Journal of Literature Pharmacy Sciences

Kanser İlaçlarında Farmakogenetik: Geleneksel Derleme
Pharmacogenetics in Cancer Drugs: Traditional Review
Esra TEKCANa, Şengül TURALa
aOndokuz Mayıs Üniversitesi Tıp Fakültesi, Tıbbi Biyoloji ABD, Samsun, Türkiye
J Lit Pharm Sci. 2022;11(3):213-20
doi: 10.5336/pharmsci.2022-90847
Article Language: TR
Full Text
ÖZET
 Farmakogenomik, ilaç tedavisine yanıtın bireyler arası farklılık göstermesi ve bu değişken ilaç yanıtlarının altında yatan genetik mekanizmaların anlaşılmasına dayanır. Tedavide aynı ilacın aynı dozunun, bir grup hastada iyi yanıt oluşturabilirken, diğer bir grupta yeterli yanıt vermemesi, farklı bir grupta da ciddi yan etkilere ve hatta ölümlere neden olabilmesi mümkündür. Bu nedenle ilaç yanıtlarında bireyler arası farklılıklara belirgin şekilde katkıda bulunan DNA varyantlarının tanımlanması, tedavilerin etkinliğini artıracak ve ilaçların olumsuz yan etkilerinin oranını azaltacaktır. Genom dizilimi ve mutasyon analizi farmakogenomikte çok önemli araçlardır. Farmakogenomik, hem hastanın hem de tümörün genomunun araştırılmasını içerir, çünkü her ikisindeki varyasyonların kanser önleyici ilacın taşınması, dışarı akışı, alıkonması ve penetrasyonu üzerinde bir etkisi olduğu gözlemlenmiştir. İlaç yanıtının, reçete edilen ilaçların farmakokinetik ve farmakodinamik özelliklerine ve ilaç metabolize eden enzimler ve taşıyıcılardaki bireysel hasta polimorfizmlerine bağlı olduğu bilinmektedir. Bu derleme, ilaç metabolize eden enzimlerdeki polimorfizmlerin ilaç yanıtları üzerindeki etkisine odaklanmaktadır. Antikanser ilaçlar, genellikle çok dar bir terapötik indekse sahiptir; bu nedenle hastayı hayatı tehdit eden toksisite riskine sokmadan maksimum faydayı elde etmek için uygun dozların kullanılması çok önemlidir. Ancak hedef proteinleri ve ilaç metabolize eden enzimleri kodlayan genlerdeki spesifik polimorfizmlerin kalıtımı nedeniyle uygun dozun ayarlanması o kadar kolay değildir. Bu derleme, bu tür polimorfizmlerin birkaç örneğini ve bunların tedaviye yanıt üzerindeki etkisini sunmaktadır.

Anahtar Kelimeler: Farmakogenetik; polimorfizm; genetik; mutasyon
ABSTRACT
 Pharmacogenomics is based on the interindividual variation in response to drug therapy and the understanding of the genetic mechanisms underlying these variable drug responses. In the treatment, it is possible that the same dose of the same drug may cause a good response in one group of patients, while it may not respond adequately in another group, and it may cause serious side effects and even death in another group. Therefore, identifying DNA variants that significantly contribute to interindividual differences in drug responses will increase the efficacy of treatments and reduce the rate of adverse side effects of drugs. Genome sequencing and mutation analysis are very important tools in pharmacogenomics. Pharmacogenomics involves investigating the genome of both the patient and the tumor, as variations in both have been observed to have an effect on the transport, efflux, retention and penetration of the anticancer drug. It is known that drug response depends on the pharmacokinetic and pharmacodynamic properties of drugs and individual patient polymorphisms in drug metabolizing enzymes and transporters. This review considers the impact of existing polymorphisms in drug metabolizing enzymes on drug responses. Anticancer drugs often have a very narrow therapeutic index; therefore, it is very important to use appropriate doses to obtain maximum benefit without putting the patient at risk of life-threatening toxicity. However, due to the inheritance of specific polymorphisms in genes encoding target proteins and drug metabolizing enzymes, it isn't so easy to adjust the appropriate dose. This review presents several examples of such polymorphisms and their impact on treatment response.

Keywords: Pharmacogenetics; polymorphism; genetics; mutation
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4.9. "Turkiye Klinikleri" may use the information provided to them by the "USERS" through the "SITE" in line with the terms of the "PRIVACY POLICY" and "USER CONTRACT". It may process the information or classify and save them on a database. "Turkiye Klinikleri" may also use the USER's or visitor's identity, address, e-mail address, phone number, IP number, which sections of the "SITE" they visited, domain type, browser type, date and time information to provide statistical evaluation and customized services.

5. PROPRIETARY RIGHTS

5.1. The information accessed through this "SITE" or provided by the users legally and all the elements (including but not limited to design, text, image, html code and other codes) of the "SITE" (all of them will be called as studies tied to "Turkiye Klinikleri"s copyrights) belongs to "Turkiye Klinikleri". Users do not have the right to resell, process, share, distribute, display or give someone permission to access or to use the "Turkiye Klinikleri" services, "Turkiye Klinikleri" information and the products under copyright protection by "Turkiye Klinikleri". Within hereby "Terms of Use" unless explicitly permitted by "Turkiye Klinikleri" nobody can reproduce, process, distribute or produce or prepare any study from those under "Turkiye Klinikleri" copyright protection.

5.2. Within hereby "Terms of Use", "Turkiye Klinikleri" reserves the rights for "Turkiye Klinikleri" services, "Turkiye Klinikleri" information, the products associated with "Turkiye Klinikleri" copyrights, "Turkiye Klinikleri" trademarks, "Turkiye Klinikleri" trade looks or its all rights for other entity and information it has through this website unless it is explicitly authorized by "Turkiye Klinikleri".

6. CHANGES IN THE TERMS OF USE

"Turkiye Klinikleri" in its sole discretion may change the hereby "Terms of Use" anytime announcing within the "SITE". The changed terms of the hereby "Terms of Use" will become valid when they are announced. Hereby "Terms of Use" cannot be changed by unilateral declarations of users.

7. FORCE MAJEURE

"Turkiye Klinikleri" is not responsible for executing late or never of this hereby "Terms of Use", privacy policy and "USER Contract" in any situation legally taken into account as force majeure. Being late or failure of performance or non-defaulting of this and similar cases like this will not be the case from the viewpoint of "Turkiye Klinikleri", and "Turkiye Klinikleri" will not have any damage liability for these situations. "Force majeure" term will be regarded as outside of the concerned party's reasonable control and any situation that "Turkiye Klinikleri" cannot prevent even though it shows due diligence. Also, force majeure situations include but not limited to natural disasters, rebellion, war, strike, communication problems, infrastructure and internet failure, power cut and bad weather conditions.

8. LAW AND AUTHORISATION TO FOLLOW

Turkish Law will be applied in practicing, interpreting the hereby "Terms of Use" and managing the emerging legal relationships within this "Terms of Use" in case of finding element of foreignness, except for the rules of Turkish conflict of laws. Ankara Courts and Enforcement Offices are entitled in any controversy happened or may happen due to hereby contract.

9. CLOSING AND AGREEMENT

Hereby "Terms of Use" come into force when announced in the "SITE" by "Turkiye Klinikleri". The users are regarded to agree to hereby contract terms by using the "SITE". "Turkiye Klinikleri" may change the contract terms and the changes will be come into force by specifying the version number and the date of change on time it is published in the "SITE".

 

30.03.2014

Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com