.: ORİJİNAL ARAŞTIRMA
Oxidant-Antioxidant Balance and Trace Elements in Children with Functional Dyspepsia
Fonksiyonel Dispepsili Çocuklarda Oksidan-Antioksidan Denge ve Eser Elementler
Turkiye Klinikleri J Med Sci. 2021;41(1):70-9
doi: 10.5336/medsci.2020-79596
Makale Dili: EN
Tam Metin
ABSTRACT
Objective: Functional dyspepsia (FD) is the most common functional abdominal pain disorder among children and adolescents according to the Rome IV criteria. The aim of the study was to determine the possible effect of the equilibrium of oxidant and antioxidant and trace elements in pediatric FD. Material and Methods: The patient group consisted of 23 children who were diagnosed with FD according to the Rome IV Questionnaire on Pediatric Gastrointestinal Disorders. The control group consisted of 23 children aged 11-17 who did not meet the Rome IV criteria and had no chronic disease. Measurements of zinc, copper levels and recently developed new generation oxidant-antioxidant balance markers were performed spectrophotometrically using a commercial kit. Routinely measured hemogram and vitamin B12 and vitamin D test results were obtained from the patient files retrospectively. Results: In comparison of the control group, the pediatric FD group had significantly higher levels of oxidized thiol, ischemia-modified albumin, neutrophil and neutrophil/lymphocyte, a significantly lower lymphocyte count and reduced thiol ratio, and significantly lower vitamin D, native thiol, and copper levels. Conclusion: FD is potentially related to inflammation, serum copper content, and oxidative stress. However, the relationship between FD and inflammation, copper levels, and oxidative stress has not been adequately investigated in children. As a conclusion of this clinical trial, thiol balance, ischemia modified albumin, neutrophil/lymphocyte ratio, vitamin D and copper content will likely be essential for diagnosis and follow-up in pediatric FD.
Keywords: Dyspepsia; child; trace elements; oxidative stress; antioxidants
Objective: Functional dyspepsia (FD) is the most common functional abdominal pain disorder among children and adolescents according to the Rome IV criteria. The aim of the study was to determine the possible effect of the equilibrium of oxidant and antioxidant and trace elements in pediatric FD. Material and Methods: The patient group consisted of 23 children who were diagnosed with FD according to the Rome IV Questionnaire on Pediatric Gastrointestinal Disorders. The control group consisted of 23 children aged 11-17 who did not meet the Rome IV criteria and had no chronic disease. Measurements of zinc, copper levels and recently developed new generation oxidant-antioxidant balance markers were performed spectrophotometrically using a commercial kit. Routinely measured hemogram and vitamin B12 and vitamin D test results were obtained from the patient files retrospectively. Results: In comparison of the control group, the pediatric FD group had significantly higher levels of oxidized thiol, ischemia-modified albumin, neutrophil and neutrophil/lymphocyte, a significantly lower lymphocyte count and reduced thiol ratio, and significantly lower vitamin D, native thiol, and copper levels. Conclusion: FD is potentially related to inflammation, serum copper content, and oxidative stress. However, the relationship between FD and inflammation, copper levels, and oxidative stress has not been adequately investigated in children. As a conclusion of this clinical trial, thiol balance, ischemia modified albumin, neutrophil/lymphocyte ratio, vitamin D and copper content will likely be essential for diagnosis and follow-up in pediatric FD.
Keywords: Dyspepsia; child; trace elements; oxidative stress; antioxidants
ÖZET
Amaç: Fonksiyonel dispepsi (FD), Roma IV kriterlerine göre çocuklar ve adölesanlar arasında en sık görülen fonksiyonel karın ağrısı bozukluğudur. Çalışmanın amacı, pediatrik FD'de oksidan ve antioksidan dengenin ve eser elementlerin olası etkisini belirlemektir. Gereç ve Yöntemler: Hasta grubu, Roma IV Pediatrik Gastrointestinal Bozukluklar Anketi'ne göre FD tanısı alan 23 çocuktan oluşturuldu. Kontrol grubu, Roma IV kriterlerini karşılamayan ve kronik hastalığı olmayan 11-17 yaş arası 23 çocuktan oluştu. Çinko, bakır seviyeleri ve yakın zamanda geliştirilen yeni nesil oksidan-antioksidan denge belirteçlerinin ölçümleri, ticari bir kit kullanılarak spektrofotometrik olarak yapıldı. Rutin ölçülen hemogram ve B12 ile D vitamini tetkik sonuçları, hasta dosyalarından retrospektif olarak alındı. Bulgular: Kontrol grubu ile karşılaştırıldığında, pediatrik FD grubunda anlamlı biçimde daha yüksek seviyelerde okside tiyol, iskemi modifiye albumin, nötrofil ve nötrofil/lenfosit, anlamlı biçimde daha düşük lenfosit sayısı ve azalmış tiyol oranı ve önemli ölçüde daha düşük D vitamini, doğal tiyol ve bakır seviyeleri bulundu. Sonuç: FD, potansiyel olarak inflamasyon, serum bakır içeriği ve oksidatif stres ile ilişkilidir. Ancak çocuklarda FD ile inflamasyon, bakır seviyeleri ve oksidatif stres arasındaki ilişki yeterince araştırılmamıştır. Bu klinik çalışmanın bir sonucu olarak tiyol dengesi, modifiye edilmiş albumin, nötrofil/lenfosit oranı, D vitamini ve bakır içeriği, pediatrik FD'de tanı ve takip için muhtemelen gerekli olacaktır.
Anahtar Kelimeler: Dispepsi; çocuk; eser elementler; oksidatif stres; antioksidanlar
Amaç: Fonksiyonel dispepsi (FD), Roma IV kriterlerine göre çocuklar ve adölesanlar arasında en sık görülen fonksiyonel karın ağrısı bozukluğudur. Çalışmanın amacı, pediatrik FD'de oksidan ve antioksidan dengenin ve eser elementlerin olası etkisini belirlemektir. Gereç ve Yöntemler: Hasta grubu, Roma IV Pediatrik Gastrointestinal Bozukluklar Anketi'ne göre FD tanısı alan 23 çocuktan oluşturuldu. Kontrol grubu, Roma IV kriterlerini karşılamayan ve kronik hastalığı olmayan 11-17 yaş arası 23 çocuktan oluştu. Çinko, bakır seviyeleri ve yakın zamanda geliştirilen yeni nesil oksidan-antioksidan denge belirteçlerinin ölçümleri, ticari bir kit kullanılarak spektrofotometrik olarak yapıldı. Rutin ölçülen hemogram ve B12 ile D vitamini tetkik sonuçları, hasta dosyalarından retrospektif olarak alındı. Bulgular: Kontrol grubu ile karşılaştırıldığında, pediatrik FD grubunda anlamlı biçimde daha yüksek seviyelerde okside tiyol, iskemi modifiye albumin, nötrofil ve nötrofil/lenfosit, anlamlı biçimde daha düşük lenfosit sayısı ve azalmış tiyol oranı ve önemli ölçüde daha düşük D vitamini, doğal tiyol ve bakır seviyeleri bulundu. Sonuç: FD, potansiyel olarak inflamasyon, serum bakır içeriği ve oksidatif stres ile ilişkilidir. Ancak çocuklarda FD ile inflamasyon, bakır seviyeleri ve oksidatif stres arasındaki ilişki yeterince araştırılmamıştır. Bu klinik çalışmanın bir sonucu olarak tiyol dengesi, modifiye edilmiş albumin, nötrofil/lenfosit oranı, D vitamini ve bakır içeriği, pediatrik FD'de tanı ve takip için muhtemelen gerekli olacaktır.
Anahtar Kelimeler: Dispepsi; çocuk; eser elementler; oksidatif stres; antioksidanlar
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