Journal of Traditional Medical Complementary Therapies

.: REVIEW
Effects of Local Anesthetics on Viruses from a Neural Therapy Perspective
Nöral Terapi Perspektifinden Lokal Anesteziklerin Virüsler Üzerindeki Etkileri
Turgay ALTINBİLEKa, Rabia TERZİa, Elif KAYAa, Sadiye MURATb
aPrivate Office, İstanbul, TURKEY b Department of Physical Medicine and Rehabilitation, İstanbul Medeniyet University Göztepe Training and Research Hospital, İstanbul, TURKEY
J Tradit Complem Med. 2021;4(3):394-9
doi: 10.5336/jtracom.2020-79906
Article Language: EN
Full Text
ABSTRACT
 Viral infections have become one of the major health problems of today's world. Especially the current coronavirus disease2019 outbreak, causing systemic complications and mortality, has led to a serious pandemic worldwide. The disease has a wide clinical spectrum ranging from asymptomatic mild form to multiorgan failure and death. Although there is no treatment for coronavirus infection, some medications are used to suppress the inflammation. For this reason, the anti-inflammatory treatments have drawn attention to itself. Local anesthetics which are anti-inflammatory drugs have been effective in several steps on inflammatory cascade. In our daily practice, one of the treatment methods with local anesthetics is neural therapy which is special injection techniques (local, segmental, ganglion and interference area injections) and are applied to certain parts of the body for diagnosis, treat inflammatory diseases, pain and dysfunctions. With the local anesthetic usage, the autonomic nervous system is regulated via inhibition of abnormal stimuli transmitted by this system and controlling information pathways between cells. At the same time, the antiviral and anti-inflammatory effects of local anesthetics have been shown in various studies. It is considered that local anesthetics have anti-inflammatory effects by regulation of synthesis and release of anti-inflammatory mediators and antiviral effects by releasing of free radicals from lysozyme and inhibiting of membrane ATP-ase. In this review, we aimed to discuss the effects of local anesthetics and neural therapy on viral infections in the light of the literature and evaluate their possible beneficial effects on coronavirus infection.

Keywords: Neural therapy; local anesthetics; coronavirus; COVID-19
ÖZET
 Viral enfeksiyonlar, günümüz dünyasının önemli sağlık sorunlarından biri hâline gelmiştir. Özellikle mevcut koronavirüs hastalığı2019 salgını, sistemik komplikasyonlara ve mortaliteye yol açarak, dünya genelinde ciddi bir pandemiye neden olmuştur. Hastalık, asemptomatik hafif formdan, çoklu organ yetersizliğine varan ve ölümle sonuçlanabilen geniş bir klinik spektruma sahiptir. Koronavirüs enfeksiyonunu tedavi edebilen bir ilaç henüz bulunmamakla beraber, tedavide kullanılan ilaçlar, inflamasyonu baskılamaya yöneliktir. Bu nedenle de inflamasyona karşı kullanılan tedaviler dikkat çekmektedir. Lokal anestezikler, inflamatuar kaskad üzerindeki birçok adımda etkili antiinflamatuar ilaçlardan biridir. Günlük pratiğimizde, lokal anesteziklerin kullanıldığı tedavilerden biri nöral terapidir. Nöral terapi, inflamatuar hastalıklar, ağrı ve fonksiyon bozukluklarının teşhis ve tedavisi amacıyla vücudun belirli bölgelerine, özel enjeksiyon tekniklerinin uygulandığı (lokal, segmental, ganglion ve bozucu alan enjeksiyonları), bir tedavi yöntemidir. Nöral terapide kullanılan lokal anestezik uygulamalarıyla otonom sinir sistemi tarafından iletilen anormal uyarılar önlenir, hücreler arası bilgi alışverişi kontrol edilir ve böylece otonom sinir sisteminin regülasyonu sağlanmış olur. Aynı zamanda nöral terapide, uzun yıllardır güvenle kullanılan lokal anesteziklerin antiviral ve antiinflamatuar etkileri çeşitli çalışmalarda gösterilmiştir. Lokal anesteziklerin, antiinflamatuar mediyatörlerin sentez ve salınımını etkileyerek, antiinflamatuar etkiyi, lizozim ile serbest radikallerin salınımı ve membran ATP az inhibisyonuyla antiviral etkiyi gerçekleştirdiği düşünülmektedir. Bu derlemede lokal anesteziklerin ve nöral tedavinin, virüs enfeksiyonları üzerindeki etkilerininin literatür ışığında tartışılması ve koronavirüs enfeksiyonu üzerindeki olası yararlı etkilerinin değerlendirilmesi amaçlanmıştır.

Anahtar Kelimeler: Nöral terapi; lokal anestezik; koronavirüs; COVID-19
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