Turkiye Klinikleri Journal of Nursing Sciences

.: ORIGINAL RESEARCH
Kırılganlığın Tek Taraflı Primer Total Diz Artroplastisi Sonrası Erken Dönem Hasta Sonuçlarına Etkisinin Belirlenmesi: Tanımlayıcı-Kesitsel Bir Çalışma
Determining the Impact of Frailty on Short-Term Outcomes After Unilateral Primary Total Knee Arthroplasty: A Descriptive-Cross Sectional Survey
Çiğdem CANBOLAT SEYMANa , Yasemin ŞARAb
aHacettepe Üniversitesi Hemşirelik Fakültesi, Cerrahi Hastalıkları Hemşireliği ABD, Ankara, Türkiye
bSelçuk Üniversitesi Hemşirelik Fakültesi, Cerrahi Hastalıkları Hemşireliği ABD, Konya, Türkiye
Turkiye Klinikleri J Nurs Sci. 2023;15(2):291-8
doi: 10.5336/nurses.2022-93834
Article Language: TR
Full Text
ÖZET
Amaç: Kırılganlık ilerleyen yaşla birlikte fizyolojik kapasitede azalma, stres intoleransı, güçsüzlük, fiziksel aktivitede ve beden kitle indeksinde azalma gibi olumsuz sağlık sonuçlarını içeren geriatrik bir sendromdur. Artroplasti hastalarının ise, osteoartrite bağlı yakınmalar nedeniyle 60'lı yaşlarda ameliyat için başvurdukları bilinmektedir. Bu araştırmada, yaşlı ve kırılgan olma ihtimalleri oldukça yüksek bir grup olan total diz artroplastisi hastalarında kırılganlığın erken dönem hasta sonuçlarına etkisini belirlemek amaçlanmıştır. Gereç ve Yöntemler: Tanımlayıcı, kesitsel türde yapılan bu çalışma, bir üniversite hastanesinin ortopedi ve travmatoloji kliniğinde Ekim 2021-Mart 2022 tarihleri arasında, 127 hasta üzerinde yürütülmüştür. Araştırmanın verileri Kişisel Bilgiler Formu, ASA skorlaması, Charlson Komorbidite İndexi ve FRAIL ölçeği aracılığıyla toplanmıştır. Tanımlayıcı istatistikler, ki kare, Mann Whitney U, Kruskal Wallis ve Independent Sample t testleri kullanılarak veriler analiz edilmiştir. Ayrıca postoperatif hasta sonuçlarını kötüleştiren risk faktörlerini belirlemek için bivariate lojistik regresyon analizi kullanılmıştır. Bulgular: Yaş ortalamaları 66,8 ve beden kitle indeksi ortalamaları 31,3 kg/m2 olan hastaların %52'si sağ diz TDA geçirmiş, %79,5'i kadın, %87,4'ünün kronik hastalıkları mevcut ve %74'ünün kırılgan olduğu bulunmuştur. Araştırmaya katılan hastaların %26,8'i postoperatif erken dönem yaşadıkları sorunlara bağlı 7 günden uzun süre (X±SS: 10,8±4,8 gün) hastanede yatmıştır. Aynı zamanda FRAIL ölçek puanı arttıkça hastanede kalma sürelerinin, yoğun bakıma yatma oranlarının, postoperatif ağrı düzeylerinin arttığı ve postoperatif ilk mobilizasyon zamanlarının anlamlı olarak daha uzun olduğu saptanmıştır. Sonuç: Kırılganlığın primer unilateral total diz artroplastisi sonrası erken dönem olumsuz hasta sonuçları için tahmin edici/belirleyici olduğu ortaya konmuştur. Bu nedenle kırılganlığın preoperatif dönemde belirlenmesi ve gerekli önlemlerin alınması postoperatif erken dönem hasta sonuçlarını optimize edecektir.

Anahtar Kelimeler: Kırılganlık; artroplasti; postoperatif; hasta sonuçları
ABSTRACT
Objective: Frailty is a geriatric syndrome that describes all of the negative health consequences such as a decrease in physiological capacity, stress intolerance, weakness, low physical activity and a decrease in body mass index with advancing age. It is known that arthroplasty patients apply for surgery in their 60s because of complaints related to osteoarthritis. In this study, it was aimed to determine the effect of frailty on shortterm patient outcomes in total knee arthroplasty (TKA) patients, who are elderly and have a high probability of being frail. Material and Methods: This descriptive, cross-sectional study was conducted on 127 patients in the orthopedics and traumatology clinic of a university hospital between October 2021 and March 2022. The data of the study were collected with Personal Information Form, ASA score Charlson Comorbidity İndex ve FRAIL questionnaire. Data were analyzed using descriptive statistics, chi-square test, Mann Whitney U test, Kruskal Wallis and Independent Sample t-test. Furthermore, bivariate logistic regression analysis was used to identify risk factors that worsened postoperative patient outcomes. Results: Patients with an mean age of 66,8 and an mean body mass index of 31,3 kg/m2 ; it was found that 52% of the patients had right knee TKA, 79,5% were women, 87,4% had chronic diseases and 74% were frail. 26,8% of the patients participating in the study were hospitalized for more than 7 days due to the problems they experienced in the early postoperative period (X±SS: 10,8±4,8 day). At the same time, as the FRAIL scale score increased, it was determined that the length of hospital stay, the rate of intensive care unit stay and the postoperative pain levels were higher, and the first postoperative mobilization times were longer. Conclusion: Frailty has been shown to be a predictor/determinant for early adverse patient outcomes after primary unilateral total knee arthroplasty. Therefore, determining frailty in the preoperative period and taking necessary precautions will optimize early postoperative patient outcomes.

Keywords: Frailty; arthroplasty; postoperative; patients outcomes
REFERENCES:
  1. Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752-62. [Crossref]  [PubMed]  [PMC] 
  2. Akın S, Mazıcıoglu MM, Mucuk S, Gocer S, Deniz Şafak E, Arguvanlı S, et al. The prevalence of frailty and related factors in community-dwelling Turkish elderly according to modified Fried Frailty Index and FRAIL scales. Aging Clin Exp Res. 2015;27(5):703-9. [Crossref]  [PubMed] 
  3. Aarts S, Patel KV, Garcia ME, Van den Akker M, Verhey FR, Metsemakers JF, et al. Co-presence of multimorbidity and disability with frailty: an examination of heterogeneity in the frail older population. J Frailty Aging. 2015;4(3):131-8. [PubMed]  [PMC] 
  4. Türkiye İstatistik Kurumu [İnternet]. İstatistiklerle yaşlılar, 2020. TÜİK Bülten: 37227. Erişim tarihi: 01.01.2023 [Link] 
  5. World Health Organization [Internet]. © 2022 WHO. Guidelines on integrated care for older people (ICOPE). 2019; [Cited: 15.01.2023] Available from: [Link] 
  6. Abizanda P, Romero L, Sánchez-Jurado PM, Martínez-Reig M, Alfonso-Silguero SA, Rodríguez-Ma-as L. Age, frailty, disability, institutionalization, multimorbidity or comorbidity. Which are the main targets in older adults? J Nutr Health Aging. 2014;18(6):622-7. [Crossref]  [PubMed] 
  7. Ensrud KE, Ewing SK, Taylor BC, Fink HA, Stone KL, Cauley JA, et al; Study of Osteoporotic Fractures Research Group. Frailty and risk of falls, fracture, and mortality in older women: the study of osteoporotic fractures. J Gerontol A Biol Sci Med Sci. 2007;62(7):744-51. [Crossref]  [PubMed] 
  8. Walston J, Hadley EC, Ferrucci L, Guralnik JM, Newman AB, Studenski SA, et al. Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc. 2006;54(6):991-1001. [Crossref]  [PubMed] 
  9. Brent L, Hommel A, Maher AB, Hertz K, Meehan AJ, Santy-Tomlinson J. Nursing care of fragility fracture patients. Injury. 2018;49(8):1409-12. [Crossref]  [PubMed] 
  10. Curtis EM, Moon RJ, Harvey NC, Cooper C. Reprint of: the impact of fragility fracture and approaches to osteoporosis risk assessment worldwide. Int J Orthop Trauma Nurs. 2017;26:7-17. [Crossref]  [PubMed]  [PMC] 
  11. McIsaac DI, Beaulé PE, Bryson GL, Van Walraven C. The impact of frailty on outcomes and healthcare resource usage after total joint arthroplasty: a population-based cohort study. Bone Joint J. 2016;98-B(6):799-805. [Crossref]  [PubMed] 
  12. Shin JI, Keswani A, Lovy AJ, Moucha CS. Simplified frailty index as a predictor of adverse outcomes in total hip and knee arthroplasty. J Arthroplasty. 2016;31(11):2389-94. [Crossref]  [PubMed] 
  13. Johnson RL, Abdel MP, Frank RD, Chamberlain AM, Habermann EB, Mantilla CB. Impact of frailty on outcomes after primary and revision total hip arthroplasty. J Arthroplasty. 2019;34(1):56-64.e5. [Crossref]  [PubMed] 
  14. Doyle DJ, Goyal A, Bansal P, Garmon EH. American society of anesthesiologists classification. Statpearls [internet]: StatPearls Publishing; 2021. [Link] 
  15. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373-83. [Crossref]  [PubMed] 
  16. Morley JE, Malmstrom TK, Miller DK. A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans. J Nutr Health Aging. 2012;16(7):601-8. [Crossref]  [PubMed]  [PMC] 
  17. Muradi BABH. Yaşlılarda kırılganlığı ölçmeye yönelik FRAİL ölçeğinin Türkçe geçerlik ve güvenirlik çalışması. [Uzmanlık tezi]. Ankara: Hacettepe Üniversitesi; 2017. Erişim tarihi: 15.01.2023 Erişim linki: [Link] 
  18. Meyer M, Parik L, Leiß F, Renkawitz T, Grifka J, Weber M. Hospital frailty risk score predicts adverse events in primary total hip and knee arthroplasty. J Arthroplasty. 2020;35(12):3498-504.e3. [Crossref]  [PubMed] 
  19. Kort NP, Bemelmans YFL, Schotanus MGM. Outpatient surgery for unicompartmental knee arthroplasty is effective and safe. Knee Surg Sports Traumatol Arthrosc. 2017;25(9):2659-67. [Crossref]  [PubMed] 
  20. Morrell AT, Layon DR, Scott MJ, Kates SL, Golladay GJ, Patel NK. Enhanced recovery after primary total hip and knee arthroplasty: a systematic review. J Bone Joint Surg Am. 2021;103(20):1938-47. [Crossref]  [PubMed] 
  21. Traven SA, Reeves RA, Slone HS, Walton ZJ. Frailty predicts medical complications, length of stay, readmission, and mortality in revision hip and knee arthroplasty. J Arthroplasty. 2019;34(7):1412-6. [Crossref]  [PubMed] 
  22. Ondeck NT, Bohl DD, Bovonratwet P, Anandasivam NS, Cui JJ, McLynn RP, et al. Predicting adverse outcomes after total hip arthroplasty: a comparison of demographics, the American Society of Anesthesiologists Class, the Modified Charlson Comorbidity Index, and the Modified Frailty Index. J Am Acad Orthop Surg. 2018;26(20):735-43. [Crossref]  [PubMed] 
  23. Özdemir C, Karazeybek E, Söyüncü Y. Relationship between quality of care and patient care outcomes for postoperative pain in major orthopedic surgery: analytical and cross-sectional study. Clin Nurs Res. 2022;31(3):530-40. [Crossref]  [PubMed] 
  24. Khalil H, Shajrawi A, Henker R. Predictors of severe postoperative pain after orthopedic surgery in the immediate postoperative period. Int J Orthop Trauma Nurs. 2021;43:100864. [Crossref]  [PubMed] 
  25. Esses GJ, Liu X, Lin HM, Khelemsky Y, Deiner S. Preoperative frailty and its association with postsurgical pain in an older patient cohort. Reg Anesth Pain Med. 2019:rapm-2018-100247. [Crossref]  [PubMed] 
  26. Runner RP, Bellamy JL, Vu CCL, Erens GA, Schenker ML, Guild GN 3rd. Modified Frailty Index is an effective risk assessment tool in primary total knee arthroplasty. J Arthroplasty. 2017;32(9S):S177-82. [Crossref]  [PubMed] 

.: Up To Date

.: Process List

Login



Contact


Ortadoğu Reklam Tanıtım Yayıncılık Turizm Eğitim İnşaat Sanayi ve Ticaret A.Ş.

.: Address

Turkocagi Caddesi No:30 06520 Balgat / ANKARA
Phone: +90 312 286 56 56
Fax: +90 312 220 04 70
E-mail: info@turkiyeklinikleri.com

.: Manuscript Editing Department

Phone: +90 312 286 56 56/ 2
E-mail: yaziisleri@turkiyeklinikleri.com

.: English Language Redaction

Phone: +90 312 286 56 56/ 145
E-mail: tkyayindestek@turkiyeklinikleri.com

.: Marketing Sales-Project Department

Phone: +90 312 286 56 56/ 142
E-mail: reklam@turkiyeklinikleri.com

.: Subscription and Public Relations Department

Phone: +90 312 286 56 56/ 118
E-mail: abone@turkiyeklinikleri.com

.: Customer Services

Phone: +90 312 286 56 56/ 118
E-mail: satisdestek@turkiyeklinikleri.com

1. TERMS OF USE

1.1. To use the web pages with http://www.turkiyeklinikleri.com domain name or the websites reached through the sub domain names attached to the domain name (They will be collectively referred as "SITE"), please read the conditions below. If you do not accept these terms, please cease to use the "SITE." "SITE" owner reserves the right to change the information on the website, forms, contents, the "SITE," "SITE" terms of use anytime they want.

1.2. The owner of the "SITE" is Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. (From now on it is going to be referred as "Turkiye Klinikleri", shortly) and it resides at Turkocagi cad. No:30, 06520 Balgat Ankara. The services in the "SITE" are provided by "Turkiye Klinikleri."

1.3. Anyone accessing the "SITE" with or without a fee whether they are a natural person or a legal identity is considered to agree these terms of use. In this contract hereby, "Turkiye Klinikleri" may change the stated terms anytime. These changes will be published in the "SITE" periodically and they will be valid when they are published. Any natural person or legal identity benefiting from and reaching to the "SITE" are considered to be agreed to any change on hereby contract terms done by "Turkiye Klinikleri."

1.4. The "Terms of Use" hereby is published in the website with the last change on March 30th 2014 and the "SITE" is activated by enabling the access to everyone. The "Terms of Use" hereby is also a part of the any "USER Contract" was and/or will be done with the users using "Turkiye Klinikleri" services with or without a fee an inseparable.

2. DEFINITIONS

2.1. "SITE": A website offering different kind of services and context with a certain frame determined by "Turkiye Klinikleri" and it is accessible on-line on http://www.turkiyeklinikleri.com domain name and/or subdomains connected to the domain name.

2.2. USER: A natural person or a legal identity accessing to the "SITE" through online settings.

2.3. LINK: A link enabling to access to another website through the "SITE", the files, the context or through another website to the "SITE", the files and the context.

2.4. CONTEXT: Any visual, literary and auditory images published in the "Turkiye Klinikleri", "SITE" and/or any website or any accessible information, file, picture, number/figures, price, etc.

2.5. "USER CONTRACT": An electronically signed contract between a natural or a legal identity benefiting from special services "Turkiye Klinikleri" will provide and "Turkiye Klinikleri".

3. SCOPE OF THE SERVICES

3.1. "Turkiye Klinikleri" is completely free to determine the scope and quality of the services via the "SITE".

3.2. To benefit the services of "Turkiye Klinikleri" "SITE", the "USER" must deliver the features that will be specified by "Turkiye Klinikleri". "Turkiye Klinikleri" may change this necessity any time single-sided.

3.3. Not for a limited number, the services "Turkiye Klinikleri" will provide through the "SITE" for a certain price or for free are;

- Providing scientific articles, books and informative publications for health industry.

- Providing structural, statistical and editorial support to article preparation stage for scientific journals.

4. GENERAL PROVISIONS

4.1. "Turkiye Klinikleri" is completely free to determine which of the services and contents provided in the "SITE" will be charged.

4.2. People benefiting from the services provided by "Turkiye Klinikleri" and using the website can use the "SITE" only according to the law and only for personal reasons. Users have the criminal and civil liability for every process and action they take in the "SITE". Every USER agrees, declares and undertakes that they will not proceed by any function or action infringement of rights of "Turkiye Klinikleri"s and/or other third parties', they are the exclusive right holder on usage, processing, storage, made public and revealing any written, visual or auditory information reported to Turkiye Klinikleri" and/or "SITE" to the third parties. "USER" agrees and undertakes that s/he will not duplicate, copy, distribute, process, the pictures, text, visual and auditory images, video clips, files, databases, catalogs and lists within the "SITE", s/he will not be using these actions or with other ways to compete with "Turkiye Klinikleri", directly or indirectly.

4.3. The services provided and the context published within the "SITE" by third parties is not under the responsibility of "Turkiye Klinikleri", institutions collaborated with "Turkiye Klinikleri", "Turkiye Klinikleri" employee and directors, "Turkiye Klinikleri" authorized salespeople. Commitment to accuracy and legality of the published information, context, visual and auditory images provided by any third party are under the full responsibility of the third party. "Turkiye Klinikleri" does not promise and guarantee the safety, accuracy and legality of the services and context provided by a third party.

4.4. "USER"s cannot act against "Turkiye Klinikleri", other "USER"s and third parties by using the "SITE". "Turkiye Klinikleri" has no direct and/or indirect responsibility for any damage a third party suffered or will suffer regarding "USER"s actions on the "SITE" against the rules of the hereby "Terms of Use" and the law.

4.5. "USER"s accept and undertake that the information and context they provided to the "SITE" are accurate and legal. "Turkiye Klinikleri" is not liable and responsible for promising and guaranteeing the verification of the information and context transmitted to "Turkiye Klinikleri" by the "USER"s, or uploaded, changed and provided through the "SITE" by them and whether these information are safe, accurate and legal.

4.6. "USER"s agree and undertake that they will not perform any action leading to unfair competition, weakening the personal and commercial credit of "Turkiye Klinikleri" and a third party,  encroaching and attacking on personal rights within the "SITE" in accordance with the Turkish Commercial Code Law.

4.7. "Turkiye Klinikleri" reserves the right to change the services and the context within the "SITE"  anytime. "Turkiye Klinikleri" may use this right without any notification and timelessly. "USER"s have to make the changes and/or corrections "Turkiye Klinikleri" required immediately. Any changes and/or corrections that are required by "Turkiye Klinikleri", may be made by "Turkiye Klinikleri" when needed. Any harm, criminal and civil liability resulted or will result from changes and/or corrections required by "Turkiye Klinikleri" and were not made on time by the "USER"s belongs completely to the users.

4.8. "Turkiye Klinikleri" may give links through the "SITE" to other websites and/or "CONTEXT"s and/or folders that are outside of their control and owned and run by third parties. These links are provided for ease of reference only and do not hold qualification for support the respective web SITE or the admin or declaration or guarantee for the information inside. "Turkiye Klinikleri" does not hold any responsibility over the web-sites connected through the links on the "SITE", folders and context, the services or products on the websites provided through these links or their context.

4.9. "Turkiye Klinikleri" may use the information provided to them by the "USERS" through the "SITE" in line with the terms of the "PRIVACY POLICY" and "USER CONTRACT". It may process the information or classify and save them on a database. "Turkiye Klinikleri" may also use the USER's or visitor's identity, address, e-mail address, phone number, IP number, which sections of the "SITE" they visited, domain type, browser type, date and time information to provide statistical evaluation and customized services.

5. PROPRIETARY RIGHTS

5.1. The information accessed through this "SITE" or provided by the users legally and all the elements (including but not limited to design, text, image, html code and other codes) of the "SITE" (all of them will be called as studies tied to "Turkiye Klinikleri"s copyrights) belongs to "Turkiye Klinikleri". Users do not have the right to resell, process, share, distribute, display or give someone permission to access or to use the "Turkiye Klinikleri" services, "Turkiye Klinikleri" information and the products under copyright protection by "Turkiye Klinikleri". Within hereby "Terms of Use" unless explicitly permitted by "Turkiye Klinikleri" nobody can reproduce, process, distribute or produce or prepare any study from those under "Turkiye Klinikleri" copyright protection.

5.2. Within hereby "Terms of Use", "Turkiye Klinikleri" reserves the rights for "Turkiye Klinikleri" services, "Turkiye Klinikleri" information, the products associated with "Turkiye Klinikleri" copyrights, "Turkiye Klinikleri" trademarks, "Turkiye Klinikleri" trade looks or its all rights for other entity and information it has through this website unless it is explicitly authorized by "Turkiye Klinikleri".

6. CHANGES IN THE TERMS OF USE

"Turkiye Klinikleri" in its sole discretion may change the hereby "Terms of Use" anytime announcing within the "SITE". The changed terms of the hereby "Terms of Use" will become valid when they are announced. Hereby "Terms of Use" cannot be changed by unilateral declarations of users.

7. FORCE MAJEURE

"Turkiye Klinikleri" is not responsible for executing late or never of this hereby "Terms of Use", privacy policy and "USER Contract" in any situation legally taken into account as force majeure. Being late or failure of performance or non-defaulting of this and similar cases like this will not be the case from the viewpoint of "Turkiye Klinikleri", and "Turkiye Klinikleri" will not have any damage liability for these situations. "Force majeure" term will be regarded as outside of the concerned party's reasonable control and any situation that "Turkiye Klinikleri" cannot prevent even though it shows due diligence. Also, force majeure situations include but not limited to natural disasters, rebellion, war, strike, communication problems, infrastructure and internet failure, power cut and bad weather conditions.

8. LAW AND AUTHORISATION TO FOLLOW

Turkish Law will be applied in practicing, interpreting the hereby "Terms of Use" and managing the emerging legal relationships within this "Terms of Use" in case of finding element of foreignness, except for the rules of Turkish conflict of laws. Ankara Courts and Enforcement Offices are entitled in any controversy happened or may happen due to hereby contract.

9. CLOSING AND AGREEMENT

Hereby "Terms of Use" come into force when announced in the "SITE" by "Turkiye Klinikleri". The users are regarded to agree to hereby contract terms by using the "SITE". "Turkiye Klinikleri" may change the contract terms and the changes will be come into force by specifying the version number and the date of change on time it is published in the "SITE".

 

30.03.2014

Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com