.: ORİJİNAL ARAŞTIRMA
Uropathogens According to the Trimesters, and Their Effects on Pregnancy Outcomes: A Retrospective Clinical Study
Trimesterlere Göre Üropatojenler ve Gebelik Sonuçlarına Etkileri: Retrospektif Bir Klinik Çalışma
J Reconstr Urol. 2024;14(1):1-10
doi: 10.5336/urology.2023-95646
Makale Dili: EN
Tam Metin
Ücretsiz Erişim
ABSTRACT
Objective: The present study aimed to examine the relationship between gestational urinary tract infection (UTI) cases and pregnancy complications such as preterm delivery and/or low birth weight, and to address the possible increase in risk from these aspects. Material and Methods: Seventy-one pregnant women who were diagnosed with UTI, and 102 healthy pregnant women were included in the study. Gestational week, delivery week, delivery method and newborns's birth weight data of women with positive urine culture were compared. Results: The median week of delivery was found to be significantly higher in those who had a UTI in the first trimester compared to those who had a UTI in the next trimester (p=0.005). The median week of gestation was significantly higher in those with Gram-positive bacterial growth than those with other microorganisms (p=0.006). Median gestational week was found to be significantly lower in those with Gram-negative bacteria growth than in those with growth of other microorganisms [15 (interquartile range: 15) weeks vs. 25.5 (IQR:13) weeks] (p=0.008). The median week of gestation in those with E. coli growth was found to be significantly lower than in those with other microorganism growth [8 (interquartile range: 14) weeks vs. 25 (interquartile span: 17) weeks] (p=0.013). The groups were similar in terms of preterm birth (p=0.799) and low birth weight (p=0.347). Conclusion: These findings show that UTI during pregnancy, particularly after the first trimester, may be associated with preterm delivery. It was also observed that the risk of preterm delivery significantly increased in pregnant women over the age of 35 and development of UTI after the first trimester.
Keywords: Pregnancy; urinary tract infection; preterm delivery; low birth weight
Objective: The present study aimed to examine the relationship between gestational urinary tract infection (UTI) cases and pregnancy complications such as preterm delivery and/or low birth weight, and to address the possible increase in risk from these aspects. Material and Methods: Seventy-one pregnant women who were diagnosed with UTI, and 102 healthy pregnant women were included in the study. Gestational week, delivery week, delivery method and newborns's birth weight data of women with positive urine culture were compared. Results: The median week of delivery was found to be significantly higher in those who had a UTI in the first trimester compared to those who had a UTI in the next trimester (p=0.005). The median week of gestation was significantly higher in those with Gram-positive bacterial growth than those with other microorganisms (p=0.006). Median gestational week was found to be significantly lower in those with Gram-negative bacteria growth than in those with growth of other microorganisms [15 (interquartile range: 15) weeks vs. 25.5 (IQR:13) weeks] (p=0.008). The median week of gestation in those with E. coli growth was found to be significantly lower than in those with other microorganism growth [8 (interquartile range: 14) weeks vs. 25 (interquartile span: 17) weeks] (p=0.013). The groups were similar in terms of preterm birth (p=0.799) and low birth weight (p=0.347). Conclusion: These findings show that UTI during pregnancy, particularly after the first trimester, may be associated with preterm delivery. It was also observed that the risk of preterm delivery significantly increased in pregnant women over the age of 35 and development of UTI after the first trimester.
Keywords: Pregnancy; urinary tract infection; preterm delivery; low birth weight
ÖZET
Amaç: Bu çalışmada, gestasyonel idrar yolu enfeksiyonu (İYE) olguları ile erken doğum ve/veya düşük doğum ağırlığı gibi gebelik komplikasyonları arasındaki ilişkinin incelenmesi ve olası risk artışının bu yönlerden ele alınması amaçlanmıştır. Gereç ve Yöntemler: İYE tanısı almış 71 gebe ve 102 sağlıklı gebe çalışmaya dâhil edildi. İdrar kültürü pozitif olan kadınların gebelik haftası, doğum haftası, doğum şekli ve bebeğin doğum ağırlığı verileri karşılaştırıldı. Bulgular: İlk trimesterde İYE geçirenlerde ortanca doğum haftası sonraki trimesterde İYE geçirenlere göre anlamlı olarak yüksek bulundu (p=0,005). Medyan gebelik haftası Gram pozitif bakteri üremesi olanlarda diğer mikroorganizmaları olanlara göre anlamlı olarak daha yüksekti (p=0,006). Medyan gebelik haftası Gram negatif bakteri üremesi olanlarda diğer mikroorganizmaların üremesi olanlara göre anlamlı olarak daha düşük bulundu [15 (çeyrekler açıklığı:15) hafta vs. 25,5 (IQR:13) hafta] (p=0,008). E. coli üremesi görülenlerde de ortanca gestasyon haftası diğer mikroorganizma üremesi görülenlere göre anlamlı düşük bulundu [8 (çeyrekler açıklığı: 14) hafta vs. 25 (çeyrekler açıklığı: 17) hafta] (p=0,013). Gruplar erken doğum (p=0,799) ve düşük doğum ağırlığı (p=0,347) açısından benzerdi. Sonuç: Bu bulgular, ilk trimesterden sonra gelişen İYE'nin erken doğumla ilişkili olabileceğini göstermektedir. Ayrıca 35 yaş üstü ve ilk trimesterden sonra İYE gelişen gebelerde erken doğum riskinin anlamlı olarak arttığı gözlenmiştir.
Anahtar Kelimeler: Gebelik; idrar yolu enfeksiyonu; erken doğum; düşük ağırlıklı doğum
Amaç: Bu çalışmada, gestasyonel idrar yolu enfeksiyonu (İYE) olguları ile erken doğum ve/veya düşük doğum ağırlığı gibi gebelik komplikasyonları arasındaki ilişkinin incelenmesi ve olası risk artışının bu yönlerden ele alınması amaçlanmıştır. Gereç ve Yöntemler: İYE tanısı almış 71 gebe ve 102 sağlıklı gebe çalışmaya dâhil edildi. İdrar kültürü pozitif olan kadınların gebelik haftası, doğum haftası, doğum şekli ve bebeğin doğum ağırlığı verileri karşılaştırıldı. Bulgular: İlk trimesterde İYE geçirenlerde ortanca doğum haftası sonraki trimesterde İYE geçirenlere göre anlamlı olarak yüksek bulundu (p=0,005). Medyan gebelik haftası Gram pozitif bakteri üremesi olanlarda diğer mikroorganizmaları olanlara göre anlamlı olarak daha yüksekti (p=0,006). Medyan gebelik haftası Gram negatif bakteri üremesi olanlarda diğer mikroorganizmaların üremesi olanlara göre anlamlı olarak daha düşük bulundu [15 (çeyrekler açıklığı:15) hafta vs. 25,5 (IQR:13) hafta] (p=0,008). E. coli üremesi görülenlerde de ortanca gestasyon haftası diğer mikroorganizma üremesi görülenlere göre anlamlı düşük bulundu [8 (çeyrekler açıklığı: 14) hafta vs. 25 (çeyrekler açıklığı: 17) hafta] (p=0,013). Gruplar erken doğum (p=0,799) ve düşük doğum ağırlığı (p=0,347) açısından benzerdi. Sonuç: Bu bulgular, ilk trimesterden sonra gelişen İYE'nin erken doğumla ilişkili olabileceğini göstermektedir. Ayrıca 35 yaş üstü ve ilk trimesterden sonra İYE gelişen gebelerde erken doğum riskinin anlamlı olarak arttığı gözlenmiştir.
Anahtar Kelimeler: Gebelik; idrar yolu enfeksiyonu; erken doğum; düşük ağırlıklı doğum
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