Mandibulada patolojik kırıklar sık görülmemekle birlikte komplike faktörler eşlik ettiğinden tedavileri zordur. Bu çalışmanın amacı, patolojik kırığın görüldüğü mandibulalarda karşılaşılan zorluklar ve ilgili tedavi yöntemleri konusunda edindiğimiz tecrübeleri rapor etmektir. Bu klinik durum ile ilgili literatürde analiz edilmiştir. Mandibulada patolojik kırık ile başvuran olguların kayıtları retrospektif olarak toplanmıştır. Yaş, cinsiyet, kırığa sebep olan travma, patolojik kırığın etiyolojisi, kırığın lokalizasyonu, tedavi ve komplikasyonlar ile ilgili veriler toplanmıştır. Patolojik kırığı olan 7 hasta (yaş ortalaması: 60,1) ve atrofik kırığı olan 2 hasta değerlendirilmiştir. Osteoradyonekroz, bifosfonat nekrozu ve osteomyelit patolojik mandibula kırıklarına neden olan etiyolojik faktörlerdir. Bütün olgularda cerrahi yaklaşım uygulanmıştır. Plak ekspozu ve enfeksiyon komplikasyonları geliştiği rapor edilmiştir. Nekroze kemiğin rezeksiyonu ve rekonstrüksiyon plağı ile segmentlerin stabilizasyonu en yaygın uygulanan tedavi şeklidir. Hastalarda genel durumun bozuk olması ve lokal faktörlerin de olumsuz olması patolojik mandibula kırıklarında komplikasyon oranının daha fazla olmasına neden olmaktadır.
Keywords: Mandibula; patolojik kırık; osteoradyonekroz; çenenin bifosfonat ile ilişkili nekrozu
Pathological fractures of mandible are uncommon and challenging due to several complicating factors. The aim of the study is to report our experience concerning treatment strategies and difficulties in handling mandible with pathological fracture. Data concerning this condition in the literature has been analysed. This study reviewed retrospectively the records of patients who presented with a pathological fracture of the mandible. The collected data included age, sex, mechanism of injury, aetiology, anatomic site of fracture, treatment and complications. There were 7 patients with pathological fracture (mean age of 60.1 years) and two patients with atrophic fracture. Aetiologic factors of pathological mandibular fractures were osteoradionecrosis, bisphophonates osteonecrosis and osteomyelitis. All cases were treated with surgical approach. Some complications such as plate expose and infection have developed. The most frequent primary treatment utilized was resection of diseased part of bone and fixation with reconstruction plates. Complications occur more often because of local and general conditions of patients.
Anahtar Kelimeler: Mandible; pathological fracture; osteoradionecrosis; bisphophonates osteonecrosis of the jaw
- Boffano P, Roccia F, Gallesio C, Berrone S. Pathological mandibular fractures: a review of the literature of the last two decades. Dent Traumatol. 2013;29(3):185-96. [Crossref] [PubMed]
- Carlsen A, Marcussen M. Spontaneous fractures of the mandible concept & treatment strategy. Med Oral Patol Oral Cir Bucal. 2016;21(1):e88-94. [Crossref] [PubMed] [PMC]
- Coletti D, Ord RA. Treatment rationale for pathological fractures of the mandible: a series of 44 fractures. Int J Oral Maxillofac Surg. 2008;37(3):215-22. [Crossref] [PubMed]
- Gerhards F, Kuffner HD, Wagner W. Pathological fractures of the mandible. A review of the etiology and treatment. Int J Oral Maxillofac Surg. 1998;27(3):186-90. [Crossref] [PubMed]
- Abir B, Guerrouani A, Abouchadi A. Pathological fractures of the mandible: a report of ten cases and a review of the literature. Open J Somatol. 2013;3(8):419-24. [Crossref]
- Algahtani M, Alqudah M, Alshehri S, Binahmed A, Sándor GK. Pathologic fracture of the mandible caused by metastatic follicular thyroid carcinoma. J Can Dent Assoc. 2009;75(6):457-60. [PubMed]
- Shi S, Liu Y, Fu T, Li X, Zhao S. Multifocal Langerhans cell histiocytosis in an adult with a pathological fracture of the mandible and spontaneous malunion: A case report. Oncol Lett. 2014;8(3):1075-9. [Crossref] [PubMed] [PMC]
- Furutani M, Ohnishi M, Tanaka Y. Mandibular involvement in patients with multiple myeloma. J Oral Maxillofac Surg. 1994;52(1):23-5. [Crossref] [PubMed]
- Kouhsoltani M, Mesgarzadeh AH, Moradzadeh Khiavi M. Mandibular fracture associated with a dentigerous cyst: report of a case and literature review. J Dent Res Dent Clin Dent Prospects. 2015;9(3):193-8. [Crossref] [PubMed] [PMC]
- Cezairli, B, Yıldız K, Çandırlı C, Üngör C. Aktinomikoz osteomyelitine bağlı patolojik mandibula fraktürü: olgu sunumu. [A pathologıcal fracture of the mandıble due to actınomıcosıs osteomyelitis: a case report]. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi. 2014;24(Supplement 8), 36-40. [Crossref]
- Yüce MO, Solmaz MC, Koyuncu BO, Turk G, Gunbay T. Giant cell reparative granuloma associated with mandibular fracture in an elderly edentulous patient: case report. Turkish Journal of Geriatrics. 2017;20(2):151-6. [Link]
- Vorrasi JS, Domenick PC, John FC. Diagnosis and management of mandible fractures. In: Fonseca RJ. Oral and Maxillofacial Surgery. 3rd ed. Louis, Missouri: Elsevier; 2017. p.151. [Link]
- Castro-Nú-ez J, Cunningham LL, Van Sickels JE. A historical perspective with current opinion on the management of atrophic mandibular fractures. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124(6):e276-e282 [Crossref] [PubMed]
- Brucoli M, Boffano P, Romeo I, Corio C, Benech A, Ruslin M, et al. The epidemiology of edentulous atrophic mandibular fractures in Europe. J Craniomaxillofac Surg. 2019;47(12):1929-34. [Crossref] [PubMed]
- Bormann KH, Wild S, Gellrich NC, Kokemüller H, Stühmer C, Schmelzeisen R, et al. Five-year retrospective study of mandibular fractures in Freiburg, Germany: incidence, etiology, treatment, and complications. J Oral Maxillofac Surg. 2009;67(6):1251-5. [Crossref] [PubMed]
- Linderup MW, Bregendahl S, Helleberg M, Schytte S, Pikelis A, Nørholt SE. Deep head and neck infection causing pathological fracture of the mandibular condyle. BJR Case Rep. 2017;3(2):20160093. [Crossref] [PubMed] [PMC]
- Jowett A, Abdullakutty A, Bailey M. Pathological fracture of the coronoid process secondary to medication-related osteonecrosis of the jaw (MRONJ). Int J Surg Case Rep. 2015;10:162-5. [Crossref] [PubMed] [PMC]
- Giles DL, McDonald PJ. Pathologic fracture of mandibular condyle due to carcinoma of the rectum. Oral Surg Oral Med Oral Pathol. 1982;53(3):247-9. [Crossref] [PubMed]
- van Merkesteyn JP, Balm AJ, Bakker DJ, Borgmeyer-Hoelen AM. Hyperbaric oxygen treatment of osteoradionecrosis of the mandible with repeated pathologic fracture. Report of a case. Oral Surg Oral Med Oral Pathol. 1994;77(5):461-4. [Crossref] [PubMed]
- Hirsch DL, Bell RB, Dierks EJ, Potter JK, Potter BE. Analysis of microvascular free flaps for reconstruction of advanced mandibular osteoradionecrosis: a retrospective cohort study. J Oral Maxillofac Surg. 2008;66(12):2545-56. [Crossref] [PubMed]
- Suh JD, Blackwell KE, Sercarz JA, Cohen M, Liu JH, Tang CG, et al. Disease relapse after segmental resection and free flap reconstruction for mandibular osteoradionecrosis. Otolaryngol Head Neck Surg. 2010;142(4):586-91. [Crossref] [PubMed]
- Cannady SB, Dean N, Kroeker A, Albert TA, Rosenthal EL, Wax MK. Free flap reconstruction for osteoradionecrosis of the jaws--outcomes and predictive factors for success. Head Neck. 2011;33(3):424-8. [PubMed]
- Marx RE. A new concept in the treatment of osteoradionecrosis. J Oral Maxillofac Surg. 1983;41(6):351-7. [Crossref] [PubMed]
- Epstein JB, Wong FL, Stevenson-Moore P. Osteoradionecrosis: clinical experience and a proposal for classification. J Oral Maxillofac Surg. 1987;45(2):104-10. [Crossref] [PubMed]
- Sawhney R, Ducic Y. Management of pathologic fractures of the mandible secondary to osteoradionecrosis. Otolaryngol Head Neck Surg. 2013;148(1):54-8. [Crossref] [PubMed]
- Pogrel MA, Podlesh S, Anthony JP, Alexander J. A comparison of vascularized and nonvascularized bone grafts for reconstruction of mandibular continuity defects. J Oral Maxillofac Surg. 1997;55(11):1200-6. [Crossref] [PubMed]
- Çapar GD, Yalçın Ülker GM, Cabbar F, Özçakır Tomruk C. Oral bifosfonat kullanımına bağlı çene kemiği osteonekrozu olgusunda patolojik mandibular kırık: derleme ve olgu sunumu. [Oral bisphosphonate induced osteonecrosis of the jaw causing pathological mandibular fracture: literature review and a case report]. 7tepe Klinik Dergisi. 2016;12(1):57-63. [Crossref]
- Wongchuensoontorn C, Liebehenschel N, Wagner K, Fakler O, Gutwald R, Schmelzeisen R, et al. Pathological fractures in patients caused by bisphosphonate-related osteonecrosis of the jaws: report of 3 cases. J Oral Maxillofac Surg. 2009;67(6):1311-6. [Crossref] [PubMed]
- Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, et al; International Task force on osteonecrosis of the jaw. Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res. 2015;30(1):3-23. [Crossref] [PubMed]
- Pichardo SEC, Ten Broek FW, Richard van Merkesteyn JP. Treatment of pathologic fractures of the mandible in stage III medication-related osteonecrosis of the jaw-an observational study. J Craniomaxillofac Surg. 2018;46(8):1241-6. [Crossref] [PubMed]
- Engroff SL, Kim DD. Treating bisphosphonate osteonecrosis of the jaws: is there a role for resection and vascularized reconstruction? J Oral Maxillofac Surg. 2007;65(11):2374-85. [Crossref] [PubMed]
- Caldroney S, Ghazali N, Dyalram D, Lubek JE. Surgical resection and vascularized bone reconstruction in advanced stage medication-related osteonecrosis of the jaw. Int J Oral Maxillofac Surg. 2017;46(7):871-6 [Crossref] [PubMed]
- O'Sullivan D, King P, Jagger D. Osteomyelitis and pathological mandibular fracture related to a late implant failure: a clinical report. J Prosthet Dent. 2006;95(2):106-10. [Crossref] [PubMed]
- Ogasawara T, Sano K, Hatsusegawa C, Miyauchi K, Nakamura M, Matsuura H. Pathological fracture of the mandible resulting from osteomyelitis successfully treated with only intermaxillary elastic guiding. Int J Oral Maxillofac Surg. 2008;37(6):581-3. [Crossref] [PubMed]
- Luhr HG, Reidick T, Merten HA. Results of treatment of fractures of the atrophic edentulous mandible by compression plating: a retrospective evaluation of 84 consecutive cases. J Oral Maxillofac Surg. 1996;54(3):250-4; discussion 254-5. [Crossref] [PubMed]
- Bruce RA, Ellis E 3rd. The second Chalmers J. Lyons Academy study of fractures of the edentulous mandible. J Oral Maxillofac Surg. 1993;51(8):904-11. [Crossref] [PubMed]
- Madsen MJ, Haug RH, Christensen BS, Aldridge E. Management of atrophic mandible fractures. Oral Maxillofac Surg Clin North Am. 2009;21(2):175-83, [Crossref] [PubMed]
- Sikes JW Jr, Smith BR, Mukherjee DP. An in vitro study of the effect of bony buttressing on fixation strength of a fractured atrophic edentulous mandible model. J Oral Maxillofac Surg. 2000;58(1):56-61; [Crossref] [PubMed]
- Ioannides C, Fossion E, Boeckx W, Hermans B, Jacobs D. Surgical management of the osteoradionecrotic mandible with free vascularised composite flaps. J Craniomaxillofac Surg. 1994;22(6):330-4. [Crossref] [PubMed]
- Stramandinoli-Zanicotti RT, Silva WP, Schussel JL, Dissenha JL, Sassi LM. Pathological fracture of the mandible associated to osteoradionecrosis with necrotic bone and reconstruction plate exposure: case report. Dentistry S2. 2014;1-3 [Crossref]
.: İşlem Listesi