.: ORİJİNAL ARAŞTIRMA
Evaluation of the Association Between Acute-to-Chronic Glycemic Ratio and Erectile Dysfunction in Diabetic Men: A Retrospective Case-Control Study Diabetes
Mellituslu Erkek Hastalarda Akut-Kronik Glisemik Oran ile Erektil Disfonksiyon Arasındaki İlişkinin Değerlendirilmesi: Retrospektif, Olgu-Kontrol Çalışması
J Reconstr Urol. 2021;11(1):23-8
doi: 10.5336/urology.2021-81576
Makale Dili: EN
Tam Metin
ABSTRACT
Objective: The aim of this study was to investigate the possible association between the acute to chronic (A/C) glycemic ratio and the presence of erectile dysfunction (ED) in diabetic men. Material and Methods: A total of 104 diabetic men, 45 of whom had ED while 59 did not, were retrospectively enrolled in this study. Clinical examination and laboratory analyses including A/C glycemic ratio, serum fasting glucose, hemoglobin A1c, lipid profile, and total testosterone were analyzed. Results: The total testosterone levels were lower in the diabetic ED patients compared to the non-ED diabetic participants (4.49 ng/dL vs 4.80 ng/dL, respectively). However, the difference was not statistically significant (p=0.093). Mean high-density lipoprotein cholesterol levels were significantly lower in the diabetic ED patients than in the controls (40±9 mg/dL vs 44±10 mg/dL; respectively; p=0.030). Although the median A/C glycemic ratios were higher in the diabetic ED patients (1.28±0.23 vs. 1.18±0.32), no statistical significant differences were noted between the two groups (p=0.054) Conclusion: The strong relationship between diabetes mellitus (DM) and ED demands caution since DM is a common disease in the population. We believe that developing biomarkers for the early diagnosis of ED will help provide treatment and improve the life quality of patients. Although we could not find a statistical relationship between the A/C glycemic ratio and ED in our study results, we think that further welldesigned prospective studies are needed in this area.
Keywords: Acute to chronic glycemic ratio; diabetes mellitus; erectile dysfunction
Objective: The aim of this study was to investigate the possible association between the acute to chronic (A/C) glycemic ratio and the presence of erectile dysfunction (ED) in diabetic men. Material and Methods: A total of 104 diabetic men, 45 of whom had ED while 59 did not, were retrospectively enrolled in this study. Clinical examination and laboratory analyses including A/C glycemic ratio, serum fasting glucose, hemoglobin A1c, lipid profile, and total testosterone were analyzed. Results: The total testosterone levels were lower in the diabetic ED patients compared to the non-ED diabetic participants (4.49 ng/dL vs 4.80 ng/dL, respectively). However, the difference was not statistically significant (p=0.093). Mean high-density lipoprotein cholesterol levels were significantly lower in the diabetic ED patients than in the controls (40±9 mg/dL vs 44±10 mg/dL; respectively; p=0.030). Although the median A/C glycemic ratios were higher in the diabetic ED patients (1.28±0.23 vs. 1.18±0.32), no statistical significant differences were noted between the two groups (p=0.054) Conclusion: The strong relationship between diabetes mellitus (DM) and ED demands caution since DM is a common disease in the population. We believe that developing biomarkers for the early diagnosis of ED will help provide treatment and improve the life quality of patients. Although we could not find a statistical relationship between the A/C glycemic ratio and ED in our study results, we think that further welldesigned prospective studies are needed in this area.
Keywords: Acute to chronic glycemic ratio; diabetes mellitus; erectile dysfunction
ÖZET
Amaç: Bu çalışmanın amacı, diyabetik erkeklerde akut-kronik (A/K) glisemik oran ile erektil disfonksiyon (ED) arasındaki muhtemel ilişkiyi araştırmaktır. Gereç ve Yöntemler: Kırk beşinde ED olan 59'unda olmayan toplam 104 diyabetik erkek retrospektif olarak çalışmaya dâhil edildi. Klinik muayeneleri ve A/K glisemik oranı, serum açlık glukoz, hemoglobin A1c, lipid profili ve total testosteron düzeyleri dâhil olmak üzere laboratuvar bulguları incelendi. Bulgular: Total testosteron düzeyleri diyabetik ED hastalarında ED olmayan diyabetik katılımcılara göre daha düşüktü (4,49 ng/dL vs 4,80 ng/dL, sırasıyla) ancak bu fark istatistiksel olarak anlamlı değildi (p=0,093). Ortalama yüksek-yoğunluklu lipoprotein kolesterol düzeyleri diyabetik ED hastalarında kontrollere göre anlamlı olarak daha düşüktü (40±9 mg/dL vs 44±10 mg/dL; sırasıyla; p=0,030). Ortanca A/K glisemik oranları ED hastalarında daha yüksek olsa da (1,28±0,23 vs. 1,18±0,32), 2 grup arasında istatistiksel anlamlı farklılık izlenmedi (p=0,054). Sonuç: Diabetes mellitus (DM) ve ED arasındaki güçlü bir bağ bulunması ve DM'nin toplumda sık bir hastalık olması sebebiyle bu ilişkiye dikkat edilmelidir. ED'nin erken tanısı için biyobelirteçler geliştirmenin tedavide ve hastaların yaşam kalitesini artırmada yardımcı olacağına inanıyoruz. Çalışma sonuçlarımızda, A/K glisemik oranı ve ED arasında istatistiksel anlamlı ilişki bulamasak da bu konuda gelecekte iyi tasarlanmış prospektif çalışmalara ihtiyaç duyulduğu düşüncesindeyiz.
Anahtar Kelimeler: Akut-kronik glisemik oran; diyabetes mellitus; erektil disfonksiyon
Amaç: Bu çalışmanın amacı, diyabetik erkeklerde akut-kronik (A/K) glisemik oran ile erektil disfonksiyon (ED) arasındaki muhtemel ilişkiyi araştırmaktır. Gereç ve Yöntemler: Kırk beşinde ED olan 59'unda olmayan toplam 104 diyabetik erkek retrospektif olarak çalışmaya dâhil edildi. Klinik muayeneleri ve A/K glisemik oranı, serum açlık glukoz, hemoglobin A1c, lipid profili ve total testosteron düzeyleri dâhil olmak üzere laboratuvar bulguları incelendi. Bulgular: Total testosteron düzeyleri diyabetik ED hastalarında ED olmayan diyabetik katılımcılara göre daha düşüktü (4,49 ng/dL vs 4,80 ng/dL, sırasıyla) ancak bu fark istatistiksel olarak anlamlı değildi (p=0,093). Ortalama yüksek-yoğunluklu lipoprotein kolesterol düzeyleri diyabetik ED hastalarında kontrollere göre anlamlı olarak daha düşüktü (40±9 mg/dL vs 44±10 mg/dL; sırasıyla; p=0,030). Ortanca A/K glisemik oranları ED hastalarında daha yüksek olsa da (1,28±0,23 vs. 1,18±0,32), 2 grup arasında istatistiksel anlamlı farklılık izlenmedi (p=0,054). Sonuç: Diabetes mellitus (DM) ve ED arasındaki güçlü bir bağ bulunması ve DM'nin toplumda sık bir hastalık olması sebebiyle bu ilişkiye dikkat edilmelidir. ED'nin erken tanısı için biyobelirteçler geliştirmenin tedavide ve hastaların yaşam kalitesini artırmada yardımcı olacağına inanıyoruz. Çalışma sonuçlarımızda, A/K glisemik oranı ve ED arasında istatistiksel anlamlı ilişki bulamasak da bu konuda gelecekte iyi tasarlanmış prospektif çalışmalara ihtiyaç duyulduğu düşüncesindeyiz.
Anahtar Kelimeler: Akut-kronik glisemik oran; diyabetes mellitus; erektil disfonksiyon
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