Turkiye Klinikleri Journal of Health Sciences

.: REVIEW
Bağımlılıkta Aşerme ve Nüks Üzerinde Bilişsel Yanlılık Modifikasyonunun Klinik ve Nörobiyolojik Etkisi Çalışmalarının Derlenmesi: Geleneksel Derleme
Cognitive Bias Modification in Addiction Research: Clinical and Neurobiological Effects on Craving and Relapse: Traditional Review
Sevgül TÜRKOĞLUa
aKıbrıs İlim Üniversitesi İktisadi İdari ve Sosyal Bilimler Fakültesi, Psikoloji Bölümü, Deneysel Psikoloji ABD, Girne, KKTC
Turkiye Klinikleri J Health Sci. 2024;9(3):628-34
doi: 10.5336/healthsci.2023-99530
Article Language: TR
Full Text
ÖZET
Bağımlılıkta önemli yeri olan ve örtük bilişsel süreçler içinde yer alan bilişsel yanlılığı manipüle etmek amaçlı Bilişsel Yanlılık Modifikasyonu eğitim programı geliştirilmiştir. Bu eğitim programının temel hedefi, bağımlılık yapıcı maddeye karşı bilişsel yanlılık geliştirmiş olan hastaların bilişsel kalıplarını doğrudan değiştirerek aşerme ve nüksü önlemektir. Bilişsel yanlılığı değiştirebilmek için tasarlanan bu eğitim, dikkat yanlılığı veya yaklaşım yanlılığını manipüle etme yoluyla uygulanabilmektedir. Bu derleme makalesinde, Bilişsel Yanlılık Modifikasyonu eğitiminin aşerme ve nüks üzerindeki davranışsal ve nörolojik etkilerini inceleyen çalışmalar özetlenmiştir. İlgili literatüre göre alkol-madde Bilişsel Yanlılık Modifikasyonu eğitimi kişilerin aşerme seviyelerini azaltıcı özelliğe sahiptir. Ayrıca eğitim programı nüksü önleme ve/veya geciktirme üzerinde etkilidir. Nörobiyolojik açıdan eğitim programının istenmeyen davranışı kontrol etmeden sorumlu mediyal prefrontal bölgeyi aktive ettiği bulunmuştur. Bilişsel Yanlılık Modifikasyonu eğitim programı kavramsal olarak kanıtlanmıştır. Bundan sonraki konuyla ilgili yapılacak olan çalışmalar randomize kontrollü ve olası klinik etkiyi araştırma üzerine yapılmalıdır. Günümüzde, Bilişsel Yanlılık Modifikasyonu çalışmalarının küçük örneklem gruplarıyla çalışılması programın etkinliğinin genellenebilirliğini düşürmektedir. Bu nedenle, Bilişsel Yanlılık Modifikasyonu'nun her zamanki tedaviye ek olarak destekleyici tedavi şeklinde uygulanması için kontrollü ve büyük örnekleme sahip çalışmalara ihtiyaç vardır. Bağımlılık yapıcı maddenin düzenli olarak kullanımı maddeyle ilgili uyarana kişinin hassaslaşarak daha hızlı fark etmesine neden olur. Örtük olarak gerçekleşen bu bilişsel süreç bilişsel yanlılık olarak adlandırılır. Bilişsel yanlılık aşerme ve nüks riski ile pozitif ilişkilidir.

Anahtar Kelimeler: Bilişsel yanlılık modifikasyonu; dikkat yanlılığı; yaklaşım yanlılığı; bağımlılık; nüks
ABSTRACT
Cognitive Bias Modification (CBM) has been developed to manipulate cognitive bias that play an important role in addiction research and are part of the implicit cognitive process. The primary goal of this training program is to directly modify the cognitive patterns of patients who have developed cognitive bias towards addictive subtances in order to prevent craving and relapse. CBM can be implemented by manipulating attentional bias or approach bias to modify cognitive bias. This review summarizes studies that examine the behavioral and neurological effects of CBM on craving and relapse. According to the relevant literature, CBM training for alcohol and subtance addiction has been found to reduce craving level. Additionally, the program is effective in preventing or delaying relapse. Neurobiologically, CBM has been found to activate the medial prefrontal cortex region where is responsible for controlling and inhibiting behavior. Moreover, CBM training has been conceptually proven. Future studies on this topic should be conducted using randomized controlled trials to investigate the potentional clinical effects. Currently, CBM studies with small sample size limit the generalizability of the program effectiveness. Therefore, controlled studies with large sample size are needed to apply CBM as a supportive treatment in addiction to treament as usual. Regular use of addictive products facilities the recognition of the substance-related stimuli faster. This cognitive process is called as a cognitive bias. Cognitive bias is positively correlated with craving and relapse.

Keywords: Cognitive bias modification; attentional bias; apporach bias; addiction; relapse
REFERENCES:
  1. Uzbay İT. Madde Bağımlılığı. 1. Baskı. İstanbul: İstanbul Tıp Kitabevi; 2015.
  2. Stacy AW, Wiers RW. Implicit cognition and addiction: a tool for explaining paradoxical behavior. Annu Rev Clin Psychol. 2010;6:551-75. [Crossref]  [PubMed]  [PMC] 
  3. Robinson TE, Berridge KC. The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev. 1993;18(3):247-91. [Crossref]  [PubMed] 
  4. Macleod C. Cognitive bias modification procedures in the management of mental disorders. Curr Opin Psychiatry. 2012;25(2):114-20. [Crossref]  [PubMed] 
  5. Cox WM, Hogan LM, Kristian MR, Race JH. Alcohol attentional bias as a predictor of alcohol abusers' treatment outcome. Drug Alcohol Depend. 2002;68(3):237-43. [Crossref]  [PubMed] 
  6. Waters AJ, Shiffman S, Bradley BP, Mogg K. Attentional shifts to smoking cues in smokers. Addiction. 2003;98(10):1409-17. [Crossref]  [PubMed] 
  7. Marissen MA, Franken IH, Waters AJ, Blanken P, van den Brink W, Hendriks VM. Attentional bias predicts heroin relapse following treatment. Addiction. 2006;101(9):1306-12. [Crossref]  [PubMed] 
  8. Türkoğlu S, Amado S, Gönül AS, Eker MÇ. Comparison of alcohol attentional bias and craving among alcohol abusers and non-abusers. Psikiyatride Güncel Yaklaşımlar. 2022;14(Supp 1):75-82. [Crossref] 
  9. Field M, Cox WM. Attentional bias in addictive behaviors: a review of its development, causes, and consequences. Drug Alcohol Depend. 2008;97(1-2):1-20. [Crossref]  [PubMed] 
  10. Klinger E. Emotional influences on cognitive processing, with implications for theories of both. In: Gollwitzer PM, Bargh JA, eds. The Psychology of Action: Linking Cognition and Motivation to Behavior. 1st ed. New York: The Guilford; 1996.
  11. MacLeod C, Mathews A, Tata P. Attentional bias in emotional disorders. J Abnorm Psychol. 1986;95(1):15-20. [Crossref]  [PubMed] 
  12. Stroop JR. Studies of interference in serial verbal reactions. Journal of Experimental Psychology. 1935;18(6):643-62. [Crossref] 
  13. Raymond JE, Shapiro KL, Arnell KM. Temporary suppression of visual processing in an RSVP task: an attentional blink? . J Exp Psychol Hum Percept Perform. 1992;18(3):849-60. [Crossref]  [PubMed] 
  14. Rinck M, Becker ES. Approach and avoidance in fear of spiders. J Behav Ther Exp Psychiatry. 2007;38(2):105-20. [Crossref]  [PubMed] 
  15. Cox WM, Fadardi JS, Pothos EM. The addiction-stroop test: Theoretical considerations and procedural recommendations. Psychol Bull. 2006;132(3):443-76. [Crossref]  [PubMed] 
  16. Field M, Werthmann J, Franken I, Hofmann W, Hogarth L, Roefs A. The role of attentional bias in obesity and addiction. Health Psychol. 2016;35(8):767-80. [Crossref]  [PubMed] 
  17. Sanna A, Fattore L, Badas P, Corona G, Cocco V, Diana M. Intermittent Theta Burst Stimulation of the Prefrontal Cortex in Cocaine Use Disorder: A Pilot Study. Front Neurosci. 2019;13:765. [Crossref]  [PubMed]  [PMC] 
  18. Mogg K, Bradley BP, Field M, De Houwer J. Eye movements to smoking-related pictures in smokers: relationship between attentional biases and implicit and explicit measures of stimulus valence. Addiction. 2003;98(6):825-36. [Crossref]  [PubMed] 
  19. Watson P, De Wit S, Cousijn J, Hommel B, Wiers RW. Motivational mechanisms underlying the approach bias to cigarettes. Journal of Experimental Psychopathology. 2013;4(3):250-62. [Crossref] 
  20. Cox WM, Fadardi JS, Intriligator JM, Klinger E. Attentional bias modification for addictive behaviors: clinical implications. CNS Spectr. 2014;19(3):215-24. [Crossref]  [PubMed] 
  21. Wiers RW, Stacy AW. Implicit cognition and addiction. current directions in psychological science. 2006;15(6):292-96. [Crossref] 
  22. Fadardi JS, Cox WM. Reversing the sequence: reducing alcohol consumption by overcoming alcohol attentional bias. Drug Alcohol Depend. 2009;101(3):137-45. [Crossref]  [PubMed] 
  23. Cabrera EA, Wiers CE, Lindgren E, Miller G, Volkow ND, Wang GJ. Neuroimaging the effectiveness of substance use disorder treatments. J Neuroimmune Pharmacol. 2016;11(3):408-33. [Crossref]  [PubMed] 
  24. Schoenmakers TM, de Bruin M, Lux IF, Goertz AG, Van Kerkhof DH, Wiers RW. Clinical effectiveness of attentional bias modification training in abstinent alcoholic patients. Drug Alcohol Depend. 2010;109(1-3):30-6. [Crossref]  [PubMed] 
  25. Boendermaker WJ, Prins PJ, Wiers RW. Cognitive Bias Modification for adolescents with substance use problems--Can serious games help? J Behav Ther Exp Psychiatry. 2015;49(Pt A):13-20. [Crossref]  [PubMed] 
  26. Ziaee SS, Fadardi JS, Cox WM, Yazdi SA. Effects of attention control training on drug abusers' attentional bias and treatment outcome. J Consult Clin Psychol. 2016;84(10):861-73. [Crossref]  [PubMed] 
  27. MacLeod C, Rutherford E, Campbell L, Ebsworthy G, Holker L. Selective attention and emotional vulnerability: assessing the causal basis of their association through the experimental manipulation of attentional bias. J Abnorm Psychol. 2002;111(1):107-23. [Crossref]  [PubMed] 
  28. Heeren A, Mogoașe C, Philippot P, McNally RJ. Attention bias modification for social anxiety: A systematic review and meta-analysis. Clin Psychol Rev. 2015;40:76-90. [Crossref]  [PubMed] 
  29. Linetzky M, Pergamin-Hight L, Pine DS, Bar-Haim Y. Quantitative evaluation of the clinical efficacy of attention bias modification treatment for anxiety disorders. Depress Anxiety. 2015;32(6):383-91. Erratum in: Depress Anxiety. 2018;35(1):111-112. [Crossref]  [PubMed] 
  30. Price RB, Wallace M, Kuckertz JM, Amir N, Graur S, Cummings L, et al. Pooled patient-level meta-analysis of children and adults completing a computer-based anxiety intervention targeting attentional bias. Clin Psychol Rev. 2016;50:37-49. [Crossref]  [PubMed]  [PMC] 
  31. Clerkin EM, Magee JC, Wells TT, Beard C, Barnett NP. Randomized controlled trial of attention bias modification in a racially diverse, socially anxious, alcohol dependent sample. Behav Res Ther. 2016;87:58-69. [Crossref]  [PubMed]  [PMC] 
  32. Wiers RW, Eberl C, Rinck M, Becker ES, Lindenmeyer J. Retraining automatic action tendencies changes alcoholic patients' approach bias for alcohol and improves treatment outcome. Psychol Sci. 2011;22(4):490-7. [Crossref]  [PubMed] 
  33. Eberl C, Wiers RW, Pawelczack S, Rinck M, Becker ES, Lindenmeyer J. Approach bias modification in alcohol dependence: do clinical effects replicate and for whom does it work best? Dev Cogn Neurosci. 2013;4:38-51. [Crossref]  [PubMed]  [PMC] 
  34. Rinck M, Wiers RW, Becker ES, Lindenmeyer J. Relapse prevention in abstinent alcoholics by cognitive bias modification: Clinical effects of combining approach bias modification and attention bias modification. J Consult Clin Psychol. 2018;86(12):1005-16. [Crossref]  [PubMed] 
  35. Boffo M, Zerhouni O, Gronau QF, van Beek RJJ, Nikolaou K, Marsman M, et al. Cognitive bias modification for behavior change in alcohol and smoking addiction: bayesian meta-analysis of individual participant data. Neuropsychol Rev. 2019;29(1):52-78. [Crossref]  [PubMed]  [PMC] 
  36. Bradley BP, Field M, Healy H, Mogg K. Do the affective properties of smoking-related cues influence attentional and approach biases in cigarette smokers? J Psychopharmacol. 2008;22(7):737-45. [Crossref]  [PubMed] 
  37. Palfai TP, Ostafin BD. Alcohol-related motivational tendencies in hazardous drinkers: assessing implicit response tendencies using the modified-IAT. Behav Res Ther. 2003;41(10):1149-62. [Crossref]  [PubMed] 
  38. Veenstra EM, de Jong PJ. Reduced automatic motivational orientation towards food in restricting anorexia nervosa. J Abnorm Psychol. 2011;120(3):708-18. [Crossref]  [PubMed] 
  39. Cousijn J, Goudriaan AE, Wiers RW. Reaching out towards cannabis: approach-bias in heavy cannabis users predicts changes in cannabis use. Addiction. 2011;106(9):1667-74. Erratum in: Addiction. 2011;106(11):2053. [Crossref]  [PubMed]  [PMC] 
  40. Wiers RW, van Woerden N, Smulders FTY, de Jong PJ. Implicit and explicit alcohol-related cognitions in heavy and light drinkers. J Abnorm Psychol. 2002;111(4):648-58. [Crossref]  [PubMed] 
  41. Luijten M, Veltman DJ, van den Brink W, Hester R, Field M, Smits M, et al. Neurobiological substrate of smoking-related attentional bias. Neuroimage. 2011;54(3):2374-81. [Crossref]  [PubMed] 
  42. Vollstädt-Klein S, Loeber S, Richter A, Kirsch M, Bach P, von der Goltz C, et al. Validating incentive salience with functional magnetic resonance imaging: association between mesolimbic cue reactivity and attentional bias in alcohol-dependent patients. Addict Biol. 2012;17(4):807-16. [Crossref]  [PubMed] 
  43. Goldstein RZ, Volkow ND. Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nat Rev Neurosci. 2011;12(11):652-69. [Crossref]  [PubMed]  [PMC] 
  44. Ray RD, Zald DH. Anatomical insights into the interaction of emotion and cognition in the prefrontal cortex. Neurosci Biobehav Rev. 2012;36(1):479-501. [Crossref]  [PubMed]  [PMC] 
  45. Wiers CE, Stelzel C, Gladwin TE, Park SQ, Pawelczack S, Gawron CK, et al. Effects of cognitive bias modification training on neural alcohol cue reactivity in alcohol dependence. Am J Psychiatry. 2015;172(4):335-43. [Crossref]  [PubMed] 
  46. Phan KL, Taylor SF, Welsh RC, Ho SH, Britton JC, Liberzon I. Neural correlates of individual ratings of emotional salience: a trial-related fMRI study. Neuroimage. 2004;21(2):768-80. [Crossref]  [PubMed] 
  47. Wiers CE, Kühn S, Javadi AH, Korucuoglu O, Wiers RW, Walter H, et al. Automatic approach bias towards smoking cues is present in smokers but not in ex-smokers. Psychopharmacology (Berl). 2013;229(1):187-97. [Crossref]  [PubMed] 
  48. Contreras-Rodríguez O, Albein-Urios N, Perales JC, Martínez-Gonzalez JM, Vilar-López R, Fernández-Serrano MJ, et al. Cocaine-specific neuroplasticity in the ventral striatum network is linked to delay discounting and drug relapse. Addiction. 2015;110(12):1953-62. [Crossref]  [PubMed] 
  49. Levy DJ, Glimcher PW. The root of all value: a neural common currency for choice. Curr Opin Neurobiol. 2012;22(6):1027-38. [Crossref]  [PubMed]  [PMC] 
  50. Waters AJ, Shiffman S, Sayette MA, Paty JA, Gwaltney CJ, Balabanis MH. Attentional bias predicts outcome in smoking cessation. Health Psychol. 2003;22(4):378-87. [Crossref]  [PubMed]  [PMC] 

.: Up To Date

.: Process List

Login



Contact


Ortadoğu Reklam Tanıtım Yayıncılık Turizm Eğitim İnşaat Sanayi ve Ticaret A.Ş.

.: Address

Turkocagi Caddesi No:30 06520 Balgat / ANKARA
Phone: +90 312 286 56 56
Fax: +90 312 220 04 70
E-mail: info@turkiyeklinikleri.com

.: Manuscript Editing Department

Phone: +90 312 286 56 56/ 2
E-mail: yaziisleri@turkiyeklinikleri.com

.: English Language Redaction

Phone: +90 312 286 56 56/ 145
E-mail: tkyayindestek@turkiyeklinikleri.com

.: Marketing Sales-Project Department

Phone: +90 312 286 56 56/ 142
E-mail: reklam@turkiyeklinikleri.com

.: Subscription and Public Relations Department

Phone: +90 312 286 56 56/ 118
E-mail: abone@turkiyeklinikleri.com

.: Customer Services

Phone: +90 312 286 56 56/ 118
E-mail: satisdestek@turkiyeklinikleri.com

1. TERMS OF USE

1.1. To use the web pages with http://www.turkiyeklinikleri.com domain name or the websites reached through the sub domain names attached to the domain name (They will be collectively referred as "SITE"), please read the conditions below. If you do not accept these terms, please cease to use the "SITE." "SITE" owner reserves the right to change the information on the website, forms, contents, the "SITE," "SITE" terms of use anytime they want.

1.2. The owner of the "SITE" is Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. (From now on it is going to be referred as "Turkiye Klinikleri", shortly) and it resides at Turkocagi cad. No:30, 06520 Balgat Ankara. The services in the "SITE" are provided by "Turkiye Klinikleri."

1.3. Anyone accessing the "SITE" with or without a fee whether they are a natural person or a legal identity is considered to agree these terms of use. In this contract hereby, "Turkiye Klinikleri" may change the stated terms anytime. These changes will be published in the "SITE" periodically and they will be valid when they are published. Any natural person or legal identity benefiting from and reaching to the "SITE" are considered to be agreed to any change on hereby contract terms done by "Turkiye Klinikleri."

1.4. The "Terms of Use" hereby is published in the website with the last change on March 30th 2014 and the "SITE" is activated by enabling the access to everyone. The "Terms of Use" hereby is also a part of the any "USER Contract" was and/or will be done with the users using "Turkiye Klinikleri" services with or without a fee an inseparable.

2. DEFINITIONS

2.1. "SITE": A website offering different kind of services and context with a certain frame determined by "Turkiye Klinikleri" and it is accessible on-line on http://www.turkiyeklinikleri.com domain name and/or subdomains connected to the domain name.

2.2. USER: A natural person or a legal identity accessing to the "SITE" through online settings.

2.3. LINK: A link enabling to access to another website through the "SITE", the files, the context or through another website to the "SITE", the files and the context.

2.4. CONTEXT: Any visual, literary and auditory images published in the "Turkiye Klinikleri", "SITE" and/or any website or any accessible information, file, picture, number/figures, price, etc.

2.5. "USER CONTRACT": An electronically signed contract between a natural or a legal identity benefiting from special services "Turkiye Klinikleri" will provide and "Turkiye Klinikleri".

3. SCOPE OF THE SERVICES

3.1. "Turkiye Klinikleri" is completely free to determine the scope and quality of the services via the "SITE".

3.2. To benefit the services of "Turkiye Klinikleri" "SITE", the "USER" must deliver the features that will be specified by "Turkiye Klinikleri". "Turkiye Klinikleri" may change this necessity any time single-sided.

3.3. Not for a limited number, the services "Turkiye Klinikleri" will provide through the "SITE" for a certain price or for free are;

- Providing scientific articles, books and informative publications for health industry.

- Providing structural, statistical and editorial support to article preparation stage for scientific journals.

4. GENERAL PROVISIONS

4.1. "Turkiye Klinikleri" is completely free to determine which of the services and contents provided in the "SITE" will be charged.

4.2. People benefiting from the services provided by "Turkiye Klinikleri" and using the website can use the "SITE" only according to the law and only for personal reasons. Users have the criminal and civil liability for every process and action they take in the "SITE". Every USER agrees, declares and undertakes that they will not proceed by any function or action infringement of rights of "Turkiye Klinikleri"s and/or other third parties', they are the exclusive right holder on usage, processing, storage, made public and revealing any written, visual or auditory information reported to Turkiye Klinikleri" and/or "SITE" to the third parties. "USER" agrees and undertakes that s/he will not duplicate, copy, distribute, process, the pictures, text, visual and auditory images, video clips, files, databases, catalogs and lists within the "SITE", s/he will not be using these actions or with other ways to compete with "Turkiye Klinikleri", directly or indirectly.

4.3. The services provided and the context published within the "SITE" by third parties is not under the responsibility of "Turkiye Klinikleri", institutions collaborated with "Turkiye Klinikleri", "Turkiye Klinikleri" employee and directors, "Turkiye Klinikleri" authorized salespeople. Commitment to accuracy and legality of the published information, context, visual and auditory images provided by any third party are under the full responsibility of the third party. "Turkiye Klinikleri" does not promise and guarantee the safety, accuracy and legality of the services and context provided by a third party.

4.4. "USER"s cannot act against "Turkiye Klinikleri", other "USER"s and third parties by using the "SITE". "Turkiye Klinikleri" has no direct and/or indirect responsibility for any damage a third party suffered or will suffer regarding "USER"s actions on the "SITE" against the rules of the hereby "Terms of Use" and the law.

4.5. "USER"s accept and undertake that the information and context they provided to the "SITE" are accurate and legal. "Turkiye Klinikleri" is not liable and responsible for promising and guaranteeing the verification of the information and context transmitted to "Turkiye Klinikleri" by the "USER"s, or uploaded, changed and provided through the "SITE" by them and whether these information are safe, accurate and legal.

4.6. "USER"s agree and undertake that they will not perform any action leading to unfair competition, weakening the personal and commercial credit of "Turkiye Klinikleri" and a third party,  encroaching and attacking on personal rights within the "SITE" in accordance with the Turkish Commercial Code Law.

4.7. "Turkiye Klinikleri" reserves the right to change the services and the context within the "SITE"  anytime. "Turkiye Klinikleri" may use this right without any notification and timelessly. "USER"s have to make the changes and/or corrections "Turkiye Klinikleri" required immediately. Any changes and/or corrections that are required by "Turkiye Klinikleri", may be made by "Turkiye Klinikleri" when needed. Any harm, criminal and civil liability resulted or will result from changes and/or corrections required by "Turkiye Klinikleri" and were not made on time by the "USER"s belongs completely to the users.

4.8. "Turkiye Klinikleri" may give links through the "SITE" to other websites and/or "CONTEXT"s and/or folders that are outside of their control and owned and run by third parties. These links are provided for ease of reference only and do not hold qualification for support the respective web SITE or the admin or declaration or guarantee for the information inside. "Turkiye Klinikleri" does not hold any responsibility over the web-sites connected through the links on the "SITE", folders and context, the services or products on the websites provided through these links or their context.

4.9. "Turkiye Klinikleri" may use the information provided to them by the "USERS" through the "SITE" in line with the terms of the "PRIVACY POLICY" and "USER CONTRACT". It may process the information or classify and save them on a database. "Turkiye Klinikleri" may also use the USER's or visitor's identity, address, e-mail address, phone number, IP number, which sections of the "SITE" they visited, domain type, browser type, date and time information to provide statistical evaluation and customized services.

5. PROPRIETARY RIGHTS

5.1. The information accessed through this "SITE" or provided by the users legally and all the elements (including but not limited to design, text, image, html code and other codes) of the "SITE" (all of them will be called as studies tied to "Turkiye Klinikleri"s copyrights) belongs to "Turkiye Klinikleri". Users do not have the right to resell, process, share, distribute, display or give someone permission to access or to use the "Turkiye Klinikleri" services, "Turkiye Klinikleri" information and the products under copyright protection by "Turkiye Klinikleri". Within hereby "Terms of Use" unless explicitly permitted by "Turkiye Klinikleri" nobody can reproduce, process, distribute or produce or prepare any study from those under "Turkiye Klinikleri" copyright protection.

5.2. Within hereby "Terms of Use", "Turkiye Klinikleri" reserves the rights for "Turkiye Klinikleri" services, "Turkiye Klinikleri" information, the products associated with "Turkiye Klinikleri" copyrights, "Turkiye Klinikleri" trademarks, "Turkiye Klinikleri" trade looks or its all rights for other entity and information it has through this website unless it is explicitly authorized by "Turkiye Klinikleri".

6. CHANGES IN THE TERMS OF USE

"Turkiye Klinikleri" in its sole discretion may change the hereby "Terms of Use" anytime announcing within the "SITE". The changed terms of the hereby "Terms of Use" will become valid when they are announced. Hereby "Terms of Use" cannot be changed by unilateral declarations of users.

7. FORCE MAJEURE

"Turkiye Klinikleri" is not responsible for executing late or never of this hereby "Terms of Use", privacy policy and "USER Contract" in any situation legally taken into account as force majeure. Being late or failure of performance or non-defaulting of this and similar cases like this will not be the case from the viewpoint of "Turkiye Klinikleri", and "Turkiye Klinikleri" will not have any damage liability for these situations. "Force majeure" term will be regarded as outside of the concerned party's reasonable control and any situation that "Turkiye Klinikleri" cannot prevent even though it shows due diligence. Also, force majeure situations include but not limited to natural disasters, rebellion, war, strike, communication problems, infrastructure and internet failure, power cut and bad weather conditions.

8. LAW AND AUTHORISATION TO FOLLOW

Turkish Law will be applied in practicing, interpreting the hereby "Terms of Use" and managing the emerging legal relationships within this "Terms of Use" in case of finding element of foreignness, except for the rules of Turkish conflict of laws. Ankara Courts and Enforcement Offices are entitled in any controversy happened or may happen due to hereby contract.

9. CLOSING AND AGREEMENT

Hereby "Terms of Use" come into force when announced in the "SITE" by "Turkiye Klinikleri". The users are regarded to agree to hereby contract terms by using the "SITE". "Turkiye Klinikleri" may change the contract terms and the changes will be come into force by specifying the version number and the date of change on time it is published in the "SITE".

 

30.03.2014

Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com