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Obezite ile İlgili Güncel İki Hormon: Nesfatin-1 ve Omentin-1
Two Current Hormones Related to Obesity: Nesfatin-1 and Omentin-1
Turkiye Klinikleri J Health Sci. 2019;4(1):57-61
doi: 10.5336/healthsci.2018-59989
Makale Dili: TR
Tam Metin
ÖZET
Hipotalamus, gastrointestinal sistemden, adipoz dokudan ve serebral korteksten (görme, tat, koku) aldığı sinyallerle beslenme davranışını ve iştahı düzenlemektedir. Nesfatin-1, hipotalamustan salgılanan ve tokluk peptidi olarak bilinen nükleobindin 2'den sentezlenen, iştah mekanizması ile beslenme durumu üzerine etkileri bulunan bir nörohormondur. İştah kontrolünde etkisi bulunan bir diğer mekanizma ise günümüzde enerji metabolizmasının önemli bir parçası olarak kabul edilen, endokrin bir organ gibi görev yapan, salgıladığı adipokinlerle iştah, enerji dengesi, insülin, glukoz ve lipit metabolizması, kan basıncının düzenlenmesi ve inflamasyon gibi vücudun birçok fizyolojik döngüsünde rol oynayan "adipoz doku"dur. Viseral adipoz dokudan salgılanan adipositokinlerden biri olan omentin-1, enerji homeostazında önemli rollere sahiptir. Bunun yanı sıra; antiinflamatuar, antiaterojenik, antikardiyovasküler, antidiyabetik ve obeziteyle ilişkili metabolik sendroma karşı koruyucu etkileri bulunmaktadır. Yeni keşfedilen bu iki hormon, obezite veya obezite ilişkili metabolik sonuçları ile obeziteye eşlik eden hastalıkların erken tanısında ajan olarak kullanılabilir.
Anahtar Kelimeler: Obezite; adipokinler; nükleobindin; ITLN-1 protein insan
Hipotalamus, gastrointestinal sistemden, adipoz dokudan ve serebral korteksten (görme, tat, koku) aldığı sinyallerle beslenme davranışını ve iştahı düzenlemektedir. Nesfatin-1, hipotalamustan salgılanan ve tokluk peptidi olarak bilinen nükleobindin 2'den sentezlenen, iştah mekanizması ile beslenme durumu üzerine etkileri bulunan bir nörohormondur. İştah kontrolünde etkisi bulunan bir diğer mekanizma ise günümüzde enerji metabolizmasının önemli bir parçası olarak kabul edilen, endokrin bir organ gibi görev yapan, salgıladığı adipokinlerle iştah, enerji dengesi, insülin, glukoz ve lipit metabolizması, kan basıncının düzenlenmesi ve inflamasyon gibi vücudun birçok fizyolojik döngüsünde rol oynayan "adipoz doku"dur. Viseral adipoz dokudan salgılanan adipositokinlerden biri olan omentin-1, enerji homeostazında önemli rollere sahiptir. Bunun yanı sıra; antiinflamatuar, antiaterojenik, antikardiyovasküler, antidiyabetik ve obeziteyle ilişkili metabolik sendroma karşı koruyucu etkileri bulunmaktadır. Yeni keşfedilen bu iki hormon, obezite veya obezite ilişkili metabolik sonuçları ile obeziteye eşlik eden hastalıkların erken tanısında ajan olarak kullanılabilir.
Anahtar Kelimeler: Obezite; adipokinler; nükleobindin; ITLN-1 protein insan
ABSTRACT
Hypothalamus, the gastrointestinal tract, adipose tissue and the cerebral cortex (seeing, taste, smell) regulates feeding behavior with the signal received. Nesfatin-1, known as nucleobindin 2 toughness peptide synthesized, appetite than the effects of the mechanism and nutritional status is a neurohormon. One of the mechanisms, which functions as an endocrine organ, accepted as an important part of energy metabolism in today's world, is adipose tissue that, by secreting adipokine, has an important role on many physiological cycle of body such as appetite, energy expenditure, insulin, glucose, lipid metabolism and inflammation. Visceral adipose tissue is one of adipocytokines secreted omentin-1, has an important role in energy homeostasis. In addition, antiinflammatory, anti-atherogenic, anti-cardiovascular, anti-diabetic, and obesity is associated with protection against effects of metabolic syndrome. Newly discovered serum levels of these two molecules obesity or obesity-related metabolic diseases early diagnosis results and obesity can be used as an accompanying agent.
Keywords: Obesity; adipokines; nucleobindin; ITLN-1 protein human
Hypothalamus, the gastrointestinal tract, adipose tissue and the cerebral cortex (seeing, taste, smell) regulates feeding behavior with the signal received. Nesfatin-1, known as nucleobindin 2 toughness peptide synthesized, appetite than the effects of the mechanism and nutritional status is a neurohormon. One of the mechanisms, which functions as an endocrine organ, accepted as an important part of energy metabolism in today's world, is adipose tissue that, by secreting adipokine, has an important role on many physiological cycle of body such as appetite, energy expenditure, insulin, glucose, lipid metabolism and inflammation. Visceral adipose tissue is one of adipocytokines secreted omentin-1, has an important role in energy homeostasis. In addition, antiinflammatory, anti-atherogenic, anti-cardiovascular, anti-diabetic, and obesity is associated with protection against effects of metabolic syndrome. Newly discovered serum levels of these two molecules obesity or obesity-related metabolic diseases early diagnosis results and obesity can be used as an accompanying agent.
Keywords: Obesity; adipokines; nucleobindin; ITLN-1 protein human
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