Turkiye Klinikleri Journal of Ophthalmology

.: ORIGINAL RESEARCH
Factors Affecting Refractive Status in Babies Followed for Retinopathy of Prematurity; 2 Years Outcomes: A Retrospective Research
Prematürite Retinopatisi Nedeniyle Takip Edilen Bebeklerde Refraktif Durumu Etkileyen Faktörler; 2 Yıllık Sonuçlar: Retrospektif Bir Çalışma
Tülin ARAS ÖĞREDENa, Hülya GÜNGELb, Furkan ÜÇTEPEb
aClinic of Ophtalmology, Başakşehir Çam ve Sakura City Hospital, İstanbul, TURKEY
bClinic of Ophtalmology, İstanbul Training and Research Hospital, İstanbul, TURKEY
Turkiye Klinikleri J Ophthalmol. 2021;30(3):178-86
doi: 10.5336/ophthal.2020-80291
Article Language: EN
Full Text
ABSTRACT
 Objective: To evaluate the refractive changes in the first two years of life and to investigate the effect of prematurity, retinopathy of prematurity (ROP) and its treatment on refraction. Material and Methods: This is a single center retrospective study. Ninety eight patients and 196 eyes were investigated between 2016 and 2019. Refractive status was evaluated at 6th month, 1st and 2nd years. Results: Mean spherical value was +2.10±2.36, +1.50±2.13 and +1.13±2.30 at 6 months, 1 year and 2 years, respectively. There was a positive correlation between gestational week (GW) and spherical equivalent (SE) values at each follow-up (r=0.21 p=0.002, r=0.26 p=0.000, r=0.28 p=0.000 respectively). SE values in cases born before and after 32 GW did not show any difference at 6th month (p=0.138) at the 1st year and 2nd years, SE values were lower (p=0.028, p=0.009). All cases of high myopic were aggressive posterior-ROP (APROP). Treated and untreated groups were compared and significant differences were observed (p=0.000, p=0.000, p=0.000, respectively). The study did not reveal any significant differences between diode laser and intravitreal bevacizumab group (p=0.22, p=0.634 and p=0.885, respectively). Astigmatism is not affected by these factors. Conclusion: Higher myopia was detected in those born under 32 GW at 1st year and 2nd years, in APROP cases and in those treated for ROP. Severity of ROP disease itself significantly affects refraction in these type of cases. Astigmatism is not affected by these factors.

Keywords: s: Retinopathy of prematurity; refractive errors; neonatal screening; lasers; intravitreal injections
ÖZET
 Amaç: Yaşamın ilk 2 yılındaki refraktif değişiklikleri değerlendirmek ve prematürite, prematüre retinopatisi [retinopathy of prematurity (ROP)] ve tedavisinin refraksiyon üzerindeki etkisini araştırmak. Gereç ve Yöntemler: Bu tek merkezli retrospektif bir çalışmadır. 2016 ve 2019 yılları arasında 98 hasta ve 196 göz incelendi. Refraksiyon; 6. ay, 1 ve 2. yılda değerlendirildi. Bulgular: Ortalama sikloplejinli sferik eşdeğer (SE) 6. ayda +2,10±2,36, 1. yılda +1,50±2,13 ve 2. yılda +1,13± 2,30 idi. Altıncı ay, 1 ve 2. yıl gestasyon haftası [gestational week (GW)] ile SE değerleri arasında pozitif korelasyon vardı (sırasıyla r=0,21 p=0,002, r=0,26 p=0,000, r=0,28 p=0,000). 32 GW öncesi ve sonrası doğanlarda SE değerleri 6. ayda farklılık göstermedi (p= 0,138). Ancak 1 ve 2. yılda SE değerleri farklıydı (p=0,028, p=0,009). Yüksek miyop vakalarının tümü agresif posterior ROP (APROP) idi. Tedavi edilen ve tedavi edilmeyen gruplar karşılaştırıldığında SE değerlerinde anlamlı fark izlendi (sırasıyla p=0,000, p=0,000, p=0,000). Diod lazer ve intravitreal bevacizumab grubu arasında SE değerlerinde anlamlı fark yoktu (sırasıyla p=0,22, p=0,634 ve p=0,885). Astigmatik değerlerin ve eksenin dağılımında hiçbir grupta anlamlı fark yoktu. Sonuç: Birinci ve ikinci yılda, 32 gebelik haftasından önce doğanlarda, APROP tanısı alanlarda ve ROP tedavisi görenlerde miyopi anlamlı derecede fazladır. ROP hastalığının ciddiyeti bu tür vakalarda refraksiyonu önemli ölçüde etkiler. Astigmatizma bu değişkenler ile ilişkisizdir.

Anahtar Kelimeler: Prematüre retinopatisi; refraksiyon kusurları; yenidoğan taraması; lazerler; intravitreal enjeksiyon
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