Turkiye Klinikleri Journal of Veterinary Sciences

.: REVIEW
Pulmoner Arteriyel Hipertansiyona Bağlı Gelişen Epitel ve Endotel Hasarının Belirlenmesinde Kullanılan Biyobelirteçler: Geleneksel Derleme
Use of Biomarkers for Detecting of Epithelial and Endothelial Damage Due to Pulmonary Arterial Hypertension: Traditional Review
Nimet İSMAİLOĞLUa, Mahmut OKa, Mutlu SEVİNÇa
aKonya Selçuk Üniversitesi Veteriner Fakültesi, İç Hastalıkları ABD, Konya, TÜRKİYE
Turkiye Klinikleri J Vet Sci. 2021;12(2):92-101
doi: 10.5336/vetsci.2020-78244
Article Language: TR
Full Text
ÖZET
 Pulmoner arteriyel hipertansiyon (PAH), ortalama pulmoner arter basıncında ve pulmoner vasküler dirençte artışla karakterize bir hastalıktır. PAH'ın etiyolojisi tam olarak anlaşılamamış olsa da altında birçok neden yattığı bildirilmektedir. Etiyolojisinde birçok etmenin rol oynadığı PAH'da, semptomlar çoğunlukla spesifik değildir. PAH'ın, birçok doku ve organda hasara neden olduğu bildirilmiştir. Son yıllarda PAH'ın solunum ve dolaşım sistemi üzerindeki etkilerinden dolayı üzerinde durulan bir hastalık hâline gelmesine neden olmuştur. PAH'ın teşhisinde invaziv yöntemlerin kullanılıyor olması, hastalığın takibini zorlaştırmaktadır. Noninvaziv yöntem olarak doku ve organlardaki hasarların erken belirlenmesini sağlayan biyobelirteçler kullanılmaya başlanmıştır. Biyobelirteçler yardımıyla hastalığın daha kolay izlenmesi, teşhis ve tedaviye daha çabuk ulaşılması hedeflenilmiştir. Son yıllarda hastalıkların teşhis ve takibinde, doku ve organlara özgü biyobelirteçler ön plana çıkmıştır. Bu derlemede, PAH'a bağlı gelişen kardiyopulmoner endotel ve epitel hasarın erken belirlenmesinde, noninvaziv tanı yöntem olarak oldukça faydalı olduğu kabul edilen biyobelirteçler hakkında yeni ve detaylı bilgi sunulmuştur.

Anahtar Kelimeler: Pulmoner arteriyel hipertansiyon; tanı yöntemi; endotel ve epitel hasar biyobelirteçleri
ABSTRACT
 Pulmonary arterial hypertension (PAH) is a disease characterized by an increase in mean pulmonary arterial pressure and pulmonary vascular resistance. Although the etiology of PAH is not fully understood, it is reported that many reasons under it. Where many factors play a role in etiology of PAH, the symptoms are mostly nonspecific. PAH has been reported to cause damage to many tissues and organs. In recent years, PAH has become a disease that is emphasized due to its effects on the respiratory and circulatory system. The use of invasive methods in the diagnosis of PAH makes the follow-up of the disease difficult. Biomarkers that enable early detection of damage to tissues and organs have begun to be used as a noninvasive method. With the help of biomarkers, it is aimed to monitor the disease more easily, to reach diagnosis and treatment faster. In recent years, tissue and organspecific biomarkers have come to the fore in the diagnosis and followup of diseases. In this review, new and detailed information about biomarkers, which are considered to be very useful as a noninvasive diagnostic method in the early determination of cardiopulmonary endothelium and epithelial damage due to PAH is presented.

Keywords: Pulmonary arterial hypertension; diagnostic method; endothelium and epithelial damage biomarkers
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4.9. "Turkiye Klinikleri" may use the information provided to them by the "USERS" through the "SITE" in line with the terms of the "PRIVACY POLICY" and "USER CONTRACT". It may process the information or classify and save them on a database. "Turkiye Klinikleri" may also use the USER's or visitor's identity, address, e-mail address, phone number, IP number, which sections of the "SITE" they visited, domain type, browser type, date and time information to provide statistical evaluation and customized services.

5. PROPRIETARY RIGHTS

5.1. The information accessed through this "SITE" or provided by the users legally and all the elements (including but not limited to design, text, image, html code and other codes) of the "SITE" (all of them will be called as studies tied to "Turkiye Klinikleri"s copyrights) belongs to "Turkiye Klinikleri". Users do not have the right to resell, process, share, distribute, display or give someone permission to access or to use the "Turkiye Klinikleri" services, "Turkiye Klinikleri" information and the products under copyright protection by "Turkiye Klinikleri". Within hereby "Terms of Use" unless explicitly permitted by "Turkiye Klinikleri" nobody can reproduce, process, distribute or produce or prepare any study from those under "Turkiye Klinikleri" copyright protection.

5.2. Within hereby "Terms of Use", "Turkiye Klinikleri" reserves the rights for "Turkiye Klinikleri" services, "Turkiye Klinikleri" information, the products associated with "Turkiye Klinikleri" copyrights, "Turkiye Klinikleri" trademarks, "Turkiye Klinikleri" trade looks or its all rights for other entity and information it has through this website unless it is explicitly authorized by "Turkiye Klinikleri".

6. CHANGES IN THE TERMS OF USE

"Turkiye Klinikleri" in its sole discretion may change the hereby "Terms of Use" anytime announcing within the "SITE". The changed terms of the hereby "Terms of Use" will become valid when they are announced. Hereby "Terms of Use" cannot be changed by unilateral declarations of users.

7. FORCE MAJEURE

"Turkiye Klinikleri" is not responsible for executing late or never of this hereby "Terms of Use", privacy policy and "USER Contract" in any situation legally taken into account as force majeure. Being late or failure of performance or non-defaulting of this and similar cases like this will not be the case from the viewpoint of "Turkiye Klinikleri", and "Turkiye Klinikleri" will not have any damage liability for these situations. "Force majeure" term will be regarded as outside of the concerned party's reasonable control and any situation that "Turkiye Klinikleri" cannot prevent even though it shows due diligence. Also, force majeure situations include but not limited to natural disasters, rebellion, war, strike, communication problems, infrastructure and internet failure, power cut and bad weather conditions.

8. LAW AND AUTHORISATION TO FOLLOW

Turkish Law will be applied in practicing, interpreting the hereby "Terms of Use" and managing the emerging legal relationships within this "Terms of Use" in case of finding element of foreignness, except for the rules of Turkish conflict of laws. Ankara Courts and Enforcement Offices are entitled in any controversy happened or may happen due to hereby contract.

9. CLOSING AND AGREEMENT

Hereby "Terms of Use" come into force when announced in the "SITE" by "Turkiye Klinikleri". The users are regarded to agree to hereby contract terms by using the "SITE". "Turkiye Klinikleri" may change the contract terms and the changes will be come into force by specifying the version number and the date of change on time it is published in the "SITE".

 

30.03.2014

Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com