Turkiye Klinikleri Journal of Veterinary Sciences

.: REVIEW
Kedi ve Köpeklerin Yangısal Bağırsak Hastalığında Terapötik Helmintler
Therapeutic Helminths in Inflammatory Bowel Disease in Cats and Dogs
Bengü BİLGİÇa, Berna BAYSAL BAKAYb, Sinem ÜLGEN SAKAa, Mehmet Erman ORa
aİstanbul Üniversitesi-Cerrahpaşa Veteriner Fakültesi, İç Hastalıkları ABD, İstanbul, TÜRKİYE
bCumhuriyet Üniversitesi Gürün Meslek Yüksekokulu, Tıbbi Parazitoloji Bölümü, Sivas, TÜRKİYE
Turkiye Klinikleri J Vet Sci. 2020;11(2):92-8
doi: 10.5336/vetsci.2020-75067
Article Language: TR
Full Text
ÖZET
 Yangısal bağırsak hastalığı (IBD) insanlarda olduğu gibi kedi ve köpeklerde de yaygın olarak görülen ishal ve kusma gibi gastrointestinal bulgularla karakterize, yangısal ve otoimmün bir hastalıktır. Günümüzde hijyenik yaşam koşullarının yaygınlaşmasıyla birlikte helmintlerin bağırsağa kolonizasyonunun çeşitli yollarla engellenmesi, hastalığın artışında rol oynayan önemli faktörlerden biri olarak düşünülmektedir. Kedi ve köpeklerde lenfositik-plazmasitik, eozinofilik ve granulomatoz yangı, beşeri hekimlikte ise Krohn hastalığı ve ülseratif kolit şeklinde görülen bu yangısal hastalıkta, Th1 hücreleri tarafından IL-10, IL-12, IL-13, IFNγ gibi sitokinler salınır. Bunun yanı sıra, canlılarda helmint invazyonlarına maruziyet durumunda benzer şekilde bağırsak mukozasında Th2 hücreleri tarafından IL-4, IL-5, IL-9, IL-10, IL-13 gibi sitokinler salınmaktadır. IBD ve helmint invazyonuna maruz kalan canlılarda, bağırsak mukozasından Th1 ve Th2 hücre aracılı salınan bu sitokinlerde kendi aralarında polarizasyonlar şekillenir. Beşeri hekimlikte yapılan pek çok çalışmada, polarizasyonlar sonucu IBD oluşumunda rol oynayan sitokinlerde meydana gelen bu baskılanmaların aşırı yangısal reaksiyonları engellediği ve hastalığın klinik semptomlarında azalmaya neden olduğu gösterilmiştir. veteriner hekimliğinde IBD ile ilgili yapılan bazı çalışmalarda, insanlarda olduğu gibi kedi ve köpeklerde de Th1 aracılı benzer sitokin üretimlerinin olduğu gösterilmiştir. Bu derlemede beşeri hekimlikte bu konu ile ilgili yapılan çalışmalardan yola çıkılarak, helmintlerin terapötik etkinliğinin veteriner hekimliğinde de IBD vakalarında önemli olabileceğine dikkat çekmek amaçlanmıştır.

Anahtar Kelimeler: Yangısal bağırsak hastalıkları; helmintler; köpekler
ABSTRACT
 Inflammatory bowel disease (IBD) is an inflammatory and autoimmune disease characterized by gastrointestinal symptoms such as diarrhea and vomiting which are common in humans, cats and dogs. As hygienic living conditions become widespread today, prevention of helmintic colonizations in the intestine is considered as an important factor that plays a role in increase of the disease. In this inflammatory disease which is seen as Krohn's disease and Ulcerative colitis in human medicine and lymphocytic-plasmacytic, eosinophilic and granulomatous inflammation in veterinary medicine, IL-10, IL12, IL-13 and IFNγ cytokines are released by Th1 cells. On the other hand, in case of helminth infections IL-4, IL-5, IL-9, IL-10, IL-13 released by Th2 cells in the intestinal mucosa. In several studies, some polarizations were shown between these Th1 and Th2 mediated cytokine types. In human medicine, several studies showed that, as a result of polarizations, suppression of cytokines involved in the formation of IBD leads to the prevention of excessive inflammatory reactions and a reduction in the clinical symptoms of the disease. Cats and dogs have similar cytokine production. In this review, based on the studies conducted in human medicine, it is aimed to draw attention to the therapeutic efficacy of helminths may be important in IBD cases in veterinary medicine.

Keywords: Inflammatory bowel diseases; helminths; dogs
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www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com