Turkiye Klinikleri Journal of Dental Sciences

.: REVIEW
Süt Dişi Amputasyon Tedavilerinde Güncel Yaklaşımlar
Current Approaches to Primary Teeth Amputation Therapies
Arife KAPTANa, Çiğdem ÇUKURCUa
aCumhuriyet Üniversitesi Diş Hekimliği Fakültesi, Çocuk Diş Hekimliği ABD, Sivas, TÜRKİYE
Turkiye Klinikleri J Dental Sci. 2020;26(1):122-31
doi: 10.5336/dentalsci.2018-64371
Article Language: TR
Full Text
ÖZET
 Amputasyon tedavisi, kısmen veya total olarak enfekte koronal diş pulpasının çıkarılıp normal yapıdaki kök pulpasının etkili ve bakterisid bir madde ile korunmasıyla fonksiyonun sürdürülmesi işlemi olarak tanımlanmaktadır. Süt dişi amputasyon tedavisinde en yaygın olarak kullanılan materyal formokrezoldür, ancak formokrezolün içeriğindeki formaldehitten dolayı güvenirliliği konusunda şüpheler bulunmaktadır. Formokrezolün toksisitesine dair tartışmaların artması, fiksasyon sınırlarının tam olarak belirlenememesi ve geri dönüş riskinin bulunması amputasyon tedavilerinde değişik materyallerin kullanılmasını gündeme getirmiştir. Vital pulpa tedavisinde antimikrobiyal toksik ajanları elimine etmek isteyen araştırmacılar, alternatif yöntemlere ve materyallere yönelmişlerdir. Bu çalışmada, amputasyon tedavisinde kullanılan yöntem ve materyallerin özelliklerinin ortaya konularak değerlendirilmesi amaçlanmıştır.

Anahtar Kelimeler: Pulpotomi; diş, geçici; amputasyon
ABSTRACT
 Pulpotomy therapy is defined as the process of maintaining the function of the tooth by removing partially/completely infected coronal pulp and protecting the normal structure of the root pulp with an effective and bactericidal agent. The most commonly used material in the treatment of primary teeth pulpotomy is formocresol, but there are doubts about its reliability due to formaldehyde in the content of formocresol. The increase in the discussions about the toxicity of the formocresol, the lack of fixation limits and the risk of return have brought the use of different materials in pulpotomy therapies. Researchers who wanted to eliminate antimicrobial toxic agents in the treatment of vital pulp, directed to alternative methods and materials. The aim of this study is to evaluate the characteristics of the methods and materials used in pulpotomy therapy.

Keywords: Pulpotomy; tooth, deciduous; amputation
REFERENCES:
  1. Pinkham J, Casamassimo P, Fields H, McTigue D, Nowak A. Pulp therapy for the primary dentition. Pediatric Dentistry: Infancy Through Adolescence. 2nd ed. New Delhi, India: WB Saunders Co; 2001. p.675.
  2. Fuks AB. Vital pulp therapy with new materials for primary teeth: new directions and treatment perspectives. Pediatr Dent. 2008;30(3):211-9. [Crossref] 
  3. Ranly DM. Pulpotomy therapy in primary teeth: new modalities for old rationales. Pediatr Dent. 1994;16(6):403-9.
  4. Alaçam A. [Endodontic approaches in pedodontics]. Alaçam T editör. Endodonti. 1. Baskı. Ankara: Özyurt Matbaacılık; 2012. p.1264-6.
  5. Kahl J, Easton J, Johnson G, Zuk J, Wilson S, Galinkin J. Formocresol blood levels in children receiving dental treatment under general anesthesia. Pediatr Dent. 2008;30(5):393-9.
  6. Srinivasan V, Patchett CL, Waterhouse PJ. Is there life after Buckley's formocresol? Part I--A narrative review of alternative interventions and materials. Int J Paediatr Dent. 2006;16(2):117-27. [Crossref]  [PubMed] 
  7. Berger JE. A review of the erroneously labeled "mummification" techniques of pulp therapy. Oral Surg Oral Med Oral Pathol. 1972;34(1): 131-44. [Crossref] 
  8. Magnusson B. Therapeutic pulpotomy in primary molars--clinical and histological follow-up. II. Zinc oxide-eugenol as wound dressing. Odontol Revy. 1971;22(1):45-54.
  9. Hansen HP, Ravn JJ, Ulrich D. Vital pulpotomy in primary molars: a clinical and histologic investigation of the effect of zinc oxide-eugenol cement and Ledermix. Scand J Dent Res 1971;79(1):13-25. [Crossref]  [PubMed] 
  10. Hui-Derksen EK, Chen CF, Majewski R, Tootla RG, Boynton JR. Retrospective record review: reinforced zinc oxide-eugenol pulpotomy: a retrospective study. Pediatr Dent. 2013;35(1):43-6.
  11. Fuks AB, Eidelman E, Cleaton-Jones P, Michaeli Y. Pulp response to ferric sulfate, diluted formocresol and IRM in pulpotomized primary baboon teeth. ASDC J Dent Child. 1997;64(4):254-9.
  12. Doyle W, McDonald R, Mitchell D. Formocresol versus calcium hydroxide in pulpotomy. ASDC J Dent Child. 1962;29:86-97.
  13. Ranly DM, Garcia-Godoy F, Horn D. Time, concentration, and pH parameters for the use of glutaraldehyde as a pulpotomy agent: an in vitro study. Pediatr Dent. 1987;9(3):199-203.
  14. Maria S, Gama P, Cristina Marchiori É. Comparative study between formocresol and glutaraldehyde in pulpotomy-literature review. Rev Sul-bras Odontol. 2005;2:27-32.
  15. Garcia-Godoy F. A 42 month clinical evaluation of glutaraldehyde pulpotomies in primary teeth. J Pedod. 1986;10(2):148-55.
  16. Landau M, Johnsen D. Pulpal responses to ferric sulfate in monkeys. J Dent Res. 1988;67:215.
  17. Cotes O, Boj JR, Canalda C, Carreras M. Pulpal tissue reaction to formocresol vs. ferric sulfate in pulpotomized rat teeth. J Clin Pediatr Dent. 1997;21(3):247-53.
  18. Zander H. Reaction of the pulp to calcium hydroxide. J Dent Res. 1939;18(4):373-9. [Crossref] 
  19. Percinoto C, de Castro AM, Pinto LM. Clinical and radiographic evaluation of pulpotomies employing calcium hydroxide and trioxide mineral aggregate. Gen Dent. 2006;54(4):258-61.
  20. Schröder U. A 2-year follow-up of primary molars, pulpotomized with a gentle technique and capped with calcium hydroxide. Scand J Dent Res. 1978;86(4):273-8. [Crossref]  [PubMed] 
  21. Markovic D, Zivojinovic V, Vucetic M. Evaluation of three pulpotomy medicaments in primary teeth. Eur J Paediatr Dent. 2005;6(3): 133-8.
  22. Briso AL, Rahal V, Mestrener SR, Dezan Junior E. Biological response of pulps submitted to different capping materials. Braz Oral Res. 2006;20(3):219-25. [Crossref]  [PubMed] 
  23. Schmitt D, Lee J, Bogen G. Multifaceted use of ProRoot MTA root canal repair material. Pediatr Dent. 2001;23(4):326-30.
  24. Jabbarifar E, Mohammad Razavi S, Ahmadi N. Histopathologic responses of dog's dental pulp to mineral trioxide aggregate, bio active glass, formocresol, hydroxyapatite. Dent Res J. 2008;4(2):83-7.
  25. Hugar SM, Deshpande SD. Comparative investigation of clinical/radiographical signs of mineral trioxide aggregate and formocresol on pulpotomized primary molars. Contemp Clin Dent. 2010;1(3):146-51. [Crossref]  [PubMed]  [PMC] 
  26. Godhi B, Sood PB, Sharma A. Effects of mineral trioxide aggregate and formocresol on vital pulp after pulpotomy of primary molars: an in vivo study. Contemp Clin Dent. 2011;2(4):296-301. [Crossref]  [PubMed]  [PMC] 
  27. Srinivasan D, Jayanthi M. Comparative evaluation of formocresol and mineral trioxide aggregate as pulpotomy agents in deciduous teeth. Indian J Dent Res. 2011;22(3):385-90. [Crossref]  [PubMed] 
  28. Olatosi OO, Sote EO, Orenuga OO. Effect of mineral trioxide aggregate and formocresol pulpotomy on vital primary teeth: a clinical and radiographic study. Niger J Clin Pract. 2015;18(2):292-6. [Crossref]  [PubMed] 
  29. Perea MB, Mendoza BS, Garcia-Godoy F, Mendoza AM, Iglesias-Linares A. Clinical and radiographic evaluation of white MTA versus formocresol pulpotomy: a 48-month follow-up study. Am J Dent. 2017;30(3):131-6.
  30. Erdem AP, Guven Y, Balli B, Ilhan B, Sepet E, Ulukapi I, et al. Success rates of mineral trioxide aggregate, ferric sulfate, and formocresol pulpotomies: a 24-month study. Pediatr Dent. 2011;33(2):165-70.
  31. Odabaş ME, Alaçam A, Sillelioğlu H, Deveci C. Clinical and radiographic success rates of mineral trioxide aggregate and ferric sulphate pulpotomies performed by dental students. Eur J Paediatr Dent. 2012;13(2):118-22.
  32. Yildiz E, Tosun G. Evaluation of formocresol, calcium hydroxide, ferric sulfate, and MTA primary molar pulpotomies. Eur J Dent. 2014;8(2):234-40. [Crossref]  [PubMed]  [PMC] 
  33. Malkondu Ö, Karapinar Kazandağ M, Kazazoğlu E. A review on biodentine, a contemporary dentine replacement and repair material. Biomed Res Int. 2014;2014:160951. [Crossref]  [PubMed]  [PMC] 
  34. Cuadros C, Garcia J, Sandra S, Lorente A, Montse M. Clinical and radiographic evaluation of biodentine and MTA in pulpotomies of primary molars. 12th Congress of EAPD, Sopot; 2014.
  35. Rajasekharan S, Martens LC, Cauwels RG, Verbeeck RM. BiodentineTM material characteristics and clinical applications: a review of the literature. Eur Arch Paediatr Dent. 2014;15(3):147-58. [Crossref]  [PubMed] 
  36. Shayegan A, Jurysta C, Atash R, Petein M, Abbeele AV. Biodentine used as a pulp-capping agent in primary pig teeth. Pediatr Dent. 2012;34(7):e202-8.
  37. Rubanenko M, Moskovitz M, Petel R, Fuks A. Effectiveness of Biodentine versus Formocresol as dressing agents in pulpotomized primary molars: preliminary results. 12th Congress of EAPD, Sopot; 2014.
  38. Rajasekharan S, Cauwels R, Vandenbulcke J, Martens L. Efficacy of 3 pulpotomy medicaments in primary molars-A Randomised Control Trial with one year follow up. 12th Congress of EAPD, Sopot; 2014.
  39. Çelik BN, Mutluay MS, Arıkan V, Sarı Ş. The evaluation of MTA and Biodentine as a pulpotomy materials for carious exposures in primary teeth. Clin Oral Investig. 2018;1-6. [Crossref]  [PubMed] 
  40. Carti O, Oznurhan F. Evaluation and comparison of mineral trioxide aggregate and biodentine in primary tooth pulpotomy: clinical and radiographic study. Niger J Clin Pract. 2017;20(12):1604-9.
  41. Caruso S, Dinoi T, Marzo G, Campanella V, Giuca MR, Gatto R, et al. Clinical and radiographic evaluation of biodentine versus calcium hydroxide in primary teeth pulpotomies: a retrospective study. BMC Oral Health. 2018;18(1):54. [Crossref]  [PubMed]  [PMC] 
  42. Akimoto N, Momoi Y, Kohno A, Suzuki S, Otsuki M, Suzuki S, et al. Biocompatibility of Clearfil Liner Bond 2 and Clearfil AP-X system on nonexposed and exposed primate teeth. Quintessence Int. 1998;29(3):177-88.
  43. Hafez AA, Cox CF, Tarim B, Otsuki M, Akimoto N. An in vivo evaluation of hemorrhage control using sodium hypochlorite and direct capping with a one-or two-component adhesive system in exposed nonhuman primate pulps. Quintessence Int. 2002;33(4):261-72.
  44. Vargas KG, Packham B, Lowman D. Preliminary evaluation of sodium hypochlorite for pulpotomies in primary molars. Pediatr Dent. 2006;28(6):511-7.
  45. Haghgoo R, Abbasi F. A histopathological comparison of pulpotomy with sodium hypochlorite and formocresol. Iran Endod J. 2012;7(2):60-2.
  46. Chauhan SP, Gupta M, Ahmed H, Tongya R, Sharma D, Chugh B. Evaluation and comparison between formocresol and sodium hypochlorite as pulpotomy medicament: a randomized study. J Contemp Dent Pract. 2017;18(11):1029-33. [Crossref]  [PubMed] 
  47. Goker H, Haznedaroglu IC, Ercetin S, Kirazli S, Akman U, Ozturk Y, et al. Haemostatic actions of the folkloric medicinal plant extract Ankaferd Blood Stopper. J Int Med Res. 2008;36(1):163-70. [Crossref]  [PubMed] 
  48. Odabaş ME, Cinar C, Tulunoğlu O, Işik B. A new haemostatic agent's effect on the success of calcium hydroxide pulpotomy in primary molars. Pediatr Dent. 2011;33(7):529-34.
  49. Yaman E, Görken F, Pinar Erdem A, Sepet E, Aytepe Z. Effects of folk medicinal plant extract Ankaferd Blood Stopper(®) in vital primary molar pulpotomy. Eur Arch Paediatr Dent. 2012;13(4):197-202. [Crossref]  [PubMed] 
  50. Cantekin K, Gümüş H. Success rates of ankaferd blood stopper and ferric sulfate as pulpotomy agents in primary molars. Int Sch Res Notices. 2014;2014:819605. [Crossref]  [PubMed]  [PMC] 
  51. Yıldırım S, Alaçam A. [The protein and gene therapies for vital pulp treatments]. Hacettepe Dishek Fak Derg. 2007;31(2):54-63.
  52. Nakashima M, Reddi AH. The application of bone morphogenetic proteins to dental tissue engineering. Nat Biotechnol. 2003;21(9):1025-32. [Crossref]  [PubMed] 
  53. Rutherford RB, Wahle J, Tucker M, Rueger D, Charette M. Induction of reparative dentine formation in monkeys by recombinant human osteogenic protein-1. Arch Oral Biol. 1993;38(7):571-6. [Crossref] 
  54. da Silva LA, de Paula e Silva FW, Leonardo MR, Assed S. Pulpal and periapical response of dogs' teeth after pulpotomy and use of recombinant human bone morphogenetic protein-7 as a capping agent. J Dent Child (Chic). 2007;74(2):79-84.
  55. Kumar Praveen N, Rashmi N, Bhaskar Vipin K, Mopkar Pujan P. Pulpotomy medicaments: continued search for new alternatives-a review. Oral Health Dent Manag. 2014;13(4): 883-90.
  56. Yıldırım S, Alaçam A, Sarıtaş ZK, Oygür T. [The histopathological research of transforming growth factor-β1 for pulpal therapies]. Acta Odontol Turc. 2001;18(3):123-32.
  57. Özerol NB, Yılmaz NA, Bodrumlu E. [Emdogain in dentistry]. Acta Odontol Turc. 2014;31(1):43-8. [Crossref] 
  58. Inai T, Kukita T, Ohsaki Y, Nagata K, Kukita A, Kurisu K. Immunohistochemical demonstration of amelogenin penetration toward the dental pulp in the early stages of ameloblast development in rat molar tooth germs. Anat Rec. 1991;229(2):259-70. [Crossref]  [PubMed] 
  59. He J, Jiang J, Safavi KE, Spångberg LS, Zhu Q. Emdogain promotes osteoblast proliferation and differentiation and stimulates osteoprotegerin expression. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;97(2): 239-45. [Crossref]  [PubMed] 
  60. Yamamura T. Differentiation of pulpal cells and inductive influences of various matrices with reference to pulpal wound healing. J Dent Res. 1985;64 Spec No:530-40. [Crossref]  [PubMed] 
  61. Kaida H, Hamachi T, Anan H, Maeda K. Wound healing process of injured pulp tissues with emdogain gel. J Endod. 2008;34(1):26-30. [Crossref]  [PubMed] 
  62. Sabbarini J, Mounir M, Dean J. Histological evaluation of enamel matrix derivative as a pulpotomy agent in primary teeth. Pediatr Dent. 2007;29(6):475-9.
  63. Nakamura Y, Hammarström L, Lundberg E, Ekdahl H, Matsumoto K, Gestrelius S, et al. Enamel matrix derivative promotes reparative processes in the dental pulp. Adv Dent Res. 2001;15(1):105-7. [Crossref]  [PubMed] 
  64. Garrocho-Rangel A, Flores H, Silva-Herzog D, Hernandez-Sierra F, Mandeville P, Pozos-Guillen AJ. Efficacy of EMD versus calcium hydroxide in direct pulp capping of primary molars: a randomized controlled clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107(5):733-8. [Crossref]  [PubMed] 
  65. Marx RE. Platelet-rich plasma (PRP): what is PRP and what is not PRP? Implant Dent. 2001;10(4):225-8. [Crossref]  [PubMed] 
  66. Kevy SV, Jacobson MS. Comparison of methods for point of care preparation of autologous platelet gel. J Extra Corpor Technol. 2004;36(1):28-35.
  67. Somani R, Zaidi I, Jaidka S. Platelet rich plasma-a healing aid and perfect enhancement factor: review and case report. Int J Clin Pediatr Dent. 2011;4(1):69-75. [Crossref]  [PubMed]  [PMC] 
  68. Aroca S, Keglevich T, Barbieri B, Gera I, Etienne D. Clinical evaluation of a modified coronally advanced flap alone or in combination with a platelet-rich fibrin membrane for the treatment of adjacent multiple gingival recessions: a 6-month study. J Periodontol. 2009;80(2):244-52. [Crossref]  [PubMed] 
  69. Agrawal M, Agrawal V. Platelet rich fibrin and its applications in dentistry-a review article. NJMDR. 2014;2(3):51-8.
  70. Keswani D, Pandey RK. Revascularization of an immature tooth with a necrotic pulp using platelet-rich fibrin: a case report. Int Endod J. 2013;46(11):1096-104. [Crossref]  [PubMed] 
  71. Hiremath H, Saikalyan S, Kulkarni SS, Hiremath V. Second-generation platelet concentrate (PRF) as a pulpotomy medicament in a permanent molar with pulpitis: a case report. Int Endod J. 2012;45(1):105-12. [Crossref]  [PubMed] 
  72. Patidar S, Kalra N, Khatri A, Tyagi R. Clinical and radiographic comparison of platelet-rich fibrin and mineral trioxide aggregate as pulpotomy agents in primary molars. J Indian Soc Pedod Prev Dent. 2017;35(4):367-73. [Crossref]  [PubMed] 
  73. Kalaskar RR, Damle SG. Comparative evaluation of lyophilized freeze dried platelet derived preparation with calcium hydroxide as pulpotomy agents in primary molars. J Indian Soc Pedod Prev Dent. 2004;22(1):24-9.
  74. Rodríguez WdCG, Carpio M, Ramos M, Milanés M, Antúnez L. Pulpotomies of dead pulps in temporal molars using 10% propolis tinction. Rev Cubana Estomatol [online]. 2007;44(3).
  75. Lima RV, Esmeraldo MR, de Carvalho MG, de Oliveira PT, de Carvalho RA, da Silva FL, et al. Pulp repair after pulpotomy using different pulp capping agents: a comparative histologic analysis. Pediatr Dent. 2011;33(1):14-8.
  76. Ozório JE, Carvalho LF, de Oliveira DA, de Sousa-Neto MD, Perez DE. Standardized propolis extract and calcium hydroxide as pulpotomy agents in primary pig teeth. J Dent Child (Chic). 2012;79(2):53-8.
  77. Maeda T, Matsunuma A, Kawane T, Horiuchi N. Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells. Biochem Biophys Res Commun. 2001;280(3): 874-7. [Crossref]  [PubMed] 
  78. van Nieuw Amerongen GP, Vermeer MA, Nègre-Aminou P, Lankelma J, Emeis JJ, van Hinsbergh VW. Simvastatin improves disturbed endothelial barrier function. Circulation. 2000;102(23):2803-9. [Crossref]  [PubMed] 
  79. Okamoto Y, Sonoyama W, Ono M, Akiyama K, Fujisawa T, Oshima M, et al. Simvastatin induces the odontogenic differentiation of human dental pulp stem cells in vitro and in vivo. J Endod. 2009;35(3):367-72. [Crossref]  [PubMed] 
  80. Min KS, Lee YM, Hong SO, Kim EC. Simvastatin promotes odontoblastic differentiation and expression of angiogenic factors via heme oxygenase-1 in primary cultured human dental pulp cells. J Endod. 2010;36(3):447-52. [Crossref]  [PubMed] 
  81. Pettiette MT, Zhong S, Moretti AJ, Khan AA. Potential correlation between statins and pulp chamber calcification. J Endod. 2013;39(9): 1119-23. [Crossref]  [PubMed] 
  82. Jamali Z, Alavi V, Najafpour E, Aminabadi NA, Shirazi S. Randomized controlled trial of pulpotomy in primary molars using MTA and formocresol compared to 3Mixtatin: a novel biomaterial. J Clin Pediatr Dent. 2018;42(5): 361-6. [Crossref]  [PubMed] 
  83. Vivan RR, Mecca CE, Biguetti CC, Rennó AC, Okamoto R, Cavenago BC, et al. Experimental maxillary sinus augmentation using a highly bioactive glass ceramic. J Mater Sci Mater Med. 2016;27(2):41. [Crossref]  [PubMed] 
  84. Montazerian M, Dutra Zanotto E. History and trends of bioactive glass-ceramics. J Biomed Mater Res A. 2016;104(5):1231-49. [Crossref]  [PubMed] 
  85. Salako N, Joseph B, Ritwik P, Salonen J, John P, Junaid TA. Comparison of bioactive glass, mineral trioxide aggregate, ferric sulfate, and formocresol as pulpotomy agents in rat molar. Dent Traumatol. 2003;19(6):314-20. [Crossref]  [PubMed] 
  86. Pepla E, Besharat LK, Palaia G, Tenore G, Migliau G. Nano-hydroxyapatite and its applications in preventive, restorative and regenerative dentistry: a review of literature. Ann Stomatol (Roma). 2014;5(3):108-14. [Crossref] 
  87. Shayegan A, Atash R, Petein M, Abbeele AV. Nanohydroxyapatite used as a pulpotomy and direct pulp capping agent in primary pig teeth. J Dent Child (Chic). 2010;77(2):77-83.
  88. Komath M, Varma HK. Fully injectable calcium phosphate cement--a promise to dentistry. Indian J Dent Res. 2004;15(3):89-95.
  89. Chaung HM, Hong CH, Chiang CP, Lin SK, Kuo YS, Lan WH, et al. Comparison of calcium phosphate cement mixture and pure calcium hydroxide as direct pulp-capping agents. J Formos Med Assoc. 1996;95(7):545-50.
  90. Sena M, Yamashita Y, Nakano Y, Ohgaki M, Nakamura S, Yamashita K, et al. Octacalcium phosphate-based cement as a pulp-capping agent in rats. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;97(6):749-55. [Crossref]  [PubMed] 
  91. Zhang W, Walboomers XF, Jansen JA. The formation of tertiary dentin after pulp capping with a calcium phosphate cement, loaded with PLGA microparticles containing TGF-beta1. J Biomed Mater Res A. 2008;85(2):439-44. [Crossref]  [PubMed] 
  92. Jose B, Ratnakumari N, Mohanty M, Varma HK, Komath M. Calcium phosphate cement as an alternative for formocresol in primary teeth pulpotomies. Indian J Dent Res. 2013;24(4): 522. [Crossref]  [PubMed] 
  93. Omar OM, Khattab NM, Khater DS. Nigella sativa oil as a pulp medicament for pulpotomized teeth: a histopathological evaluation. J Clin Pediatr Dent. 2012;36(4):335-41. [Crossref]  [PubMed] 

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4. GENERAL PROVISIONS

4.1. "Turkiye Klinikleri" is completely free to determine which of the services and contents provided in the "SITE" will be charged.

4.2. People benefiting from the services provided by "Turkiye Klinikleri" and using the website can use the "SITE" only according to the law and only for personal reasons. Users have the criminal and civil liability for every process and action they take in the "SITE". Every USER agrees, declares and undertakes that they will not proceed by any function or action infringement of rights of "Turkiye Klinikleri"s and/or other third parties', they are the exclusive right holder on usage, processing, storage, made public and revealing any written, visual or auditory information reported to Turkiye Klinikleri" and/or "SITE" to the third parties. "USER" agrees and undertakes that s/he will not duplicate, copy, distribute, process, the pictures, text, visual and auditory images, video clips, files, databases, catalogs and lists within the "SITE", s/he will not be using these actions or with other ways to compete with "Turkiye Klinikleri", directly or indirectly.

4.3. The services provided and the context published within the "SITE" by third parties is not under the responsibility of "Turkiye Klinikleri", institutions collaborated with "Turkiye Klinikleri", "Turkiye Klinikleri" employee and directors, "Turkiye Klinikleri" authorized salespeople. Commitment to accuracy and legality of the published information, context, visual and auditory images provided by any third party are under the full responsibility of the third party. "Turkiye Klinikleri" does not promise and guarantee the safety, accuracy and legality of the services and context provided by a third party.

4.4. "USER"s cannot act against "Turkiye Klinikleri", other "USER"s and third parties by using the "SITE". "Turkiye Klinikleri" has no direct and/or indirect responsibility for any damage a third party suffered or will suffer regarding "USER"s actions on the "SITE" against the rules of the hereby "Terms of Use" and the law.

4.5. "USER"s accept and undertake that the information and context they provided to the "SITE" are accurate and legal. "Turkiye Klinikleri" is not liable and responsible for promising and guaranteeing the verification of the information and context transmitted to "Turkiye Klinikleri" by the "USER"s, or uploaded, changed and provided through the "SITE" by them and whether these information are safe, accurate and legal.

4.6. "USER"s agree and undertake that they will not perform any action leading to unfair competition, weakening the personal and commercial credit of "Turkiye Klinikleri" and a third party,  encroaching and attacking on personal rights within the "SITE" in accordance with the Turkish Commercial Code Law.

4.7. "Turkiye Klinikleri" reserves the right to change the services and the context within the "SITE"  anytime. "Turkiye Klinikleri" may use this right without any notification and timelessly. "USER"s have to make the changes and/or corrections "Turkiye Klinikleri" required immediately. Any changes and/or corrections that are required by "Turkiye Klinikleri", may be made by "Turkiye Klinikleri" when needed. Any harm, criminal and civil liability resulted or will result from changes and/or corrections required by "Turkiye Klinikleri" and were not made on time by the "USER"s belongs completely to the users.

4.8. "Turkiye Klinikleri" may give links through the "SITE" to other websites and/or "CONTEXT"s and/or folders that are outside of their control and owned and run by third parties. These links are provided for ease of reference only and do not hold qualification for support the respective web SITE or the admin or declaration or guarantee for the information inside. "Turkiye Klinikleri" does not hold any responsibility over the web-sites connected through the links on the "SITE", folders and context, the services or products on the websites provided through these links or their context.

4.9. "Turkiye Klinikleri" may use the information provided to them by the "USERS" through the "SITE" in line with the terms of the "PRIVACY POLICY" and "USER CONTRACT". It may process the information or classify and save them on a database. "Turkiye Klinikleri" may also use the USER's or visitor's identity, address, e-mail address, phone number, IP number, which sections of the "SITE" they visited, domain type, browser type, date and time information to provide statistical evaluation and customized services.

5. PROPRIETARY RIGHTS

5.1. The information accessed through this "SITE" or provided by the users legally and all the elements (including but not limited to design, text, image, html code and other codes) of the "SITE" (all of them will be called as studies tied to "Turkiye Klinikleri"s copyrights) belongs to "Turkiye Klinikleri". Users do not have the right to resell, process, share, distribute, display or give someone permission to access or to use the "Turkiye Klinikleri" services, "Turkiye Klinikleri" information and the products under copyright protection by "Turkiye Klinikleri". Within hereby "Terms of Use" unless explicitly permitted by "Turkiye Klinikleri" nobody can reproduce, process, distribute or produce or prepare any study from those under "Turkiye Klinikleri" copyright protection.

5.2. Within hereby "Terms of Use", "Turkiye Klinikleri" reserves the rights for "Turkiye Klinikleri" services, "Turkiye Klinikleri" information, the products associated with "Turkiye Klinikleri" copyrights, "Turkiye Klinikleri" trademarks, "Turkiye Klinikleri" trade looks or its all rights for other entity and information it has through this website unless it is explicitly authorized by "Turkiye Klinikleri".

6. CHANGES IN THE TERMS OF USE

"Turkiye Klinikleri" in its sole discretion may change the hereby "Terms of Use" anytime announcing within the "SITE". The changed terms of the hereby "Terms of Use" will become valid when they are announced. Hereby "Terms of Use" cannot be changed by unilateral declarations of users.

7. FORCE MAJEURE

"Turkiye Klinikleri" is not responsible for executing late or never of this hereby "Terms of Use", privacy policy and "USER Contract" in any situation legally taken into account as force majeure. Being late or failure of performance or non-defaulting of this and similar cases like this will not be the case from the viewpoint of "Turkiye Klinikleri", and "Turkiye Klinikleri" will not have any damage liability for these situations. "Force majeure" term will be regarded as outside of the concerned party's reasonable control and any situation that "Turkiye Klinikleri" cannot prevent even though it shows due diligence. Also, force majeure situations include but not limited to natural disasters, rebellion, war, strike, communication problems, infrastructure and internet failure, power cut and bad weather conditions.

8. LAW AND AUTHORISATION TO FOLLOW

Turkish Law will be applied in practicing, interpreting the hereby "Terms of Use" and managing the emerging legal relationships within this "Terms of Use" in case of finding element of foreignness, except for the rules of Turkish conflict of laws. Ankara Courts and Enforcement Offices are entitled in any controversy happened or may happen due to hereby contract.

9. CLOSING AND AGREEMENT

Hereby "Terms of Use" come into force when announced in the "SITE" by "Turkiye Klinikleri". The users are regarded to agree to hereby contract terms by using the "SITE". "Turkiye Klinikleri" may change the contract terms and the changes will be come into force by specifying the version number and the date of change on time it is published in the "SITE".

 

30.03.2014

Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com