Objective: Ureteropelvic junction obstruction (UPJO) is a disease often diagnosed in childhood, but it can rarely be detected in adults. Dismembered pyeloplasty is the gold standard treatment method. In this study, we evaluated the success of pyeloplasty in adult patients with UPJO. Material and Methods: We retrospectively reviewed the data of the adult patients who underwent pyeloplasty between January 2012 and July 2021. Preoperative and postoperative differential renal function (DRF), the time required for the clearance of half of the radioisotope from the renal pelvis (T1/2), presence of symptoms, degree of hydronephrosis, anteroposterior (AP) diameter of the renal pelvis, and parenchymal thickness were compared. Results: A total of 30 patients with a mean age of 32.43±7.18 were included in the study. No statistically significant difference was detected between preoperative and postoperative mean DRF (37.6±12.08 and 38±11.35, respectively) (p=0.775). In 19 (63.33%) patients DRF remained unchanged. In 7 (23.33%) patients DRF was improved, and in 4 (13.34%) patients DRF deteriorated. The mean AP diameter and grade of hydronephrosis were significantly improved after pyeloplasty. The ratio of patients with a T1/2>20 minutes significantly decreased from 83.33% to 26.67% (p=0.001). Before the operation 26 (86.67%) patients were symptomatic. After the operation only 8 (26.67%) patients were symptomatic. This change was statistically significant (p=0.001). Conclusion: There were significant improvements in T1/2, AP diameter of the renal pelvis, and the degree of hydronephrosis. Renal function was preserved after the surgery. Also, pyeloplasty was effective in pain relief and should be recommended to adults with UPJO.
Keywords: Ureteral obstruction; adult; hydronephrosis; kidney
Amaç: Üreteropelvik bileşke obstrüksiyonu (UPJO) sıklıkla çocukluk çağında tanı konulan bir hastalıktır ancak nadiren erişkin dönemde de saptanabilir. Dismembered pyeloplasti altın standart tedavi yöntemidir. Bu çalışmada, UPJO'lu erişkin hastalarda dismembered pyeloplasti operasyonunun başarısını değerlendirdik. Gereç ve Yöntemler: Ocak 2012 ile Temmuz 2021 tarihleri arasında dismembered pyeloplasti yapılan erişkin hastaların verileri geriye dönük olarak incelendi. Preoperatif ve postoperatif diferansiyel renal fonksiyon (DRF), radyoizotopun yarısının renal pelvisten temizlenmesi için gereken süre (T1/2), semptom varlığı, hidronefroz derecesi, renal pelvis anteroposterior (AP) çapı ve parankim kalınlığı karşılaştırıldı. Bulgular: Çalışmaya yaş ortalaması 32,43±7,18 olan toplam 30 hasta dâhil edildi. Ameliyat öncesi ve ameliyat sonrası ortalama DRF değerleri (sırasıyla 37,6±12,08 ve 38±11,35) arasında istatistiksel olarak anlamlı fark saptanmadı (p=0,775). DRF, 19 (%63,33) hastada değişmeden kaldı, 7 (%23,33) hastada düzeldi ve 4 (%13,34) hastada kötüleşti. Ortalama AP çapı ve hidronefroz derecesi piyeloplasti sonrası önemli ölçüde düzeldi. T1/2>20 dk olan hastaların oranı %83,33'ten %26,67'ye düştü (p=0,001). Ameliyat öncesi 26 (%86,67) hasta semptomatik iken, ameliyat sonrası sadece 8 (%26,67) hastada semptom mevcuttu. Bu değişiklik istatistiksel olarak anlamlıydı (p=0,001). Sonuç: Ameliyattan sonra T1/2'de, renal pelvis AP çapında ve hidronefroz derecesinde anlamlı iyileşmeler olduğu ve böbrek fonksiyonlarının korunduğu ortaya konuldu. Ayrıca pyeloplastinin ağrının giderilmesinde etkili bir yöntem olduğu ve UPJO'lu erişkinlere önerilmesi gerektiği sonuçlarına ulaşıldı.
Anahtar Kelimeler: Üreteral obstrüksiyon; erişkin; hidronefroz; böbrek
- Hashim H, Woodhouse CRJ. Ureteropelvic junction obstruction. Eur Urol Suppl. 2012;11(2):25-32. [Crossref]
- Ellerkamp V, Kurth RR, Schmid E, Zundel S, Warmann SW, Fuchs J. Differences between intrinsic and extrinsic ureteropelvic junction obstruction related to crossing vessels: histology and functional analyses. World J Urol. 2016;34(4):577-83. [Crossref] [PubMed]
- Zhang X, Li HZ, Wang SG, Ma X, Zheng T, Fu B, et al. Retroperitoneal laparoscopic dismembered pyeloplasty: experience with 50 cases. Urology. 2005;66(3):514-7. [Crossref] [PubMed]
- Mesrobian HG, Mirza SP. Hydronephrosis: a view from the inside. Pediatr Clin North Am. 2012;59(4):839-51. [Crossref] [PubMed]
- Grasso M, Caruso RP, Phillips CK. UPJ obstruction in the adult population: Are crossing vessels significant? Rev Urol. 2001;3(1):42-51. [PubMed] [PMC]
- Chertin B, Pollack A, Koulikov D, Rabinowitz R, Hain D, Hadas-Halpren I, et al. Conservative treatment of ureteropelvic junction obstruction in children with antenatal diagnosis of hydronephrosis: lessons learned after 16 years of follow-up. Eur Urol. 2006;49(4):734-8. [Crossref] [PubMed]
- O'Reilly PH, Brooman PJ, Mak S, Jones M, Pickup C, Atkinson C, et al. The long-term results of Anderson-Hynes pyeloplasty. BJU Int. 2001;87(4):287-9. [Crossref] [PubMed]
- Arap MA, Torricelli FC, Mitre AI, Chambo JL, Duarte RJ, Srougi M. Lessons from 90 consecutive laparoscopic dismembered pyeloplasties in a residency program. Scand J Urol. 2013;47(4):323-7. [Crossref] [PubMed]
- Autorino R, Eden C, El-Ghoneimi A, Guazzoni G, Buffi N, Peters CA, et al. Robot-assisted and laparoscopic repair of ureteropelvic junction obstruction: a systematic review and meta-analysis. Eur Urol. 2014;65(2):430-52. [Crossref] [PubMed]
- Borin JF. Ureteropelvic junction obstruction in adults. Rev Urol. 2017;19(4):261-4. [PubMed] [PMC]
- Riehle RA Jr, Vaughan ED Jr. Renin participation in hypertension associated with unilateral hydronephrosis. J Urol. 1981;126(2):243-6. [Crossref] [PubMed]
- Jacobs JA, Berger BW, Goldman SM, Robbins MA, Young JD Jr. Ureteropelvic obstruction in adults with previously normal pyelograms: a report of 5 cases. J Urol. 1979;121(2):242-4. [Crossref] [PubMed]
- Lam JS, Breda A, Schulam PG. Ureteropelvic junction obstruction. J Urol. 2007;177(5):1652-8. [Crossref] [PubMed]
- El-Nahas AR, Abou-El-Ghar M, Shoma AM, Eraky I, El-Kenawy MR, El-Kappany H. Role of multiphasic helical computed tomography in planning surgical treatment for pelvi-ureteric junction obstruction. BJU Int. 2004;94(4):582-7. [Crossref] [PubMed]
- Radmayr C, Bogaert G, Castagnetti M, Dogan HS, Kennedy UK, O'kelly F, et al. EAU Guidelines on Paediatric Urology. EAU Guidelines, Edition Presented at the Annual EAU Congress Amsterdam. 2022. [Link]
- Huang Y, Wu Y, Shan W, Zeng L, Huang L. An updated meta-analysis of laparoscopic versus open pyeloplasty for ureteropelvic junction obstruction in children. Int J Clin Exp Med. 2015;8(4):4922-31. [PubMed] [PMC]
- Menon P, Rao KL, Bhattacharya A, Mittal BR. Outcome analysis of pediatric pyeloplasty in units with less than 20% differential renal function. J Pediatr Urol. 2016;12(3):171.e1-7. [Crossref] [PubMed]
- Nayyar R, Yadav S, Singh P, Kumar R, Seth A, Dogra PN. Outcomes of pyeloplasty in very poorly functioning kidneys: examining the myths. Urology. 2016;92:132-5. [Crossref] [PubMed]
- Ortapamuk H, Naldoken S, Tekdogan UY, Aslan Y, Atan A. Differential renal function in the prediction of recovery in adult obstructed kidneys after pyeloplasty. Ann Nucl Med. 2003;17(8):663-8. [Crossref] [PubMed]
- Fernbach SK, Maizels M, Conway JJ. Ultrasound grading of hydronephrosis: introduction to the system used by the Society for Fetal Urology. Pediatr Radiol. 1993;23(6):478-80. [Crossref] [PubMed]
- Strother MC, Mucksavage P. Minimally invasive techniques for the management of adult UPJ obstruction. Curr Urol Rep. 2016;17(5):39. [Crossref] [PubMed]
- Nishi M, Matsumoto K, Fujita T, Iwamura M. Improvement in renal function and symptoms of patients treated with laparoscopic pyeloplasty for ureteropelvic junction obstruction with less than 20% split renal function. J Endourol. 2016;30(11):1214-8. [Crossref] [PubMed]
- Bhat GS, Maregowda S, Jayaram S, Siddappa S. Is renal biopsy a better predictor of the outcome of pyeloplasty in adult ureteropelvic junction obstruction? Urology. 2012;79(2):321-5. [Crossref] [PubMed]
- Elbaset MA, Zahran MH, Sharaf MA, Elmeniar AM, Ezzat O, Elgamal M, et al. Long term functional success after pyeloplasty for pelvi-ureteral junction obstruction in unilateral poorly functioning kidney in exclusively adults population. Urology. 2019;131:234-9. [Crossref] [PubMed]
- Nascimento B, Andrade HS, Miranda EP, Barbosa JABA, Moscardi PR, Arap MA, et al. Laparoscopic pyeloplasty as an alternative to nephrectomy in adults with poorly functioning kidneys due to ureteropelvic junction obstruction. Int Urol Nephrol. 2021;53(2):269-73. [Crossref] [PubMed]
- Elbaset MA, Elmeniar AM, Sharaf MA, Ezzat O, Elgamal M, Edwan M, et al. Critical analysis of pyeloplasty role in adults with late diagnosis of ureteropelvic junction obstruction-a comparative study. Int Urol Nephrol. 2021;53(10):2051-6. [Crossref] [PubMed]
- Wu AK, Tran TC, Sorensen MD, Durack JC, Stoller ML. Relative renal function does not improve after relieving chronic renal obstruction. BJU Int. 2012;109(10):1540-4. [Crossref] [PubMed]
- Low ZY, Allen SE, Arumuham V, Davis LM, Allen C, Bomanji J, et al. Does relative renal function improve after intervention for chronic ureteric obstruction? Cent European J Urol. 2021;74(1):64-70. [Crossref] [PubMed] [PMC]
- Harraz AM, Taha DE, Shalaby I, Hafez AT. Evaluation of factors predicting recoverability of renal function after pyeloplasty in adults. Urol Int. 2014;93(4):403-5. [Crossref] [PubMed]
- Isoyama T, Iwamoto H, Inoue S, Morizane S, Hinata N, Yao A, et al. Hydronephrosis after retroperitoneal laparoscopic dismembered Anderson-Hynes pyeloplasty in adult patients with ureteropelvic junction obstruction: A longitudinal analysis. Cent European J Urol. 2014;67(1):101-5. [Crossref] [PubMed] [PMC]
- Chalieopanyarwong V, Attawettayanon W. Renal cortical thickness after pyeloplasty in pediatric ureteropelvic junction obstruction. Res Rep Urol. 2021;13:699-704. [Crossref] [PubMed] [PMC]
- Merder E, Arıman A, Sabuncu K, Altunrende F. Functional, morphological and operative outcome after pyeloplasty in adult patients: Laparoscopic versus open. Urologia. 2021;88(3):227-31. [Crossref] [PubMed]
- Ozayar A, Friedlander JI, Shakir NA, Gahan JC, Cadeddu JA, Morgan MS. Equivocal ureteropelvic junction obstruction on diuretic renogram--should minimally invasive pyeloplasty be offered to symptomatic patients? J Urol. 2015;193(4):1278-82. [Crossref] [PubMed]
- Li XD, Wu YP, Wei Y, Chen SH, Zheng QS, Cai H, et al. Predictors of Recoverability of Renal Function after Pyeloplasty in Adults with Ureteropelvic Junction Obstruction. Urol Int. 2018;100(2):209-15. [Crossref] [PubMed]
.: İşlem Listesi