Journal of Literature Pharmacy Sciences

Madde Bağımlılığının Tedavisi için Bitkisel Kaynak Araştırmaları Üzerine Bir Derleme
A Review on Herbal Resource Researches for Treatment of Drug Addiction
Seren GÜNDOĞDUa, Sümeyye AYHANa, Ayşe KURUÜZÜM UZa
aHacettepe Üniversitesi Eczacılık Fakültesi, Farmakognozi ABD, Ankara, TÜRKİYE
J Lit Pharm Sci. 2020;9(3):229-39
doi: 10.5336/pharmsci.2019-72972
Article Language: TR
Full Text
ÖZET
 Psikolojik ve nörolojik boyutları olan madde bağımlılığı, zararlı sonuçları olmasına rağmen kompulsif madde arayışı ve kullanımı ile karakterize kronik, tekrarlayan bir beyin hastalığıdır. Dünya genelindeki yaygınlığı gibi ülkemizde de mutlaka önüne geçilmesi gereken son derece tehlikeli bir halk sağlığı sorunu olan madde bağımlılığında modern, kanıta dayalı bir tedavi yaklaşımının benimsendiği tedavi süreci, kullanılan maddenin cinsine, kullanım süresine, hastanın yoksunluk belirtilerine, fiziksel ve ruhsal sorunlarına göre değişkenlik göstermektedir ve tedavi amacıyla kullanılabilecek kaynaklar ele alındığında, var olan ilaçların yanında yeni ilaçlar için öncü olabilecek doğal kaynakların da ele alınması ihtiyaç duyulan ve önemli bir husustur. Bu amaçla yapılan çalışmada, madde bağımlılığı kavramından, bağımlılık türleri ve bu türlerin yapılan bilimsel araştırmalar sonucunda çözümlenen oluşum mekanizmalarından, bu oluşum mekanizmalarından yola çıkılarak geliştirilen deneysel çalışmalardan ve tedavi basamağında etkili olan madde bağımlılığı tedavisinde kullanılabilecek ilaçların geliştirilmesine öncü olabilecek tıbbi bitkilerden özetle bahsedilmiştir. Bitkisel kaynaklar ile ilgili bugüne kadar yapılan çalışmalar derlenmiştir. Çeşitli madde bağımlılıklarında bitkilerin ekstrelerinin ve/veya alkaloit, flavonoid, polifenol ve terpen gibi farklı fitokimyasal yapılar taşıyan aktif izole bileşiklerinin in vitro ve/veya in vivo olarak etkili olabileceğini gösteren bilimsel çalışmaların sonucunda ortaya çıkan kanıtların, etkinlikleri sınırlı kalan mevcut tedavi yöntemlerini bir adım daha öteye taşıması ve hastanın sonsuz yararının gözetildiği standardize bir tedavinin insanlığın hizmetine sunulmasını hızlandırması umut edilmektedir.

Anahtar Kelimeler: Madde bağımlılığı; tıbbi bitki; Hypericum perforatum; hiperforin
ABSTRACT
 Drug addiction with psychological and neurological dimensions; is a chronic, recurrent brain disease characterized by the search for and use of compulsive substances, although it has detrimental consequences. The treatment process in which a modern, evidence-based treatment approach is adopted in drug addiction, which is an extremely dangerous public health problem that must be prevented in our country as well as its prevalence throughout the world; It varies according to the type of substance used, the duration of use, the withdrawal symptoms of the patient, physical and mental problems, and considering the available resources for treatment purposes, it is necessary and important to consider natural resources that may be the pioneer for new drugs. In this study; The concept of drug addiction, the types of dependence and the formation mechanisms that are solved as a result of scientific research, experimental studies developed based on these formation mechanisms and medicinal plants that can be used in the treatment of drug addiction that are effective in the treatment step are summarized. Studies on plant resources have been compiled. The evidence obtained as a result of these scientific studies showing that extracts of plants and / or active isolated compounds carrying different phytochemical structures such as alkaloids, flavonoids, polyphenols and terpenes in various drug addictions may be effective in vitro and/or in vivo is a step forward of current treatment methods with limited efficacy and it is expected to accelerate the delivery of a standardized treatment to the service of humanity.

Keywords: Drug addiction; medicinal plant; Hypericum perforatum; hyperforin
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30.03.2014

Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com