.: ORİJİNAL ARAŞTIRMA
Optical Coherence Tomography Angiography Findings in Obese Women
Obez Kadınlarda Optik Koherens Tomografi Bulguları
Turkiye Klinikleri J Ophthalmol. 2020;29(3):218-23
doi: 10.5336/ophthal.2019-72059
Makale Dili: EN
Tam Metin
ABSTRACT
Objective: Microvascular changes accompanying obesity can result in various complications in many organs. The aim of this study is to investigate the retinal microvascular changes in obese women by using optical coherence tomography angiography (OCTA), which has become increasingly common in recent years. Material and Methods: The study included a total of 61 female volunteers, 30 were obese volunteers with a body mass index (BMI) of over 30 kg/m² with no accompanying systemic disease and 31 were non-obese volunteers. Results of OCT and OCTA examinations of the participants' both eyes were compared. Results: The mean age of the participants was 42.7 ± 10 years in the obese group and 41.36 ± 10.73 in the non-obese group (p=0.615). In the obese group, OCTA examinations revealed that retinal vessel density (VD) in superficial capillary plexus and deep capillary plexus was found to be lower in both eyes, compared to those of non-obese group (p<0.05 for all). There was no significant difference between the two groups in terms of foveal avascular zone (FAZ) measurements. Similarly, no significant difference was observed between the two groups in terms of peripapillary retinal nerve fiber layer thickness, central macular thickness, and central macular volume measurements. Conclusion: It was observed in the OCTA examinations that superficial and deep retinal layer VD is lower in obese women and the FAZ measurements are not affected. optical coherence tomography angiograph method was found to be beneficial in revealing the changes occurred in microvascular structures accompanying obesity.
Keywords: Obesity; retina; optical coherence tomography angiography
Objective: Microvascular changes accompanying obesity can result in various complications in many organs. The aim of this study is to investigate the retinal microvascular changes in obese women by using optical coherence tomography angiography (OCTA), which has become increasingly common in recent years. Material and Methods: The study included a total of 61 female volunteers, 30 were obese volunteers with a body mass index (BMI) of over 30 kg/m² with no accompanying systemic disease and 31 were non-obese volunteers. Results of OCT and OCTA examinations of the participants' both eyes were compared. Results: The mean age of the participants was 42.7 ± 10 years in the obese group and 41.36 ± 10.73 in the non-obese group (p=0.615). In the obese group, OCTA examinations revealed that retinal vessel density (VD) in superficial capillary plexus and deep capillary plexus was found to be lower in both eyes, compared to those of non-obese group (p<0.05 for all). There was no significant difference between the two groups in terms of foveal avascular zone (FAZ) measurements. Similarly, no significant difference was observed between the two groups in terms of peripapillary retinal nerve fiber layer thickness, central macular thickness, and central macular volume measurements. Conclusion: It was observed in the OCTA examinations that superficial and deep retinal layer VD is lower in obese women and the FAZ measurements are not affected. optical coherence tomography angiograph method was found to be beneficial in revealing the changes occurred in microvascular structures accompanying obesity.
Keywords: Obesity; retina; optical coherence tomography angiography
ÖZET
Amaç: Obeziteye eşlik eden mikrovasküler değişiklikler birçok organda çeşitli komplikasyonlara sebep olabilmektedir. Bu çalışmanın amacı kullanımı son senelerde giderek yaygınlaşan optik koherens tomografi anjiografi (OKTA) cihazı eşliğinde obez kadınlarda ortaya çıkan retinal mikrovasküler değişiklikleri araştırmaktı. Gereç ve Yöntemler: Eşlik eden herhangi bir sistemik rahatsızlığı bulunmayan, beden kitle indeksi (BKİ) değeri > 30 kg/m² olan 30 obez ile obez olmayan 31 kadın gönüllü çalışmaya dahil edildi. Katılımcıların her iki gözlerine ait OKT ve OKTA incelemeleri karşılaştırıldı. Bulgular: Katılımcıların yaş ortalamaları obez grupta 42.7±10, obez olmayan grupta 41,36±10,73 yıl idi (p=0,615). OKTA incelemelerinde yüzeyel ve derin kapiller pleksusta retina damar dansitesinin obez kadınların her iki gözlerinde de obez olmayan kadınlara göre daha düşük olduğu görüldü (hepsi için p<0,05). Foveal avasküler zon (FAZ) ölçümleri açısından ise her iki grup arasında anlamlı bir farklılık yoktu. Yine iki grup arasında retina sinir lifi tabakası kalınlığı, santral makular kalınlık, santral makular hacim ölçümleri açısından da anlamlı bir farklılık mevcut değildi. Sonuç: OKTA incelemesinde obez kadınlardaki yüzeyel ve derin tabakada yer alan retina damar dansitesinin daha düşük olduğu, FAZ ölçümlerinin ise etkilenmediği saptanmıştır. Obeziteye eşlik eden mikrovasküler yapılardaki değişiklikleri ortaya koymada OKTA başarılı bulunmuştur.
Anahtar Kelimeler: Obezite; retina; optik koherens tomografi anjiografi
Amaç: Obeziteye eşlik eden mikrovasküler değişiklikler birçok organda çeşitli komplikasyonlara sebep olabilmektedir. Bu çalışmanın amacı kullanımı son senelerde giderek yaygınlaşan optik koherens tomografi anjiografi (OKTA) cihazı eşliğinde obez kadınlarda ortaya çıkan retinal mikrovasküler değişiklikleri araştırmaktı. Gereç ve Yöntemler: Eşlik eden herhangi bir sistemik rahatsızlığı bulunmayan, beden kitle indeksi (BKİ) değeri > 30 kg/m² olan 30 obez ile obez olmayan 31 kadın gönüllü çalışmaya dahil edildi. Katılımcıların her iki gözlerine ait OKT ve OKTA incelemeleri karşılaştırıldı. Bulgular: Katılımcıların yaş ortalamaları obez grupta 42.7±10, obez olmayan grupta 41,36±10,73 yıl idi (p=0,615). OKTA incelemelerinde yüzeyel ve derin kapiller pleksusta retina damar dansitesinin obez kadınların her iki gözlerinde de obez olmayan kadınlara göre daha düşük olduğu görüldü (hepsi için p<0,05). Foveal avasküler zon (FAZ) ölçümleri açısından ise her iki grup arasında anlamlı bir farklılık yoktu. Yine iki grup arasında retina sinir lifi tabakası kalınlığı, santral makular kalınlık, santral makular hacim ölçümleri açısından da anlamlı bir farklılık mevcut değildi. Sonuç: OKTA incelemesinde obez kadınlardaki yüzeyel ve derin tabakada yer alan retina damar dansitesinin daha düşük olduğu, FAZ ölçümlerinin ise etkilenmediği saptanmıştır. Obeziteye eşlik eden mikrovasküler yapılardaki değişiklikleri ortaya koymada OKTA başarılı bulunmuştur.
Anahtar Kelimeler: Obezite; retina; optik koherens tomografi anjiografi
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