.: ORİJİNAL ARAŞTIRMA
Relationship Between Allergic Conjunctivitis and Hepatitis B, C, and Antinuclear Antibody: Case-Control Research
Alerjik Konjonktivit Hepatit B, C ve Antinükleer Antikor Arasındaki İlişki: Vaka-Kontrol Araştırması
Turkiye Klinikleri J Ophthalmol. 2022;31(1):13-9
doi: 10.5336/ophthal.2021-83715
Makale Dili: EN
Tam Metin
ABSTRACT
Objective: The etiopathogenesis of allergy and autoimmune diseases involves genetic and environmental factors which might be common to both immunopathologies and infection also plays a significant role in the induction of allergy and autoimmunity. In this study, we aimed to evaluate the prevalence of hepatitis B, C, and antinuclear antibody (ANA) in patients with allergic conjunctivitis (AC). Material and Methods: A total of 128 patients with AC were enrolled and divided into 3 groups according to etiology: mite, pollen, and pollen/mite. Patients who complained of rhinoconjunctivitis underwent a skin-prick test. Hepatitis B surface antigen (HBsAg), anti-hepatitis C virus antibody (anti-HCV Ab), erythrocyte sedimentation rate (ESR), and ANA values of patients were evaluated. ANA screening was investigated with indirect immunofluorescence. p values <0.05 were accepted as statistically significant. Results: One hundred (78.1%) of the patients were women. Seventy-three (57%) patients were allergic to pollen, 33 (25.8%) to mites, and 22 (17.2%) to both pollen and mites. ANA test results were positive in 11 (8.6%) patients. HBsAg was detected in only (0.8%) 1 patient. Anti-HCV test was negative in all patients. The mean age of the patients was 37.45±10.46 years and mean ESR was 14.10±7.32 mm/h. Sex, ANA, and HBsAg distributions were statistically similar among the groups. No relationship was detected between AC and hepatitis B, C, or ANA positivity. Conclusion: AC was not significantly associated with hepatitis B, C, or ANA positivity. The prevalence of hepatitis B was lower among the AC patients than in the general population of Turkey, whereas the prevalence of hepatitis C was consistent at 0%. These results should be supported with larger numbers of patients with AC.
Keywords: Allergic conjunctivitis; antinuclear antibody; HBsAg; hepatitis C virus; autoimmunity
Objective: The etiopathogenesis of allergy and autoimmune diseases involves genetic and environmental factors which might be common to both immunopathologies and infection also plays a significant role in the induction of allergy and autoimmunity. In this study, we aimed to evaluate the prevalence of hepatitis B, C, and antinuclear antibody (ANA) in patients with allergic conjunctivitis (AC). Material and Methods: A total of 128 patients with AC were enrolled and divided into 3 groups according to etiology: mite, pollen, and pollen/mite. Patients who complained of rhinoconjunctivitis underwent a skin-prick test. Hepatitis B surface antigen (HBsAg), anti-hepatitis C virus antibody (anti-HCV Ab), erythrocyte sedimentation rate (ESR), and ANA values of patients were evaluated. ANA screening was investigated with indirect immunofluorescence. p values <0.05 were accepted as statistically significant. Results: One hundred (78.1%) of the patients were women. Seventy-three (57%) patients were allergic to pollen, 33 (25.8%) to mites, and 22 (17.2%) to both pollen and mites. ANA test results were positive in 11 (8.6%) patients. HBsAg was detected in only (0.8%) 1 patient. Anti-HCV test was negative in all patients. The mean age of the patients was 37.45±10.46 years and mean ESR was 14.10±7.32 mm/h. Sex, ANA, and HBsAg distributions were statistically similar among the groups. No relationship was detected between AC and hepatitis B, C, or ANA positivity. Conclusion: AC was not significantly associated with hepatitis B, C, or ANA positivity. The prevalence of hepatitis B was lower among the AC patients than in the general population of Turkey, whereas the prevalence of hepatitis C was consistent at 0%. These results should be supported with larger numbers of patients with AC.
Keywords: Allergic conjunctivitis; antinuclear antibody; HBsAg; hepatitis C virus; autoimmunity
ÖZET
Amaç: Alerji ve otoimmün hastalıkların etiyopatogenezi, her iki immünopatolojide ortak olabilecek genetik ve çevresel faktörleri içerir, enfeksiyonda alerji ve otoimmünitenin indüksiyonunda önemli bir rol oynar. Bu çalışmada, alerjik konjonktiviti (AK) olan hastalarda hepatit B, C ve antinükleer antikor (ANA) prevalansını değerlendirmeyi amaçladık. Gereç ve Yöntemler: Total olarak AK olan 128 hasta kaydedildi ve etiyolojiye göre 3 gruba ayrıldılar: Akar, polen ve polen/akar. Rinokonjonktivit şikâyeti olan hastalara skin-prick testi yapıldı. Hastaların hepatit B yüzey antijeni (HBsAg), anti-hepatit C virüs antikoru (anti-HCV Ab), eritrosit sedimantasyon hızı (ESH) ve ANA değerleri değerlendirildi. ANA taraması indirekt immünofloresan ile araştırıldı. p<0,05 değerleri istatistiksel olarak anlamlı kabul edildi. Bulgular: Hastaların 100'ü (%78,1) kadındı. Yetmiş üç (%57) hastada polen, 33'ünde (%25,8) akar ve 22'sinde (%17,2) hem polen hem de akar alerjisi vardı. ANA testi 11 (%8,6) hastada pozitifti. HBsAg sadece 1 (%0,8) hastada saptandı. Tüm hastalarda anti-HCV testi negatifti. Hastaların ortalama yaşı 37,45±10,46 yıl ve ortalama ESH 14,10±7,32 mm/saat idi. Gruplar arasında cinsiyet, ANA ve HBsAg dağılımları istatistiksel olarak benzerdi. AK ile hepatit B, C veya ANA pozitifliği arasında ilişki saptanmadı. Sonuç: AK, hepatit B, C veya ANA pozitifliği ile anlamlı olarak ilişkili değildi. AK hastalarında hepatit B prevalansı Türkiye geneline göre daha düşük iken, hepatit C prevalansı %0 ile tutarlı idi. Bu sonuçlar, daha fazla sayıda AK olan hasta ile desteklenmelidir.
Anahtar Kelimeler: Alerjik konjonktivit; antinükleer antikor; HBsAg; hepatit C virüs; otoimmünite
Amaç: Alerji ve otoimmün hastalıkların etiyopatogenezi, her iki immünopatolojide ortak olabilecek genetik ve çevresel faktörleri içerir, enfeksiyonda alerji ve otoimmünitenin indüksiyonunda önemli bir rol oynar. Bu çalışmada, alerjik konjonktiviti (AK) olan hastalarda hepatit B, C ve antinükleer antikor (ANA) prevalansını değerlendirmeyi amaçladık. Gereç ve Yöntemler: Total olarak AK olan 128 hasta kaydedildi ve etiyolojiye göre 3 gruba ayrıldılar: Akar, polen ve polen/akar. Rinokonjonktivit şikâyeti olan hastalara skin-prick testi yapıldı. Hastaların hepatit B yüzey antijeni (HBsAg), anti-hepatit C virüs antikoru (anti-HCV Ab), eritrosit sedimantasyon hızı (ESH) ve ANA değerleri değerlendirildi. ANA taraması indirekt immünofloresan ile araştırıldı. p<0,05 değerleri istatistiksel olarak anlamlı kabul edildi. Bulgular: Hastaların 100'ü (%78,1) kadındı. Yetmiş üç (%57) hastada polen, 33'ünde (%25,8) akar ve 22'sinde (%17,2) hem polen hem de akar alerjisi vardı. ANA testi 11 (%8,6) hastada pozitifti. HBsAg sadece 1 (%0,8) hastada saptandı. Tüm hastalarda anti-HCV testi negatifti. Hastaların ortalama yaşı 37,45±10,46 yıl ve ortalama ESH 14,10±7,32 mm/saat idi. Gruplar arasında cinsiyet, ANA ve HBsAg dağılımları istatistiksel olarak benzerdi. AK ile hepatit B, C veya ANA pozitifliği arasında ilişki saptanmadı. Sonuç: AK, hepatit B, C veya ANA pozitifliği ile anlamlı olarak ilişkili değildi. AK hastalarında hepatit B prevalansı Türkiye geneline göre daha düşük iken, hepatit C prevalansı %0 ile tutarlı idi. Bu sonuçlar, daha fazla sayıda AK olan hasta ile desteklenmelidir.
Anahtar Kelimeler: Alerjik konjonktivit; antinükleer antikor; HBsAg; hepatit C virüs; otoimmünite
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