.: ORİJİNAL ARAŞTIRMA
Serum Levels of 25-Hydroxyvitamin-D and C-Reactive Protein in Acne Vulgaris Patients
Akne Vulgaris Hastalarında 25-Hidroksivitamin D ve C-Reaktif Protein Düzeyleri
Turkiye Klinikleri J Dermatol. 2019;29(1):1-6
doi: 10.5336/dermato.2018-63846
Makale Dili: EN
Tam Metin
ABSTRACT
Objective: Acne vulgaris is a disease of pilosebaceous unit. Although multiple factors contribute to the development of acne, inflammation is the key component in the pathogenesis. Creactive protein (CRP) is a well-known marker of inflammation and there are few reports studying the antioxidant, and anti-inflammatory effects of vitamin D in acne. In the present study, the aim was to compare serum vitamin D and CRP levels in acne patients with control subjects. Material and Methods: 65 patients with acne vulgaris, and 41 healthy subjects were enrolled in this crosssectional study. Serum vitamin D and CRP levels of both groups were evaluated. Results: No significant association was found between the occurence of acne vulgaris and serum 25-hydroxyvitamin D and CRP levels (p=0.692, p=0.300, respectively). Conclusion: Vitamin D deficiency was determined to be equivalent in both acne patients and healthy subjects. This result might be due to the affection of the whole Turkish population with the same problem. Larger size studies which investigate the status of vitamin D levels in patients with acne, could provide making more precise interpretations.
Keywords: Acne vulgaris; c-reactive protein; inflammation; vitamin D
Objective: Acne vulgaris is a disease of pilosebaceous unit. Although multiple factors contribute to the development of acne, inflammation is the key component in the pathogenesis. Creactive protein (CRP) is a well-known marker of inflammation and there are few reports studying the antioxidant, and anti-inflammatory effects of vitamin D in acne. In the present study, the aim was to compare serum vitamin D and CRP levels in acne patients with control subjects. Material and Methods: 65 patients with acne vulgaris, and 41 healthy subjects were enrolled in this crosssectional study. Serum vitamin D and CRP levels of both groups were evaluated. Results: No significant association was found between the occurence of acne vulgaris and serum 25-hydroxyvitamin D and CRP levels (p=0.692, p=0.300, respectively). Conclusion: Vitamin D deficiency was determined to be equivalent in both acne patients and healthy subjects. This result might be due to the affection of the whole Turkish population with the same problem. Larger size studies which investigate the status of vitamin D levels in patients with acne, could provide making more precise interpretations.
Keywords: Acne vulgaris; c-reactive protein; inflammation; vitamin D
ÖZET
Amaç: Akne vulgaris pilosebase ünitenin bir hastalığıdır. Akne gelişimine pek çok faktör katkıda bulunsa da, inflamasyon patogenezdeki ana bileşendir. C-reaktif protein (CRP) iyi bilinen bir inflamatuar belirteçtir ve vitamin D'nin aknedeki antioksidan ve antiinflamatuar etkilerini inceleyen birkaç çalışma bulunmaktadır. Bu çalışmanın amacı akne hastaları ile kontrol grubu arasında serum vitamin D ve CRP düzeylerini karşılaştırmaktır. Gereç ve Yöntemler: 65 akne vulgaris ve 41 sağlıklı kontrol kişileri bu kesitsel çalışmaya dâhil edilmiştir. Her iki grupta da serum vitamin D ve CRP düzeyleri değerlendirilmiştir. Bulgular: Akne vulgaris varlığı ile serum 25-hidroksi-vitamin D ve CRP düzeyleri arasında bir ilişki gösterilememiştir (p=0,692, p=0,300, sırasıyla). Sonuç: Vitamin D eksikliğinin hem akne hem de kontrol grubunda eşit olarak bulunması, bu sorunun tüm Türkiye popülasyonunu ekileyen genel bir problem olmasına bağlanabilir. Akne hastalarında vitamin D düzeyinin araştırılması için daha geniş gruplarla yapılacak çalışmalar, daha net yorumların yapılabilmesini sağlayabilir.
Anahtar Kelimeler: Akne vulgaris; c-reaktif protein; inflamasyon; vitamin D
Amaç: Akne vulgaris pilosebase ünitenin bir hastalığıdır. Akne gelişimine pek çok faktör katkıda bulunsa da, inflamasyon patogenezdeki ana bileşendir. C-reaktif protein (CRP) iyi bilinen bir inflamatuar belirteçtir ve vitamin D'nin aknedeki antioksidan ve antiinflamatuar etkilerini inceleyen birkaç çalışma bulunmaktadır. Bu çalışmanın amacı akne hastaları ile kontrol grubu arasında serum vitamin D ve CRP düzeylerini karşılaştırmaktır. Gereç ve Yöntemler: 65 akne vulgaris ve 41 sağlıklı kontrol kişileri bu kesitsel çalışmaya dâhil edilmiştir. Her iki grupta da serum vitamin D ve CRP düzeyleri değerlendirilmiştir. Bulgular: Akne vulgaris varlığı ile serum 25-hidroksi-vitamin D ve CRP düzeyleri arasında bir ilişki gösterilememiştir (p=0,692, p=0,300, sırasıyla). Sonuç: Vitamin D eksikliğinin hem akne hem de kontrol grubunda eşit olarak bulunması, bu sorunun tüm Türkiye popülasyonunu ekileyen genel bir problem olmasına bağlanabilir. Akne hastalarında vitamin D düzeyinin araştırılması için daha geniş gruplarla yapılacak çalışmalar, daha net yorumların yapılabilmesini sağlayabilir.
Anahtar Kelimeler: Akne vulgaris; c-reaktif protein; inflamasyon; vitamin D
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