Turkiye Klinikleri Journal of Sports Sciences

.: ORIGINAL RESEARCH
Diyabetik Ratlarda Aerobik Egzersizin Kortizol ve Tiroid Hormonları Üzerine Etkisi: Deneysel Araştırma
The Effect of Aerobic Exercise on Cortisol and Thyroid Hormones in Diabetic Rats: Experimental Research
Canan CEYLANa , Nurcan DÖNMEZb , Göktuğ ŞENTÜRKc
aSelçuk Üniversitesi Sağlık Bilimleri Enstitüsü, Fizyoloji ABD, Konya, Türkiye
bSelçuk Üniversitesi Veteriner Fakültesi, Fizyoloji ABD, Konya, Türkiye
cAksaray Üniversitesi Veteriner Fakültesi, Fizyoloji ABD, Aksaray, Türkiye
Turkiye Klinikleri J Sports Sci. 2023;15(3):399-404
doi: 10.5336/sportsci.2023-96652
Article Language: TR
Full Text
ÖZET
 Amaç: Bu araştırmada, deneysel diyabet oluşturulan ratlarda aerobik egzersizin kortizol ve tiroid hormonları üzerine etkilerinin belirlenmesi amaçlanmıştır. Gereç ve Yöntemler: Araştırmada, 6 haftalık, 36 adet Wistar Albino rat kullanıldı. Hayvanlar canlı ağırlıkları birbirine benzer olacak şekilde Kontrol (K), Diyabet (D), Egzersiz (E) ve Diyabet+Egzersiz (DE) olmak üzere 4 gruba ayrıldı. D ve DE gruplarına tek doz 60 mg/kg streptozotosin solüsyonu intraperitoneal olarak enjekte edildi. E ve DE gruplarına 4 hafta, 20 m/dk hızda ve günlük 45 dk koşu bandında egzersiz yaptırıldı. Deneme sonunda elde edilen serumlar ticari kit (Abbott) protokolüne uygun olarak belirlendi. Bulgular: Deneme sonunda elde edilen veriler incelendiğinde, D ve DE gruplarının glukoz değerlerinin kontrol gruplarına (K ve E) göre anlamlı düzeyde yüksek olduğu (p<0,05), ancak DE grubundaki değerlerin D grubuna göre azaldığı tespit edildi. D grubunda tiroid stimüle edici hormon [thyroid stimulating hormone (TSH)], T3 ve T4 seviyeleri K ve E grubuna kıyasla düşüş gösterdi (p<0,05). Kortizol düzeyi ise E grubunda diğer 3 gruptan daha düşük iken, en yüksek kortizol düzeyi diyabetik grupta ölçüldü (p<0,05). DE grubunda serum TSH düzeylerinin D grubuna kıyasla önemli oranda arttığı ve kontrol gruplarına (K ve E) benzerlik gösterdiği belirlendi (p<0,05). Yine DE grubunda T3, T4 düzeylerinin D grubuna göre artma eğiliminde olduğu belirlendi. Sonuç: Diyabetiklerde 4 hafta süren aerobik egzersiz uygulamasının, hem glukoz metabolizmasını iyileştirmesinde hem de kortizol ve tiroid hormon seviyelerini artırmasında oldukça etkili olduğu görülmektedir.

Anahtar Kelimeler: Aerobik egzersiz; diabetes mellitus; glukoz; kortizol; tiroid hormonları
ABSTRACT
 Objective: In this study, it was aimed to determine the effects of aerobic exercise on cortisol and thyroid hormones in rats with experimental diabetes. Material and Methods: In the study, 36 Wistar Albino rats, 6 weeks old, were used. The animals were divided into 4 groups as Control (C), Diabetes (D), Exercise (E) and Diabetes+Exercise (DE) with similar body weights. A single dose of 60 mg/kg streptozotocin solution was injected intraperitoneally into groups D and DE. E and DE groups exercised on a treadmill for 4 weeks at a speed of 20 m/min and for 45 minutes per day. The sera obtained at the end of the experiment were determined in accordance with the commercial kit (Abbott) protocol. Results: When the data obtained at the end of the experiment were examined, it was determined that the glucose values of the D and DE groups were significantly higher than the control groups (C and E) (p<0.05), but the values in the DE group were decreased compared to the D group. Thyroid stimulating hormone (TSH), T3 and T4 levels in D group decreased compared to C and E groups (p<0.05). Cortisol levels between groups were the lowest in group E and highest in group D. It was determined that serum TSH levels in the DE group increased significantly compared to the D group and showed similarity to the control groups (C and E) (p<0.05). Again, it was determined that T3, T4 levels in the DE group tended to increase compared to the D group. Conclusion: It is seen that aerobic exercise lasting 4 weeks in diabetics is very effective in both improving glucose metabolism and increasing cortisol and thyroid hormone levels.

Keywords: Aerobic exercise; diabetes mellitus; glucose; cortisol; thyroid hormones
REFERENCES:
  1. Saygılı Ü, Dönmez N. The effect of curcumin on some plasma cytokine levels in experimentally-induced diabetic rats. J Tradit Complem Med. 2021;4(1):57-64. [Crossref] 
  2. Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract. 2014;103(2):137-49. [Crossref]  [PubMed] 
  3. Mastracci TL, Evans-Molina C. Pancreatic and islet development and function: the role of thyroid hormone. J Endocrinol Diabetes Obes. 2014;2(3):1044. [PubMed]  [PMC] 
  4. Hage M, Zantout MS, Azar ST. Thyroid disorders and diabetes mellitus. J Thyroid Res. 2011;2011:439463. [Crossref]  [PubMed]  [PMC] 
  5. Mastorakos G, Pavlatou M. Exercise as a stress model and the interplay between the hypothalamus-pituitary-adrenal and the hypothalamus-pituitary-thyroid axes. Horm Metab Res. 2005;37(9):577-84. [Crossref]  [PubMed] 
  6. Gür C, Boz M, Müderrisoğlu C, Polat H. İnsülin direnci ve kortizol düzeyleri arasındaki ilişkiler [The relationship between insulin resistance and cortisole levels]. İstanb Med J. 2015;16:73-6. [Crossref] 
  7. Elahi-Moghaddam Z, Behnam-Rassouli M, Mahdavi-Shahri N, Hajinejad-Boshroue R, Khajouee E. Comparative study on the effects of type 1 and type 2 diabetes on structural changes and hormonal output of the adrenal cortex in male Wistar rats. J Diabetes Metab Disord. 2013;12(1):9. [Crossref]  [PubMed]  [PMC] 
  8. Gerber M, Imboden C, Beck J, Brand S, Colledge F, Eckert A, et al. Effects of aerobic exercise on cortisol stress reactivity in response to the trier social stress test in inpatients with major depressive disorders: a randomized controlled trial. J Clin Med. 2020;9(5):1419. [Crossref]  [PubMed]  [PMC] 
  9. Caplin A, Chen FS, Beauchamp MR, Puterman E. The effects of exercise intensity on the cortisol response to a subsequent acute psychosocial stressor. Psychoneuroendocrinology. 2021;131:105336. [Crossref]  [PubMed] 
  10. Dönmez N, Keskin E, Özsan M, Shoshın OMA, Mehtap B. The favorable effect of swimming on some blood parameters in diabetic rats. Ataturk Univ Vet Bilim Derg. 2020;15(1):31-7. [Crossref] 
  11. Ugurlu I, Baltaci SB, Unal O, Mogulkoc R, Ucaryilmaz H, Baltaci AK. Chronic running exercise regulates cytotoxic cell functions and zinc transporter SLC39A10/ZIP10 levels in diabetic rats. Biol Trace Elem Res. 2022;200(2):699-705. [Crossref]  [PubMed] 
  12. Cao S, Li B, Yi X, Chang B, Zhu B, Lian Z, et al. Effects of exercise on AMPK signaling and downstream components to PI3K in rat with type 2 diabetes. PLoS One. 2012;7(12):e51709. [Crossref]  [PubMed]  [PMC] 
  13. Arantes LM, Bertolini NO, de Moura RF, de Mello MA, Luciano E. Insulin concentrations in cerebellum and body balance in diabetic male rats: aerobic training effects. Physiol Behav. 2013;118:58-62. [Crossref]  [PubMed] 
  14. Dastah S, Tofighi A, Bonab SB. The effect of aerobic exercise on the expression of mir-126 and related target genes in the endothelial tissue of the cardiac muscle of diabetic rats. Microvasc Res. 2021;138:104212. [Crossref]  [PubMed] 
  15. Riahi S, Mohammadi MT, Sobhani V, Ababzadeh S. Chronic aerobic exercise decreases lectin-like low density lipoprotein (LOX-1) receptor expression in heart of diabetic rat. Iran Biomed J. 2016;20(1):26-32. [PubMed]  [PMC] 
  16. Ko JR, Seo DY, Park SH, Kwak HB, Kim M, Ko KS, et al. Aerobic exercise training decreases cereblon and increases AMPK signaling in the skeletal muscle of STZ-induced diabetic rats. Biochem Biophys Res Commun. 2018;501(2):448-53. [Crossref]  [PubMed] 
  17. Coskun O, Ocakci A, Bayraktaroglu T, Kanter M. Exercise training prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Tohoku J Exp Med. 2004;203(3):145-54. [Crossref]  [PubMed] 
  18. Kılıçarslan G, Dönmez N. The effects of quercetin on antioxidant system and some blood parameters in experimental diabetic rats. Bull Env Pharmacol Life Sci. 2016;5:28-32. [Link] 
  19. Eom YS, Wilson JR, Bernet VJ. Links between thyroid disorders and glucose homeostasis. Diabetes Metab J. 2022;46(2):239-56. [Crossref]  [PubMed]  [PMC] 
  20. Panveloski-Costa AC, Silva Teixeira S, Ribeiro IM, Serrano-Nascimento C, das Neves RX, Favaro RR, et al. Thyroid hormone reduces inflammatory cytokines improving glycaemia control in alloxan-induced diabetic wistar rats. Acta Physiol (Oxf). 2016;217(2):130-40. [Crossref]  [PubMed] 
  21. Teixeira SD, Panveloski-Costa AC, Carvalho A, Monteiro Schiavon FP, Ruiz Marque AC, Campello RS, et al. Thyroid hormone treatment decreases hepatic glucose production and renal reabsorption of glucose in alloxan-induced diabetic Wistar rats. Physiol Rep. 2016;4(18):e12961. [Crossref]  [PubMed]  [PMC] 
  22. Saravanan G, Ponmurugan P. Antidiabetic effect of S-allylcysteine: effect on thyroid hormone and circulatory antioxidant system in experimental diabetic rats. J Diabetes Complications. 2012;26(4):280-5. [Crossref]  [PubMed] 
  23. Sarir H, Nemati F, Saghebjoo M, Moudi M. The effect of pistacia atlantica extract and aerobic training on the levels of triiodothyronine, thyroxine and lipid profile in streptozotocin-diabetic rats. J Kerman Univ Medical Sci. 2018;25(6):509-18. [Link] 
  24. Lehrke M, Broedl UC, Biller-Friedmann IM, Vogeser M, Henschel V, Nassau K, et al. Serum concentrations of cortisol, interleukin 6, leptin and adiponectin predict stress induced insulin resistance in acute inflammatory reactions. Crit Care. 2008;12(6):R157. [Crossref]  [PubMed]  [PMC] 
  25. Chan O, Inouye K, Vranic M, Matthews SG. Hyperactivation of the hypothalamo-pituitary-adrenocortical axis in streptozotocin-diabetes is associated with reduced stress responsiveness and decreased pituitary and adrenal sensitivity. Endocrinology. 2002;143(5):1761-8. [Crossref]  [PubMed] 
  26. Obaya HE, Salem AA, Labeb HA, Shawky AF. Effect of mindfulness meditation and aerobic exercise on serum cortisol levels in type 2 diabetic patients. Med J Cairo Univ. 2021;89(December):2779-85. [Crossref] 
  27. Smitha KK, Mukkadan JK. Effect of different forms of acute stress in the generation of reactive oxygen species in albino Wistar rats. Indian J Physiol Pharmacol. 2014;58(3):229-32. [PubMed] 
  28. Alghadir AH, Gabr SA, Aly FA. The effects of four weeks aerobic training on saliva cortisol and testosterone in young healthy persons. J Phys Ther Sci. 2015;27(7):2029-33. [Crossref]  [PubMed]  [PMC] 
  29. Ehiaghe F, Agbonlahor D, Etikerentse S, Osadolor H. Effect of exercise induced stress on serum cortisol level and cd4 cell count in rats. Afr J Cell Path. 2013;1(1):14-8. [Crossref] 
  30. Ibrahimaj Gashi A, Azemi A, Zivkovic V, Gontarev S, Gjorgovski I. The effect of regular aerobic activity on cortisol levels in female Wistar rats. Biomed Res Ther. 2021;8(2):4219-27. [Crossref] 
  31. Pranoto A, Wahyudi E, Prasetya R, Fauziyah S, Kinanti RG, Sugiharto S, et al. High intensity exercise increases brain derived neurotrophic factor expression and number of hippocampal neurons in rats. Comp Exerc Physiol. 2020;16(4):325-32. [Crossref] 
  32. Abdelhamid Fathy M. Effect of chronic aerobic exercise training on serum irisin level in type 2 diabetic rats. Al-Azhar Med J. 2017;46(4):919-38. [Crossref] 
  33. Zar A, Hosseini SA, Bagheri V, Hashemi Z, Salehi OR. Effect of swimming training in withdrawal period on thyroid hormones of addicted rats. Rep Health Care. 2016;2(1):29-37. [Link] 
  34. Onsori M, Galedari M. Effects of 12 weeks aerobic exercise on plasma level of TSH and thyroid hormones in sedentary women. Eur J Sports Exerc Sci. 2015;4(1):45-9. [Link] 
  35. Pancar Z. Effects of core exercises on thyroid metabolism in men. Gaziantep Üniv Spor Bilim Derg. 2020;5(4):590-7. [Crossref] 

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