Yaşlanma fiziksel, bellek dâhil bilişsel ve sosyal işlevlerde gerilemenin meydana geldiği bir yaşam sürecidir. Bu süreçte yaşlılar arasında yüksek prevalans gösteren hastalıklara sık rastlanmakta ve yaşlı bireyler için bir ya da birden fazla kronik hastalıkla mücadele etmeyi gerekli kılmaktadır. Bu durum yaşlı birey açısından bakım gereksiniminin artması, yaşam kalitesinde azalma, bakım verenler için bakım yükünün artışı, sağlık sistemlerinin sürdürülebilirliği açısından yüksek ölümlülük oranları ve sağlık harcamalarındaki aşırı artışa neden olması ile bir tehdit anlamına gelmektedir. Bu hastalıklardan biri olan Alzheimer, etiyolojisi bilinemeyen, zayıf ilaç etkinliği olan fiziksel ve bilişsel işlevlerin azalması ile karakterize progresif nörodejeneratif bir hastalıktır. Tıp ve sağlık bilimlerinde meydana gelen gelişme ve ilerlemelere rağmen Alzheimer hastalığı tedavisinde başarıya tam olarak ulaşılamamıştır. Bu nedenle Alzheimer ve bu hastalığı bağlı bilişsel bozulma ile yaşlanan bir popülasyonda, fiziksel ve bilişsel işlevlerde azalmayı yavaşlatmak ve hastalıkla mücadele etmek adına çeşitli stratejiler gerekmektedir. Bu derlemede, değiştirilebilir risk faktörleri ile bu stratejilerden, nörolojik mekanizmaları hedef alan fiziksel egzersizin, Alzheimerlı yaşlılarda rolü üzerinde durulmuştur. Literatürde yer alan çalışmalar, fiziksel egzersizin hem fiziksel ve bilişsel performanstaki düşüşleri azalttığını hem de hastalığın ilerlemesini yavaşlattığı yönünde kanıtlar sunmuştur. Ayrıca Alzheimer hastalığı ve diğer demans türleri gibi nörodejeneratif hastalıklarla ilgili değişikliklere karşı koruma sağlayabildiği gösterilmiştir.
Anahtar Kelimeler: Alzheimer hastalığı; egzersiz; yaşlı
Aging is a course of life in which there is a regression in physical, cognitive including memory and social functions. In this period, the elders go through diseases with high prevalence often and they make it essential for old people to struggle with one or more chronicle diseases. This situation poses a threat to the old people due to the increase in their need for care, decrease in the life quality, increase in the care responsibilities of caretakers, high mortality rate and excessive increase in the health expenses in terms of the sustainability of healthcare systems. Alzheimer, one of these diseases, is a progressive neuro-degenerative disease whose etiology cannot be known, drug activity is weak and which is characterized with decrease in the physical and cognitive functions. The treatment of alzheimer disease has not been succeeded completely despite the advancements and progress in the medical and health sciences. Therefore, various strategies are required to slow down the regression in the physical and cognitive functions, and to fight with the disease in a population which is growing old with alzheimer and cognitive impairment deriving from alzheimer. In this review, the role of physical exercise in alzheimeri elderly, focusing on neurological mechanisms and modifiable risk factors and these strategies are discussed. The studies in the literature presented evidence indicating that physical exercise both decreases the regression in the physical and cognitive performance and slows down the progress of the disease. Furthermore, they showed that it can provide a protection against the alterations concerning neuro-degenerative diseases such as alzheimer disease and other types of dementia.
Keywords: Alzheimer's disease; exercise; elderly
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