Turkiye Klinikleri Cardiovascular Sciences

.: ORIGINAL RESEARCH
Restenoz Hastalarında Serum ApoM ve Serum Lipid Seviyeleri Arasındaki İlişkinin Araştırılması
The Relationship Between Serum ApoM and Lipid Levels in Restenosis Patients
Gülçin ÖZKARAa, Zahra JAVADOVAa, Ezgi Irmak ASLANa, Onur KILIÇARSLANb, Özgür Selim SERb, Oğuz ÖZTÜRKa, Ahmet YILDIZb, Hülya YILMAZ AYDOĞANa
aİstanbul Üniversitesi Aziz Sancar Deneysel Tıp Araştırma Enstitüsü, Moleküler Tıp ABD, İstanbul, TÜRKİYE
bİstanbul Üniversitesi-Cerrahpaşa Kardiyoloji Enstitüsü, Kardiyoloji Bölümü, İstanbul, TÜRKİYE
Turkiye Klinikleri J Cardiovasc Sci. 2020;32(2):75-83
doi: 10.5336/cardiosci.2020-75998
Article Language: TR
Full Text
ÖZET
 Amaç: Apolipoprotein M (ApoM) çoğunlukla (~%5) yüksek yoğunluklu lipoprotein (HDL) ve az miktarda (<%2) düşük yoğunluklu lipoprotein (LDL) içeriğinde bulunan yeni bir antiaterosklerotik proteindir. Ters kolesterol transportu aracılığıyla HDL metabolizmasında önemli rol oynadığı bilinen ApoM'nin, son çalışmalarda LDL oksidasyonu ve ateroskleroza karşı koruyucu etkileri olduğu belirtilmiştir. Buna karşın ApoM ve hastalıkların ilişkisini araştıran klinik çalışmalar sınırlı sayıdadır. Bu sebeple ApoM'nin kolesterol metabolizmasındaki etkilerine dayanarak çalışmamızda, restenoz hastalarında ve sağlıklı kontrollerde serum ApoM ve lipid seviyeleri arasındaki ilişkiyi araştırmayı amaçladık. Bu çalışma, restenoz hastalarında serum ApoM ve lipid seviyeleri arasındaki ilişkiyi gösteren literatürdeki ilk çalışmadır. Gereç ve Yöntemler: Çalışmamıza, 36 restenoz hastası ve 42 sağlıklı kontrol dâhil edilmiştir. Serum ApoM seviyeleri, ELISA yöntemiyle ölçülmüştür. Bulgular: Hasta grubunda serum ApoM (p=0,022), totalkolesterol (Total-K) (p=0,008) ve HDL-kolesterol (HDL-K) (p<0,001) seviyeleri sağlıklı kontrollerden daha düşük bulunurken, açlık kan glukozu ve HbA1c (p<0,001) ve trigliserid (TG) seviyeleri (p=0,002) yüksek bulunmuştur. Ayrıca restenoz hastalarında yüksek TG (≥150 mg/dL) ve LDL-kolesterol (LDL-K) (≥130 mg/dL) risk eşik değerlerinin, yüksek ApoM seviyeleri ile ilişkili olduğu tespit edilmiştir (sırasıyla, p=0,038; p=0,041). Bu ilişki kontrol grubunda gözlenmemiştir (p>0,05). Sonuç: Restenoz hastalarında, serum ApoM seviyeleri yalnızca HDL-K ile değil aynı zamanda Total-K, TG ve LDL-K seviyeleri ile de anlamlı pozitif korelasyon göstermiştir. Bu sonuçlar ApoM seviyelerinin, TG ve kolesterol seviyelerine etki ederek restenoz gelişimine katkı sağlayabileceğini göstermektedir.

Anahtar Kelimeler: Apolipoprotein M; HDL; LDL; kolesterol; trigliserid; restenoz
ABSTRACT
 Objective: Apolipoprotein M (ApoM) is a novel antiatherosclerotic protein which is present predominantly (~5%) in high density lipoprotein (HDL) and in trace amounts (<2%) in low density lipoprotein (LDL). In recent studies, it is reported that ApoM which is known to play important role in HDL metabolism via revers cholesterol transport, has protective effects against LDL oxidation and atherosclerosis. However, clinical studies revealing the association between ApoM and diseases are very limited. Therefore, we aimed to investigate the relationship between serum ApoM and lipid levels in restenosis patients and healthy controls on the basis of its effects on cholesterol metabolism. This is the first study revealing the association between serum ApoM and lipid levels in restenosis patients. Material and Methods: Thirty-six restenosis patients and 42 healthy controls were included in our study. Serum ApoM levels were measured by ELISA method. Results: The serum ApoM (p=0.022), total-cholesterol (Total-C) (p=0.008) and HDLcholesterol (HDL-C) (p<0.001) levels of patients were lower than the control group, while fasting blood glucose, HbA1c (p<0.001) and triglyceride (TG) (p=0.002) levels were higher. In addition, higher risk threshold values for serum TG (≥150 mg/dL) and LDL-cholesterol (LDL-C) (≥130 mg/dL) in the restenosis group were detected to be associated with higher ApoM levels in the restenosis patient group (p=0.038 and p=0.041, respectively). However, this relationship was not observed in control group (p>0.05). Conclusion: Serum ApoM level exhibited a significant, positive correlation not only with the HDL-C level, but also with the Total-C, TG and LDL-C levels in patients with restenosis. These results indicated that the serum ApoM levels may affects the serum TG and cholesterol levels so that contributes to the development of restenosis.

Keywords: Apolipoprotein M; HDL; LDL; cholesterol; triglyceride; restenosis
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-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

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Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

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Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

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