Lösemi, çocukluk çağı kanserlerinin önemli bir kısmını oluşturan, uzun ve zorlu tedavi süreci gerektiren malign bir hastalık grubudur. Ülkemizde ve dünyada her yıl binlerce çocuk bu hastalıktan dolayı kaybedilmektedir. Lösemili çocuklarda anemi, ateş, splenomegali, hepatomegali gibi birçok klinik belirti bulunmaktadır. Hastaların tedavileri süresince sık sık enfeksiyöz, renal, gastrointestinal, endokrinolojik ve nörolojik sistemlere ait komplikasyonlar görülmektedir. Lösemili çocukların tedavi ve iyileşme dönemlerinde yeterli ve dengeli beslenme büyük bir öneme sahiptir. Hastalık tedavisinin ilk dönemlerinde komplikasyonlar, ilaç tedavileri ve hastalık psikolojisi nedeniyle yetersiz ve dengesiz beslenme görülmekte, bu durum malnütrisyon ve büyüme geriliği ile sonuçlanabilmektedir. Fakat tedavinin ileri dönemleri veya iyileşme dönemlerinde kullanılan ilaç tedavisi, besin tüketim özlemi, psikolojik hastalık yükü ve düzensiz yaşam tarzı kaynaklı obezite, sarkopenik obezite, kardiyovasküler hastalıklar ve beraberinde getirdiği yeni hastalık semptomları görülebilmektedir. Uzun süreli yaşanan düzensiz beslenme ile besin ögesi yetersizlikleri ve anemi gibi komplikasyonları ortaya çıkmaktadır. Bu dönemde çocukların beslenme düzenlerinde ebeveynlerin rolü de önem arz etmektedir. Ebeveynler çocukların tedavilerinin ilk dönemlerinde aşırı beslenme baskısı yaparken, iyileşme sonrasında durumu kontrol altına almakta zorlanmaktadırlar. Bu yüzden tedavi sonrası sağkalım görülen çocuklarda yaşıtlarına kıyasla kronik hastalıklara yakalanma riski yüksek görülmektedir. Bu durum hastalığın beslenme ile ilişkisinin önemli olduğu ve konunun uzmanı diyetisyenlere ihtiyaç olduğunu göstermektedir.
Anahtar Kelimeler: Lösemi; çocuk; malnütrisyon; obezite
Leukemia is a malignant disease group that constitutes an important part of childhood cancer and requires a long and demanding treatment process. Every year thousands of children are died in our country and in the world due to this disease. Children with leukemia have many clinical symptoms such as anemia, fever, splenomegaly, and hepatomegaly. Complications of infectious, renal, gastrointestinal, endocrinological and neurological systems are frequently observed during the treatment of patients. Adequate and balanced nutrition is of great importance in the treatment and recovery periods of children with leukemia. In the early stages of disease treatment, inadequate and unbalanced nutrition is observed due to complications, drug treatments and disease psychology, which may result in malnutrition and growth retardation. However, drug therapy, nutrient consumption craving, psychological disease burden and irregular lifestyle-induced obesity, sarcopenic obesity, cardiovascular diseases and accompanying new disease symptoms can be seen in the advanced stages of treatment or in recovery periods. Complications such as nutritional deficiencies and anemia occur with long-term irregular nutrition. During this period, the role of parents in children's diet is also important. While parents put pressure on excessive nutrition in the early stages of their children's treatment, they find it difficult to control the situation after recovery. Therefore, the risk of developing chronic diseases appears to be higher in children with post-treatment survival compared to their peers. This condition shows that the relationship of the disease with nutrition is important and dieticians who are experts in the subject are needed.
Keywords: Leukemia; child; malnutrition; obesity
- Juliusson G, Lazarevic V, Hörstedt AS, Hagberg O, Höglund M; Swedish Acute Leukemia Registry Group. Acute myeloid leukemia in the real world: why population-based registries are needed. Blood. 2012;119(17):3890-9. [Crossref] [PubMed] [PMC]
- Redner A. Leukemias. In: Lanzkowsky P, ed. Manual of Peadiatric Hematology and Oncology. 5th ed. New York: Elsevier; 2011. p.518-66. [Crossref]
- Ataseven E, Kantar M, Anacak M, Kamer S, Ertan Y, Caner A, et al. Ege Üniversitesi Hastanesi çocukluk çağı tümörlerinde epidemiyoloji ve sağ kalım özellikleri. [Epidemiology and survival characteristics of childhood tumors in Ege University Hospital]. Ege Journal of Medicine. 2019;58(Ek sayı):105-13. [Crossref]
- Lim JY, Bhatia S, Robison LL, Yang JJ. Genomics of racial and ethnic disparities in childhood acute lymphoblastic leukemia. Cancer. 2014;120(7):955-62. [Crossref] [PubMed] [PMC]
- Hunger SP, Mullighan CG. Acute Lymphoblastic Leukemia in Children. N Engl J Med. 2015;373(16):1541-52. [Crossref] [PubMed]
- Juliusson G, Hough R. Leukemia. Prog Tumor Res. 2016;43:87-100. [Crossref] [PubMed]
- Howard SC, Riberio RC, Pui CH. Acute complications. In: Pui CH, ed. Childhood Leukemias. 3rd ed. Cambridge: Cambridge University Press; 2012. p. 660-700. [Link]
- O'Connor D, Bate J, Wade R, Clack R, Dhir S, Hough R, et al. Infection-related mortality in children with acute lymphoblastic leukemia: an analysis of infectious deaths on UKALL2003. Blood. 2014;124(7):1056-61. [Crossref] [PubMed]
- Yazbeck N, Samia L, Saab R, Abboud MR, Solh H, Muwakkit S. Effect of malnutrition at diagnosis on clinical outcomes of children with acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2016;38(2):107-10. [Crossref] [PubMed]
- Bauer J, Jürgens H, Frühwald MC. Important aspects of nutrition in children with cancer. Adv Nutr. 2011;2(2):67-77. [Crossref] [PubMed] [PMC]
- Thomsen M, Vitetta L. Adjunctive treatments for the prevention of chemotherapy- and radiotherapy-ınduced mucositis. Integr Cancer Ther. 2018;17(4):1027-47. [Crossref] [PubMed] [PMC]
- Büntzel J, Riesenbeck D, Glatzel M, Berndt-Skorka R, Riedel T, Mücke R, et al. Limited effects of selenium substitution in the prevention of radiation-associated toxicities. results of a randomized study in head and neck cancer patients. Anticancer Res. 2010;30(5):1829-32. [PubMed]
- Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, et al; Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO). MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2014;120(10):1453-61. Erratum in: Cancer. 2015;121(8):1339. [Crossref] [PubMed] [PMC]
- Arends J, Bachmann P, Baracos V, Barthelemy N, Bertz H, Bozzetti F, et al. ESPEN guidelines on nutrition in cancer patients. Clin Nutr. 2017;36(1):11-48. [Crossref] [PubMed]
- Wise DR, Thompson CB. Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci. 2010;35(8):427-33. [Crossref] [PubMed] [PMC]
- Antillon F, Rossi E, Molina AL, Sala A, Pencharz P, Valsecchi MG, et al. Nutritional status of children during treatment for acute lymphoblastic leukemia in Guatemala. Pediatr Blood Cancer. 2013;60(6):911-5. [Crossref] [PubMed]
- Pribnow AK, Ortiz R, Báez LF, Mendieta L, Luna-Fineman S. Effects of malnutrition on treatment-related morbidity and survival of children with cancer in Nicaragua. Pediatr Blood Cancer. 2017;64(11). [Crossref] [PubMed]
- Tan SY, Poh BK, Nadrah MH, Jannah NA, Rahman J, Ismail MN. Nutritional status and dietary intake of children with acute leukaemia during induction or consolidation chemotherapy. J Hum Nutr Diet. 2013;26 Suppl 1:23-33. [Crossref] [PubMed]
- Shams-White M, Kelly MJ, Gilhooly C, Liu S, Must A, Parsons SK, et al. Food craving and obesity in survivors of pediatric ALL and lymphoma. Appetite. 2016;96:1-6. [Crossref] [PubMed] [PMC]
- Galitzky J, Bouloumié A. Human visceral-fat-specific glucocorticoid tuning of adipogenesis. Cell Metab. 2013;18(1):3-5. [Crossref] [PubMed]
- Cohen J, Wakefield CE, Tapsell LC, Walton K, Fleming CA, Cohn RJ. Exploring the views of parents regarding dietary habits of their young cancer-surviving children. Support Care Cancer. 2015;23(2):463-71. [Crossref] [PubMed]
- Winter C, Müller C, Hoffmann C, Boos J, Rosenbaum D. Physical activity and childhood cancer. Pediatr Blood Cancer. 2010;54(4):501-10. [PubMed]
- Zhang FF, Kelly MJ, Saltzman E, Must A, Roberts SB, Parsons SK. Obesity in pediatric ALL survivors: a meta-analysis. Pediatrics. 2014 Mar;133(3):e704-15. [Crossref] [PubMed] [PMC]
- Zhang FF, Liu S, Chung M, Kelly MJ. Growth patterns during and after treatment in patients with pediatric ALL: A meta-analysis. Pediatr Blood Cancer. 2015;62(8):1452-60. [Crossref] [PubMed] [PMC]
- Withycombe JS, Smith LM, Meza JL, Merkle C, Faulkner MS, Ritter L, et al. Weight change during childhood acute lymphoblastic leukemia induction therapy predicts obesity: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2015;62(3):434-9. [Crossref] [PubMed] [PMC]
- Marriott CJC, Beaumont LF, Farncombe TH, Cranston AN, Athale UH, Yakemchuk VN, et al. Body composition in long-term survivors of acute lymphoblastic leukemia diagnosed in childhood and adolescence: A focus on sarcopenic obesity. Cancer. 2018;124(6):1225-31. [Crossref] [PubMed]
- Inaba H, Surprise HC, Pounds S, Cao X, Howard SC, Ringwald-Smith K, et al. Effect of body mass index on the outcome of children with acute myeloid leukemia. Cancer. 2012;118(23):5989-96. [Crossref] [PubMed] [PMC]
- Esbenshade AJ, Simmons JH, Koyama T, Koehler E, Whitlock JA, Friedman DL. Body mass index and blood pressure changes over the course of treatment of pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer. 2011;56(3):372-8. [Crossref] [PubMed] [PMC]
- Armenian SH, Gibson CJ, Rockne RC, Ness KK. Premature aging in young cancer survivors. J Natl Cancer Inst. 2019;111(3):226-32. [Crossref] [PubMed]
- Hudson MM, Ness KK, Gurney JG, Mulrooney DA, Chemaitilly W, Krull KR, et al. Clinical ascertainment of health outcomes among adults treated for childhood cancer. JAMA. 2013;309(22):2371-81. Erratum in: JAMA. 2013;310(1):99. [Crossref] [PubMed] [PMC]
- Landy DC, Lipsitz SR, Kurtz JM, Hinkle AS, Constine LS, Adams MJ, et al. Dietary quality, caloric intake, and adiposity of childhood cancer survivors and their siblings: An analysis from the cardiac risk factors in childhood cancer survivors study. Nutr Cancer. 2013;65(4):547-55. [Crossref] [PubMed]
- Smith WA, Li C, Nottage KA, Mulrooney DA, Armstrong GT, Lanctot JQ, et al. Lifestyle and metabolic syndrome in adult survivors of childhood cancer: a report from the St. Jude Lifetime Cohort Study. Cancer. 2014;120(17): 2742-50. [Crossref] [PubMed] [PMC]
- Tonorezos ES, Robien K, Eshelman-Kent D, Moskowitz CS, Church TS, Ross R, et al. Contribution of diet and physical activity to metabolic parameters among survivors of childhood leukemia. Cancer Causes Control. 2013;24(2):313-21. [Crossref] [PubMed] [PMC]
- Zhang FF, Ojha RP, Krull KR, Gibson TM, Lu L, Lanctot J, et al. Adult survivors of childhood cancer have poor adherence to dietary guidelines. J Nutr. 2016;146(12):2497-505. [Crossref] [PubMed] [PMC]
- Wampler MA, Galantino ML, Huang S, Gilchrist LS, Marchese VG, Morris GS, et al. Physical activity among adult survivors of childhood lower-extremity sarcoma. J Cancer Surviv. 2012;6(1):45-53. [Crossref] [PubMed] [PMC]
- Stern M, Lamana L, Russell C, Edwin L, Thompson A, Trapp S, et al. Adaptation of an obesity ıntervention program for pediatric cancer survivors (NOURISH-T). Clinical Practical in Pediatrik Psychology. 2013:1(3):264-75. [Crossref]
- Fleming CA, Cohen J, Murphy A, Wakefield CE, Cohn RJ, Naumann FL. Parent feeding interactions and practices during childhood cancer treatment. A qualitative investigation. Appetite. 2015;89:219-25. [Crossref] [PubMed]
- Zhang FF, Kelly M, Du M, Welch JG, Santacruz N, Rhoades J, et al. Early lifestyle intervention for obesity prevention in pediatric survivors of acute lymphoblastic leukemia. Nutrients. 2019;11(11):2631. [Crossref] [PubMed] [PMC]
- Aldhafiri F, Al-Nasser A, Al-Sugair A, Al-Mutairi H, Young D, Reilly JJ. Obesity and metabolic syndrome in adolescent survivors of standard risk childhood acute lymphoblastic leukemia in Saudi Arabia. Pediatr Blood Cancer. 2012;59(1):133-7. [Crossref] [PubMed]
- Pludowski P, Holick MF, Pilz S, Wagner CL, Hollis BW, Grant WB, et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. Autoimmun Rev. 2013;12(10):976-89. [Crossref] [PubMed]
- Sun J. Vitamin D and mucosal immune function. Curr Opin Gastroenterol. 2010;26(6):591-5. [Crossref] [PubMed] [PMC]
- Ladas EJ, Orjuela M, Stevenson K, Cole PD, Lin M, Athale UH, et al. Dietary intake and childhood leukemia: The Diet and Acute Lymphoblastic Leukemia Treatment (DALLT) cohort study. Nutrition. 2016;32(10):1103-09.e1. [Crossref] [PubMed] [PMC]
- Genc DB, Vural S, Yagar G. The incidence of and factors associated with vitamin d deficiency in newly diagnosed children with cancer. Nutr Cancer. 2016;68(5):756-61. [Crossref] [PubMed]
- Neville KA, Walker JL, Cohn RJ, Cowell CT, White CP. The prevalence of Vitamin D deficiency is higher in adult survivors of childhood cancer. Clin Endocrinol (Oxf). 2015;82(5):657-62. [Crossref] [PubMed]
- Muggeo P, Muggeo VMR, Giordano P, Delvecchio M, Altomare M, Novielli C, et al. Cardiovascular dysfunction and vitamin D status in childhood acute lymphoblastic leukemia survivors. World J Pediatr. 2019;15(5):465-70. [Crossref] [PubMed]
- Wallace G, Jodele S, Howell J, Myers KC, Teusink A, Zhao X, et al. Vitamin D deficiency and survival in children after hematopoietic stem cell transplant. Biol Blood Marrow Transplant. 2015;21(9):1627-31. [Crossref] [PubMed] [PMC]
- Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al; Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-30. Erratum in: J Clin Endocrinol Metab. 2011;96(12):3908. [Crossref] [PubMed]
- Demirsoy U, Sarper N, Aylan Gelen S, Zengin E, Kum T, Demir H. The association of oral vitamin D and calcium supplementation with bone mineral density in pediatric acute lymphoblastic leukemia patients. J Pediatr Hematol Oncol. 2017;39(4):287-92. [Crossref] [PubMed]
- Lee JY, So TY, Thackray J. A review on vitamin d deficiency treatment in pediatric patients. J Pediatr Pharmacol Ther. 2013;18(4):277-91. [Crossref] [PubMed] [PMC]
- Kühl S, Götz H, Brochhausen C, Jakse N, Filippi A, d'Hoedt B, et al. The influence of substitute materials on bone density after maxillary sinus augmentation: a microcomputed tomography study. Int J Oral Maxillofac Implants. 2012;27(6):1541-6. [PubMed]
- Caballero-Velázquez T, Montero I, Sánchez-Guijo F, Parody R, Salda-a R, Valcarcel D, et al; GETH (Grupo Espa-ol de Trasplante Hematopoyético). Immunomodulatory Effect of Vitamin D after Allogeneic Stem Cell Transplantation: Results of a Prospective Multicenter Clinical Trial. Clin Cancer Res. 2016;22(23):5673-81. [Crossref] [PubMed]
- Steele M, Narendran A. Mechanisms of defective erythropoiesis and anemia in pediatric acute lymphoblastic leukemia (ALL). Ann Hematol. 2012;91(10):1513-8. [Crossref] [PubMed]
- Pattnaik J, Kayal S, Dubashi B, Basu D, Vinod KV, Nandeesha H, et al. Profile of anemia in acute lymphoblastic leukemia patients on maintenance therapy and the effect of micronutrient supplementation. Support Care Cancer. 2020;28(2):731-8. d [Crossref] [PubMed]
- Tandon S, Moulik NR, Kumar A, Mahdi AA, Kumar A. Effect of Pre-treatment nutritional status, folate and vitamin B12 Levels on Induction chemotherapy in children with acute lymphoblastic leukemia. Indian Pediatr. 2015;52(5):385-9. [Crossref] [PubMed]
- Wien TN, Pike E, Wisløff T, Staff A, Smeland S, Klemp M. Cancer risk with folic acid supplements: a systematic review and meta-analysis. BMJ Open. 2012;2(1):e000653. [Crossref] [PubMed] [PMC]
- Liu Y, Wang B, Liu X, Xie X, Gu W, Li H, et al. Clinical variations of serum levels of ferritin, folic acid and vitamin B12 in acute leukemia patients. J Med Coll PLA. 2011;26(5):264-70. [Crossref]
.: Process List