Turkiye Klinikleri Journal of Ophthalmology

.: ORIGINAL RESEARCH
Akne Vulgaris Hastalarında Meibomian Bez Kaybı ve Gözyaşı Film İnstabilitesinde İnflamasyonun Rolü: Bir Korelasyon Çalışması
The Role of Inflammation in Meibomian Gland Loss and Tear Film Instability in Patients with Acne Vulgaris: A Correlation Study
Yakup ACETa, Yaşar DAĞb
aClinic of Ophthalmology, Mardin Training and Research Hospital, Mardin, Türkiye
bClinic of Ophthalmology, İstanbul Başakşehir Çam and Sakura City Hospital, İstanbul, Türkiye
Turkiye Klinikleri J Ophthalmol. 2023;32(3):184-90
doi: 10.5336/ophthal.2023-96320
Article Language: TR
Full Text
ÖZET
 Amaç: Akne vulgaris (AV) tanılı kadın katılımcılarda, gözyaşı filmi instabilitesinin ve meibomian bez (MB) kaybının inflamatuar belirteçler ile olan ilişkisini incelemek. Gereç ve Yöntemler: AV tanılı 75 kadın katılımcının 75 gözü çalışmaya alındı. Bütün katılımcılar, dermatoloji polikliniğine başvuran ve isotretinoin tedavisi başlanacak hastalardan oluşmaktadır. Katılımcıların invaziv olmayan ilk gözyaşı kırılma zamanı (İOilk-GKZ) ve her katılımcı için ölçüm süresince, invaziv olmayan tüm gözyaşı kırılma zamanlarının ortalama (İOort-GKZ) değerlerine bakıldı. Meibografideki MB kayıp miktarları incelendi Katılımcıların İO-GKZ parametrelerinin ve MB kayıp miktarının nötrofil/lenfosit oranı (NLO), platelet/lenfosit oranını (PLO) ve platelet sayısı×(NLO)'dan elde edilen değer olan Sistemik İmmün-İnflamasyon İndeksi (Sİİ) arasındaki korelasyon incelendi. Bulgular: Katılımcıların ortama yaşı 24,7±5 idi. Ortama İOilk-GKZ değeri 4,8±3,4 sn olarak saptandı. Ortama İOort-GKZ değeri 7,4±3,1 sn olarak saptandı. Üst kapaktaki MB kayıp oranı %37,4±%14,6 olarak saptandı. Alt kapaktaki MB kayıp oranı %48±15,9 olarak saptandı. İOilk-GKZ değeri ile NLO, PLO ve Sİİ arasında korelasyon saptanmadı (p>0,05). Aynı şekilde İOort-GKZ değeri ile NLO, PLO ve Sİİ arasında korelasyon saptanmadı (p>0,05). Alt kapaktaki MB kayıp oranı ile NLO, PLO ve Sİİ arasında korelasyon saptanmadı (p>0,05). Üst kapaktaki MB kayıp oranı ile NLO, PLO ve Sİİ arasında da korelasyon saptanmadı (p>0,05). Sonuç: AV hastalarında invaziv olmayan gözyaşı kırılma zamanı parametreleri ile MB kaybının inflamatuar belirteçlerle bir korelasyon göstermediğini gözlemledik. AV hastalarındaki MB kaybı ve gözyaşı film düzensizliğinin etiyolojik faktörü olarak inflamatuar parametrelerin dışında başka etmenlerin araştırması gerektiğini düşünmekteyiz.

Anahtar Kelimeler: Meibomian bezler; akne vulgaris; kuru göz sendromları; gözyaşları; inflamasyon
ABSTRACT
 Objective: To examine the relationship of tear film instability and meibomian gland (MG) loss with inflammatory markers in female participants diagnosed with acne vulgaris (AV). Material and Methods: 75 eyes of 75 female participants diagnosed with AV were included in the study. All participants consist of patients who applied to the dermatology outpatient clinic and will be treated with isotretinoin. MG losses in meibography were examined. The correlation between the participants' NI-BUT parameters and the amount of MG loss with the Systemic Immune-Inflammation Index (SII), which is the value obtained from the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and platelet count×(NLR) was examined. Results: The mean age of the participants was 24.7±5 year. Mean NIfirst-BUT value was found to be 4.8±3.4 sec. Mean NIaverage-BUT value was found to be 7.4±3.1 sec. MG loss in the upper lid was found to be 37.4%±14.6%. The rate of MG loss in the lower lid was found to be 48.0 %±15.9%. There was no significant correlation between NIfirstBUT and NIaverage-BUT value and NLR, PLR and SII (p>0.05). There was no significant correlation between upper& lower lid MG loss rate and NLR, PLR and SII (p>0.05). Conclusion: We observed that noninvasive tear break-up time parameters and MG loss were not correlated with inflammatory markers in patients with AV. We think that factors other than inflammatory parameters should be investigated as the etiological factor of MG loss and tear film instability in patients with AV.

Keywords: Meibomian glands; acne vulgaris; dry eye syndrome; tears; inflammation
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