Turkiye Klinikleri Journal of Ophthalmology

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Anizometropik Ambliyopide Retina Sinir Lifi Kalınlığı ve Makuler Pigment Optik Yoğunluğunun Değerlendirilmesi
Evaluation of Retinal Nerve Fiber Layer and Macular Pigment Optical Density in Unilateral Anisometropic Amblyopia
Ayşenur ÇELİKa, Mualla ŞAHİN HAMURCUb, Murat Sinan SARICAOĞLUb
aGöz Hastalıkları Kliniği, Dr. Abdurrahman Yurtaslan Ankara Onkoloji Eğitim ve Araştırma Hastanesi,
bGöz Hastalıkları Kliniği, Ankara Numune Eğitim ve Araştırma Hastanesi, Ankara, TÜRKİYE
Turkiye Klinikleri J Ophthalmol. 2019;28(3):167-73
doi: 10.5336/ophthal.2018-63790
Article Language: TR
Full Text
ÖZET
 Amaç: Tek taraflı anizometropik ambliyop gözlerde retina sinir lifi kalınlığı (RSLT) ve makula pigment optik yoğunluğu (MPOY) testlerinin yapılarak diğer gözleriyle karşılaştırılmasıdır. Gereç ve Yöntemler: Anizometropiye bağlı tek taraflı ambliyopisi olan 94 hasta ileriye dönük olarak değerlendirilmeye alındı. Tüm hastalara tam bir oftalmolojik muayene yapıldı. Farklı oturumlarda optik koherens tomografi (OKT) ile merkez makula kalınlığı (MMK) ve RSLT ölçümü, makula pigmenti optik yoğunluğu cihazı ile MPOY ölçümü yapıldı. Sonuçlar ambliyop ve diğer gözleri arasında karşılaştırıldı. Bulgular: Hastaların 55'i kadın, 39'u erkek olup, yaş ortalamaları 36,11±9,49 (18-55) yıl idi. Ambliyop hastaların 68'i hipermetropik anizometrop, sekizi miyopik anizometrop, 18'i astigmatik anizometrop idi. Anizometropik hastaların ambliyop ve diğer gözlerinin ortalama RSLT kalınlıkları sırasıyla 99,05±7,28 μm ve 95,17±6,17 μm idi. Anizometropik hipermetrop, miyop ve astigmatik ambliyop gözlerin ortalama RSLT kalınlıkları sırası ile 99,79±0,87, 98,00±2,42, 96,72±1,77 olarak saptandı. Ambliyop gözlerin ortalama MMK değerleri 248,12±19,12 μm ve diğer gözlerin ortalama MMK değeri 247,89±21,71 μm idi. Anizometropik hipermetrop, miyop ve astigmatik ambliyop gözlerinin ortalama MMK değerleri sırası ile 248,29±2,31, 249,88±8,30, 246,38±4,62 bulundu. Ortalama MPOY değeri anizometropik ambliyop gözlerde 0,38±0,16, diğer gözlerde 0,50±0,15 saptandı. Sonuç: Ambliyopide retina değişiklikleri tartışmalıdır. Anizometropik ambliyopisi olan gözlerde diğer gözlere göre istatistiksel olarak anlamlı olmak üzere RSLT kalınlığı daha fazla, MPOY daha az yoğun olarak saptandı. Ambliyop hastaların da artmış RSLT kalınlığı ambliyopik gözlerde organik değişimlerin olabileceğini düşündürmektedir.

Anahtar Kelimeler: Ambliyopi; anizometropi, optik koherens tomografi
ABSTRACT
 Objective: The aim of this study is to evaluate retinal nerve fiber layer (RNFL) thickness and macular pigment optical density (MPOD) tests in unilateral anisometropic amblyopic patients, and to compare the amblyopic eyes with the fellow eyes. Material and Methods: Ninety-four unilateral anisometropic amblyopic patients were evaluated prospectively. All the patients had ophalmological examination. Central macular thickness (CMT) and RNFL thickness were measured using optical coherence tomography (OCT) in different sessions. In addition, MPOD was measured with heterochromatic flicker photometry. The results were compared between amblyopic eyes and fellow eyes. Results: The study included 55 female and 39 male patients and the mean age of the study population was 36.11+9.49 (18-55) years. Of the 94 patients 68 were hyperopic, 8 were myopic and 18 were astigmatic. The mean RNFL thickness of amblyopic anisometropic patients and fellow eyes were 99.05±7.28 μm and 95.17±6.17 μm, and the mean CMT were 248.12±19.12 μm and 247.89±21.71 μm, with the same order. The RNFL thickness of anisometropic hyperopic, myopic and astigmatic eyes were 99.79±0.87, 98.00±2.42, 96.72±1.77 respectively. The mean CMT of anisometropic hiperopic, myopic and astigmatic eyes were 248.29±2.31, 249.88±8.30, 246.38±4.62, respectively. The mean MPOD were 0.38±0.16 in amblyopic eyes and 0.50 ±0.15 in fellow eyes. Conclusion: Retinal changes is controversial in amblyopia. RNFL thickness was statistically significantly higher and MPOD was statistically lower in amblyopic eyes. The increased RNLF thickness in patients with amblyopia suggests that organic changes may occur in amblyopic eyes.

Keywords: Amblyopia; anisometropia, optical coherence tomography
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