Objective: To determine the correlation between complete blood count and the risk of coronary heart disease (CHD). Material and Methods: All CHD patients treated in Aisyiyah Hospital during January 2011 to December 2017 were enrolled for the study. Information related to demographic, clinical, and complete blood count were extracted from medical record. Multiple logistic regression test was employed to evaluate the correlation between complete blood count and CHD incidence. In addition, a meta-analysis was also conducted to summarize findings from other regions. Results: A total of 516 CHD patients and 102 controls were included in our study. We found that elevated hemoglobin (OR 95%CI=4.92 [2.02-12.01], p=0.002), leukocyte (OR 95 CI=5.35 [3.17-9.03], p=0.001), hematocrit (OR 95%CI=2.31 [1.40-3.83], p=0.010), eosinophil (OR 95%CI= 2.78 [1.68-4.26], p=0.001), and monocyte (OR 95%CI=1.31 [0.80-2.16], p=0.023) were associated with the incidence of CHD. Furthermore, our meta-analysis revealed that elevated levels of leukocyte, eosinophil, and monocyte increased the risk of CHD approximately 3.57, 5.34, and 2.77 times, respectively. Conclusion: There is strong evidence that elevated levels of leukocyte, eosinophil, and monocyte are the risk factor for CHD.
Keywords: Complete blood count; coronary heart disease; risk factor
Amaç: Tam kan ayımı ile koroner kalp hastalığı (KKH) arasında korelasyon olup olmadığını araştırmak amaçlandı. Gereç ve Yöntemler: Aisyiyah Hastanesi?nde Ocak 2011-Aralık 2017 arasında tedavi gören tüm KKH hastaları çalışma kapsamına alındı. Hastalarla ilgili demografik bilgiler, klinik veriler ve tam kan sayımları tıbbi kayıtlardan alındı. Aradaki bağlantıyı incelemek için multipl lojistik regresyon analizi yapıldı. KKH insidansı analizine ilaveten diğer yayınlardan elde edilen özet verilerin meta-analizi yapıldı. Bulgular: Toplam 516 KKH hastası ve 102 kontrol kişisi çalışmaya alındı. KKH insidansı ile ilişkili olarak hemoglobin (OR %95 GA=4,92 [2,02-12,01] p=0,002, lökosit (OR %95 GA=5,35 [3,17-9,03] p=0,001, hematokrit (OR %95 GA=2,31 [1,40-3,83] p=0,010, eozinofil (OR %95 GA=2,78 [1,68-4,26] p=0,001 ve monosit (OR %95 GA=1,31 [0,80-2,16] p=0,023 değerlerini yükselmiş olarak bulduk. Üstelik, yaptığımız meta-analize göre, KKH riskinde yükselmiş lökosit, eozinofil ve monosit değerlerinin yaklaşık 3,57; 5,34; ve 2,77 kat artma yarattığını saptadık (sırasıyla). Sonuç: KKH risk faktörü olarak yükselmiş lökosit, eozinofil ve monosit değerlerinin kuvvetli etkin olduğu tespit edilmiştir.
Anahtar Kelimeler: Tam kan sayımı; koroner kalp hastalığı; risk faktörü
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