Turkiye Klinikleri Journal of Dermatology

.: ORIGINAL RESEARCH
Local and Systemic Adverse Effects of CoronaVac Vaccine in Risk Groups: Prospective, Cross-Sectional Study
CoronaVac Aşısının Risk Gruplarında Lokal ve Sistemik İstenmeyen Etkilerinin Değerlendirilmesi: Prospektif, Kesitsel Çalışma
Esra İNAN DOĞANa, Akın AKTAŞb
aDepartment of Dermatology, Adıyaman University Faculty of Medicine, Adıyaman, TURKEY
bDepartment of Dermatology, Yıldırım Beyazıt University Faculty of Medicine, Ankara, TURKEY
Turkiye Klinikleri J Dermatol. 2021;31(3):186-94
doi: 10.5336/dermato.2021-85208
Article Language: EN
Full Text
ABSTRACT
 Objective: Coronavirus disease-2019 (COVID-19) infection progresses as an asymptomatic disease in some cases, whereas as a symptomatic disease and fatal in other cases. Due to its high spread, vaccines have been produced in many countries to control the infection. We aimed to evaluate local and allergic adverse effects of the CoronaVac vaccine in the risk group such as healthcare workers, individuals over 65 years of age, individuals who had COVID-19 infection. Material and Methods: A total of 189 healthcare workers and 122 individuals over the age of 65 who received the 2nd dose of CoronaVac vaccine 20 days ago were included in the study. Allergic, systemic and local symptoms were evaluted through a questionnaire which included 50 questions. Results: The most common local symptom was pain at the injection site (48.6%) and the most common systemic skin symptom after vaccination is pruritus outside the injection site (2.3%). There was a significant increase in symptoms of pruritus outside the injection site, rash outside the injection site, maculopapular rash, swelling around the eyelids, lips, or mouth, pale, sweaty, cold skin (vasovagal reflex) fever, chills, shortness of breath in participants who had COVID-19 infection (p<0.05). Symptoms of swelling around the eyelids, lips, and mouth, urticarial lesions outside the injection site were found to be significantly increase in indivuduals with a positive allergy history (p<0.05). Conclusion: Our study determined that the inactivated CoronaVac vaccine is safe in terms of serious adverse reactions in risk group. Therefore, CoronaVac vaccine has also adverse effect profile like other vaccines.

Keywords: Local adverse effects; systemic adverse effects; CoronaVac vaccine
ÖZET
 Amaç: Koronavirüs hastalığı-2019 [coronavirus disease-2019 (COVID-19)] enfeksiyonu, bazı durumlarda asemptomatik bir hastalık olarak ilerlerken, bazı durumlarda semptomatik ve ölümcül olabilmektedir. Yüksek yayılımı nedeniyle birçok ülkede bu enfeksiyonu kontrol altına almak için aşılar üretilmiştir. Çalışmamızda; sağlık çalışanları, COVID-19 enfeksiyonu geçiren ve 65 yaş üstü gibi risk grubunda olan bireylerin, CoronaVac aşısının lokal ve sistemik istenmeyen ve alerjik etkilerini değerlendirmeyi amaçladık. Gereç ve Yöntemler: Çalışmaya 20 gün önce 2. doz CoronaVac aşısı olan 189 sağlık çalışanı ve 65 yaş üstü 122 birey dâhil edildi. Sistemik, lokal istenmeyen ve alerjik semptomlar 50 soruluk bir anket ile değerlendirildi. Bulgular: Aşı sonrası gelişen en sık gözlenen lokal semptom enjeksiyon yerinde ağrı (%48,6) ve en sık gözlenen sistemik deri semptomu ise enjeksiyon bölgesi dışında kaşıntı (%2,3) idi. COVID-19 enfeksiyonu geçiren katılımcılarda bu enfeksiyonu geçirmeyenlere göre enjeksiyon bölgesi dışında kaşıntı, enjeksiyon bölgesi dışında döküntü, makülopapüler döküntü, göz kapakları, dudaklar veya ağız çevresinde şişlik, soluk, terli, soğuk cilt (vazovagal refleks), ateş, titreme, nefes darlığı semptomlarında önemli bir artış vardı (p<0,05). Alerjik hastalık öyküsü pozitif olanlar ve olmayanlar kıyaslandığında, alerjik hastalık öyküsü pozitif olanlar da göz kapakları, dudaklar ve ağız çevresinde şişlik, enjeksiyon bölgesi dışındaki ürtiker gözlenen birey sayısında belirgin artış saptandı (p<0,05). Sonuç: Çalışmamız, inaktif CoronaVac aşısının risk grubunda bulunan bireylerde ciddi yan etkiler açısından güvenli olduğunu göstermiştir. CoronaVac aşısının, daha önce kullanılan diğer aşılarla benzer oranda yan etki profiline sahip olduğu kanaatine varılmıştır.

Anahtar Kelimeler: Lokal yan etkiler; sistemik yan etkiler; CoronaVac aşısı
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