Objective: The present study aims to examine investigation the -actinin-3 (ACTN3) gene polymorphism (rs1815739) and functional movement screen (FMS) values in young runners competing at the national level. Material and Methods: Forty-five young runners (29 male 64.4%, 16 female 35.6%) competing at the national level in different clubs affiliated to the Turkish Athletic Federation and training regularly at least 5 days a week voluntarily participated in the study. The DNA isolation of oral swab samples was carried out using the spin column (MN Macherey-Nagel, Germany) method. The genotyping process was performed using the real-time polymerase chain reaction method. Results: The FMS test battery was used to determine the functional capacity. According to the findings obtained, it was determined that in the FMS evaluation of the female runners, the runners with the CC genotype had a significantly higher mean score compared to the runners with the CT genotype (p0.205). Conclusion: It is thought that the FMS test battery and the ACTN3 gene polymorphism, which is among the important variables responsible for non-impact injuries, can be effective in the level of muscle damage, the type of muscle injury, the prediction of injuries and reducing the risk factors that may cause injuries.
Keywords: Athletic performance; FMS; runners; risk of injury; polymorphism rs1815739
Amaç: Sunulan çalışma, ulusal düzeyde yarışan genç koşucularda -aktinin-3 [-actinin-3 (ACTN3)] gen polimorfizmi (rs1815739) ve fonksiyonel hareket analizi [functional movement screen (FMS)] değerlerini incelemeyi amaçlamaktadır. Gereç ve Yöntemler: Araştırmaya, Türkiye Atletizm Federasyonuna bağlı farklı kulüplerde lisanslı olarak ulusal düzeyde yarışan, haftada en az 5 gün düzenli antrenman yapan 45 genç koşucu (29'u erkek %64,4, 16'sı kadın %35,6) gönüllü olarak katılmıştır. Ağız sürüntü örneklerinin DNA izolasyonu spin kolon (MN Macherey-Nagel, Almanya) yöntemi ile gerçekleştirilmiştir. Genotipleme işlemi gerçek zamanlı polimeraz zincir reaksiyonu metodu ile gerçekleştirilmiştir. Fonksiyonel kapasitenin belirlenmesi için FMS test bataryası kullanılmıştır. Bulgular: Elde edilen bulgulara göre kadın koşucuların FMS değerlendirmesinde, CC genotipe sahip koşucuların ortalama puanının CT genotipe sahip koşuculardan (p0,205). Sonuç: Darbelere bağlı olmayan yaralanmalardan sorumlu önemli değişkenlerden ACTN3 gen polimorfizmi ve FMS test bataryasının, koşucularda kas hasarı düzeyine, kas yaralanma tipine, yaralanmaların önceden tahmin edilmesine ve yaralanmalara neden olabilecek risk faktörlerinin azaltılmasına etkili olacağı düşünülmektedir.
Anahtar Kelimeler: Atletik performans; FMS; koşucular; yaralanma riski; polimorfizmi rs1815739
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