the effects of oral isotretinoin and acitretin, on hearing functions detected by serial odiometric examinations. Material and Methods: A total of thirty patients with moderate acne vulgaris and other thirty patients diagnosed as psoriasis vulgaris with a PASI score between 30-50% were included in this study. Isotretinoin and acitretin were prescribed for acne vulgaris and psoriasis vulgaris, respectively. The hearing of patients were tested with pure tone odiometric examination before, at the first and third months of the treatment in the remaining 55 patients (110 ears). The differences between the mean values of pretreatment and posttreatment pure tone hearing thresholds at 500, 1000, 2000, 4000, 8000 and 10000 Hz frequencies were evaluated for each group. Results: No significant difference was detected between the mean values of the pretreatment and posttreatment pure tone hearing thresholds of acitretin group (p>0.05); while in the isotretinoin group, a significant difference was detected between the pretreatment and posttreatment values at 500 Hz frequencies at first and third months of the treatment which was progressively decreasing (p<0.05).Conclusion: It can be concluded that, according to the results of our study, acitretin has no significant effect on hearing systems, while isotretinoin may lead to bilateral hearing threshold changes in a period of three months.

Keywords: Acitretin; hearing loss; isotretinoin; pure tone audiometry
ÖZET
 Amaç: Bu çalışmanın amacı, oral izotretinoin ve asitretinin işitme fonksiyonları üzerine olan etkilerinin seri odyometrik incelemelerle değerlendirilmesidir. Gereç ve Yöntemler: Orta şiddetli akne vulgaris tanısı olan 30 hasta ve PASI skoru % 30-50 arasında değişen 30 psoriazis vulgaris tanılı hasta çalışmaya dahil edildi. Akne vulgaris tanılı hastalara izotretinoin, psoriazis tanılı olanlara asitretin tedavileri verildi. Asitretin grubunda beş hasta yan etkiler ve düzensiz takipler nedeniyle çalışmadan çıkarıldı. Hastaların işitme düzeyleri tedavinin başlangıcı, birinci ve üçüncü aylarında saf ton odyometrik inceleme ile değerlendirildi. Her grup için tedavi öncesi ve tedavi sonrası saf ses işitme eşikleri ortalamaları arasındaki fark 500, 1000, 2000, 4000, 8000 ve 10000 Hz frekanslarında değerlendirildi. Bulgular: Asitretin grubunun tedavi öncesi ve tedavi sonrası saf ton işitme eşik değerlerinin ortalama değerleri arasında anlamlı fark bulunmazken (p>0,05); izotretinoin grubunda , tedavinin birinci ve üçüncü aylarında 500 Hz frekanslarında tedavi öncesi ve tedavi sonrası değerler arasında anlamlı bir fark olduğu saptandı (p <0,05). Sonuç: Sonuç olarak, çalışmamızın bulguları, asitretinin işitme sistemleri üzerinde anlamlı bir etkisi olmadığını, izotretinoinin ise üç aylık bir süre içinde bilateral işitme eşiği değişikliklerine neden olabileceğini göstermiştir.

Anahtar Kelimeler: Asitretin; işitme kaybı; izotretinoin; saf ton odyometri
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