Turkiye Klinikleri Journal of Dermatology

.: ORIGINAL RESEARCH
Klinik ve Histopatolojik Olarak Enfeksiyöz Olmayan Granülomatöz Dermatit Tanısı Almış Olguların Retrospektif Olarak Değerlendirilmesi: 17 Yıllık Tek Merkez Deneyimi
Retrospective Evaluation of Patients Diagnosed with Clinically and Histopathologically Non-Infectious Granulomatous Dermatitis: 17-Year Single Center Experience
Tubanur ÇETİNARSLANa , Abdullah Kutay MASATa , Peyker TEMİZb , Aylin TÜREL ERMERTCANa
aManisa Celal Bayar Üniversitesi Tıp Fakültesi, Deri ve Zührevi Hastalıkları ABD, Manisa, Türkiye
bManisa Celal Bayar Üniversitesi Tıp Fakültesi, Patoloji ABD, Manisa, Türkiye
Turkiye Klinikleri J Dermatol. 2024;34(2):75-81
doi: 10.5336/dermato.2024-101932
Article Language: TR
Full Text
ÖZET
 Amaç: Granülomatöz dermatitler (GD), enfeksiyöz ve enfeksiyöz olmayan olmak üzere 2 ana başlık altında toplanan, histopatolojik olarak granülomlarla karakterize, sistemik bulgularla da seyredebilen bir hastalık grubudur. Granülomatöz inflamasyon, sadece deri ile sınırlı olabileceği gibi sistemik bir hastalığın bulgusu olarak da ortaya çıkabilmektedir. Gereç ve Yöntemler: Çalışmamıza kliniğimizde 2006-2023 tarihleri arasında klinik ve histopatolojik olarak enfeksiyöz olmayan GD tanısı alan 105 hasta dâhil edilmiştir. Bulgular: Araştırmamızda incelenen 105 hastanın 79'u kadın, 26'sı erkekti. Hastaların ortalama yaşı 45,72 idi (yaş aralığı 2-77 arası). Hastaların 12'si 18 yaş altı iken 12 hasta 65 yaş üstü idi. Hastaların tanı dağılımına bakıldığında ilk sırada granüloma anülare (n=43), takiben sırasıyla sarkoidoz (n=24), nekrobiyozis lipoidika (n=12), interstisyel GD (n=6), granülomatöz rozasea (n=5), pannikülit (n=5), granüloma fasiale (n=2), Crohn hastalığı (n=2), granülomatöz vaskülit (n=2), piyoderma gangrenozum (n=1), postherpetik GD (n=1), lupus miliaris disseminatus fasiei (n=1), granülomatöz mikozis fungoides (n=1) ve elastolitik dev hücreli granülom (n=1) yer almaktaydı. Sonuç: GD'ler, klinik ve histopatolojik bulguları farklılık gösteren heterojen bir hastalık grubudur. Tek başına histopatolojik morfoloji nadiren spesifiktir ve etiyolojide rol oynayan hastalığın kesin tanısını koymada tek başına yeterli değildir. Histopatolojik bulgular, mikrobiyolojik inceleme ve klinik veriler eşliğinde GD'lerin ayırıcı tanısı yapılmalıdır.

Anahtar Kelimeler: Granülom; granüloma anülare; granülomatöz dermatit; sarkoidoz; nekrobiyozis lipoidika
ABSTRACT
 Objective: Granulomatous dermatitis (GD) is a group of diseases grouped under two main headings: infectious and non-infectious, characterized histopathologically by granulomas and may also present with systemic findings. Granulomatous inflammation may be limited to the skin only or may occur as a symptom of a systemic disease. Material and Methods: 105 patients included who were clinically and histopathologically diagnosed with non-infectious GD in our clinic between 2006 and 2023. Results: Of the 105 patients included in our study, 79 were female and 26 were male. The mean age of the patients was 45.72 (age range 2-77). While 12 of the patients were under the age of 18, 12 patients were over the age of 65. The diagnosis of the patients were granuloma annulare (n=43), followed by sarcoidosis (n=24), necrobiosis lipoidica (n=12), interstitial GD (n=6), granulomatous rosacea (n=5), panniculitis (n=5), granuloma fasciale (n=2), Crohn's disease (n=2), granulomatous vasculitis (n=2), piyoderma gangrenozum (n=1), post herpetic GD (n=1), lupus miliaris disseminatus faciei (n=1), granulomatous mycosis fungoides (n=1) and elastolytic giant cell granuloma (n=1). Conclusion: GDs are a heterogeneous group of diseases with varying clinical and histopathological findings. Histopathological morphology alone is rarely specific and is not sufficient to make a definitive diagnosis of the disease that plays a role in etiology. Conclusion: Differential diagnosis of GDs should be made in the light of histopathological findings, microbiological examination and clinical data.

Keywords: Granuloma; granuloma annulare; granulomatous dermatitis; sarcoidosis; necrobiosis lipoidica
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