Amaç: Ürtiker sınıflaması yapılırken, ilk olarak ürtiker akut ve kronik olarak, kronik ürtiker ise spontan ve indüklenebilir ürtiker olarak sınıflandırılır. Semptomatik dermografizm (SD), kronik indüklenebilir ürtikerin en yaygın türüdür. SD'de hastalık aktivitesini ve tedavi yanıtını yansıtan serum biyobelirteçleri yoktur. Rutin tam kan sayımından elde edilen inflamatuar biyobelirteç olarak incelenen bazı parametreler mevcuttur. Bu çalışmada, SD'li hasta grubu ve sağlıklı kontrol grubunda, tam kan sayımı parametrelerinin ve kan bazlı sistemik inflamasyon biyobelirteç düzeylerinin araştırılması amaçlandı. Gereç ve Yöntemler: Yüz on dört SD hastası ve 116 sağlıklı kontrolden oluşan retrospektif bir çalışma yapıldı. Hastalar ve kontroller arasında; kan grupları, tiroid hormonları, eritrosit sedimentasyon oranı [erythrocyte sedimentation rate (ESR)], C-reaktif protein (CRP), hemogram seviyeleri incelendi. Nötrofil/lenfosit oranı [neutrophil/lymphocyte ratio (NLR)], trombosit/lenfosit oranı [platelet/lymphocyte ratio (PLR)], ortalama trombosit hacmi/platelet sayısı [mean platelet volume/platelet count (MPV/PC)] seviyeleri hesaplandı. Bulgular: Yaş ve cinsiyetleri bakımından gruplar arasında anlamlı farklılık yoktu (p>0,05). SD hastalarında lenfosit ve eozinofil değerlerinin, kontrol grubuna göre anlamlı derecede yüksek olduğu belirlendi (p0,05). Kan grupları ile hastalık arasındaki ilişki de istatistiki olarak önemli değildi (p>0,05). Sonuç: Çalışmamızda, SD'li hastalarda ESR ve CRP ile NLR, PLR ve MPV/PLT değişkenleri arasında istatistiksel fark olmaması, hastalığın altta yatan bir inflamatuar tablodan çok indüklenebilir bir hastalık olduğunu desteklemektedir. Bu değişkenlerin, SD'li hastalarda inflamasyon belirteçleri olarak kullanılmasının uygun olmadığını ve bu konuda daha geniş katılımlı çalışmalara ihtiyaç olduğunu ortaya koymaktadır.
Anahtar Kelimeler: Semptomatik dermografizm; nötrofil/lenfosit oranı; trombosit/lenfosit oranı; ortalama trombosit hacmi/trombosit sayısı
Objective: When urticaria is classified, firstly, urticaria is classified as acute and chronic, and chronic urticaria is classified as spontaneous and inducible urticaria. Symptomatic dermographism (SD) is the most common type of chronic inducible urticaria. There are no serum biomarkers reflecting disease activity and treatment response in SD. There are some parameters examined as inflammatory biomarkers obtained from routine complete blood count. In this study, it was aimed to investigate the complete blood count parameters and the levels of blood-based systemic inflammation biomarkers in the SD patient group and healthy control group. Material and Methods: A retrospective study of 114 SD patients and 116 healthy controls was conducted. Between patients and controls; blood groups, thyroid hormones, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), hemogram levels were examined. Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), mean platelet volume/platelet count (MPV/PC) levels were calculated. Results: There was no significant difference between the groups in terms of age and gender of the subjects (p>0.05). It was determined that lymphocyte and eosinophil values in SD patients were significantly higher than the control group (p0.05). The relationship between blood groups and disease was not statistically significant (p>0.05). Conclusion: In our study, the lack of statistical difference between ESR and CRP and NLR, PLR and MPV/PLT variables in patients with SD supports that the disease is an inducible disease rather than an underlying inflammatory picture. It reveals that the use of these variables as markers of inflammation in patients with SD is not appropriate, and further studies with larger participation are needed on this subject.
Keywords: Symptomatic dermographism; neutrophil/lymphocyte ratio; platelet/lymphocyte ratio; mean platelet volume/platelet count
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