Objective: The objective of this study is to investigate the effect of consumption of wheat germ on the anthropometric measurements, severity of tinnitus and blood biochemical parameters in patients with tinnitus. Material and Methods: The study was performed on 40 adult patients between the ages of 19-65, who have had tinnitus complaints for at least one month between October 2014 and April 2015. Fifty g of wheat germ was added to the diet of 20 randomly selected tinnitus patients for 1 month (study group) while 20 tinnitus patients made no change to their diet (control group). None of the patients received medical treatment. A Tinnitus Disability Questionnaire (TDQ), Visual Analog Scale (VAS) and Beck Depression Inventory were applied to the patients. Biochemical parameters were retrieved from their records at the beginning and end of the study. Results: As a result, a decrease was observed in VAS and TDQ scores of the patients in the study group at the end of the study compared to the beginning of the study (p=0.011, p=0.048), in the control group, only TDQ score decreased (p=0.016). No difference was found between VAS and TDQ at the beginning and at the end. Also in the study group; a significant negative correlation was found between the change in VAS and TDQ scales and dietary protein intake (r=-0.599, p=0.005; r=-0.468, p=0.038), and a positive correlation was found between soluble fiber intake (r=0.478, p=0.033; r=0.638, p=0.002). Conclusion: When the decrease in VAS and TDQ scores of tinnitus patients who are not trained about nutrition is evaluated, it can contribute to the decrease in the severity of rhinney tinnitus, which is rich in some minerals and dietary fiber added to their diet. In addition, the closer followup of the patients included in the study may have provided psychological support and decreased the perception of tinnitus. Further studies are needed in this regard.
Keywords: Tinnitus; nutrition therapy; whole grains; wheat germ
Amaç: Bu çalışmanın amacı, buğday ruşeymi tüketiminin antropometrik ölçümler, tinnitus şiddeti ve biyokimyasal parametreler üzerindeki etkisini araştırmaktır. Gereç ve Yöntemler: Çalışma, Ekim 2014 ve Nisan 2015 tarihleri arasında, 19-65 yaş arası, en az 1 aydır tinnitus şikâyeti süren 40 erişkin hasta üzerinde yapılmıştır. Rastgele seçilen 20 tinnitus hastasının diyetine 1 ay boyunca 50 g buğday ruşeymi eklenirken (çalışma grubu), diyetinde herhangi bir değişiklik yapılmayan 20 tinnituslu hasta kontrol grubu olarak alınmıştır. Hastaların hiçbiri tıbbi bir tedavi almamıştır. Hastalara, Tinnitus Engellilik Anketi (TEA) Ölçeği, Vizüel Analog Skala (VAS) ve Beck Depresyon Ölçeği uygulanmıştır. Çalışma başlangıcı ve sonunda biyokimyasal parametreler, hasta dosyalarından alınmıştır. Bulgular: Çalışma sonunda, çalışma grubundaki hastaların VAS ve TEA skorlarında, çalışmanın başlangıcına göre azalma gözlenirken (p=0,011, p=0,048), kontrol grubunda yalnızca TEA skorunda azalma görülmüştür (p=0,016). Gruplar arası karşılaştırmalarda, VAS ve TEA arasında başlangıçta ve bitişte fark bulunmamıştır. Ayrıca çalışma grubunda; VAS ve TEA ölçeklerinde gözlenen değişiklik ile diyet proteini alımı arasında negatif (r=-0,599, p=0,005; r=-0,468, p=0,038), çözünür lif alımı arasında pozitif (r=0,478, p=0,033; r=0,638, p=0,002) yönlü bir ilişki bulunmuştur. Sonuç: Beslenme hakkında herhangi bir eğitim verilmeyen tinnitus hastalarında, VAS ve TEA skorlarındaki azalma değerlen-dirildiğinde, beslenmelerine eklenen bazı mineraller ve diyet lifi açısından zengin olan ruşeym, tinnitus şiddetinde azalmaya katkıda bulunabilir. Bununla birlikte çalışmaya alınan hastaların daha yakın takip edilmiş olması da psikolojik destek sağlayarak tinnitusun algılanmasında azalma sağlamış olabilir. Bu konuda daha ileri çalışmalara ihtiyaç vardır.
Anahtar Kelimeler: Tinnitus; beslenme tedavisi; tam tahıl; buğday ruşeymi
- Bal U, Sürmegözlüer O, Akpınar E. [The association between anxiety level and tinnitus severity in unspesific tinnitus without organic cause]. Euras J Fam Med. 2013;2(3):115-20. [Link]
- Dağlı M, Karabulur H, İriz A, Eryılmaz A. [Evaluation of the patients with tinnitus by Tinnitus Severity Index]. KBB ve BBC Dergisi. 2007;15(1):12-7. [Link]
- Sajadi S, Forogh B, ZoghAli M. Cervical trigger point acupuncture for treatment of somatic tinnitus. J Acupunct Meridian Stud. 2019;12(6):197-200. [Crossref] [PubMed]
- Crummer RW, Hassan GA. Diagnostic approach to tinnitus. Am Fam Physician. 2004;69(1):120-6. [PubMed]
- Al-Swiahb J, Park SN. Charecterization of Tinnitus in Different Age Groups: A Retrospective Review. Noise Health. 2016;18(83):214-9. [Crossref] [PubMed] [PMC]
- Caner Mercan G, Öztürk K, Kirazlı T, Bilgen C, Kılıç MA, Öğüt F. [Methodology of clinical trials on diagnosis and treatment of subjective tinnitus: Proposal for a national protocol]. Ege Journal of Medicine. 2013;52(3):125-30. [Link]
- Hoffman HJ, Reed GW. Epidemiyology of tinnitus. In: Snow JB, ed. Tinnitus: Theory and Management. London: BC Decker; 2004. p.16-41. ISBN: 1-55009-243-X
- Langguth B, Kreuzer PM, Kleinjung T, De Ridder D. Tinnitus: causes and clinical management. Lancet Neurol. 2013;12(9):920-30. [Crossref]
- Langguth B, Goodey R, Azevedo A, Bjorne A, Cacace A, Crocetti A, et al. Consensus for tinnitus patient assessment and treatment outcome measurement: Tinnitus Research Initiative meeting, Regensburg, July 2006. Prog Brain Res. 2007;166:525-36. [Crossref] [PubMed] [PMC]
- Meneses-Barriviera CL, Bazoni JA, Doi MY, Marchiori LLM. Probable association of hearing loss, hypertension and diabetes mellitus in the elderly. Int Arch Otorhinolaryngol. 2018;22(4):337-41. [Crossref] [PubMed] [PMC]
- Chang NC, Dai CY, Lin WY, Yang HL, Wang HM, Chien CY, et al. Prevalence of persistent tinnitus and dizziness in an elderly population in Southern Taiwan. J Int Adv Otol. 2019;15(1):99-105. [Crossref] [PubMed] [PMC]
- Singh C, Kawatra R, Gupta J, Awasthi V, Dungana H. Therapeutic role of Vitamin B12 in patients of chronic tinnitus: a pilot study. Noise Health. 2016;18(81):93-7. [Crossref] [PubMed] [PMC]
- Tanrıöver Ö, Doğan M, Tezvaran Z, Küçük Ceyhan A. [Approach to the patient with tinnitus in primary care]. Türk Aile Hek Derg. 2011;15(1):24-8. [Crossref]
- Almeida TA, Samelli AG, Mecca Fdel N, De Martino E, Paulino AM. Tinnitus sensation pre and post nutritional intervention in metabolic disorders. Pro Fono. 2009;21(4):291-7. [Crossref] [PubMed]
- Hameed HM, Eleue AH, Al Mosawi AMT. The use of distortion product otoacoustic emissions (DPOAE) records to estimate effect of vitamin B complex on changing severity of tinnitus. Ann Med Surg (Lond). 2018;36:203-11. [Crossref] [PubMed] [PMC]
- Yeh CW, Tseng LH, Yang CH, Hwang CF. Effects of oral zinc supplementation on patients with noise-induced hearing loss associated tinnitus: a clinical trial. Biomed J. 2019;42(1):46-52. [Crossref] [PubMed] [PMC]
- Hilton MP, Zimmermann EF, Hunt WT. Ginkgo biloba for tinnitus. Cochrane Database Syst Rev. 2013;(3):CD003852. [Crossref] [PubMed]
- Polanski JF, Soares AD, de Mendonça Cruz OL. Antioxidant therapy in the elderly with tinnitus. Braz J Otorhinolaryngol. 2016;82(3):269-74. [Crossref] [PubMed]
- Baysal A. Dietary fiber. Beslenme. Ankara: Hatipoğlu Yayınevi; 2014. p.363-72.
- Çakmur H, Güneş ÜB. [Research the relationship between obesity and depression in outpatient clinics]. Türk Aile Hek Derg. 2018;22(2):58-65. [Crossref]
- Eğilmez OK, Kalcıoğlu MT, Kökten N. [Questionnaire methods used in the psychosomatic evaluation of tinnitus]. Kulak Burun Bogaz Ihtis Derg. 2014;24(5):303-10. [Crossref]
- Aksoy S, Firat Y, Alpar R. The Tinnitus Handicap Inventory: a study of validity and reliability. Int Tinnitus J. 2007;13(2):94-8. [PubMed]
- Kaźmierczak H, Doroszewska G. Metabolic disorders in vertigo, tinnitus, and hearing loss. Int Tinnitus J. 2001;7(1):54-8. [PubMed]
- Torriani M, Gill CM, Daley S, Oliveira AL, Azevedo DC, Bredella MA. Compartmental neck fat accumulation and its relation to cardiovascular risk and metabolic syndrome. Am J Clin Nutr. 2014;100(5):1244-51. [Crossref] [PubMed] [PMC]
- Martines F, Bentivegna D, Martines E, Sciacca V, Martinciglio G. Assessing audiological, pathophysiological and psychological variables in tinnitus patients with or without hearing loss. Eur Arch Otorhinolaryngol. 2010;267(11):1685-93. [Crossref] [PubMed]
- Martines F, Sireci F, Cannizzaro E, Costanzo R, Martines E, Mucia M, et al. Clinical observations and risk factors for tinnitus in a Sicilian cohort. Eur Arch Otorhinolaryngol. 2015;272(10):2719-29. [Crossref] [PubMed]
- Livesey G, Taylor R, Hulshof T, Howlett J. Glycemic response and health--a systematic review and meta-analysis: relations between dietary glycemic properties and health outcomes. Am J Clin Nutr. 2008;87(1):258S-68S. [Crossref] [PubMed]
- Jarrar AH, Beasley JM, Ohuma EO, Cheikh Ismail L, Qeshta DA, Mohamad MN, et al. Effect of high fiber cereal intake on satiety and gastrointestinal symptoms during Ramadan. Nutrients. 2019;11(4):939. [Crossref] [PubMed] [PMC]
- Mann JI, De Leeuw I, Hermansen K, Karamanos B, Karlström B, Katsilambros N, et al; Diabetes and Nutrition Study Group (DNSG) of the European Association. Evidence-based nutritional approaches to the treatment and prevention of diabetes mellitus. Nutr Metab Cardiovasc Dis. 2004;14(6):373-94. [Crossref] [PubMed]
- Wang Y, Duan Y, Zhu L, Fang Z, He L, Ai D, et al. Whole grain and cereal fiber intake and the risk of type 2 diabetes: a meta-analysis. Int J Mol Epidemiol Genet. 2019;10(3):38-46. [PubMed] [PMC]
- McCormack A, Edmondson-Jones M, Mellor D, Dawes P, Munro KJ, Moore DR, et al. Association of dietary factors with presence and severity of tinnitus in a middle-aged UK population. PLoS One. 2014;9(12):e114711. Erratum in: PLoS One. 2015;10(4):e0123053. [Crossref] [PubMed] [PMC]
- Lavinsky L, Oliveira MW, Bassanesi HJ, D'Avila C, Lavinsky M. Hyperinsulinemia and tinnitus: a historical cohort. Int Tinnitus J. 2004;10(1):24-30. [PubMed]
- Sutbas A, Yetiser S, Satar B, Akcam T, Karahatay S, Saglam K. Low-cholesterol diet and antilipid therapy in managing tinnitus and hearing loss in patients with noise-induced hearing loss and hyperlipidemia. Int Tinnitus J. 2007;13(2):143-9. [PubMed]
- Ostlund RE Jr, Racette SB, Stenson WF. Inhibition of cholesterol absorption by phytosterol-replete wheat germ compared with phytosterol-depleted wheat germ. Am J Clin Nutr. 2003;77(6):1385-9. [Crossref] [PubMed]
- Günay O, Borlu A, Horoz D, Gün İ. Tinnitus prevalence among the primary care patients in Kayseri, Turkiye. Erciyes Medical Journal. 2011;33(1):39-46.
- European Food Safety Authority. Scientific Opinion. EFSA Journal. 2010;8(10):1762. [Link]
- Yurdakök K, İnce OT. [Strategies for prevention of iron deficiency anemia in children]. Çocuk Sağlığı ve Hastalıkları Dergisi. 2009;52:224-31. [Link]
- Özkaya B. [The effect of variety and extraction on phytic acid content of bread]. Ankara Üniversitesi Bilimsel Araştırma Projeleri. Ankara, 2004. [Link]
- Rubin W. Nutrition, biochemistry, and tinnitus. Int Tinnitus J. 1999;5(2):144-5. [PubMed]
- Yaşar M, Şahin Mİ, Karakükçü Ç, Güneri E, Doğan M, Sağıt M. The role of trace elements in tinnitus. Biol Trace Elem Res. 2017;176(1):65-72. [Crossref] [PubMed]
- Le Pajolec C, Ohresser M, Nevoux J. [Good practices with tinnitus in adult]. Presse Med. 2017;46(11):1064-70. [Crossref] [PubMed]
- TUBİTAK National Food Composition Database. [Link]
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