Turkiye Klinikleri Journal of Dental Sciences

.: ORIGINAL RESEARCH
Ailevi Akdeniz Ateşi Tanılı Erişkinlerde Ağız Sağlığının Değerlendirilmesi: Vaka-Kontrol Çalışması
Evaluation of Oral Health in Adults with Familial Mediterranean Fever: A Case-Control Study
Müşerref BAŞDEMİRCİa, Rabia KARAKUŞb, Melek TAŞSÖKERb
aKonya Şehir Hastanesi, Tıbbi Genetik Kliniği, Konya, Türkiye
bNecmettin Erbakan Üniversitesi Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Radyolojisi ABD, Konya, Türkiye
Turkiye Klinikleri J Dental Sci. 2023;29(1):52-7
doi: 10.5336/dentalsci.2022-93898
Article Language: TR
Full Text
ÖZET
 Amaç: Bu çalışmanın amacı, ailevi Akdeniz ateşi [familial Mediterranian fever (FMF)] hastalarının, sistemik açıdan sağlıklı bireyler ile karşılaştırmalı olarak ağız-diş sağlığı problemlerinin derecesini ve çeşitlerini saptamaktır. Gereç ve Yöntemler: Çalışmaya dental muayene amacı ile kliniğimize müracaat eden medikal anamnezinde FMF tanısı olan ve kolşisin kullanan bireyler dâhil edilmiştir. Kontrol grubunu herhangi bir sistemik hastalığa sahip olmayan, yaş ve cinsiyet açısından vaka grubu ile eşleşen bireyler oluşturmuştur. Gen mutasyonlarına ilişkin hasta öyküleri, Genetik bölümünün arşiv kayıtlarından elde edilmiştir. Katılımcıların çürük, kayıp, dolgulu dişler [decay, missing, filled teeth (DMFT)] indeksleri, temporomandibular eklem (TME) muayene bulguları (disk deplasmanı, osteoartrit, ankiloz vb), oral lezyon (aftöz ülserler) varlığı, alveolar kemik kaybı varlığı ve derecesi kayıt altına alınmıştır. Alveolar kemik kaybı en şiddetli olduğu alanda <%15, %15-33, >%33 olmasına göre derecelendirilmiştir. Çalışmada elde edilen veriler SPSS v.21 (IBM, SPSS inc., Armonk, NY) paket programı kullanılarak değerlendirilmiş, p<0,05 düzeyinde anlamlı kabul edilmiştir. Bulgular: Yaş ve cinsiyet bakımından eşleştirilmiş 30 kadın, 30 erkek olmak üzere 60 hastanın yaş ortalaması (19-30) 24,53'tür. FMF'li bireylerde en sık görülen (10 hasta) mutasyon heterozigot M694V'tür. FMF'li bireylerin DMFT indeksi, alveolar kemik kaybı şiddeti, TME hastalıkları ve oral lezyonların görülmesi bakımından kontrol grubu ile aralarında anlamlı farklılık görülmemiştir (p>0,05), bununla birlikte bu problemlerin görülme frekansları FMF'li bireylerde daha yüksektir. Sonuç: FMF'li bireylerde ağız, diş ve çene problemleri sağlıklı bireylerden daha sık görülebileceğinden bu hastalar düzenli takip edilmelidir.

Anahtar Kelimeler: Ailevi Akdeniz ateşi; periodontitis; çürük, kayıp, dolgulu dişler
ABSTRACT
 Objective: The aim of this study is to determine the degree and types of oral-dental health problems in familial Mediterranian fever (FMF) patients compared with systemically healthy individuals. Material and Methods: Individuals who applied to our clinic for dental examination with a diagnosis of FMF in their medical history and who used colchicine were included in the study. The control group consisted of individuals who did not have any systemic disease and matched with the case group in terms of age and gender. Patient histories of gene mutations were obtained from the archive records of the Genetics department. Participants' decay, missing, filled teeth (DMFT) indexes, temporomandibular joint (TMJ) examination findings (disc displacement, osteoarthritis, ankylosis, etc.), presence of oral lesions (aphthous ulcers), presence and degree of alveolar bone loss were recorded. Alveolar bone loss was graded as 33% in the most severe area. The data obtained in the study were evaluated using the SPSS v.21 (IBM, SPSS inc., Armonk, NY) package program, and it was considered significant at the p0.05), however, the frequency of these problems is higher in individuals with FMF. Conclusion: Since the frequency of oral, dental and jaw problems in individuals with FMF can be seen more frequently than in healthy individuals, these patients should be followed up regularly.

Keywords: Familial mediterranean fever; periodontitis; decay, missing, filled teeth
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