.: ORİJİNAL ARAŞTIRMA
Is Gastroesophageal Reflux Disease a Common Complication in Infants with Congenital Heart Disease?
Konjenital Kalp Hastalığı Olan Bebeklerde Gastroözofageal Reflü Hastalığı Yaygın Bir Komplikasyon mudur?
Turkiye Klinikleri J Pediatr. 2019;28(1):19-27
doi: 10.5336/pediatr.2018-63316
Makale Dili: EN
Tam Metin
Ücretsiz Erişim
ABSTRACT
Objective: Gastroesophageal reflux disease (GERD) is believed to be one of the most common complications of congenital heart disease (CHD) in infants though the exact prevalence is not known. In this study, we aimed to investigate GERD symptoms in infants with CHD. Material and Methods: Infant Gastroesophageal Reflux Questionnaire Revised was applied twice for 109 infants with CHD and 81 healthy infants, both with a median age of 5 months, two months apart and data were analyzed. Results: Mean reflux score was 4.81±0.56 (0-23)and 5.1±5.71 (0-24) in the CHD and control groups, respectively (p=0.62). According to ROC curve analysis, we considered a score of 7 (95% CI=53%-76.6%) as being a cut-off value for GERD. Thirteen infants, 7 with CHD (6.42%) and 6 healthy infants (7.40%) had reflux score≥16 (p==0.79). Conclusion: GERD is not more common in CHD than in healthy babies. As the only difference in terms of individual symptom prevalence is in apnea and cyanosis, symptoms of CHD as well, it was concluded that there is a need for more objective methods and new questionnaires to be used for infants with CHD.
Keywords: Congenital heart disease; gastroesophageal reflux disease; infant, survey
Objective: Gastroesophageal reflux disease (GERD) is believed to be one of the most common complications of congenital heart disease (CHD) in infants though the exact prevalence is not known. In this study, we aimed to investigate GERD symptoms in infants with CHD. Material and Methods: Infant Gastroesophageal Reflux Questionnaire Revised was applied twice for 109 infants with CHD and 81 healthy infants, both with a median age of 5 months, two months apart and data were analyzed. Results: Mean reflux score was 4.81±0.56 (0-23)and 5.1±5.71 (0-24) in the CHD and control groups, respectively (p=0.62). According to ROC curve analysis, we considered a score of 7 (95% CI=53%-76.6%) as being a cut-off value for GERD. Thirteen infants, 7 with CHD (6.42%) and 6 healthy infants (7.40%) had reflux score≥16 (p==0.79). Conclusion: GERD is not more common in CHD than in healthy babies. As the only difference in terms of individual symptom prevalence is in apnea and cyanosis, symptoms of CHD as well, it was concluded that there is a need for more objective methods and new questionnaires to be used for infants with CHD.
Keywords: Congenital heart disease; gastroesophageal reflux disease; infant, survey
ÖZET
Amaç: Gastroözofageal reflü hastalığı (GÖRH), doğuştan kalp hastalığı olan bebeklerde en sık görülen komplikasyonlarından biri olduğuna inanılmakta olup, kesin prevalansı bilinmemektedir. Bu çalışmada, konjenital kalp hastalığı (KKH) olan bebeklerde GÖRH semptomlarını araştırmayı amaçladık. Gereç ve Yöntemler: Düzeltilmiş Gastroözofageal Reflü Anketi KKH olan 109 hasta ile 81 sağlıklı bebek üzerinde iki ay arayla uygulandı. Her bir sorunun cevabı hem KKH olan (siyanotik ve asiyanotik) hem de sağlıklı gruplarda karşılaştırıldı. Her iki grubun medyan yaşı 5 ay olarak saptandı. Bulgular: Ortalama reflü skoru, KKH ve kontrol grubunda sırasıyla 4,81±0,56 (0-23) ve 5,1±5,71 (0-24) idi (p=0,62). ROC analizine göre, GÖRH için cut-off değerini 7 olarak (%95 CI=%53-%76,6) kabul ettik. Yedisi KKH (%6,42) ve altısı sağlıklı olmak üzere toplam 13 bebekte (%7,40) reflü skoru ≥16 (p==0,79) idi. Sonuç: GÖRH, sağlıklı olan bebeklere göre KKH olanlarda daha yaygın değildir. Semptomların prevalansı açısından tek fark, KKH'nin da semptomları olan apne ve siyanoz olarak bulunmuştur. KKH'lı bebeklerde GÖRH açısından daha objektif yöntemlere ve yeni anketlere ihtiyaç olduğu sonucuna varılmıştır.
Anahtar Kelimeler: Konjenital kalp hastalığı; gastroözofageal reflü hastalığı; bebek, anket
Amaç: Gastroözofageal reflü hastalığı (GÖRH), doğuştan kalp hastalığı olan bebeklerde en sık görülen komplikasyonlarından biri olduğuna inanılmakta olup, kesin prevalansı bilinmemektedir. Bu çalışmada, konjenital kalp hastalığı (KKH) olan bebeklerde GÖRH semptomlarını araştırmayı amaçladık. Gereç ve Yöntemler: Düzeltilmiş Gastroözofageal Reflü Anketi KKH olan 109 hasta ile 81 sağlıklı bebek üzerinde iki ay arayla uygulandı. Her bir sorunun cevabı hem KKH olan (siyanotik ve asiyanotik) hem de sağlıklı gruplarda karşılaştırıldı. Her iki grubun medyan yaşı 5 ay olarak saptandı. Bulgular: Ortalama reflü skoru, KKH ve kontrol grubunda sırasıyla 4,81±0,56 (0-23) ve 5,1±5,71 (0-24) idi (p=0,62). ROC analizine göre, GÖRH için cut-off değerini 7 olarak (%95 CI=%53-%76,6) kabul ettik. Yedisi KKH (%6,42) ve altısı sağlıklı olmak üzere toplam 13 bebekte (%7,40) reflü skoru ≥16 (p==0,79) idi. Sonuç: GÖRH, sağlıklı olan bebeklere göre KKH olanlarda daha yaygın değildir. Semptomların prevalansı açısından tek fark, KKH'nin da semptomları olan apne ve siyanoz olarak bulunmuştur. KKH'lı bebeklerde GÖRH açısından daha objektif yöntemlere ve yeni anketlere ihtiyaç olduğu sonucuna varılmıştır.
Anahtar Kelimeler: Konjenital kalp hastalığı; gastroözofageal reflü hastalığı; bebek, anket
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