Turkiye Klinikleri Journal of Dental Sciences

.: ORIGINAL RESEARCH
Comparison of Bioabsorbable Calcified Triglyceride Bone Cement Versus Deproteinized Bovine Bone in Guided Bone Regeneration: Experimental Study
Yönlendirilmiş Kemik Rejenerasyonunda Biyoabsorbe Kalsifiye Trigliserid Kemik Simanı ile Deproteinize Sığır Kemiğinin Karşılaştırılması: Deneysel Çalışma
Feyza OTAN ÖZDENa , Seda KOÇYİĞİTb , Esra DEMİRc, Mehmet Önder KARAYİĞİTd
aDepartment of Periodontology, Ondokuz Mayıs University Faculty of Dentistry, Samsun, Türkiye
bPrivate Dentistry, İstanbul, Türkiye
cDepartment of Periodontology, Bezmiâlem Vakıf University Faculty of Dentistry, İstanbul, Türkiye
dDepartment of Pathology, Çukurova University Faculty of Ceyhan Veterinary Medicine, Adana, Türkiye
Turkiye Klinikleri J Dental Sci. 2023;29(2):331-7
doi: 10.5336/dentalsci.2022-93394
Article Language: EN
Full Text
ABSTRACT
 Objective: The aim of this study was to evaluate, for the first time, the effect of bioabsorbable calcified triglyceride bone cement (CTBC) on bone formation when used as an adjunct to guided bone regeneration (GBR) and compare it with the results obtained with deproteinized bovine bone (DBB). Material and Methods: Forty-eight rats were randomly divided into three equal-sized groups. Following incisions along with the inferior border of the mandible, full thickness flaps were elevated via an extraoral approach. Custom-made rigid, hemispherical teflon capsules were packed with CTBC, or DBB, or were left empty and placed facing the lateral surface of the mandibular ramus. At the postoperative 4th months, all rats were sacrificed and tissue samples were processed for decalcified histological evaluation of the newly formed bone, residual graft particles, and soft connective tissue within the space created by the capsules. Results: It was observed that the amount of mineralized bone formation in the capsules filled with CTBC and DBB was similar, and most of the capsules were filled with biomaterial particles embedded in the connective tissue. There was no significant difference between the 2 groups in terms of newly formed bone, graft particles or connective tissue (p>0.05). On the other hand, it was determined that a greater amount of new mineralized bone was formed in the control group compared to the CTBC or DBB groups (p<0.05). Conclusion: Grafting with CTBC or DBB did not make any difference when used as an adjunct to GBR.

Keywords: Guided bone regeneration; deproteinized bovine bone; calcified triglyceride bone cement
ÖZET
 Amaç: Mevcut çalışmanın amacı, yönlendirilmiş kemik rejenerasyonunda biyoabsorbe kalsifiye trigliserid kemik simanının (KTKS) etkisini ilk defa değerlendirmek ve sonuçlarını deproteinize sığır kemiği (DSK) ile karşılaştırmaktır. Gereç ve Yöntemler: Kırk sekiz sıçan rastgele 3 eşit büyüklükte gruba ayrıldı. Mandibula alt kenarı boyunca yapılan kesilerin ardından, ekstraoral yaklaşımla tam kalınlıkta flep kaldırıldı. Özel yapım sert, yarı küresel teflon kapsüller KTKS, DSK ile dolduruldu veya boş bırakıldı (kontrol) ve mandibular ramusun lateral yüzeyine bakacak şekilde yerleştirildi. Ameliyat sonrası 4. ayda tüm sıçanlar sakrifiye edilerek, greft alanlarından alınan doku örnekleri kapsüller tarafından oluşturulan boşluk içinde yeni oluşan kemik, rezidüel greft partikülleri ve yumuşak bağ dokusu açısından histolojik olarak değerlendirildi. Bulgular: KTKS ve DSK ile doldurulmuş kapsüllerde mineralize kemik oluşumunun benzer şekilde ve kapsüllerin büyük kısmının bağ dokusu içine gömülü biyomateryal partikülleri ile dolu olduğu gözlendi. Yeni oluşan kemik, greft partikülleri veya bağ dokusu açısından 2 grup arasında anlamlı bir farklılık bulunmadı (p>0,05). Buna karşılık, kontrol grubunda KTKS veya DSK grupları ile karşılaştırıldığında daha büyük miktarda yeni mineralize kemik oluştuğu belirlendi (p<0,05). Sonuç: KTKS veya DSK ile greftleme, yönlendirilmiş kemik rejenerasyonuna ek olarak kullanıldığında herhangi bir farklılık yaratmadı.

Anahtar Kelimeler: Yönlendirilmiş kemik rejenerasyonu; deproteinize sığır kemiği; kalsifiye trigliserid kemik simanı
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